Fabrication of conductive electrospun silk fibroin scaffolds by coating with polypyrrole for biomedical applications

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• 作者：Salvador Aznar-Cervantes^a ; Maria I. Roca^b ; Jose G. Martinez^b ; Luis Meseguer-Olmo^c ; Jose L. Cenis^a ; Jose M. Moraleda^c ; Toribio F. Otero^b ; ^{toribio.fotero@upct.es}
• 关键词：Fibroin-polypyrrole meshes ; Electroactivity ; Anion storage ; Human fibroblast ; Adult human mesenchymal stem cells
• 刊名：Bioelectrochemistry
• 出版年：2012
• 期刊代码：7_15675394
• 类别：ch
• 出版时间：June, 2012
• 卷：85
• 期：Complete
• 页码：36-43
• 文件大小：1070 K

摘要

Scaffolds constituted by micro and nanofibers of silk fibroin were obtained by electrospinning. Fibers of fibroin meshes were coated with polypyrrole (pPy) by chemical polymerization; chemical linkages between polymers were observed by SEM and IR spectroscopy. Mechanical resistance of the meshes was improved by polypyrrole coating. Furthermore, coated meshes present a high electroactivity allowing anion storage and delivery during oxidation/reduction reactions in aqueous solutions. Uncoated and pPy coated materials support the adherence and proliferation of adult human mesenchymal stem cells (ahMSCs) or human fibroblasts (hFb). The bioactivity of fibroin mesh overcomes that of the polypyrrole coated meshes.