紫杉醇联合卡铂治疗宫颈癌的临床效果及与宫颈癌组织MLVD及MVD的关系

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英文篇名：Clinical efficacy of paclitaxel combined with carboplatin in the treatment of cervical cancer and its relationship with MLVD and MVD in cervical cancer tissues 作者：王祝荣 ; 于克 ; 杨霞 ; 王丽 英文作者：WANG Zhurong;YU Ke;YANG Xia;WANG Li;Department of Gynecology,Affiliated Hospital of Yangzhou University;Department of Gynecologic Oncology,Affiliated Hospital of Yangzhou University; 关键词：宫颈癌 ; 紫杉醇 ; 卡铂 ; 微淋巴管 ; 微血管 英文关键词：cervical cancer;;paclitaxel;;carboplatin;;microlymphatic vessel;;microvessel 中文刊名：AZJZ 英文刊名：Oncology Progress 机构：扬州大学附属医院妇科;扬州大学附属医院妇科肿瘤科; 出版日期：2019-02-10 出版单位：癌症进展 年：2019 期：v.17 语种：中文; 页：AZJZ201903028 页数：3 CN：03 ISSN：11-4971/R 分类号：109-111

摘要

目的探讨紫杉醇联合卡铂对宫颈癌患者的治疗效果,并分析其与宫颈癌组织微淋巴管密度(MLVD)和微血管密度(MVD)的关系。方法选取宫颈癌患者30例,所有患者术前均进行紫杉醇联合顺铂方案化疗,术后收集患者的病灶组织和病灶周围组织,对不同组织中MLVD和MVD进行观察,并对化疗效果与宫颈癌组织中MLVD及MVD的关系进行分析。结果化疗结束后,30例宫颈癌患者的治疗总有效率为93.33%;高MLVD组、高MVD组患者的完全缓解率分别明显高于低MLVD组和低MVD组,差异均有统计学意义(P﹤0.01)。绝经患者病灶组织和病灶周围组织中MLVD均明显高于未绝经患者(P﹤0.01);绝经患者病灶组织及病灶周围组织中MVD均明显高于未绝经患者(P﹤0.01);FIGO分期越高的宫颈癌患者,病灶组织和病灶周围组织中MLVD、MVD越大(P﹤0.01)。结论宫颈癌患者病灶组织中MLVD和MVD关系紧密,MLVD和MVD可以作为宫颈癌发展的预测指标之一。
        Objective To investigate the therapeutic effect of paclitaxel combined with carboplatin in patients with cervical cancer,and to analyze the relationship between the combined regimen and microlymphatic vessel density(MLVD) and microvessel density(MVD) in the cancer tissues.Method Thirty patients with cervical cancer were included and treated with paclitaxel combined with cisplatin before operation,from which the specimens of lesions and adjacent tissues were collected after operation.MLVD and MVD in these tissue samples were observed.The relationship between chemotherapy and MLVD and MVD in cervical cancer tissues was analyzed.Result The overall remission rate of the 30 cases of cervical cancer was 93.33% after chemotherapy.The complete remission rate of patients with high MLVD and MVD were significantly higher than those with low MLVD and MVD,with statistically significant difference observed(P<0.01).The MVD in adjacent tissues was significantly higher in menopausal patients compared with those who had not experienced menopause(P<0.01);besides,higher FIGO stage was associated with higher MLVD and MVD in lesions and adjacent tissues,with statistically significant differences observed(P<0.01).Conclusion There is a close relationship between MLVD and MVD in the lesions of cervical cancer tissues,thus MLVD and MVD can be potential predictive indicators for the development of cervical cancer.

引文

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