Polymorphisms of interleukin-1 and interleukin-6 genes on the risk of ischemic stroke in a meta-analysis

详细信息	查看全文 | 推荐本文 |

• 作者：Fei Ye^a ; ^c ; Xiao-Qing Jin^b ; Guang-Hui Chen^a ; Xiao-Ling Den^a ; Yong-Qiang Zheng^a ; Cheng-Yan Li^c ; ^{lcy_doctor@126.com}
• 关键词：IS ; ischemic stroke ; HS ; hemorrhagic stroke ; OR ; odds ratio ; 95%CI ; 95%confidence interval ; IL-6 ; interleukin-6 ; TNF-伪 ; tumor necrosis factor-伪 ; IL-1 ; interleukin-1 ; IL1-Ra ; IL-1 receptor antagonist ; IL1-Ra ; IL-1 receptor antagonist ; HWE ; Hardy&ndash
• 刊名：Gene
• 出版年：2012
• 期刊代码：73_03781119
• 类别：bio
• 出版时间：10 May, 2012
• 卷：499
• 期：1
• 页码：61-69
• 文件大小：769 K

摘要

Many epidemiological studies have investigated the associations between polymorphisms of interleukin-1 (IL1) and interleukin-6 (IL6) genes and risk of ischemic stroke (IS), but no conclusions are available because of conflicting results. The aim of this study was to assess the relationships by meta-analysis. The databases of Pubmed, Embase and Wangfang, updated to August 1st, 2011, were retrieved. Odds ratio (OR) and corresponding 95%confidence interval (95%CI) as effect size were calculated by a fixed- or random-effect model. In total, three case-control studies for IL1伪-889C/T, eight studies for IL1尾-511C/T, eight studies for IL1-Ra and seven studies for IL6-147G/C were included in this meta-analysis. Combined analysis indicated that IL1尾-511C/T polymorphism was not overall associated with risk of IS [OR (95%CI) = 1.22 (0.85-1.87) for TT vs. CC]. However, when subgroup analyses for countries were conducted, the results indicated that T allele was associated with increased risk of IS for Polish and associated with a trend of increased risk of IS for Chinese although it did not reach statistical significance [TT vs. CC: OR (95%CI) = 1.97 (1.22-3.17) for Polish and 1.40 (0.99-1.99) for Chinese]. In addition, overall and subgroup analyses indicated that IL1伪-889C/T, IL1-Ra and IL6-147G/C polymorphisms were also not associated with risk of IS [OR (95%CI) = 1.21 (0.86-1.70) for TT vs. CC of IL1伪-889C/T, 1.22 (0.85-1.75) for RN2/RN2 vs. RN1/RN1 for IL1-Ra and 1.09 (0.84-1.40) for G carriers vs. C carriers for IL6-147G/C]. This study inferred that IL1尾-511C/T polymorphism might be moderately associated with increased risk of IS, but no sufficient evidence was available to support any associations between IL1-Ra and IL6-147G/C polymorphisms and IS. We could not draw a conclusion between IL1伪-889C/T polymorphism and risk of IS based on the limited data, and further large sample-sized studies were required.