籽瓜浓缩汁的降血糖及降血脂活性研究
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摘要
通过建立高血糖高血脂小鼠模型,研究籽瓜浓缩汁的降血糖及降血脂活性。利用四氧嘧啶,链脲佐菌素建立高血糖高血脂小鼠模型,记录小鼠体重,分别测定高血糖小鼠模型的血糖值,糖耐量和高血脂小鼠模型的总胆固醇和甘油三酯含量,并研究对高血脂小鼠肝脏的影响。结果表明籽瓜浓缩汁对正常小鼠的血糖血脂无影响,与模型组相比,籽瓜浓缩汁中,低剂量组的降血糖及降血脂效果优于高剂量组,改善糖耐量,并降低高血脂小鼠的血脂水平,同时对肝脏细胞还具有一定的保护作用。
The hypoglycemic and hypolipidemic activities of seed watermelon juice concentrate were studied by establishing a model of hyperglycemia and hyperlipemia in mice. The model of hyperglycemia and hyperlipidemia was established by alloxan and streptozotocin. The body weight of the hyperglycemia mice model was recorded,both the blood glucose level and glucose tolerance were measured;at the same time,the total cholesterol and triglyceride content of hyperlipemia mice model were determined respectively. The effects on the liver of hyperlipidemic mice were also studied.The results showed that the watermelon juice concentrate had no effect on blood glucose and blood lipids in normal mice. Compared with the model group,the hypoglycemic and hypolipidemic effects of medium-dose and low-dose groups were better than high-dose group,improving glucose tolerance and reducing hyperlipidemia lipid levels in mice,in the meantime it has certain protective effect on liver cells.
The hypoglycemic and hypolipidemic activities of seed watermelon juice concentrate were studied by establishing a model of hyperglycemia and hyperlipemia in mice. The model of hyperglycemia and hyperlipidemia was established by alloxan and streptozotocin. The body weight of the hyperglycemia mice model was recorded,both the blood glucose level and glucose tolerance were measured;at the same time,the total cholesterol and triglyceride content of hyperlipemia mice model were determined respectively. The effects on the liver of hyperlipidemic mice were also studied.The results showed that the watermelon juice concentrate had no effect on blood glucose and blood lipids in normal mice. Compared with the model group,the hypoglycemic and hypolipidemic effects of medium-dose and low-dose groups were better than high-dose group,improving glucose tolerance and reducing hyperlipidemia lipid levels in mice,in the meantime it has certain protective effect on liver cells.
引文
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[2]李倩楠,田丽萍,王金辉,等.籽瓜汁化学成分的分离与鉴定[J].中国实验方剂学杂志,2016,22(1):44-47
[3]苟兴能,张克英,勾宗蓉,等.川麦冬多糖对四氧嘧啶糖尿病小鼠的降血糖作用的实验研究[J].食品工业科技,2012(13):359-360,391
[4]王瑞坡,王珂,李姣,等.桑椹乙酸乙酯萃取物对链脲佐菌素致高血糖大鼠的降血糖作用[J].中成药,2011,33(10):1668-1672
[5]许继艳,胡哲,高燕,等.山茱萸提取物对糖尿病小鼠降血糖作用的研究[J].时珍国医国药,2014(10):2386-2388
[6]侯小涛,邓家刚,李爱媛,等.甘蔗叶不同提取物对3种糖尿病模型的降血糖作用[J].华西药学杂志,2011,26(5):451-453
[7]胡文兵,赵静,陈婷婷,等.青钱柳多糖对高脂血症小鼠的降血脂作用及机制初探[J].现代食品科技,2015,31(11):39-44
[8]王欣,李游,桂辛蕊,等.二肽基肽酶-4及其抑制剂的研究进展[J].中国药学杂志,2013(21):1789-1796
[9]李铁海,郭利娜,李中华,等.O-Glc NAcase抑制剂[J].化学进展,2011(8):1657-1664
[10]万惠新,沈竞康.2型糖尿病治疗靶点钠-葡萄糖共转运蛋白2抑制剂研究进展[J].药学学报,2012(6):716-724
[11]杨少波,张其安,王娟.降血糖天然食品资源及其降血糖机理研究进展[J].食品研究与开发,2012,33(4):211-215
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