血清肿瘤异常蛋白联合经阴道超声对早期子宫内膜癌诊断价值分析

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英文篇名：Diagnostic value of serum tumor abnormal protein combined with transvaginal ultrasound in the diagnosis of early endometrial cancer 作者：张宇华 ; 王晓彬 ; 佟晓晶 ; 杨迪 英文作者：ZHANG Yuhua;WANG Xiaobin;TONG Xiaojing;YANG Di;Department of Gynecology, Cancer Hospital of China Medical University/Liaoning Cancer Hospital and Institute; 关键词：肿瘤异常蛋白 ; 经阴道超声检查 ; 早期子宫内膜癌 ; 联合诊断 英文关键词：tumor abnormal protein;;transvaginal ultrasound;;early endometrial cancer;;combined diagnosis 中文刊名：AZJZ 英文刊名：Oncology Progress 机构：中国医科大学肿瘤医院/辽宁省肿瘤医院妇科; 出版日期：2019-03-25 出版单位：癌症进展 年：2019 期：v.17 语种：中文; 页：AZJZ201906014 页数：4 CN：06 ISSN：11-4971/R 分类号：61-63+82

摘要

目的比较普通超声检查和血清肿瘤异常蛋白(TAP)检测联合经阴道超声检查在早期子宫内膜癌中的诊断价值。方法对200例早期子宫内膜癌疑似患者术前行超声检查和TAP检测,根据病理学检查证实子宫内膜癌的良恶性,比较普通超声检查和TAP检测联合经阴道超声检查对早期子宫内膜癌的诊断效能。结果经病理结果证实,200例早期子宫内膜癌疑似患者中,早期子宫内膜癌患者68例,子宫良性病变患者132例。子宫内膜癌患者血清中TAP的检测阳性率明显高于子宫良性病变患者(P﹤0.01)。TAP检测联合经阴道超声检查对早期子宫内膜癌的灵敏度高于普通超声检查(P﹤0.05)。TAP检测联合经阴道超声检查对早期子宫内膜癌诊断的灵敏度、特异度、阳性预测值、阴性预测值和准确度均较高。结论 TAP检测联合经阴道超声检查对早期子宫内膜癌的诊断效能较高,值得临床推广。
        Objective To compare the diagnostic value of conventional ultrasound and serum tumor abnormal protein(TAP) combined with transvaginal ultrasound in early endometrial cancer. Method 200 patients with suspected endometrial cancer were examined by ultrasound and TAP before operation. According to the pathology examination confirmed of benign and malignant endometrial cancer, compare the diagnostic efficacy of common ultrasound and TAP combined with transvaginal ultrasound for early endometrial cancer. Result There were 68 cases of early endometrial cancer and132 cases of benign lesions of the uterus among the 200 cases of suspected endometrial cancer. The positive rate of TAP in the serum of patients with endometrial cancer was significantly higher than that of patients with benign uterine lesions(P<0.01). The diagnostic sensitivity of TAP combined with transvaginal ultrasound for endometrial cancer was significantly higher than that of conventional ultrasound(P<0.05). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of TAP combined with transvaginal ultrasound were consistently higher compared with conventional ultrasound. Conclusion TAP combined with transvaginal ultrasound has fairly high diagnostic efficiency for early endometrial cancer, so it is worthy of clinical application.

引文

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