红玉赔赈颗粒对脓毒症气分证患者炎症指标的干预效果

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英文篇名：Effect of Hongyu Peizhen Granule on inflammatory indicators in sepsis patients differentiated as pathogen involving Qifen 作者：赵雷 ; 朱亮 ; 蒋锦琪 ; 沈梦雯 ; 钱风华 ; 钱义明 英文作者：ZHAO Lei;ZHU Liang;JIANG Jinqi;SHEN Mengwen;QIAN Fenghua;QIAN Yiming;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai Hospital of Traditional Chinese Medicine;Chest Hospital Affiliated to Shanghai Jiaotong University; 关键词：脓毒症 ; 红玉赔赈颗粒 ; 炎症指标 ; 气分证 英文关键词：sepsis;;Hongyu Peizhen Granule;;inflammation index;;Qifen syndrome 中文刊名：XYZL 英文刊名：Journal of Clinical Medicine in Practice 机构：上海中医药大学附属岳阳中西医结合医院;上海交通大学附属胸科医院; 出版日期：2019-04-23 出版单位：实用临床医药杂志 年：2019 期：v.23 基金：上海市卫生计生委委级科研项目(201540234);; 上海市卫生和计划生育委员会中医药科研项目(2016LP048) 语种：中文; 页：XYZL201908025 页数：4 CN：08 ISSN：32-1697/R 分类号：91-93+97

摘要

目的探讨红玉赔赈颗粒对脓毒症患者血白细胞计数(WBC)、中性粒细胞百分比(N%)、超敏C反应蛋白(hs-CRP)、红细胞沉降率(ESR)、血清降钙素原(PCT)、动脉血乳酸(Lac)炎症指标的干预作用。方法将70例符合脓毒症诊断标准的急危重病症患者随机分为2组,试验组在西医常规治疗的基础上予以连续7 d口服或鼻饲红玉赔赈颗粒,对照组在西医常规治疗组基础上加用1/10的红玉赔赈颗粒安慰剂,检测2组患者治疗前以及治疗后第1天、第3天、第7天的血清WBC、N%、hs-CRP、ESR、Pct、动脉血Lac水平。结果与对照组比较,治疗后第7天试验组N%、hs-CRP、ESR、PCT、动脉血Lac指标水平均降低更显著(P <0. 05)。结论红玉赔赈颗粒能对脓毒症患者炎症反应起抑制作用,可改善脓毒症患者因组织缺氧及低灌注所致的高乳酸血症,从而改善预后。
        Objective To investigate effect of Hongyu Peizhen Granule on inflammatory indicators such as white blood cell( WBC),neutrophil percentage( N%),hypersensitive C reaction protein( hs-CRP),erythrocyte sedimentation rate( ESR),serum procalcitonin( PCT),arterial blood lactic acid( Lac) in sepsis patients. Methods Seventy acute and critical illness patients in accordance with the diagnostic criteria of sepsis were randomly divided into two groups. The patients of two groups were all given routine western medicine treatment,the experimental group was orally or nasally given Hongyu Peizhen Granule for 7 consecutive days in addition,while the control group additionally received 1/10 dose of Hongyu Peizhen Granule as placebo. The serum levels of WBC,N%,hs-CRP,ESR,PCT and Lac in arterial blood before treatment,and at 1,3,7 d after treatment were measured. Results Compared with the control group,the levels of N%,hs-CRP,ESR,PCT,arterial blood Lac at 7 d in the experimental group decreased more significantly( P < 0. 05). Conclusion Hongyu Peizhen Granule can inhibit the inflammatory reaction of sepsis patients and improve their hyperlacticemia caused by tissue hypoxia and hypoperfusion thereby improving the prognosis of sepsis patients.

引文

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