新型飞行时间质谱离子移除装置的研制
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摘要
本文介绍了一种用于飞行时间质谱离子检测器选择性移除非目标检测离子的脉冲电场装置。通过调节脉冲电压时序、优化脉冲电压值,实现对非目标检测离子的有效移除,使离子选择性地进入离子检测器,减少离子检测器的消耗,延长其使用寿命。结果表明,除了由脉冲上升沿和下降沿引起的质谱信号振荡对相邻飞行时间区域内的离子产生一定的影响外,该装置和方法可以选择性地、有效地移除非目标检测离子,以减少MCP离子检测器的消耗,延长其使用寿命,为飞行时间质谱非目标离子的移除提供一种简单、可行的方法。
A pulsed electric field device for selective removal of target ions at the front of the ion detector for a time-of-flight mass spectrometer was introduced. The pulsed electric field device had three grid meshes: MCP grid mesh, pulse grid mesh and ACCE grid mesh. The effective removal of the non-target ions was achieved by adjusting the pulse voltage and its width on pulse grid mesh to impede the non-target ions reaching the ion detector, in order to reduce the consumption of ion detector and prolong the life time of the ion detector. The experimental results showed that the pulsed electric field device could remove one or more interval ions through changing pulse voltage to adjust the removal rate and changing pulse width to adjust the removal span range. Except for spectral signal oscillations caused by the rising and falling edges of the pulse for neighbor ions, the device could effectively remove the non-target ions, and kept the other target ions stable. This specific ion removal method can provide an easy way to improve the existing TOF MS instruments.
A pulsed electric field device for selective removal of target ions at the front of the ion detector for a time-of-flight mass spectrometer was introduced. The pulsed electric field device had three grid meshes: MCP grid mesh, pulse grid mesh and ACCE grid mesh. The effective removal of the non-target ions was achieved by adjusting the pulse voltage and its width on pulse grid mesh to impede the non-target ions reaching the ion detector, in order to reduce the consumption of ion detector and prolong the life time of the ion detector. The experimental results showed that the pulsed electric field device could remove one or more interval ions through changing pulse voltage to adjust the removal rate and changing pulse width to adjust the removal span range. Except for spectral signal oscillations caused by the rising and falling edges of the pulse for neighbor ions, the device could effectively remove the non-target ions, and kept the other target ions stable. This specific ion removal method can provide an easy way to improve the existing TOF MS instruments.
引文
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[14] 谭国斌,高伟,洪义,黄正旭,李梅,董俊国,程平,傅忠. 高灵敏度膜进样VOCs在线检测质谱仪的研制[J]. 现代科学仪器,2011,10(5):59-62. TAN Guobin, GAO Wei, HONG Yi, HUANG Zhengxu, LI Mei, DONG Junguo, CHENG Ping, FU Zhong. Development of high sensitivity membrane introduction mass spectrometer for on-line detecting VOCs[J]. Modern Scientific Instruments, 2011,10(5): 59-62(in Chinese).
[15] 吴庆浩,花磊,侯可勇,崔华鹏,陈平,赵无垛,王卫国,李京华,李海洋. 新型单光子电离和光电子电离复合电离源的研究与应用[J]. 分析化学仪器装置与实验技术,2011,39(10):1 465-1 469. WU Qinghao, HUA Lei, HOU Keyong, CUI Huapeng, CHEN Ping, ZHAO Wuduo, WANG Weiguo, LI Jinghua, LI Haiyang. Characterization and applications of combined single photon ionization and photoelectron ionization source[J]. Chinese Journal of Analytical Chemistry, 2011, 39(10): 1 465-1 469(in Chinese).
[16] 洪义,高伟,谭国斌,周振. VOCs在线检测质谱仪单光子电离源的研制[J]. 自动化与仪表,2012,27(6):1-3. HONG Yi, GAO Wei, TAN Guobin, ZHOU Zhen. Research on single photon ionization sources of mass spectrometer for on-line detection of VOCs[J]. Automation & Instrumentation, 2012, 27(6): 1-3(in Chinese).
[17] 顾超峰,谭国斌,李操,麦泽斌,黄正旭,李梅,王姜,杨俊卿,程平. 封闭式单光子/光电子离子源及其在酒类质谱鉴别中的初步应用[J]. 现代科学仪器,2014,(5):29-35. GU Chaofeng, TAN Guobin, LI Cao, MAI Zebin, HUANG Zhengxu, LI Mei, WANG Jiang, YANG Junqing, CHENG Ping. Enclosed single-photon (SPI)/photoelectron (PEI) ionization complex ion source and its preliminary application in the identification of wine mass spectrometer[J]. Modern Scientific Instruments, 2014, (5): 29-35(in Chinese).
[2] SANTOS F J, GALCERAN M T. Modern developments in gas chromatography-mass spectrometry-based environmental analysis[J]. Journal of Chromatography A, 2003, 1 000(1): 125-151.
[3] SHELLIE R, MONDELLO L, MARRIOTT P, DUGO G. Characterisation of lavender essential oils by using gas chromatography-mass spectrometry with correlation of linear retention indices and comparison with comprehensive two-dimensional gas chromatography[J]. Journal of Chromatography A, 2002, 970(1): 225-234.
[4] 赵晓光,薛燕. 迅速发展中的生物质谱仪及相关高新技术[J]. 仪器仪表学报,2002,23(5):237-240. ZHAO Xiaoguang, XUE Yan. Bio-mass spectrometry in progress and related technology[J]. Chinese Journal Scientific Instrument, 2002, 23(5): 237-240(in Chinese).
[5] 伍小梅,彭真,董俊国,高伟,黄正旭,程平,周振. 在线检测挥发性有机物的质子转移反应飞行时间质谱仪的研制[J]. 质谱学报,2015,36(1):1-7. WU Xiaomei, PENG Zhen, DONG Junguo, GAO Wei, HUANG Zhengxu, CHENG Ping, ZHOU Zhen. Development of proton transfer reaction time-of-flight mass spectrometer for on-line detection of volatile organic compounds[J].Journal of Chinesee Mass Spectrometer Society, 2015, 36(1): 1-7(in Chinese).
[6] QING J, HUANG Z, ZHANG Y, ZHU H, Tan G, GAO W, YANG P Y. A miniaturised electron ionisation time-of-flight mass spectrometer that uses a unique helium ion removal pulsing technique specifically for gas analysis[J]. Analyst, 2013, 138(12): 3 394-3 401.
[7] WOLF B, MUDGETT P D, MACFARLANE R D. A new method for electrostatic ion deflection[J]. Journal of the American Society for Mass Spectrometry, 1990, 1(1): 28-36.
[8] EIDEN G C, BARINAGA C J, KOPPENAAL D W. Method for reduction of selected ion intensities in confined ion beams, US5767512[P]. 1998.
[9] FREY R, HOLLE A, WEISS G. Method and apparatus for generating ions from thermally unstable, non-volatile, large molecules, particularly for a mass spectrometer such as a time-of-flight mass spectrometer: US, US5294797[P]. 1994.
[10] UGAROV M. Ion deflection in time-of-flight mass spectrometry: US9029763[P]. 2015.
[11] WU Q, HUA L, HOU K, CUI H, CHEN P. A combined single photon ionization and photoelectron ionization source for orthogonal acceleration time-of-flight mass spectrometer[J]. International Journal of Mass Spectrometry, 2010, 295(1): 60-64.
[12] 高伟,黄正旭,郭长娟,粘慧青,董俊国,傅忠,陈少得,周振. 电子轰击源垂直加速式飞行时间质谱仪的研制[J]. 质谱学报,2008,29(4):209-217. GAO Wei, HUANG Zhengxu, GUO Changjuan, NIAN Huiqing, DONG Junguo, FU Zhong, CHEN Shaode, ZHOU Zhen. Electron ionization and orthogonal acceleration time-of-flight mass spectrometer[J]. Journal of Chinese Mass Spectrometry Society, 2008, 29(4): 209-217(in Chinese).
[13] 谭国斌,高伟,黄正旭,洪义,傅忠,董俊国,程平,周振. 真空紫外灯单光子电离源飞行时间质谱仪的研制[J]. 分析化学仪器装置与实验技术,2010,39(10):1 470-1 475. TAN Guobin, GAO Wei,HUANG Zhengxu, HONG Yi, FU Zhong, DONG Junguo, CHENG Ping, ZHOU Zhen. Vacuum ultraviolet single photon ionization time-of-flight mass spectrometer[J]. Chinese Journal of Analytical Chemistry, 2010, 39(10): 1 470-1 475(in Chinese).
[14] 谭国斌,高伟,洪义,黄正旭,李梅,董俊国,程平,傅忠. 高灵敏度膜进样VOCs在线检测质谱仪的研制[J]. 现代科学仪器,2011,10(5):59-62. TAN Guobin, GAO Wei, HONG Yi, HUANG Zhengxu, LI Mei, DONG Junguo, CHENG Ping, FU Zhong. Development of high sensitivity membrane introduction mass spectrometer for on-line detecting VOCs[J]. Modern Scientific Instruments, 2011,10(5): 59-62(in Chinese).
[15] 吴庆浩,花磊,侯可勇,崔华鹏,陈平,赵无垛,王卫国,李京华,李海洋. 新型单光子电离和光电子电离复合电离源的研究与应用[J]. 分析化学仪器装置与实验技术,2011,39(10):1 465-1 469. WU Qinghao, HUA Lei, HOU Keyong, CUI Huapeng, CHEN Ping, ZHAO Wuduo, WANG Weiguo, LI Jinghua, LI Haiyang. Characterization and applications of combined single photon ionization and photoelectron ionization source[J]. Chinese Journal of Analytical Chemistry, 2011, 39(10): 1 465-1 469(in Chinese).
[16] 洪义,高伟,谭国斌,周振. VOCs在线检测质谱仪单光子电离源的研制[J]. 自动化与仪表,2012,27(6):1-3. HONG Yi, GAO Wei, TAN Guobin, ZHOU Zhen. Research on single photon ionization sources of mass spectrometer for on-line detection of VOCs[J]. Automation & Instrumentation, 2012, 27(6): 1-3(in Chinese).
[17] 顾超峰,谭国斌,李操,麦泽斌,黄正旭,李梅,王姜,杨俊卿,程平. 封闭式单光子/光电子离子源及其在酒类质谱鉴别中的初步应用[J]. 现代科学仪器,2014,(5):29-35. GU Chaofeng, TAN Guobin, LI Cao, MAI Zebin, HUANG Zhengxu, LI Mei, WANG Jiang, YANG Junqing, CHENG Ping. Enclosed single-photon (SPI)/photoelectron (PEI) ionization complex ion source and its preliminary application in the identification of wine mass spectrometer[J]. Modern Scientific Instruments, 2014, (5): 29-35(in Chinese).
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