中西药降脂方案联合运动治疗代谢综合征临床效果观察
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摘要
目的探讨中西药降脂方案联合运动治疗代谢综合征的临床效果。方法选择我院2017年2月—2018年4月收治的代谢综合征90例,按照随机数字表法分为观察组和对照组,每组各45例。对照组予常规治疗和中西药降脂方案,观察组在此基础上加以运动治疗,两组均治疗12周。检测两组身体形态指标(体质量指数、体脂率、腰围)、血脂[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、血压、空腹血糖(fasting plasma glucose, FPG)、空腹胰岛素(fasting insulin, FINS)、胰岛素抵抗指数(HOMA-IR)等水平变化,记录临床疗效,观察不良反应发生情况。结果与本组治疗前比较,两组治疗后体重、腰围、体质量指数、体脂率、收缩压、舒张压、FPG、TG、TC、LDL-C、FINS及HOMA-IR均降低,HDL-C升高,差异有统计学意义(P<0.05);与对照组比较,观察组治疗后体重、腰围、体质量指数、体脂率、收缩压、FPG、TG、TC、LDL-C、FINS及HOMA-IR下降更为显著,HDL-C明显升高,差异有统计学意义(P<0.05)。两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论中西药降脂方案联合运动治疗代谢综合征能更好地降低体脂率和体质量指数,改善血清学各项指标,临床效果好。
Objective To investigate the clinical effect of lipid-lowering regimen by TCM and Western medicine combined with exercise on metabolic syndrome. Methods A total of 90 cases of patients with metabolic syndrome treated in in our hospital from February 2017 to April 2018 were randomly divided into the experimental group(n=45) and the control group(n=45). The control group was given conventional medical treatment and lipid-lowering regimen by TCM and Western medicine for symptomatic treatment. On this basis, the experimental group was given additional exercise treatment Both groups were treated for 12 weeks. The changes of the body shape indicators [body mass index(BMI), body fat percentage(BFP), waist circumference(WC)], blood lipids [triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C)], blood pressure(BP), fasting plasma glucose(FPG), fasting insulin(FINS) and homeostasis model assessment-insulin resistance index(HOMA-IR) were detected before and after treatment. In addition, the clinical therapeutic effects and adverse effects of the two groups were recorded and evaluated. Results Compared with those before treatment, the body weight, WC, BMI, BFP, systolic blood pressure(SBP), diastolic blood pressure(DBP), FPG, TG, TC, LDL-C, FINS and HOMA-IR were all decreased after treatment, while HDL-C was increased, suggesting significant differences(P<0.05). Compared with those in the control group, body weight, WC, BMI, BFP, SBP, FPG, TG, TC, LDL-C and HOMA-IR was more significantly decreased in the observed group after treatment, whereas HDL-C was significantly increased, and the difference was statistically significant(P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion lipid-lowering regimen by TCM and Western medicine combined with exercise for the treatment of metabolic syndrome can better reduce BFP and BMI, improve the serological indicators, and have a good clinical effect.
Objective To investigate the clinical effect of lipid-lowering regimen by TCM and Western medicine combined with exercise on metabolic syndrome. Methods A total of 90 cases of patients with metabolic syndrome treated in in our hospital from February 2017 to April 2018 were randomly divided into the experimental group(n=45) and the control group(n=45). The control group was given conventional medical treatment and lipid-lowering regimen by TCM and Western medicine for symptomatic treatment. On this basis, the experimental group was given additional exercise treatment Both groups were treated for 12 weeks. The changes of the body shape indicators [body mass index(BMI), body fat percentage(BFP), waist circumference(WC)], blood lipids [triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C)], blood pressure(BP), fasting plasma glucose(FPG), fasting insulin(FINS) and homeostasis model assessment-insulin resistance index(HOMA-IR) were detected before and after treatment. In addition, the clinical therapeutic effects and adverse effects of the two groups were recorded and evaluated. Results Compared with those before treatment, the body weight, WC, BMI, BFP, systolic blood pressure(SBP), diastolic blood pressure(DBP), FPG, TG, TC, LDL-C, FINS and HOMA-IR were all decreased after treatment, while HDL-C was increased, suggesting significant differences(P<0.05). Compared with those in the control group, body weight, WC, BMI, BFP, SBP, FPG, TG, TC, LDL-C and HOMA-IR was more significantly decreased in the observed group after treatment, whereas HDL-C was significantly increased, and the difference was statistically significant(P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion lipid-lowering regimen by TCM and Western medicine combined with exercise for the treatment of metabolic syndrome can better reduce BFP and BMI, improve the serological indicators, and have a good clinical effect.
引文
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[7]杨光燃,袁申元,傅汉菁,等.颈围、腰围、腰臀比对2型糖尿病患者超重、肥胖及代谢综合征评价作用的比较研究[J].中国全科医学,2016,19(7):781-785.
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[10]石海燕,王建荣,赛晓勇,等.代谢综合征相关因素在中年体检人群中的横断面调查[J].中华保健医学杂志,2018,20(4):286-288.
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[13]郭绍东.组织特异性胰岛素抵抗及其代谢综合征的机制探讨[J].第三军医大学学报,2014,36(15):1535-1542.
[14]李米环,李国强,江崇民.城区成年居民体力活动模式与超重及肥胖的关系研究[J].中国全科医学,2016,19(32):3933-3939.
[15]刘占锋,魏俊民.体育运动负荷等级与代谢综合征的logistic回归分析[J].武汉体育学院学报,2017,51(1):92-95.
[16]Lackland D T,Voeks J H.Metabolic syndrome and hypertension:regular exercise as part of lifestyle management[J].Curr Hypertens Rep,2014,16(11):492.
[17]中华中医药学会糖尿病分会.糖尿病合并代谢综合征中医诊疗标准[J].世界中西医结合杂志,2011,6(2):177-179.
[18]郭伟,王燕,王媛,等.半夏白术汤对高血压患者血压、血脂的影响[J].长春中医药大学学报,2015,31(5):986-987.
[19]马进,甘雨,袁媛,等.川芎赤芍干预脑缺血再灌注大鼠血管新生的实验研究[J].世界中医药,2016,11(6):1060-1062.
[20]董婧婧,刘艳菊,涂济源,等.三七粉调血脂作用及机制研究[J].中草药,2017,48(8):1597-1603.
[21]孔春妍,牟春笋,段保,等.中药联合生活方式管理对青少年代谢综合征相关代谢指标影响[J].辽宁中医药大学学报,2017,19(10):190-192.
[2]寇勇,黎英辉,季金枝,等.健康体检人群代谢综合征调查及健康管理干预的研究[J].中国卫生产业,2015,14(12):135-136.
[3]仇梦霞,龙石银,陈志军,等.代谢综合征患者血糖、血脂水平与HDL亚类组成的关系[J].中国病理生理杂志,2015,31(2):319-324.
[4]刘通,高海静,王万超,等.代谢综合征对新发胆石症的预测价值[J].中华消化外科杂志,2017,16(6):608-613.
[5]Cohen J B,Cohen D L.Cardiovascular and renal effects of weight reduction in obesity and the metabolic syndrome[J].Curr Hypertens Rep,2015,17(5):34.
[6]赵厚宇,杨俊,孙凤,等.中国3个地区体检人群代谢综合征发病风险及其危险因素分析[J].中华流行病学杂志,2017,38(12):1591-1597.
[7]杨光燃,袁申元,傅汉菁,等.颈围、腰围、腰臀比对2型糖尿病患者超重、肥胖及代谢综合征评价作用的比较研究[J].中国全科医学,2016,19(7):781-785.
[8]马中书,冯晓路,朱萍.代谢综合征与相关疾病的临床研究进展[J].中国全科医学,2015,18(17):1991-1995.
[9]张崇龙,赵刚.不同强度有氧运动对代谢综合征患者心血管危险因子的干预效果分析[J].沈阳体育学院学报,2016,35(5):68-74.
[10]石海燕,王建荣,赛晓勇,等.代谢综合征相关因素在中年体检人群中的横断面调查[J].中华保健医学杂志,2018,20(4):286-288.
[11]张凤平.肥胖是代谢综合征的核心环节[J].临床误诊误治,2006,19(11):6-7.
[12]王姗,何敏学.不同时长有氧运动对代谢综合征患者生活质量、体脂参数及代谢水平的影响[J].中国糖尿病杂志,2016,24(4):313-316.
[13]郭绍东.组织特异性胰岛素抵抗及其代谢综合征的机制探讨[J].第三军医大学学报,2014,36(15):1535-1542.
[14]李米环,李国强,江崇民.城区成年居民体力活动模式与超重及肥胖的关系研究[J].中国全科医学,2016,19(32):3933-3939.
[15]刘占锋,魏俊民.体育运动负荷等级与代谢综合征的logistic回归分析[J].武汉体育学院学报,2017,51(1):92-95.
[16]Lackland D T,Voeks J H.Metabolic syndrome and hypertension:regular exercise as part of lifestyle management[J].Curr Hypertens Rep,2014,16(11):492.
[17]中华中医药学会糖尿病分会.糖尿病合并代谢综合征中医诊疗标准[J].世界中西医结合杂志,2011,6(2):177-179.
[18]郭伟,王燕,王媛,等.半夏白术汤对高血压患者血压、血脂的影响[J].长春中医药大学学报,2015,31(5):986-987.
[19]马进,甘雨,袁媛,等.川芎赤芍干预脑缺血再灌注大鼠血管新生的实验研究[J].世界中医药,2016,11(6):1060-1062.
[20]董婧婧,刘艳菊,涂济源,等.三七粉调血脂作用及机制研究[J].中草药,2017,48(8):1597-1603.
[21]孔春妍,牟春笋,段保,等.中药联合生活方式管理对青少年代谢综合征相关代谢指标影响[J].辽宁中医药大学学报,2017,19(10):190-192.
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