纳滤膜在功能性低聚糖分离纯化中的应用研究进展
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摘要
功能性低聚糖具有抗肿瘤、抗放射、抗凝血、消炎和调节免疫力等医疗保健作用,广泛应用于食品科学和生物医药等领域。纳滤作为一种高效的膜分离技术,在功能性低聚糖的分离与纯化中的应用得到越来越多的关注。本文分析了纳滤膜对功能性低聚糖的分离机理,综述了纳滤膜在功能性多糖分离纯化中的应用进展,讨论了纳滤分离过程的影响因素,主要包括功能性多糖料液的性质、膜过程的操作参数以及膜材料本身的性质等。其中,料液的性质主要体现在组成、浓度、黏度等方面;操作参数主要体现在压力、温度、膜面流速和pH等方面;而膜材料的性质主要体现在微结构和表面性质两个方面。最后,进一步指出纳滤膜技术用于功能性多糖分离纯化时在设备成本、膜材料及膜污染等方面存在的问题,并对未来纳滤膜技术在低成本专用膜材料及系统开发和膜污染控制方面的研究进行了展望。
Functional oligosaccharides have been widely used in the fields of food and biomedicine due to their appealing characters of anti-tumor, anti-inflammatory, anti-coagulation, anti-radiation, and other health functions. As an efficient separation technology, nano-filtration has attracted more and moreattention in the separation and purification of functional oligosaccharides. In this paper, the separationmechanism of nano-filtration membranes for functional oligosaccharides was analyzed. Recent progress intheir applications for the separation and purification of functional oligosaccharides was reviewed. Thefactors affecting the nano-filtration process were discussed, including the properties of feed solution, theoperating parameters of membrane process, and the characters of membrane materials. The factors of feedsolution mainly included its composition, concentration, viscosity, etc. The operating parameters weremainly reflected in the following: temperature, pressure, membrane surface velocity, pH, etc. Thecharacters of membrane materials included both the microstructure and the surface properties. Finally, thechallenges that the nano-filtration technology for the separation and purification of functional oligosaccharides is facing, such as the cost of equipment, the characters of membrane materials, and the membrane fouling, were presented. To promote the further application of nano-filtration, it is necessary to develop special membranes with low-cost and high performance, to focus more on the optimization of membrane system and the fouling control of membrane.
Functional oligosaccharides have been widely used in the fields of food and biomedicine due to their appealing characters of anti-tumor, anti-inflammatory, anti-coagulation, anti-radiation, and other health functions. As an efficient separation technology, nano-filtration has attracted more and moreattention in the separation and purification of functional oligosaccharides. In this paper, the separationmechanism of nano-filtration membranes for functional oligosaccharides was analyzed. Recent progress intheir applications for the separation and purification of functional oligosaccharides was reviewed. Thefactors affecting the nano-filtration process were discussed, including the properties of feed solution, theoperating parameters of membrane process, and the characters of membrane materials. The factors of feedsolution mainly included its composition, concentration, viscosity, etc. The operating parameters weremainly reflected in the following: temperature, pressure, membrane surface velocity, pH, etc. Thecharacters of membrane materials included both the microstructure and the surface properties. Finally, thechallenges that the nano-filtration technology for the separation and purification of functional oligosaccharides is facing, such as the cost of equipment, the characters of membrane materials, and the membrane fouling, were presented. To promote the further application of nano-filtration, it is necessary to develop special membranes with low-cost and high performance, to focus more on the optimization of membrane system and the fouling control of membrane.
引文
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