经导管主动脉瓣置换术在二叶式主动脉瓣狭窄中的现状研究
|
摘要
经导管主动脉瓣置换术,目前已成为主动脉瓣重度狭窄高危患者的一种新的有效替代治疗手段。由于二叶式主动脉瓣伴重度钙化性狭窄的患者其瓣叶特殊病理及解剖特点,对于这类患者,经导管主动脉瓣置换术在传统观点中被认为是相对禁忌的,但近期部分案例及研究报道了这部分患者该手术治疗的安全性和有效性,并且手术成功案例也越来越多,目前还无充足的临床研究及证据提示二叶瓣患者能否应用经导管主动脉瓣置换术治疗,以及治疗后的安全性、有效性、瓣膜耐久性及术后并发症的相对优越性,但这必将为其在扩大治疗适应证方面提供新的应用前景。
Transcatheter aortic valve replacement( TAVR) has now become a new and effective alternative to severe aortic valve stenosis. Due to the special pathology and anatomic characteristics of the valve leaflets in patients with severed calcified stenosis of the bicuspid aortic valve,TAVR surgery is considered to be relatively contraindicated in the traditional view of these patients. However,some recent cases and studies have reported the safety and effectiveness of TAVR procedure in these patients,accompany with the increasing number of successful cases. At present,there are not enough clinical studies and evidence to show whether patients with bicuspid aortic valve can be treated with TAVI,as well as the relative superiority of safety,efficacy,valve durability,and postoperative complications after treatment. However,it will certainly provide new application prospects for the expansion of therapeutic indications for TAVR procedure.
Transcatheter aortic valve replacement( TAVR) has now become a new and effective alternative to severe aortic valve stenosis. Due to the special pathology and anatomic characteristics of the valve leaflets in patients with severed calcified stenosis of the bicuspid aortic valve,TAVR surgery is considered to be relatively contraindicated in the traditional view of these patients. However,some recent cases and studies have reported the safety and effectiveness of TAVR procedure in these patients,accompany with the increasing number of successful cases. At present,there are not enough clinical studies and evidence to show whether patients with bicuspid aortic valve can be treated with TAVI,as well as the relative superiority of safety,efficacy,valve durability,and postoperative complications after treatment. However,it will certainly provide new application prospects for the expansion of therapeutic indications for TAVR procedure.
引文
[1]Rashedi N,Otto CM.Aortic stenosis:changing disease concepts[J].J Cardiovasc Ultrasound,2015,23(2):59-69.
[2]Bauer T,Linke A,Sievert H,et al.Comparison of the effectiveness of transcatheter aortic valve implantation in patients with stenotic bicuspid versus tricuspid aortic valves(from the German TAVI Registry)[J].Am J Cardiol,2014,113(3):518-521.
[3]Liu XB,He YX,Liu CH,et al.First-in-man implantation of the retrievable and repositionable Venus A-Plus valve[J].World J Emerg Med,2018,9(1):64-66.
[4]Ward C.Clinical significance of the bicuspid aortic valve[J].Heart,2000,83(1):81-85.
[5]Li Y,Wei X,Zhao Z,et al.Prevalence and complications of bicuspid aortic valve in Chinese according to echocardiographic database[J].Am J Cardiol,2017,120(2):287-291.
[6]Cripe L,Andelfinger G,Martin LJ,et al.Bicuspid aortic valve is heritable[J].JAm Coll Cardiol,2004,44(1):138-143.
[7]Tutar E,Ekici F,Atalay S,et al.The prevalence of bicuspid aortic valve in newborns by echocardiographic screening[J].Am Heart J,2005,150(3):513-515.
[8]Basso C,Boschello M,Perrone C,et al.An echocardiographic survey of primary school children for bicuspid aortic valve[J].Am J Cardiol,2004,93(5):661-663.
[9]Roberts WC,Ko JM.Frequency by decades of unicuspid,bicuspid,and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis,with or without associated aortic regurgitation[J].Circulation,2005,111(7):920-925.
[10]Sievers HH,Schmidtke C.A classification system for the bicuspid aortic valve from 304 surgical specimens[J].J Thorac Cardiovasc Surg,2007,133(5):1226-1233.
[11]Hayashida K,Bouvier E,Lefèvre T,et al.Transcatheter aortic valve implantation for patients with severe bicuspid aortic valve stenosis[J].Circ Cardiovasc Interv,2013,6(3):284-291.
[12]Mathieu P,BosséY,Huggins GS,et al.The pathology and pathobiology of bicuspid aortic valve:state of the art and novel research perspectives[J].J Pathol Clin Res,2015,1(4):195-206.
[13]Wu B,Wang Y,Xiao F,et al.Developmental mechanisms of aortic valve malformation and disease[J].Annu Rev Physiol,2017,79:21-41.
[14]Ohukainen P,Syvranta S,Npnkangas J,et al.MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease[J].Ann Med,2015,47(5):423-429.
[15]Jiao J,Tian W,Qiu P,et al.Induced pluripotent stem cells with NOTCH1 gene mutation show impaired differentiation into smooth muscle and endothelial cells:implications for bicuspid aortic valve-related aortopathy[J].J Thorac Cardiovasc Surg,2018,156(2):515-522.
[16]Laforest B,Andelfinger G,Nemer M.Loss of Gata5 in mice leads to bicuspid aortic valve[J].J Clin Invest,2011,121(7):2876-2887.
[17]Balsam LB.The genetics of bicuspid aortic valve disease:shall we take it down a NOTCH?[J].J Thorac Cardiovasc Surg,2018,156(2):523-524.
[18]Michelena HI,Prakash SK,Della CA,et al.Bicuspid aortic valve:identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium(BAVCon)[J].Circulation,2014,129(25):2691-2704.
[19]Arora S,Strassle PD,Ramm CJ,et al.Transcatheter versus surgical aortic valve replacement in patients with lower surgical risk scores:a systematic review and meta-analysis of early outcomes[J].Heart Lung Circ,2017,26(8):840-845.
[20]Leon MB,Smith CR,Mack MJ,et al.Transcatheter or surgical aortic-valve replacement in intermediate-risk patients[J].N Engl J Med,2016,374(17):1609-1620.
[21]Reardon MJ,van Mieghem NM,Popma JJ,et al.Surgical or transcatheter aorticvalve replacement in intermediate-risk patients[J].N Engl J Med,2017,376(14):1321-1331.
[22]Yoon SH,Lefèvre T,Ahn JM,et al.Transcatheter aortic valve replacement with early-and new-generation devices in bicuspid aortic valve stenosis[J].J Am Coll Cardiol,2016,68(11):1195-1205.
[23]Mylotte D,Lefevre T,Sndergaard L,et al.Transcatheter aortic valve replacement in bicuspid aortic valve disease[J].J Am Coll Cardiol,2014,64(22):2330-2339.
[24]Perlman GY,Blanke P,Dvir D,et al.Bicuspid aortic valve stenosis:favorable early outcomes with a next-generation transcatheter heart valve in a multicenter study[J].JACC Cardiovasc Interv,2016,9(8):817-824.
[25]Schymik G,Lefèvre T,Bartorelli AL,et al.European experience with the second-generation Edwards SAPIEN XT transcatheter heart valve in patients with severe aortic stenosis:1-year outcomes from the SOURCE XT Registry[J].JACC Cardiovasc Interv,2015,8(5):657-669.
[26]Ben-Dor I,Stewart A.A cautionary tale of 2 leaflets:TAVR in bicuspid aortic valve stenosis[J].J Am Coll Cardiol,2017,69(21):2590-2591.
[27]Liu X,Jiang J,Zhou Q,et al.Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population[J].J Zhejiang Univ Sci B,2015,16(3):208-214.
[28]Baumgartner H,Falk V,Bax JJ,et al.2017 ESC/EACTS guidelines for the management of valvular heart disease[J].Rev Esp Cardiol(Engl Ed),2018,71(2):110.
[29]Kappetein AP,Head SJ,Généreux P,et al.Updated standardized endpoint definitions for transcatheter aortic valve implantation:the Valve Academic Research Consortium-2 consensus document[J].J Thorac Cardiovasc Surg,2013,145(1):6-23.
[30]Zegdi R,Lecuyer L,Achouh P,et al.Increased radial force improves stent deployment in tricuspid but not in bicuspid stenotic native aortic valves[J].Ann Thorac Surg,2010,89(3):768-772.
[31]Yoon SH,Sharma R,Chakravarty T,et al.Transcatheter aortic valve replacement in bicuspid aortic valve stenosis:where do we stand?[J].J Cardiovasc Surg(Torino),2018,59(3):381-391.
[32]Verma S,Siu SC.Aortic dilatation in patients with bicuspid aortic valve[J].NEngl J Med,2014,370(20):1920-1929.
[33]Borger MA,Preston M,Ivanov J,et al.Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease?[J].J Thorac Cardiovasc Surg,2004,128(5):677-683.
[34]Michelena HI,Khanna AD,Mahoney D,et al.Incidence of aortic complications in patients with bicuspid aortic valves[J].JAMA,2011,306(10):1104-1112.
[35]Hiratzka LF,Creager MA,Isselbacher EM,et al.Surgery for aortic dilatation in patients with bicuspid aortic valves:a statement of clarification from the American College of Cardiology/American Heart Association task force on clinical practice guidelines[J].J Am Coll Cardiol,2016,67(6):724-731.
[2]Bauer T,Linke A,Sievert H,et al.Comparison of the effectiveness of transcatheter aortic valve implantation in patients with stenotic bicuspid versus tricuspid aortic valves(from the German TAVI Registry)[J].Am J Cardiol,2014,113(3):518-521.
[3]Liu XB,He YX,Liu CH,et al.First-in-man implantation of the retrievable and repositionable Venus A-Plus valve[J].World J Emerg Med,2018,9(1):64-66.
[4]Ward C.Clinical significance of the bicuspid aortic valve[J].Heart,2000,83(1):81-85.
[5]Li Y,Wei X,Zhao Z,et al.Prevalence and complications of bicuspid aortic valve in Chinese according to echocardiographic database[J].Am J Cardiol,2017,120(2):287-291.
[6]Cripe L,Andelfinger G,Martin LJ,et al.Bicuspid aortic valve is heritable[J].JAm Coll Cardiol,2004,44(1):138-143.
[7]Tutar E,Ekici F,Atalay S,et al.The prevalence of bicuspid aortic valve in newborns by echocardiographic screening[J].Am Heart J,2005,150(3):513-515.
[8]Basso C,Boschello M,Perrone C,et al.An echocardiographic survey of primary school children for bicuspid aortic valve[J].Am J Cardiol,2004,93(5):661-663.
[9]Roberts WC,Ko JM.Frequency by decades of unicuspid,bicuspid,and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis,with or without associated aortic regurgitation[J].Circulation,2005,111(7):920-925.
[10]Sievers HH,Schmidtke C.A classification system for the bicuspid aortic valve from 304 surgical specimens[J].J Thorac Cardiovasc Surg,2007,133(5):1226-1233.
[11]Hayashida K,Bouvier E,Lefèvre T,et al.Transcatheter aortic valve implantation for patients with severe bicuspid aortic valve stenosis[J].Circ Cardiovasc Interv,2013,6(3):284-291.
[12]Mathieu P,BosséY,Huggins GS,et al.The pathology and pathobiology of bicuspid aortic valve:state of the art and novel research perspectives[J].J Pathol Clin Res,2015,1(4):195-206.
[13]Wu B,Wang Y,Xiao F,et al.Developmental mechanisms of aortic valve malformation and disease[J].Annu Rev Physiol,2017,79:21-41.
[14]Ohukainen P,Syvranta S,Npnkangas J,et al.MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease[J].Ann Med,2015,47(5):423-429.
[15]Jiao J,Tian W,Qiu P,et al.Induced pluripotent stem cells with NOTCH1 gene mutation show impaired differentiation into smooth muscle and endothelial cells:implications for bicuspid aortic valve-related aortopathy[J].J Thorac Cardiovasc Surg,2018,156(2):515-522.
[16]Laforest B,Andelfinger G,Nemer M.Loss of Gata5 in mice leads to bicuspid aortic valve[J].J Clin Invest,2011,121(7):2876-2887.
[17]Balsam LB.The genetics of bicuspid aortic valve disease:shall we take it down a NOTCH?[J].J Thorac Cardiovasc Surg,2018,156(2):523-524.
[18]Michelena HI,Prakash SK,Della CA,et al.Bicuspid aortic valve:identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium(BAVCon)[J].Circulation,2014,129(25):2691-2704.
[19]Arora S,Strassle PD,Ramm CJ,et al.Transcatheter versus surgical aortic valve replacement in patients with lower surgical risk scores:a systematic review and meta-analysis of early outcomes[J].Heart Lung Circ,2017,26(8):840-845.
[20]Leon MB,Smith CR,Mack MJ,et al.Transcatheter or surgical aortic-valve replacement in intermediate-risk patients[J].N Engl J Med,2016,374(17):1609-1620.
[21]Reardon MJ,van Mieghem NM,Popma JJ,et al.Surgical or transcatheter aorticvalve replacement in intermediate-risk patients[J].N Engl J Med,2017,376(14):1321-1331.
[22]Yoon SH,Lefèvre T,Ahn JM,et al.Transcatheter aortic valve replacement with early-and new-generation devices in bicuspid aortic valve stenosis[J].J Am Coll Cardiol,2016,68(11):1195-1205.
[23]Mylotte D,Lefevre T,Sndergaard L,et al.Transcatheter aortic valve replacement in bicuspid aortic valve disease[J].J Am Coll Cardiol,2014,64(22):2330-2339.
[24]Perlman GY,Blanke P,Dvir D,et al.Bicuspid aortic valve stenosis:favorable early outcomes with a next-generation transcatheter heart valve in a multicenter study[J].JACC Cardiovasc Interv,2016,9(8):817-824.
[25]Schymik G,Lefèvre T,Bartorelli AL,et al.European experience with the second-generation Edwards SAPIEN XT transcatheter heart valve in patients with severe aortic stenosis:1-year outcomes from the SOURCE XT Registry[J].JACC Cardiovasc Interv,2015,8(5):657-669.
[26]Ben-Dor I,Stewart A.A cautionary tale of 2 leaflets:TAVR in bicuspid aortic valve stenosis[J].J Am Coll Cardiol,2017,69(21):2590-2591.
[27]Liu X,Jiang J,Zhou Q,et al.Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population[J].J Zhejiang Univ Sci B,2015,16(3):208-214.
[28]Baumgartner H,Falk V,Bax JJ,et al.2017 ESC/EACTS guidelines for the management of valvular heart disease[J].Rev Esp Cardiol(Engl Ed),2018,71(2):110.
[29]Kappetein AP,Head SJ,Généreux P,et al.Updated standardized endpoint definitions for transcatheter aortic valve implantation:the Valve Academic Research Consortium-2 consensus document[J].J Thorac Cardiovasc Surg,2013,145(1):6-23.
[30]Zegdi R,Lecuyer L,Achouh P,et al.Increased radial force improves stent deployment in tricuspid but not in bicuspid stenotic native aortic valves[J].Ann Thorac Surg,2010,89(3):768-772.
[31]Yoon SH,Sharma R,Chakravarty T,et al.Transcatheter aortic valve replacement in bicuspid aortic valve stenosis:where do we stand?[J].J Cardiovasc Surg(Torino),2018,59(3):381-391.
[32]Verma S,Siu SC.Aortic dilatation in patients with bicuspid aortic valve[J].NEngl J Med,2014,370(20):1920-1929.
[33]Borger MA,Preston M,Ivanov J,et al.Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease?[J].J Thorac Cardiovasc Surg,2004,128(5):677-683.
[34]Michelena HI,Khanna AD,Mahoney D,et al.Incidence of aortic complications in patients with bicuspid aortic valves[J].JAMA,2011,306(10):1104-1112.
[35]Hiratzka LF,Creager MA,Isselbacher EM,et al.Surgery for aortic dilatation in patients with bicuspid aortic valves:a statement of clarification from the American College of Cardiology/American Heart Association task force on clinical practice guidelines[J].J Am Coll Cardiol,2016,67(6):724-731.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |