ALA-PDT联合微波治疗尖锐湿疣具有较好的疗效和安全性

详细信息    查看全文 | 推荐本文 |

英文篇名：ALA-PDT Combined with Microwave in the Treatment of Condyloma Acuminatum has Good Efficacy and Safety 作者：刘丽红 ; 王永芳 英文作者：Liu Lihong;Wang Yongfang;Langfang Health Vocational College; 关键词：氨基酮戊酸光动力疗法 ; 微波治疗 ; 尖锐湿疣 ; 临床疗效 英文关键词：Aminolevulinic acid photodynamic therapy;;Microwave therapy;;Condyloma acuminata;;Clinical efficacy 中文刊名：GXNB 英文刊名：Genomics and Applied Biology 机构：廊坊卫生职业学院; 出版日期：2018-11-25 出版单位：基因组学与应用生物学 年：2018 期：v.37 基金：廊坊卫生职业学院资助 语种：中文; 页：GXNB201811039 页数：5 CN：11 ISSN：45-1369/Q 分类号：197-201

摘要

为分析氨基酮戊酸光动力疗法(ALA-PDT)联合微波治疗尖锐湿疣的临床疗效及可靠性,本研究选取自2015年1月至2016年12月我院收治的100例尖锐湿疣患者,随机分为观察组与对照组,各50例。其中,对照组采取微波治疗,观察组在对照组的基础上联合氨基酮戊酸光动力疗法治疗。比较两组患者的治愈率和不良反应发生率,随访半年观察有复发情况并记录数据。结果显示,观察组治愈率为84.0%,对照组为60.0%,观察组治愈率显著更高,差异具有统计学意义(p<0.05);观察组中不良反应例数为9例,不良反应率为18.0%;对照组不良反应例数为11例,不良反应率为22.0%,两组患者的不良反应发生率无统计学意义(p=0.402);随访观察发现观察组复发率为12%,对照组为30%,对照组显著高于观察组,差异具有统计学意义(p<0.05)。本研究结果表明,ALA-PDT联合微波治疗尖锐湿疣具有较好的临床疗效,且具有较高的安全性、复发率低,值得在临床中推广使用。
        In order to analyze the clinical efficacy and reliability of aminolevulinic acid photodynamic therapy(ALA-PDT) combined with microwave in the treatment of condyloma acuminatum, 100 inpatients with condyloma acuminata from January 2015 to December 2016 were chosen and randomly divided into observation group and control group(n=50). The control group received microwave treatment, the observation group got addition treatment of aminolevulinic acid photodynamic therapy. Compared the clinical efficacy and adverse reaction rate in two groups, and followed up a 6-month observation to check and record the recurrence data. The results showed that the cure rate of the observation group and the control group was 84.0% and 60.0% respectively. The cure rate of the observation group was significantly higher than that of the control group, the difference was statistically significant(p<0.05). The number of adverse reactions in the observation group was 9 and the adverse reaction rate was 18.0%.The number of adverse reactions in the control group was 11 and the adverse reaction rate was 22.0%. The incidence of adverse reactions in the two groups was not statistically significant(p=0.402). Follow-up observation showed that the recurrence rate of observation group was 12%, the recurrence rate of control group was 30%, the control group was significantly higher than the observation group, the difference was statistically significant.(p<0.05). It could infer that use ALA-PDT combined with microwave in the treatment of condyloma has good clinical efficacy, and high safety, low recurrence rate, it is worth to promote in clinical.

引文

Berman B.,Nestor M.S.,Newburger J.,Park H.,and Swenson N.,2015,Treatment of facial actinic keratoses with aminolevulinic acid photodynamic therapy(ALA-PDT)or ingenol mebutate0.015%gel with and without prior treatment with ALA-PDT,J.Drugs Dermatol.,13(11):1353-1356
    Ding K.Y.,Xu S.J.,Zhang Y.,Zhao Z.G.,Yi X.F.,and Ma C.D.,2016,Microwave in combination with 5-aminolevulinic acidphotodynamic therapy for the treatment of cervical and vagi nal condyloma acuminatum,Jiangsu Daxue Xuebao(Dianziban)Journal of Jiangsu University(Medicine Edition),20(4):351-353(丁克云,徐圣经,张宇赵志国,尹雪峰,马朝东,2016,微波联合5-氨基酮戊酸光动力疗法治疗宫颈、阴道尖锐湿疣的疗效观察,江苏大学学报(医学版),20(4):351-353)
    Friedberg M.J.,and Serlin O.,1963,Condyloma acuminatum:its association with malignancy,Diseases of the Colon&Rectum,6(5):352
    Goldberg L.H.,Landau J.M.,Moody M.N.,Marquez D.,Jih M.,Kimyai-Asadi A.,Friedman P.M.,Busch A.,and VergilisKalner I.J.,2016,Evaluation of the chemopreventative effects of ALA PDT in patients with multiple actinic keratoses and a history of skin cancer,J.Drugs Dermatol.,11(5):593-597
    Han H.F.,Cao H.,Xie F.,and Wang C.C.,2015,Curative effect of topical 5-aminolevulimic acid photodynamic therapy combined with microwave in treatment of condyloma,Zhonghua Quanke Yixue(Chinese Journal of General Practice),12(5):713-714(韩洪方,曹慧,谢芳,王辰琛,2015,5-氨基酮戊酸光动力疗法联合微波治疗尖锐湿疣疗效观察,中华全科医学,12(5):713-714)
    Liu B.,Farrell T.J.,and Patterson M.S.,2015,A dynamic model for ALA-PDT of skin:simulation of temporal and spatial distributions of ground-state oxygen,photosensitizer and singlet oxygen,Phys.Med.Biol.,55(19):5913-5932
    Mizutani K.,Akita Y.,Yanagishita T.,Kimura M.,Tanaka T.,Kinoshita Y.,Nakano A.,Tamada Y.,Matsumoto Y.,and Watanabe D.,2015,Comparison of the efficacy of ALA-PDTusing an excimer-dye laser(630 nm)and a metal-halide lamp(600 to 740 nm)for treatment of Bowen's disease,Photodermatology,Photoimmunology and Photomedicine,28(3):142-146
    Purola E.,and Savia E.,1977,Cytology of gynecologic condyloma acuminatum,Acta Cytologica,21(21):26-31
    Qian F.,and Liu Y.,2016,5-amino ketones pentanoic acid-photodynamic therapy in treating patients with condyloma acuminatum and its impact on sexual life quality,Zhongguo Xingkexue(Chinese Journal of Human Sexuality),25(7):81-83(钱芳,刘园,2016,5-氨基酮戊酸光动力疗法对尖锐湿疣患者疗效及性生活质量的影响,中国性科学,25(7):81-83)
    Song H.B.,Zhu Q.Q.,Tao C.X.,Liu M.,and Shi H.M.,2015,Astudy of 5-aminolevulinic acid combined with microwave therapy on the treatment of condyloma acuminatum,Ningxia Yixue Zazhi(Ningxia Medical Journal),36(9):803-806(宋洪彬,朱勤勤,陶春霞,刘敏,施惠娟,2015,5-氨基酮戊酸光动力疗法联合微波治疗尖锐湿疣的研究,宁夏医学杂志,36(9):803-806)
    Swerdlow D.B.,and Salvati E.P.,1971,Condyloma acuminatum,Diseases of the Colon&Rectum,14(3):226-231
    Wang X.L.,Xu S.Z.,and Zhang C.R.,2016,Treatment of recurrent condyloma acumninatumn byδ-aminolevulinic acid photodynamic therapy and micro-wave,Zhongguo Mafengpifubing Zazhi(China Journal of Leprosy and Skin Diseases),18(1):20-21(王秀丽,徐世正,张春荣,2016,ALA光动力疗法联合微波治疗复发性尖锐湿疣疗效观察,中国麻风皮肤病杂志,18(1):20-21)
    Zhang F.Y.,Wang X.L.,and Wang H.W.,2015,Advances of5-aminolevulinic acid photodynamic therapy in the treatment of condyloma acuminatum,Zhongguo Pifu Xingbingxue Zazhi(The Chinese Journal of Dermatovenereology),27(1):78-80(张云凤,王秀丽,王宏伟,2015,5-氨基酮戊酸光动力疗法治疗尖锐湿疣的进展,中国皮肤性病学杂志,27(1):78-80)
    Zhang T.L.,Liu Z.,Lin C.M.,and Song W.F.,2015,Microwave in combination with 5-aminolevulinic acid and photodynamic therapy for condylomata acuminata in anal canal,Linchuang Junyi Zazhi(Clinical Journal of Medical Officers),40(3):664-666(张添龙,刘卓,林崇明,宋维芳,2015,微波联合5-氨基酮戊酸及光动力疗法治疗肛管内尖锐湿疣,临床军医杂志,40(3):664-666)