凉血止痒方配合中波紫外线治疗急性血热证寻常型银屑病
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摘要
目的探讨自拟凉血止痒方加减配合中波紫外线治疗急性期血热证寻常型银屑病的临床疗效。方法选取我院(2015年1月—2017年1月)收治的86例急性期血热证寻常型银屑病患者为研究对象,根据治疗方法不同将本组患者分为两组,两组患者均给予窄谱中波紫外线(NB-UVB)治疗,观察组在此基础上再给予自拟凉血止痒方加减治疗,对比两组患者临床疗效和治疗前后银屑病严重程度以及血清干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)水平。结果观察组总有效率97.67%,对照组总有效率81.40%,观察组临床疗效明显高于对照组,差异具有统计学意义(χ2=14.125 8,P <0.05)。观察组PASI评分、血清IFN-γ、IL-2水平明显低于对照组,差异具有统计学意义(P<0.05)。结论急性期血热证寻常型银屑病采用NB-UVB联合中药凉血止痒方剂治疗效果显著。
Objective To investigate the clinical efficacy of self cooling and blood stasis relieving itching prescription combined with UVB in the treatment of psoriasis vulgaris in acute phase of blood heat syndrome. Methods 86 cases of psoriasis vulgaris in acute period of blood heat syndrome in our hospital(from January 2015 to January 2017) were selected as the research object. According to the different treatment methods, the patients were divided into two groups, the two groups were given NB-UVB treatment. On the basis of this, the observation group was given the treatment of self-designed cold blood antipruritic prescription, and the two groups were compared. The clinical efficacy, psoriasis severity and serum levels of interferon gamma(IFN-gamma) and interleukin-2(IL-2) before and after treatment were observed. Results The total effective rate of the observation group was 97.67%, the total effective rate of the control group was 81.40%, and the clinical effect of the observation group was significantly higher than that of the control group. The difference was statistically significant(χ2=14.125 8, P < 0.05). The PASI score, serum IFNgamma and IL-2 levels in the observation group were significantly lower than those in the control group(P < 0.05). Conclusion The treatment of psoriasis vulgaris in acute phase of blood heat syndrome with NB-UVB combined with Chinese medicine cooling blood and relieving itching is effective.
Objective To investigate the clinical efficacy of self cooling and blood stasis relieving itching prescription combined with UVB in the treatment of psoriasis vulgaris in acute phase of blood heat syndrome. Methods 86 cases of psoriasis vulgaris in acute period of blood heat syndrome in our hospital(from January 2015 to January 2017) were selected as the research object. According to the different treatment methods, the patients were divided into two groups, the two groups were given NB-UVB treatment. On the basis of this, the observation group was given the treatment of self-designed cold blood antipruritic prescription, and the two groups were compared. The clinical efficacy, psoriasis severity and serum levels of interferon gamma(IFN-gamma) and interleukin-2(IL-2) before and after treatment were observed. Results The total effective rate of the observation group was 97.67%, the total effective rate of the control group was 81.40%, and the clinical effect of the observation group was significantly higher than that of the control group. The difference was statistically significant(χ2=14.125 8, P < 0.05). The PASI score, serum IFNgamma and IL-2 levels in the observation group were significantly lower than those in the control group(P < 0.05). Conclusion The treatment of psoriasis vulgaris in acute phase of blood heat syndrome with NB-UVB combined with Chinese medicine cooling blood and relieving itching is effective.
引文
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[7]石志峰.自拟凉血止痒方加减配合中波紫外线治疗急性期血热证寻常型银屑病疗效观察[J].现代中西医结合杂志,2018,27(9):966-969.
[8]周梦云,单筠筠,徐田红,等.凉血解毒方治疗寻常型银屑病的临床疗效分析[J].中华中医药杂志,2018,33(3):1189-1190.
[9]李青华.清热凉血解毒汤治疗血热型银屑病临床研究[J].内蒙古中医药,2018,37(2):5-6.
[10]张贺,李京,张晓艳.银屑病血热证患者超敏C-反应蛋白和前白蛋白的回顾分析[J].中医药导报,2018,24(3):76-78.
[11]杨雪松,叶建州,严妍,等.寻常型银屑病中医症状分布特点的文献研究[J].云南中医中药杂志,2018,39(1):17-20.
[12]赵景军.血液灌流配合中药治疗尿毒症合并银屑病皮肤瘙痒疗效评价[J].中国继续医学教育,2017,9(4):203-204.
[13]刘勇,孙丹,闫小宁.半枝莲方治疗银屑病血热证的临床观察[J].中医药导报,2018,24(2):81-83.
[2]王倩,蔡念宁,周冬梅,等.中药熏蒸疗法治疗血热型银屑病疗效评价[J].中国麻风皮肤病杂志,2018,34(2):112-113.
[3]吴苗,马丽俐,徐唯,等.犀角地黄汤加减对血热型寻常型银屑病的疗效观察[J].浙江医学,2018,40(9):998-999.
[4]徐蓉,缪晓,李欣,等.凉血潜阳药物对寻常性银屑病血热证患者程序性死亡蛋白-1及其配体影响[J].世界临床药物,2018,39(4):247-252.
[5]何婷婷,姚润娟,杨雪源.从中医角度探讨银屑病的瘥后防复[J].现代中西医结合杂志,2018,27(12):1366-1368.
[6]王莹.凉血解毒退银汤对急性银屑病患者免疫功能、炎症因子及生活质量的影响[J].中国中医急症,2018,27(4):622-624.
[7]石志峰.自拟凉血止痒方加减配合中波紫外线治疗急性期血热证寻常型银屑病疗效观察[J].现代中西医结合杂志,2018,27(9):966-969.
[8]周梦云,单筠筠,徐田红,等.凉血解毒方治疗寻常型银屑病的临床疗效分析[J].中华中医药杂志,2018,33(3):1189-1190.
[9]李青华.清热凉血解毒汤治疗血热型银屑病临床研究[J].内蒙古中医药,2018,37(2):5-6.
[10]张贺,李京,张晓艳.银屑病血热证患者超敏C-反应蛋白和前白蛋白的回顾分析[J].中医药导报,2018,24(3):76-78.
[11]杨雪松,叶建州,严妍,等.寻常型银屑病中医症状分布特点的文献研究[J].云南中医中药杂志,2018,39(1):17-20.
[12]赵景军.血液灌流配合中药治疗尿毒症合并银屑病皮肤瘙痒疗效评价[J].中国继续医学教育,2017,9(4):203-204.
[13]刘勇,孙丹,闫小宁.半枝莲方治疗银屑病血热证的临床观察[J].中医药导报,2018,24(2):81-83.
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