血脂异常危险因素的研究进展
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摘要
血脂异常不仅是动脉粥样硬化性心血管疾病的独立危险因素,而且随着年龄增加其导致冠状动脉粥样硬化性心血管疾病发病风险增加。国内外有大量关于血脂异常相关危险因素的文献报道。本文对各种危险因素按照不可干预的危险因素如年龄增加、性别、遗传因素等,和可干预的危险因素如吸烟、饮酒、不良生活方式、高血压、糖尿病、心理健康状况等做简要的综述。为血脂异常的预防和治疗以及人群的宣传教育提供依据。
Dyslipidemia is not only an independent risk factor for atherosclerotic cardiovascular disease, but also increases the risk of coronary atherosclerotic cardiovascular disease with the increase of age. There are a large number of literature reports on risk factors related to dyslipidemia at home and abroad. This article summarizes the risk factors that could not be intervened, such as age, gender, genetic factors, etc. and risk factors that could be intervened, such as smoking, drinking, unhealthy lifestyles, high blood pressure, diabetes, mental health, etc. This paper provides the basis for prevention and treatment of dyslipidemia and publicity and education for the crowd.
Dyslipidemia is not only an independent risk factor for atherosclerotic cardiovascular disease, but also increases the risk of coronary atherosclerotic cardiovascular disease with the increase of age. There are a large number of literature reports on risk factors related to dyslipidemia at home and abroad. This article summarizes the risk factors that could not be intervened, such as age, gender, genetic factors, etc. and risk factors that could be intervened, such as smoking, drinking, unhealthy lifestyles, high blood pressure, diabetes, mental health, etc. This paper provides the basis for prevention and treatment of dyslipidemia and publicity and education for the crowd.
引文
[1]中国成人血脂异常防治指南修订联合委员会.中国成人血脂异常防治指南(2016年修订版)[J].中华心血管病杂志,2016,44(10):833-853.
[2]Abdel-Maksoud MF,Hokanson JE.The complex role of triglycerides in Cardiovascular disease[J].Semin Vasc Med,2002,2(3):325-333.
[3]Moran A,Gu D,Zhao D,et a1.Future cardiovascular disease in china:markov model and risk factor scenario proiections from the coronary heart disease policy model-China[J].Circ Cardiovasc Qual Outcomes,2010,3(3):243-252.
[4]丁文清,董虹孛,米杰.中国儿童青少年血脂异常流行现状Meta分析[J].中华流行病学杂志,2015,36(1):7l-77.
[5]韦爱青.年龄与血脂的关系及临床意义[J].医学理论与实践,2011,24(22):2688-2689.
[6]赖亚新,李晨嫣,滕晓春,等.辽宁省城乡成年居民血脂异常患病率及其危险因素分析[J].中国医科大学学报,2012,41(2):151-154.
[7]叶平.老年人降脂治疗的现状与思考[C].张家界.第六届南方长城心脏病学会议.2007:37-40.
[8]刘正淑,王小林.重庆地区中、老年人群血脂异常分布及其危险因素分析[J].重庆医科大学学报,2011,36(2):249-250.
[9]Cheung AP.Acute effects of estradiol and progesterone on insulin,lipids and lipoproteins in postmenopausal women:a pilot study[J].Maturitas,2000,35(1):45-50.
[10]Waters DD,Aldennan EL,HsiaJ,et al.Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atheroselerosis in postmenopausal women:a randomized eontrolled trial[J].JAMA,2002,288(19):2432-2440.
[11]Knoblauch H,Bauerfeind A,Toliat MR,et al.Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol[J].Human molecular genetics,2004,13(10):993-1004.
[12]于霞,谭晓华,杨磊.与高脂血症相关的易感基因多态性研究进展[J].健康研究,2011,31(2):141-144.
[13]何美霞,张明明,刘琼,等.白细胞介素-6基因多态性与高脂血症的相关性[J].中国老年学杂志,2011,31(1):23-25.
[14]陈祯玥,陆国平.家族性高胆固醇血症究现状[J].国际心血管病杂志,2017,1(44):1-6.
[15]赵燕平,赵世刚.脑卒中危险因素研究进展[J].内蒙古医学院学报,2013,35(4):326-331.
[16]付奕,孙毅,董霞,等.吸烟对高校高级职称人群血脂水平的影响[J].中国老年学杂志,2014,34(19):5544-5546.
[17]潘成学.吸烟与中年男性冠心病患者的相关性研究[J].中国实用医药,2011,6(23):233-234.
[18]王洪礼,宁莉,门昆,等.老年高脂血症的临床诊断及其治疗进展[J].医学综述,2010,16(4):582-585.
[19]张智云,冯玉宝,苏平,等.内蒙古地区饮酒与男性初次急性心肌梗死的关系研究[J].中国综合临床,2014,30(12):1266-1270.
[20]范国辉,王增武,张林峰,等.吉林农村居民饮酒与血脂异常的关系研究[J].医学研究杂志,2015,44(1):28-32.
[21]叶有强,彭虹,郑芳.运动疗法对高脂血症转归的效果评价[J].中国医疗前沿,2013,(12):120-120,119.
[22]宋法明.有氧运动对中老年高血脂患者的血脂水平影响研究[J].现代预防医学,2011,38(11):2098-2099.
[23]何绍芳,李依潇,何琳惠.高脂血症非药物治疗研究概况[J].医学综述,2015,21(10):1794-1796.
[24]赵波.高脂血症患者有氧运动前后血脂分析[J].内蒙古中医药,2013,32(27):84.
[25]叶真,胡如英,沈玉华,等.静坐行为和时间与代谢综合征相关性研究[J].中华内分泌代谢杂志,2013,29(9):756-760.
[26]聂莎.高脂血症非药物治疗研究进展[J].实用中医药杂志,2013,29(3):226-227.
[27]朱晓玲.饮食与高脂血症关系研究进展[J].中国保健营养(中旬刊),2012,11(14):76-77.
[28]乔芳.省医保体检人群血脂异常及其影响因素分析[D].中南大学,2013.
[29]薛海峰,冯海英.血脂异常的膳食影响因素研究[J].中国当代医药,2010,17(24):149-150.
[30]苏颖亚.海宁市2013年农村成人肥胖与血脂异常流行病学调查[J].中国乡村医药,2017,24(5):71-72.
[31]陈建峰.上海市某社区老年人超重/肥胖与慢性病关系的调查[J].中国乡村医生,2011,13(24):72-73.
[32]徐勤毅,徐瑜,徐佰慧,等.上海某社区中老年人群超重与肥胖的现况调查[J].内科理论与实践,2012,7(4):284-288.
[33]赵露.健康体检人群超重肥胖分布与健康状况[J].公共卫生与预防医学,2016,27(6):123-125.
[34]Kannel WB.Fifty years of Framingham Study contributions to understanding hypertension[J].J hum hypertens,2000,14(2):83-90.
[35]易秀珍.糖尿病患者进行血脂检验的临床价值分析[J].中国现代药物应用,2012,6(23):24-25.
[36]Wakabayashi I,Daimon T.A strong association between lipid accumulation product and diabetes mellitus in japanese women and men[J].Atheroscler Thromb,2014,21(3):282-288.
[37]杨茂敏.66例糖尿病患者血脂检测结果分析[J].检验医学与临床,2013,10(7):893-894.
[38]汪海燕.高尿酸血症与高血压高脂血症糖尿病的关系探讨[J].中国实用乡村医生杂志,2011,18(4):36-37.
[39]Chiou WK.The relationship between serum uric acid level and metabolic syndrome:differences by sex and age in Taiwanese[J].J Epidemiol,2010,20(3):219-224.
[40]陈艺慧,闵丽.睡眠呼吸暂停低通气综合征患者睡眠监测分析[J].兵团医学,2016,47(1):10-12.
[41]胡明侠,朱爱华,王预建,等.老年人阻塞性睡眠呼吸暂停低通气综合征与高脂血症关系随访研究[J].世界睡眠医学杂志,2014,1(4):201-204.
[42]唐杭瑞,魏翠芹,方吉飞.牙周炎与动脉粥样硬化患者血脂关系综述[J].中国疗养医学,2012,21(1):59-61.
[43]卢梦婕,李馨筱,陈红,等.银行员工血脂异常患病率、心理健康状况与应对方式的调查分析[J].中国医师杂志,2015,17(7):1099-1101.
[44]赵艳君.高脂血症患者心理压力与社会支持的相关研究[D].南京中医药大学,2013.
[45]梁音心.浅谈高脂血症的中医发病因素[J].实用心脑肺心血管病杂志,2012,20(12):2014-2015.
[2]Abdel-Maksoud MF,Hokanson JE.The complex role of triglycerides in Cardiovascular disease[J].Semin Vasc Med,2002,2(3):325-333.
[3]Moran A,Gu D,Zhao D,et a1.Future cardiovascular disease in china:markov model and risk factor scenario proiections from the coronary heart disease policy model-China[J].Circ Cardiovasc Qual Outcomes,2010,3(3):243-252.
[4]丁文清,董虹孛,米杰.中国儿童青少年血脂异常流行现状Meta分析[J].中华流行病学杂志,2015,36(1):7l-77.
[5]韦爱青.年龄与血脂的关系及临床意义[J].医学理论与实践,2011,24(22):2688-2689.
[6]赖亚新,李晨嫣,滕晓春,等.辽宁省城乡成年居民血脂异常患病率及其危险因素分析[J].中国医科大学学报,2012,41(2):151-154.
[7]叶平.老年人降脂治疗的现状与思考[C].张家界.第六届南方长城心脏病学会议.2007:37-40.
[8]刘正淑,王小林.重庆地区中、老年人群血脂异常分布及其危险因素分析[J].重庆医科大学学报,2011,36(2):249-250.
[9]Cheung AP.Acute effects of estradiol and progesterone on insulin,lipids and lipoproteins in postmenopausal women:a pilot study[J].Maturitas,2000,35(1):45-50.
[10]Waters DD,Aldennan EL,HsiaJ,et al.Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atheroselerosis in postmenopausal women:a randomized eontrolled trial[J].JAMA,2002,288(19):2432-2440.
[11]Knoblauch H,Bauerfeind A,Toliat MR,et al.Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol[J].Human molecular genetics,2004,13(10):993-1004.
[12]于霞,谭晓华,杨磊.与高脂血症相关的易感基因多态性研究进展[J].健康研究,2011,31(2):141-144.
[13]何美霞,张明明,刘琼,等.白细胞介素-6基因多态性与高脂血症的相关性[J].中国老年学杂志,2011,31(1):23-25.
[14]陈祯玥,陆国平.家族性高胆固醇血症究现状[J].国际心血管病杂志,2017,1(44):1-6.
[15]赵燕平,赵世刚.脑卒中危险因素研究进展[J].内蒙古医学院学报,2013,35(4):326-331.
[16]付奕,孙毅,董霞,等.吸烟对高校高级职称人群血脂水平的影响[J].中国老年学杂志,2014,34(19):5544-5546.
[17]潘成学.吸烟与中年男性冠心病患者的相关性研究[J].中国实用医药,2011,6(23):233-234.
[18]王洪礼,宁莉,门昆,等.老年高脂血症的临床诊断及其治疗进展[J].医学综述,2010,16(4):582-585.
[19]张智云,冯玉宝,苏平,等.内蒙古地区饮酒与男性初次急性心肌梗死的关系研究[J].中国综合临床,2014,30(12):1266-1270.
[20]范国辉,王增武,张林峰,等.吉林农村居民饮酒与血脂异常的关系研究[J].医学研究杂志,2015,44(1):28-32.
[21]叶有强,彭虹,郑芳.运动疗法对高脂血症转归的效果评价[J].中国医疗前沿,2013,(12):120-120,119.
[22]宋法明.有氧运动对中老年高血脂患者的血脂水平影响研究[J].现代预防医学,2011,38(11):2098-2099.
[23]何绍芳,李依潇,何琳惠.高脂血症非药物治疗研究概况[J].医学综述,2015,21(10):1794-1796.
[24]赵波.高脂血症患者有氧运动前后血脂分析[J].内蒙古中医药,2013,32(27):84.
[25]叶真,胡如英,沈玉华,等.静坐行为和时间与代谢综合征相关性研究[J].中华内分泌代谢杂志,2013,29(9):756-760.
[26]聂莎.高脂血症非药物治疗研究进展[J].实用中医药杂志,2013,29(3):226-227.
[27]朱晓玲.饮食与高脂血症关系研究进展[J].中国保健营养(中旬刊),2012,11(14):76-77.
[28]乔芳.省医保体检人群血脂异常及其影响因素分析[D].中南大学,2013.
[29]薛海峰,冯海英.血脂异常的膳食影响因素研究[J].中国当代医药,2010,17(24):149-150.
[30]苏颖亚.海宁市2013年农村成人肥胖与血脂异常流行病学调查[J].中国乡村医药,2017,24(5):71-72.
[31]陈建峰.上海市某社区老年人超重/肥胖与慢性病关系的调查[J].中国乡村医生,2011,13(24):72-73.
[32]徐勤毅,徐瑜,徐佰慧,等.上海某社区中老年人群超重与肥胖的现况调查[J].内科理论与实践,2012,7(4):284-288.
[33]赵露.健康体检人群超重肥胖分布与健康状况[J].公共卫生与预防医学,2016,27(6):123-125.
[34]Kannel WB.Fifty years of Framingham Study contributions to understanding hypertension[J].J hum hypertens,2000,14(2):83-90.
[35]易秀珍.糖尿病患者进行血脂检验的临床价值分析[J].中国现代药物应用,2012,6(23):24-25.
[36]Wakabayashi I,Daimon T.A strong association between lipid accumulation product and diabetes mellitus in japanese women and men[J].Atheroscler Thromb,2014,21(3):282-288.
[37]杨茂敏.66例糖尿病患者血脂检测结果分析[J].检验医学与临床,2013,10(7):893-894.
[38]汪海燕.高尿酸血症与高血压高脂血症糖尿病的关系探讨[J].中国实用乡村医生杂志,2011,18(4):36-37.
[39]Chiou WK.The relationship between serum uric acid level and metabolic syndrome:differences by sex and age in Taiwanese[J].J Epidemiol,2010,20(3):219-224.
[40]陈艺慧,闵丽.睡眠呼吸暂停低通气综合征患者睡眠监测分析[J].兵团医学,2016,47(1):10-12.
[41]胡明侠,朱爱华,王预建,等.老年人阻塞性睡眠呼吸暂停低通气综合征与高脂血症关系随访研究[J].世界睡眠医学杂志,2014,1(4):201-204.
[42]唐杭瑞,魏翠芹,方吉飞.牙周炎与动脉粥样硬化患者血脂关系综述[J].中国疗养医学,2012,21(1):59-61.
[43]卢梦婕,李馨筱,陈红,等.银行员工血脂异常患病率、心理健康状况与应对方式的调查分析[J].中国医师杂志,2015,17(7):1099-1101.
[44]赵艳君.高脂血症患者心理压力与社会支持的相关研究[D].南京中医药大学,2013.
[45]梁音心.浅谈高脂血症的中医发病因素[J].实用心脑肺心血管病杂志,2012,20(12):2014-2015.
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