不同胎龄早产儿生后7天内网织红细胞血红蛋白含量变化趋势

详细信息    查看全文 | 推荐本文 |

英文篇名：Trend of reticulocyte hemoglobin content in preterm infants with different gestational ages in 7 days after birth 作者：吴艳 ; 钟晓云 ; 杨桂林 ; 朱叶芳 ; 陈功雪 ; 龚华 英文作者：WU Yan;ZHONG Xiaoyun;YANG Guilin;ZHU Yefang;CHEN Gongxue;GONG Hua;Neonatal Department, Chongqing Health Center for Children and Women;Clinical Laboratory, Chongqing Health Center for Children and Women; 关键词：早产儿 ; 网织红细胞血红蛋白含量 ; 胎龄 ; 日龄 英文关键词：premature infant;;reticulocyte hemoglobin content;;gestational age;;postnatal age 中文刊名：LCAK 英文刊名：Journal of Clinical Pediatrics 机构：重庆市妇幼保健院新生儿科;重庆市妇幼保健院检验科; 出版日期：2019-03-15 出版单位：临床儿科杂志 年：2019 期：v.37 基金：重庆市卫生计生委医学科研项目(No.2016MSXM095) 语种：中文; 页：LCAK201903001 页数：4 CN：03 ISSN：31-1377/R 分类号：7-10

摘要

目的建立不同胎龄早产儿网织红细胞血红蛋白含量(Ret-He)的参考值范围,并且评估生后7天内Ret-He的变化趋势。方法测量不同胎龄早产儿在生后24小时、2～3天、7天的Ret-He值,并分析Ret-He值与胎龄的相关性。结果纳入699例早产儿,采集1 286份血样本。生后24小时内(n=699,r=0.126,P=0.002)、2～3天(n=440,r=0.487,P<0. 001)、7天(n=147,r=0. 510,P<0. 001)Ret-He水平与胎龄呈正相关,日龄越大相关性越强。147例早产儿在生后24小时内、2～3天、7天的平均Ret-He分别为32.18、27.82、28.85 pg。不同胎龄早产儿2～3天的Ret-He水平均低于24小时内,差异有统计学意义(P<0.001);生后2～3天至生后7天的Ret-He存在轻度上升趋势,其中胎龄30～33周早产儿生后7天的Ret-He高于生后2～3天,差异有统计学意义(P<0. 001)。结论 Ret-He与胎龄存在弱的相关性,其在生后2～3天内显著下降,出生2～3天的Ret-He水平更能真实反映机体铁水平。
        Objective To establish the reference range of reticulocyte hemoglobin content(Ret-He) in premature infants with different gestational ages(GA), and to evaluate the trend of change in Ret-He within 7 days after birth. Method The RetHe values of premature infants with different gestational ages were measured at 24 hours, 2-3 days and 7 days after birth, and the correlation between Ret-He values and gestational age was analyzed. Results A total of 1286 blood samples were collected from699 premature infants. Gestational age was positively correlated with Ret-He levels at 24 hours(n=699, r=0.126, P=0.002), 2-3 days(n=440, r=0.487, P<0.001) and 7 days(n=147, r=0.510, P<0.001) after birth. The correlation was increased over the age.The average Ret-He levels of 147 premature infants at 24 hours, 2-3 days and 7 days after birth were 32.18, 27.82 and 28.85 pg respectively The Ret-He levels at 2-3 days after birth in preterm infants with different gestational ages were lower than those at 24 hours, and there was statistically difference(P<0.001). The Ret-He levels increased slightly from 2-3 days to 7 days after birth. The Ret-He levels at the 7 th day after birth was higher than that at 2-3 days in preterm infants with gestational age of 30-33 weeks, and there was statistically difference(P<0.001). Conclusion Ret-He was weakly correlated with gestational age and it is decreased significantly in 2-3 days after birth. The Ret-He level at 2-3 days after birth reflects the body's iron level more accurately.

引文

[1]Collard K,White D,Copplestone A.The effect of maximum storage on iron status,oxidative stress and antioxidant protection in paediatric packed cell units[J].Blood Transfus,2013,11(3):419-425.
    [2]Brugnara C,Zurakowski D,DiCanzio J,et a1.Reticulocyte hemoglobin content to diagnose iron deficiency in children[J].JAMA,1999,28l(23):2225-2230.
    [3]Cai J,Wu M,Ren J,et al.Evaluation of the efficiency of the reticulocyte hemoglobin content on diagnosis for iron deficiency anemia in Chinese adults[J].Nutrients,2017,9(5).pii:E450.doi:10.3390/nu9050450.
    [4]Ibá?ez-Alcalde MM,Vázquez-López Má,Ruíz-Sánchez AM,et al.Reference values of reticulocyte hemoglobin conte nt in healthy adolescents[J].J Pediatr Hematol Oncol,2018,40(4):298-303.
    [5]Toki Y,Ikuta K,Kawahara Y,et al.Reticulocyte hemoglo bin equivalent as a potential marker for diagnosis of iron deficiency[J].Int J Hematol,2017,106(1):116-125.
    [6]Christensen RD,Henry E,Bennett ST,et al.Reference intervals for reticulocyte parameters of infants during their first 90 days after birth[J].J Perinatol,2016,36(1):61-66.
    [7]Lorenz L,Peter A,Arand J,et al.Reference ranges of reticulocyte haemoglobin content in preterm and term infants:a retrospective analysis[J].Neonatology,2017,111(3):189-194.
    [8]Lorenz L,Peter A,Arand J,et al.Reticulocyte haemoglobin content declines more markedly in preterm than in term infants in the first days after birth[J].Neonatology,2017,112(3):246-250.
    [9]Al-Ghananim RT,Nalbant D,Schmidt RL,et al.Reticulocyte hemoglobin content during the first month of life in critically III very low birth weight neonates differs from term infants,children,and adults[J].J Clin Lab Anal,2016,30(4):326-334.
    [10]Widness JA.Pathophysiology of anemia during the neonatal period,including anemia of prematurity[J].Neoreviews,2008,9(11):e520.
    [11]Buonocore G,Zani S,Sargentini I,et al.Hypoxia-induced free iron release in the red cells of newborn infants[J].Acta Paediatr,1998,87(1):77-81.