祛湿法治疗流行性感冒疗效及安全性Meta分析
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摘要
目的:评价配伍祛湿药物治疗流行性感冒的疗效及安全性。方法:计算机检索PubMed、Embase、CENTRAL、中国生物医学文献数据库、维普期刊数据库、万方数据库和中国知网,查找公开发表的有关中药治疗流行性感冒的随机对照试验,检索时限均为建库至2016年5月,文献文种限中文和英文。由2位评价者根据纳入排除标准独立筛选文献,提取资料并交叉核对后进行方法学质量评价,而后运用RevMen5.3软件进行Meta分析。结果:共纳入20个随机对照试验。结果:祛湿中药组临床有效率优于西药及不含祛湿药物的中成药组[RR=1.19,95%CI(1.15,1.24)],差异有统计学意义(P<0.05)。祛湿中药组24 h完全退热率优于西药及不含祛湿药物的中成药组[RR=1.56,95%CI(1.21,2.01)],差异有统计学意义(P<0.05)。祛湿中药组不良反应发生率低于西药组[OR=0.09,95%CI(0.04,0.22)],差异有统计学意义(P<0.05)。结论:配伍祛湿功效中药治疗流行性感冒具有较好的临床疗效。
Objective:To review the curative effects and safety of Traditional Chinese Medicine With clearing Damp treatment of influenza.Methods:By using computer retrieval PubMed,Embase,CENTRAL,Chinese Biomedical Literature database(CBM),WeiPu Journal database(VIP),WanFang Data and China HowNet(CNKI),the published and unpublished randomized controlled trial(RCT) about TCM treatment of influenza was to be found.Retrieval time limit was October,2015.The language limit was both in English and Chinese.Researchers according to include and exclusion criteria to selecting the literature,and evaluated the methodological quality after extracted data and cross checked,then used RevMen5.3 software for Meta-analysis.Results:There were 20 RCT enclosed.The results showed that:①The clinical total effective rate in treatment group was better than western medicine treatment groups and TCM with no clearing damp efficacy groups [RR=1.19,95%CI(1.15,1.24)],The difference is statistically significant.②The completely antifebrile patients in 24 hours in TCM with Clearing damp efficacy groups was better than western medicine treatment group and TCM with no clearing damp efficacy groups [RR=1.56,95%CI(1.21,2.01)],the difference is statistically significant.③ TCM with Clearing damp efficacy groups lower incidence of adverse reactions than western medicine group [OR=0.09,95%CI(0.04,0.22)],the difference is statistically significant.Conclusion:TCM clearing Damp treatment of influenza is more effective than other medicine.
Objective:To review the curative effects and safety of Traditional Chinese Medicine With clearing Damp treatment of influenza.Methods:By using computer retrieval PubMed,Embase,CENTRAL,Chinese Biomedical Literature database(CBM),WeiPu Journal database(VIP),WanFang Data and China HowNet(CNKI),the published and unpublished randomized controlled trial(RCT) about TCM treatment of influenza was to be found.Retrieval time limit was October,2015.The language limit was both in English and Chinese.Researchers according to include and exclusion criteria to selecting the literature,and evaluated the methodological quality after extracted data and cross checked,then used RevMen5.3 software for Meta-analysis.Results:There were 20 RCT enclosed.The results showed that:①The clinical total effective rate in treatment group was better than western medicine treatment groups and TCM with no clearing damp efficacy groups [RR=1.19,95%CI(1.15,1.24)],The difference is statistically significant.②The completely antifebrile patients in 24 hours in TCM with Clearing damp efficacy groups was better than western medicine treatment group and TCM with no clearing damp efficacy groups [RR=1.56,95%CI(1.21,2.01)],the difference is statistically significant.③ TCM with Clearing damp efficacy groups lower incidence of adverse reactions than western medicine group [OR=0.09,95%CI(0.04,0.22)],the difference is statistically significant.Conclusion:TCM clearing Damp treatment of influenza is more effective than other medicine.
引文
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[16]庞祥源.中药处方汤剂在治疗流感中的效果分析[J].内蒙古中医药,2013,32(1):15-16.
[17]王燕,咸庆飞.普济消毒饮治疗流感临床疗效分析[J].中国中医基础医学杂志,2013,19(4):474-475.
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[19]陈和.加味麻杏石甘汤治疗流行性感冒195例疗效观察[J].国际医药卫生导报,2006,12(11):80-82.
[20]王继建.蒿芩清胆汤加减治疗流行性感冒26例[J].中医研究,2010,23(3):37-38.
[21]张春霞,郭坤霞.清瘟汤治疗流行性感冒高热28例疗效观察[J].新中医,2010,42(8):32-33.
[22]冯茂庭.麻杏石甘汤加减分型治疗流行性感冒的疗效分析[J].按摩与康复医学,2011,2(5):190-191.
[23]屈西轩.蒿芩清胆汤加减治疗流行性感冒40例疗效分析[J].中国实用医药,2011,20(2):164-165.
[24]罗亚锋.基于晁恩祥教授经验的中药治疗流感的临床研究[D].北京:北京中医药大学,2012.
[25]罗翌,严夏,李际强,等.急性上呼吸道感染发热2502例中医证侯分析[J].浙江中医杂志,2005,40(5):221-222.
[2]CHWN X Y,WU T X,LIU G J.Chinese Medicinal Herbs for Influenza:A Systematic Review[J].J Alter Com Plemen Med,2006,12(2):171-180.
[3]黄增婵,李际强.流行性感冒与湿的相关性研究进展[J].江西中医药,2015,30(2):68-71.
[4]黄兆胜.中药学[M].北京:人民卫生出版社,2008.
[5]杨华.柴葛解肌汤加味治疗流行性感冒101例[J].中国中医急症,2000,20(4):132.
[6]姚卫海,周爱国,曲剑华,等.甘露消毒丹加减治疗流感高热的临床分析[J].医学研究通讯,2003,32(5):64-65.
[7]郭晓渊,姚向花.芙朴感冒颗粒佐助治疗甲型流感80例疗效观察[J].中国中医急症,2008,28(6):745-757.
[8]曾勇,莫润田,吴定苏,等.三仁汤加减治疗流感样病例207例[J].实用中医内科杂志,2009,23(5):87-88.
[9]李亮,缪英年,林棉.羌银解热汤治疗流行性感冒疗效观察[J].中国中医急症,2009,29(6):878-879.
[10]冯华越,黄色润.蒿芩清胆汤治疗病毒性流行性感冒疗效观察[J].中国当代医药,2011,22(1):86-89.
[11]李继庭.柴胡香薷饮治疗流感疗效观察[J].新中医,2011,43(5):27-28.
[12]王华.中西医结合治疗秋冬季流感45例防治观察[J].内蒙古中医药,2010,29(5):15-16.
[13]翁炳雄,蔡悦,陆俊.清解化湿汤治疗甲型H1N1流感150例临床观察[J].国际医药卫生导报,2010,16(8):979-980.
[14]张宇.银翘散加减治疗甲型H1N1流感轻症(风热夹湿证)的临床研究[D].广州:广州中医药大学,2011.
[15]曾庆福.三仁汤加减治疗上呼吸道病毒感染湿热证的临床研究[D].广州:广州中医药大学,2012.
[16]庞祥源.中药处方汤剂在治疗流感中的效果分析[J].内蒙古中医药,2013,32(1):15-16.
[17]王燕,咸庆飞.普济消毒饮治疗流感临床疗效分析[J].中国中医基础医学杂志,2013,19(4):474-475.
[18]钟邱,周华凤,林凯,等.芦青颗粒对流感治疗作用的临床分析[J].辽宁中医杂志,2005,32(7):628-629.
[19]陈和.加味麻杏石甘汤治疗流行性感冒195例疗效观察[J].国际医药卫生导报,2006,12(11):80-82.
[20]王继建.蒿芩清胆汤加减治疗流行性感冒26例[J].中医研究,2010,23(3):37-38.
[21]张春霞,郭坤霞.清瘟汤治疗流行性感冒高热28例疗效观察[J].新中医,2010,42(8):32-33.
[22]冯茂庭.麻杏石甘汤加减分型治疗流行性感冒的疗效分析[J].按摩与康复医学,2011,2(5):190-191.
[23]屈西轩.蒿芩清胆汤加减治疗流行性感冒40例疗效分析[J].中国实用医药,2011,20(2):164-165.
[24]罗亚锋.基于晁恩祥教授经验的中药治疗流感的临床研究[D].北京:北京中医药大学,2012.
[25]罗翌,严夏,李际强,等.急性上呼吸道感染发热2502例中医证侯分析[J].浙江中医杂志,2005,40(5):221-222.
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