多巴胺能神经传输在吗啡成瘾与应激性抑郁中的作用机制
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摘要
吗啡成瘾可以引起多巴胺能神经传输功能改变,应激性抑郁与多巴胺能神经的功能降低有关,表明吗啡成瘾与应激性抑郁情感性精神障碍密切相关,他们可能具有一种或多种相同的神经生物学机制。从腹侧被盖区(ventral tegmental area, VTA)到伏隔核(nucleus accumbens, NAc)、前额叶皮层(medial prefrontal cortex, mPFC)、杏仁核(amygdala, Amy)、海马(hippocampus, Hip)以及纹状体(striatum, ST)的多巴胺能神经传输功能紊乱,在吗啡成瘾和应激性抑郁中起着重要的作用。因此,该文对多巴胺能神经传输在吗啡成瘾和应激性抑郁中的作用机制进行综述。
Morphine addiction causes the disturbance in the dopaminergic transmission. The activity of dopaminergic neurons in patients with stress depression is reduced. These studies indicate a strong correlation between morphine addiction and stress depression, which involvement of one or more common neurobiological mechanisms. The dysfunction of dopaminergic neurotransmission from the ventral tegmental area(VTA) to the nucleus accumbens(NAc), prefrontal cortex(mPFC), amygdala(Amy), hippocampus(Hip), and striatum(ST) plays an important role in regulating morphine addiction and stress depression. This article summarizes the mechanism of the dopaminergic transmission regulating morphine addiction and stress depression.
Morphine addiction causes the disturbance in the dopaminergic transmission. The activity of dopaminergic neurons in patients with stress depression is reduced. These studies indicate a strong correlation between morphine addiction and stress depression, which involvement of one or more common neurobiological mechanisms. The dysfunction of dopaminergic neurotransmission from the ventral tegmental area(VTA) to the nucleus accumbens(NAc), prefrontal cortex(mPFC), amygdala(Amy), hippocampus(Hip), and striatum(ST) plays an important role in regulating morphine addiction and stress depression. This article summarizes the mechanism of the dopaminergic transmission regulating morphine addiction and stress depression.
引文
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[22]余守洋,白威峰,涂平,等.延胡索及其有效成分抗吗啡成瘾多巴胺系统作用机制研究和效果比较[J].中国中药杂志,2016,41(19):3643-8.[22]Yu S Y,Bai W F,Tu P,et al.Effect of Corydalis Rhizoma and L-tetrahydropalmatine on dopamine system of hippocampus and striatum in morphine-induced conditioned place preference rats[J].China J Chin Mater Med,2016,41(19):3643-8.
[23]Borroto-Escuela D O,Wydra K,Ferraro L,et al.Chapter 9-Role of D 2-like heteroreceptor complexes in the effects of cocaine,morphine,and hallucinogens[J].Neuropathol Drug Addictions Substance Misuse,2016,93-101.
[24]Martínez-Rivera F J,Barreto-Estrada J L.Reply to:does high-frequency deep brain stimulation in dorsal regions of the ventral striatum impair extinction of morphine-induced place preference[J].Biol Psychiatry,2018,83(1):e21.
[25]Egervari G,Ciccocioppo R,Jentsch J D,et al.Shaping vulnerability to addiction-the contribution of behavior,neural circuits and molecular mechanisms[J].Neurosci Biobehav Rev,2018,85:117-25.
[2]张盼盼,徐文锦,刘惠芬.中枢神经系统ERK信号通路在药物成瘾中的作用机制研究进展[J].中国药理学通报,2017,33(1):1-9.[2]Zhang P P,Xu W J,Liu H F.Research progress in the mechanism of central nervous system ERK signaling pathway in drug addiction[J].Chin Pharmacol Bull,2017,33(1):1-9.
[3]Gong L,He C,Yin Y,et al.Mediating role of the reward network in the relationship between the dopamine multilocus genetic profile and depression[J].Front Mol Neurosci,2017,10:292.
[4]Bosker W M,Neuner I,Shah N J.The role of impulsivity in psychostimulant-and stress-induced dopamine release:review of human imaging studies[J].Neurosci Biobehav Rev,2017,78:82-90.
[5]Kim J,Ham S,Hong H,et al.Brain reward circuits in morphine addiction[J].Mol Cells,2016,39(9):645-53.
[6]Willuhn I,Wanat M J,Clark J J,et al.Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse[J].Curr Top Behav Neurosci,2010,3:29-71.
[7]Minami S,Satoyoshi H,Ide S,et al.Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression:differential responses to drug treatment[J].Neurosci Letter,2017,650:72-6.
[8]Avinun R,Nevo A,Knodt A R,et al.Reward-related ventral striatum activity buffers against the experience of depressive symptoms associated with sleep disturbances[J].J Neurosci,2017,37(40):9724-9.
[9]Kobrin K L,Arena D T,Heinrichs S C,et al.Dopamine D1 receptor agonist treatment attenuates extinction of morphine conditioned place preference while increasing dendritic complexity in the nucleus accumbens core[J].Behav Brain Res,2017,322(Pt A):18-28.
[10]Bakusic J,Schaufeli W,Claes S,et al.Stress,burnout and depression:a systematic review on DNA methylation mechanisms[J].J Psychosom Res,2017,92:34-44.
[11]Nakhjiri E,Saboory E,Roshan-Milani S,et al.Effect of prenatal restraint stress and morphine co-administration on plasma vasopressin concentration and anxiety behaviors in adult rat offspring[J].Stress,2017,20(2):205-11.
[12]Zhu Y,Wienecke C F,Nachtrab G,et al.A thalamic input to the nucleus accumbens mediates opiate dependence[J].Nature,2016,530(7589):219-22.
[13]Terzi8 T,Kastelic M,Dol6an V,et al.Genetic polymorphisms in dopaminergic system and treatment-resistant schizophrenia[J].Psychiatr Danub,2016,28(2):127-31.
[14]Shinohara R,Taniguchi M,Ehrlich A T,et al.Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice[J].Mol Psychiatry,2018,23(8):1717-30.
[15]Reed B,Butelman E R,Kreek M J.Endogenous opioid system in addiction and addiction-related behaviors[J].Curr Opin Behav Sci,2017,13:196-202.
[16]Zhu Z,Wang G,Ke M,et al.GABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression[J].Oncotarget,2017,8(22):35933-45.
[17]Wittenborn A K,Rahmandad H,Rick J,et al.Depression as a systemic syndrome:mapping the feedback loops of major depressive disorder[J].Psychol Med,2016,46(3):551-62.
[18]Bossert J M,Stern A L,Theberge F R,et al.Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin[J].Nat Neurosci,2011,14(4):420-2.
[19]Han H,Dong Z,Jia Y,et al.Opioid addiction and withdrawal differentially drive long-term depression of inhibitory synaptic transmission in the hippocampus[J].Sci Rep,2015,5:9666.
[20]Sharifi K A,Rezayof A,Torkaman-Boutorabi A,et al.The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental area mediate morphine-induced memory consolidation impairment[J].Neuroscience,2017,353:7-16.
[21]Russell S E,Puttick D J,Sawyer A M,et al.Nucleus accumbens AMPA receptors are necessary for morphine-withdrawal-induced negative-affective states in rats[J].J Neurosci,2016,36(21):5748-62.
[22]余守洋,白威峰,涂平,等.延胡索及其有效成分抗吗啡成瘾多巴胺系统作用机制研究和效果比较[J].中国中药杂志,2016,41(19):3643-8.[22]Yu S Y,Bai W F,Tu P,et al.Effect of Corydalis Rhizoma and L-tetrahydropalmatine on dopamine system of hippocampus and striatum in morphine-induced conditioned place preference rats[J].China J Chin Mater Med,2016,41(19):3643-8.
[23]Borroto-Escuela D O,Wydra K,Ferraro L,et al.Chapter 9-Role of D 2-like heteroreceptor complexes in the effects of cocaine,morphine,and hallucinogens[J].Neuropathol Drug Addictions Substance Misuse,2016,93-101.
[24]Martínez-Rivera F J,Barreto-Estrada J L.Reply to:does high-frequency deep brain stimulation in dorsal regions of the ventral striatum impair extinction of morphine-induced place preference[J].Biol Psychiatry,2018,83(1):e21.
[25]Egervari G,Ciccocioppo R,Jentsch J D,et al.Shaping vulnerability to addiction-the contribution of behavior,neural circuits and molecular mechanisms[J].Neurosci Biobehav Rev,2018,85:117-25.
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