VEGF-C、TIMP-2、AKT2在胃癌中表达的意义

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英文篇名：Expression and Significance of VEGF-C,TIMP-2 and AKT2 in Gastric Cancer Tissues 作者：熊利芬 ; 李蜀豫 英文作者：XIONG Li-fen;Department of gastroenterology,the third people's hospital of Hubei province; 关键词：VEGF-C ; TIMP-2 ; AKT2 ; 胃癌 ; 生存期 英文关键词：VEGF-C;;TIMP-2;;AKT2;;Gastric cancer;;Survival time 中文刊名：QQHB 英文刊名：Journal of Qiqihar Medical University 机构：湖北省第三人民医院消化内科; 出版日期：2019-01-28 出版单位：齐齐哈尔医学院学报 年：2019 期：v.40;No.468 语种：中文; 页：QQHB201902001 页数：3 CN：02 ISSN：23-1278/R 分类号：6-8

摘要

目的探讨血管内皮生长因子-C(VEGF-C)、蛋白激酶-2(AKT2)、金属蛋白酶-2(TIMP-2)在胃癌中表达的意义。方法选取本院2015年1月—2018年1月收治的胃癌患者120例,所有患者接受病理检查,HE切片由经验丰富的专家亲自复查,使用石蜡包埋并将其切割呈4μm的4片,进行TIMP-2、AKT2、VEGF-C检查。结果肿瘤大小、浸润深度、淋巴转移、分期、分化程度、肿瘤发生与VEGF-C阳性率及AKT2阳性率有关。其中肿瘤≥5 cm、浸润深度外膜、淋巴转移阳性、Ⅲ～Ⅳ期、高、中分化、残胃癌VEGF-C阳性率最高(P<0.05)。肿瘤≥5 cm、浸润深度至肌层、淋巴转移阳性、Ⅱ期、Ⅲ～Ⅳ期、高、中分化、血道转移的胃癌患者AKT2阳性率最高(P<0.05)。肿瘤大小、淋巴转移与TIMP-2阳性率有关。肿瘤≥5 cm、淋巴转移阳性的胃癌患者AKT2阳性率最高(P<0.05),其余病理因素与之无关(P>0.05)。VEGFC、TIMP-2、AKT2阳性表达在胃癌患者中,相同时间的累计生存率显著低于阴性表达,即EGF-C、TIMP-2、AKT2表达高,生存期短。结论 VEGF-C、TIMP-2、AKT2在胃癌组织中阳性率高,且影响预后。
        Objective To investigate the expression and significance of vascular endothelial growth factor-C( VEGF-C),protein kinase-2( AKT2) and tissue inhibitor of metalloproteinase-2( TIMP-2) in gastric cancer tissues.Methods 120 patients with gastric cancer admitted to our hospital from January to February 2018 were enrolled and underwent pathological examination by experienced experts,and then the gastric cancer tissues were collected for the detection of TIMP-2,AKT2,and VEGF-C. Results Tumor size,depth of invasion,lymphatic metastasis,stage,degree of differentiation,and the incidence of tumor were associated with positive rate of VEGF-C and AKT2.The tumor size over 5 cm,invasion depth of adventitia,lymphatic metastasis,stage Ⅲ ～ Ⅳ,moderate-to-high differentiation and residual gastric cancer induced the highest positive rate of VEGF-C( P< 0.05).The positive rate of AKT2 was the highest in gastric cancer patients with tumor over 5 cm,depth of invasion to muscular layer,lymphatic metastasis,stage,stage Ⅲ ～ Ⅳ,moderate-to-high differentiation and blood metastasis( P<0.05).Tumor size and lymph node metastasis were associated with the positive rate of AKT2.The positive rate of TIMP-2 was the highest in gastric cancer patients with tumors size over 5 cm and lymphatic metastasis( P<0.05),but with no relation to the other pathological factors( P > 0. 05). The cumulative survival rate of gastric cancer patients with positive expression of VEGF-C,TIMP-2 and AKT2 was significantly lower than that of patients with negative expression,indicating that patients with high expression of VEGF-C,TIMP-2 and AKT2 had short survival time. Conclusions The positive rate of VEGF-C,TIMP-2 and AKT2 in gastric cancer tissues is high and affects prognosis.

引文

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