半夏厚朴汤联合西药治疗反流性食管炎临床观察

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英文篇名：Clinical Observation of Banxia Houpu Decoction Combined with Western Medicine in the Treatment of Reflux Esophagitis 作者：蔡爽 ; 苗丰 英文作者：CAI Shuang;MIAO Feng;Department of Digestive Endoscopy, Fourth Affiliated Hospital of China Medical University; 关键词：半夏厚朴汤 ; 反流性食管炎 ; 中西医结合疗法 ; 反酸 英文关键词：Banxia Houpu decoction;;reflux esophagitis;;therapy of integrated medicine;;sour regurgitation 中文刊名：ZZYY 英文刊名：Chinese Medicine Modern Distance Education of China 机构：中国医科大学附属第四医院消化内镜科; 出版日期：2019-05-25 出版单位：中国中医药现代远程教育 年：2019 期：v.17;No.306 语种：中文; 页：ZZYY201910048 页数：3 CN：10 ISSN：11-5024/R 分类号：116-118

摘要

目的观察半夏厚朴汤联合莫沙必利与雷贝拉唑钠治疗反流性食管炎临床疗效以及对血清炎症因子的影响。方法选择2017年9月—2018年9月收治的100例反流性食管炎患者,按照随机数字表法将患者分为观察组与对照组,各50例。观察组患者采用半夏厚朴汤联合莫沙必利与雷贝拉唑钠治疗,对照组患者采用莫沙必利与雷贝拉唑钠治疗,2组患者均连续治疗8周。比较2组患者的疗效,血清炎症因子以及不良反应。结果观察组患者临床疗效明显高于对照组(96.00%vs78.00%,P<0.05);治疗前,2组患者各血清炎症因子比较无明显差异(P>0.05);治疗后,观察组TNF-α、IL-6水平均显著低于对照组(P<0.05),且同组内治疗后血清炎症因子水平明显低于治疗前(P<0.05);观察组不良反应发生率明显低于对照组(6.00%vs24.00%,P<0.05)。结论半夏厚朴汤联合莫沙必利与雷贝拉唑钠治疗反流性食管炎临床效果明显,能够降低血清TNF-α、IL-6水平以及不良反应,具有一定的推广价值。
        Objective To observe the clinical cuative effect and the effect on serum inflammatory factors in the treatment of anti-flow anti-inflammatory drugs by the combination of Banxia Houpu decoction combined with mosapride and rabeprazole sodium. Methods From September 2017 to September 2018, the patients were divided into observation group and control group, with 50 cases in each group. The patients in the observation group were treated with the combination of the Banxia Houpu decoction combined with moxabalin sodium, and the control group was treated with moxabili and Rebellar sodium. The two groups were treated for 8 weeks for continuous treatment. The curative effect, serum inflammatory factors and adverse reactions were compared between the two groups.Results The clinical effect of the observation group was significantly higher than that of the control group(96.00 % vs 78.00% P<0.05), and there was no significant difference between the two groups before treatment( P>0.05). After treatment, the levels of TNF-αand IL-6 in the observation group were significantly lower than those in the control group( P <0.05), and the levels of serum inflammatory factors in the same group were significantly lower than those before treatment( P <0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group(6.00 % vs 24.00% P <0.05). Conclusion Banxia Houpu decoction combined with mosapride and rabeprazole sodium treatment of reflux esophagitis has obvious clinical effect,and can reduce serum TNF-α, IL-6 levels and adverse reactions.

引文

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