非甾体抗炎药超敏反应
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摘要
非甾体抗炎药(non-steroidal anti-inflammatory drugs, NSAIDs)在临床上应用非常广泛,亦为引发药物超敏反应第2位常见药物,且涉及不同机制、临床表现多样。本文就NSAIDs引发超敏反应的分型、机制、诊断方法及流程进行综述,以期提高广大医务工作者的认识。
Non-steroidal anti-inflammatory drugs(NSAIDs) are extensively used in clinical practice. It is the second most common drug, which can lead to hypersensitivity reactions. Moreover, the hypersensitivity reactions caused by NSAIDs involve a variety of different mechanisms, and the clinical manifestations are various. The classification, mechanisms, diagnostic methods, and procedure of hypersensitivity reactions induced by NSAIDs was reviewed in his paper, with the hope to facilitate the improvement of awareness among medical workers.
Non-steroidal anti-inflammatory drugs(NSAIDs) are extensively used in clinical practice. It is the second most common drug, which can lead to hypersensitivity reactions. Moreover, the hypersensitivity reactions caused by NSAIDs involve a variety of different mechanisms, and the clinical manifestations are various. The classification, mechanisms, diagnostic methods, and procedure of hypersensitivity reactions induced by NSAIDs was reviewed in his paper, with the hope to facilitate the improvement of awareness among medical workers.
引文
[1] Buer JK. Origins and impact of the term ‘NSAID'[J]. Inflammopharmacology,2014, 22: 263-267.
[2] Samter M, Beers RF.Intolerance to aspirin. Clinical studies and consideration of its pathogenesis[J]. Ann Intern Med,1968, 68: 975-983.
[3] Gomes ER. Demoly P.Epidemiology of hypersensitivity drug reactions[J]. Curr Opin Allergy Clin Immunol, 2005,5: 309-316.
[4] Settipane RA, Constantine HP, Settipane GA. Aspirin intolerance and recurrent urticaria in normal adults and children. Epidemiology and review[J]. Allergy,1980,35: 149-154.
[5] Gomes E, Cardoso MF, Praca F, et al. Self-reported drug allergy in a general adult Portuguese population[J]. Clin Exp Allergy, 2004, 34: 1597-1601.
[6] Kasper L, Sladek K, Duplaga M, et al, Prevalence of asthma with aspirin hypersensitivity in the adult population of Poland[J]. Allergy,2003,58: 1064-1066.
[7] Kim JE, Kountakis SE. The prevalence of Samter's triad in patients undergoing functional endoscopic sinus surgery[J]. Ear Nose Throat J,2007, 86: 396-399.
[8] Erbagci Z. Multiple NSAID intolerance in chronic idiopathic urticaria is correlated with delayed, pronounced and prolonged autoreactivity[J]. J Dermatol,2004, 31: 376-382.
[9] Ye YM, Kim MK, Kang HR, et al.Predictors of the severity and serious outcomes of anaphylaxis in korean adults: a multicenter retrospective case study[J]. Allergy Asthma Immunol Res,2015,7: 22-29.
[10] Tian XY, Liu B, Shi H, et al. Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study[J]. Arch Dermatol Res,2015,307: 829-834.
[11] Kowalski ML, Asero R, Bavbek S, et al. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs[J]. Allergy,2013,68: 1219-1232.
[12] Kowalski ML, Cieslak M, Perez-Novo CA, et al. Clinical and immunological determinants of severe/refractory asthma (SRA): association with Staphylococcal superantigen-specific IgE anti-bodies[J]. Allergy,2011,66: 32-38.
[13] Yoshimine F, Hasegawa T, Suzuki E, et al. Contribution of aspirin-intolerant asthma to near fatal asthma based on a questionnaire survey in Niigata Prefecture, Japan. [J].Respirology, 2005,10: 477-484.
[14] Price KS, Thomson DM. Localized unilateral periorbital edema induced by aspirin[J]. Ann Allergy Asthma Immunol,1997, 79: 420-422.
[15] Quiralte J, Blanco C, Delgado J, et al. Challenge-based clinical patterns of 223 Spanish patients with nonsteroidal anti-inflammatory-drug-induced-reactions[J].J Investig Allergol Clin Immunol,2007, 17: 182-188.
[16] Canto MG, Andreu I, Fernandez J, et al. Selective immediate hypersensitivity reactions to NSAIDs[J]. Curr Opin Allergy Clin Immunol, 2009. 9: 293-297.
[17] Quiralte J, Blanco C, Castillo R, et al. Anaphylactoid reactions due to nonsteroidal antiinflammatory drugs: clinical and cross-reactivity studies[J]. Ann Allergy Asthma Immunol, 1997,78: 293-296.
[18] Lee SY, Nam YH, Koh YI, et al. Phenotypes of Severe Cutaneous Adverse Reactions Caused by Nonsteroidal Anti-inflammatory Drugs[J]. Allergy Asthma Immunol Res, 2019, 11: 212-221.
[19] Demir S, Olgac M, Unal D, et al. Evaluation of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs according to the latest classification[J]. Allergy,2015, 70: 1461-1467.
[20] Dona I, Barrionuevo E, Salas M, et al. NSAIDs-hypersensitivity often induces a blended reaction pattern involving multiple organs[J]. Sci Rep,2018, 8: 16710.
[21] Picaud J, Beaudouin E, Renaudin JM, et al. Anaphylaxis to diclofenac: nine cases reported to the Allergy Vigilance Network in France[J]. Allergy,2014,69: 1420-1423.
[22] Brockow K, Garvey LH, Aberer W, et al. Skin test concentrations for systemically administered drugs -- an ENDA/EAACI Drug Allergy Interest Group position paper[J]. Allergy, 2013,68: 702-712.
[23] Nizankowska-Mogilnicka E, Bochenek G, Mastalerz L, et al. EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity[J]. Allergy,2007, 62: 1111-1118.
[24] Berges-Gimeno MP, Simon RA,Stevenson DD. The natural history and clinical characteristics of aspirin-exacerbated respiratory disease[J]. Ann Allergy Asthma Immunol,2002, 89: 474-478.
[25] Nizankowska E, Bestynska-Krypel A, Cmiel A, et al. Oral and bronchial provocation tests with aspirin for diagnosis of aspirin-induced asthma[J]. Eur Respir J,2000,15: 863-869.
[26] Kowalski ML, Ptasinska A, Jedrzejczak M, et al, Aspirin-triggered 15-HETE generation in peripheral blood leukocytes is a specific and sensitive Aspirin-Sensitive Patients Identification Test (ASPITest)[J]. Allergy,2005,60: 1139-1145.
[27] Modena B, White AA,Woessner KM. Aspirin and Nonsteroidal Antiinflammatory Drugs Hypersensitivity and Management[J]. Immunol Allergy Clin North Am, 2017, 37: 727-749.
[28] Kowalski ML, Woessner K. Sanak M. Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug-related urticaria and angioedema[J]. J Allergy Clin Immunol, 2015, 136: 245-51.
[29] Simon RA. Prevention and treatment of reactions to NSAIDs[J]. Clin Rev Allergy Immunol, 2003, 24: 189-198.
[30] Slowik SM, Slavin RG. Aspirin desensitization in a patient with aspirin sensitivity and chronic idiopathic urticaria[J]. Ann Allergy Asthma Immunol, 2009, 102: 171-172.
[31] Berges-Gimeno MP, Simon RA,Stevenson DD. Long-term treatment with aspirin desensitization in asthmatic patients with aspirin-exacerbated respiratory disease[J]. J Allergy Clin Immunol, 2003, 111: 180-186.
[32] Rozsasi A, Polzehl D, Deutschle T, et al. Long-term treatment with aspirin desensitization: a prospective clinical trial comparing 100 and 300 mg aspirin daily[J]. Allergy, 2008, 63: 1228-1234.
[33] Berges-Gimeno MP, Simon RA. Stevenson DD. Early effects of aspirin desensitization treatment in asthmatic patients with aspirin-exacerbated respiratory disease[J]. Ann Allergy Asthma Immunol, 2003, 90: 338-341.
[34] Lee JY, Simon RA, Stevenson DD. Selection of aspirin dosages for aspirin desensitization treatment in patients with aspirin-exacerbated respiratory disease[J]. J Allergy Clin Immunol, 2007, 119: 157-164.
[2] Samter M, Beers RF.Intolerance to aspirin. Clinical studies and consideration of its pathogenesis[J]. Ann Intern Med,1968, 68: 975-983.
[3] Gomes ER. Demoly P.Epidemiology of hypersensitivity drug reactions[J]. Curr Opin Allergy Clin Immunol, 2005,5: 309-316.
[4] Settipane RA, Constantine HP, Settipane GA. Aspirin intolerance and recurrent urticaria in normal adults and children. Epidemiology and review[J]. Allergy,1980,35: 149-154.
[5] Gomes E, Cardoso MF, Praca F, et al. Self-reported drug allergy in a general adult Portuguese population[J]. Clin Exp Allergy, 2004, 34: 1597-1601.
[6] Kasper L, Sladek K, Duplaga M, et al, Prevalence of asthma with aspirin hypersensitivity in the adult population of Poland[J]. Allergy,2003,58: 1064-1066.
[7] Kim JE, Kountakis SE. The prevalence of Samter's triad in patients undergoing functional endoscopic sinus surgery[J]. Ear Nose Throat J,2007, 86: 396-399.
[8] Erbagci Z. Multiple NSAID intolerance in chronic idiopathic urticaria is correlated with delayed, pronounced and prolonged autoreactivity[J]. J Dermatol,2004, 31: 376-382.
[9] Ye YM, Kim MK, Kang HR, et al.Predictors of the severity and serious outcomes of anaphylaxis in korean adults: a multicenter retrospective case study[J]. Allergy Asthma Immunol Res,2015,7: 22-29.
[10] Tian XY, Liu B, Shi H, et al. Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study[J]. Arch Dermatol Res,2015,307: 829-834.
[11] Kowalski ML, Asero R, Bavbek S, et al. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs[J]. Allergy,2013,68: 1219-1232.
[12] Kowalski ML, Cieslak M, Perez-Novo CA, et al. Clinical and immunological determinants of severe/refractory asthma (SRA): association with Staphylococcal superantigen-specific IgE anti-bodies[J]. Allergy,2011,66: 32-38.
[13] Yoshimine F, Hasegawa T, Suzuki E, et al. Contribution of aspirin-intolerant asthma to near fatal asthma based on a questionnaire survey in Niigata Prefecture, Japan. [J].Respirology, 2005,10: 477-484.
[14] Price KS, Thomson DM. Localized unilateral periorbital edema induced by aspirin[J]. Ann Allergy Asthma Immunol,1997, 79: 420-422.
[15] Quiralte J, Blanco C, Delgado J, et al. Challenge-based clinical patterns of 223 Spanish patients with nonsteroidal anti-inflammatory-drug-induced-reactions[J].J Investig Allergol Clin Immunol,2007, 17: 182-188.
[16] Canto MG, Andreu I, Fernandez J, et al. Selective immediate hypersensitivity reactions to NSAIDs[J]. Curr Opin Allergy Clin Immunol, 2009. 9: 293-297.
[17] Quiralte J, Blanco C, Castillo R, et al. Anaphylactoid reactions due to nonsteroidal antiinflammatory drugs: clinical and cross-reactivity studies[J]. Ann Allergy Asthma Immunol, 1997,78: 293-296.
[18] Lee SY, Nam YH, Koh YI, et al. Phenotypes of Severe Cutaneous Adverse Reactions Caused by Nonsteroidal Anti-inflammatory Drugs[J]. Allergy Asthma Immunol Res, 2019, 11: 212-221.
[19] Demir S, Olgac M, Unal D, et al. Evaluation of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs according to the latest classification[J]. Allergy,2015, 70: 1461-1467.
[20] Dona I, Barrionuevo E, Salas M, et al. NSAIDs-hypersensitivity often induces a blended reaction pattern involving multiple organs[J]. Sci Rep,2018, 8: 16710.
[21] Picaud J, Beaudouin E, Renaudin JM, et al. Anaphylaxis to diclofenac: nine cases reported to the Allergy Vigilance Network in France[J]. Allergy,2014,69: 1420-1423.
[22] Brockow K, Garvey LH, Aberer W, et al. Skin test concentrations for systemically administered drugs -- an ENDA/EAACI Drug Allergy Interest Group position paper[J]. Allergy, 2013,68: 702-712.
[23] Nizankowska-Mogilnicka E, Bochenek G, Mastalerz L, et al. EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity[J]. Allergy,2007, 62: 1111-1118.
[24] Berges-Gimeno MP, Simon RA,Stevenson DD. The natural history and clinical characteristics of aspirin-exacerbated respiratory disease[J]. Ann Allergy Asthma Immunol,2002, 89: 474-478.
[25] Nizankowska E, Bestynska-Krypel A, Cmiel A, et al. Oral and bronchial provocation tests with aspirin for diagnosis of aspirin-induced asthma[J]. Eur Respir J,2000,15: 863-869.
[26] Kowalski ML, Ptasinska A, Jedrzejczak M, et al, Aspirin-triggered 15-HETE generation in peripheral blood leukocytes is a specific and sensitive Aspirin-Sensitive Patients Identification Test (ASPITest)[J]. Allergy,2005,60: 1139-1145.
[27] Modena B, White AA,Woessner KM. Aspirin and Nonsteroidal Antiinflammatory Drugs Hypersensitivity and Management[J]. Immunol Allergy Clin North Am, 2017, 37: 727-749.
[28] Kowalski ML, Woessner K. Sanak M. Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug-related urticaria and angioedema[J]. J Allergy Clin Immunol, 2015, 136: 245-51.
[29] Simon RA. Prevention and treatment of reactions to NSAIDs[J]. Clin Rev Allergy Immunol, 2003, 24: 189-198.
[30] Slowik SM, Slavin RG. Aspirin desensitization in a patient with aspirin sensitivity and chronic idiopathic urticaria[J]. Ann Allergy Asthma Immunol, 2009, 102: 171-172.
[31] Berges-Gimeno MP, Simon RA,Stevenson DD. Long-term treatment with aspirin desensitization in asthmatic patients with aspirin-exacerbated respiratory disease[J]. J Allergy Clin Immunol, 2003, 111: 180-186.
[32] Rozsasi A, Polzehl D, Deutschle T, et al. Long-term treatment with aspirin desensitization: a prospective clinical trial comparing 100 and 300 mg aspirin daily[J]. Allergy, 2008, 63: 1228-1234.
[33] Berges-Gimeno MP, Simon RA. Stevenson DD. Early effects of aspirin desensitization treatment in asthmatic patients with aspirin-exacerbated respiratory disease[J]. Ann Allergy Asthma Immunol, 2003, 90: 338-341.
[34] Lee JY, Simon RA, Stevenson DD. Selection of aspirin dosages for aspirin desensitization treatment in patients with aspirin-exacerbated respiratory disease[J]. J Allergy Clin Immunol, 2007, 119: 157-164.
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