地塞米松与曲安奈德分别配合氧氟沙星治疗慢性中耳炎的疗效观察
|
摘要
目的探究地塞米松与曲安奈德分别配合氧氟沙星应用于慢性化脓性中耳炎的治疗效果。方法选取2016年1月～2017年1月本院收治的慢性化脓性中耳炎患者74例为研究对象。根据治疗方式差异,随机将患者分为两组,每组37例。对照组行曲安奈德配合氧氟沙星治疗;观察组行地塞米松配合氧氟沙星治疗。对比两组临床疗效、听力改善情况、临床症状改善时间以及不良反应发生情况。以评估慢性化脓性中耳炎治疗中氧氟沙星与地塞米松的联合应用效果。结果观察组患者治疗总有效率94.6%,显著高于对照组患者67.6%(χ~2=4.472,P<0.05);观察组患者听力改善率97.3%,显著高于对照组患者(70.3%)(χ~2=4.365,P<0.05);观察组鼓膜充血消失、穿孔愈合、耳痛消退以及中耳积脓消失时间分别(6.9±4.3)d、(7.9±5.1)d、(5.7±3.7)d、(7.6±4.7)d,均显著对于对照组患者的(10.4±5.2)d、(15.4±6.5)d、(9.8±4.9)d、(13.8±5.8)d (P<0.05);观察组不良反应发生率8.1%,对照组13.5%,两组对比无显著统计学差异(χ~2=1.632,P>0.05)。结论地塞米松配合氧氟沙星治疗慢性化脓性中耳炎疗效优于曲安奈德配合氧氟沙星,更利于改善患者听力,缩短恢复时间,不良反应少,安全性高,值得推广应用。
Objective To explore the efficacy of dexamethasone and triamcinolone acetonide combined with ofloxacin in the treatment of chronic suppurative otitis media. Methods From January 2016 to January 2017, 74 patients with chronic suppurative otitis media were selected. Patients were randomly divided into two groups according to the difference in treatment methods, with 37 cases in each group. The control group was treated with triamcinolone acetonide combined with ofloxacin and the study group was treated with dexamethasone combined with ofloxacin. The clinical efficacy, the improvement of hearing, the improvement time of clinical symptoms and the incidence of adverse reactions were compared between two groups to evaluate the combined effect of ofloxacin and dexamethasone in the treatment of chronic suppurative otitis media. Results The total effective rate of the treatment group was 94.6%,which was significantly higher than that of the control group(67.6%, χ~2=4.472, P<0.05);The improvement rate of hearing in the study group was 97.3%, which was significantly higher than that in the control group(70.3%)(χ~2=4.365, P<0.05);The study group of tympanic membrane perforation healing, congestion disappeared, earache subsided and middle ear empyema disappeared time(6.9 ±4.3) d respectively,(7.9±5.1) d,(5.7±3.7) d,(7.6±4.7) d, significantly for the patients in the control group(10.4±5.2) d,(15.4± 6.5) d,(9.8±4.9) d,(13.8±5.8) d(P<0.05);The incidence of adverse reactions was 8.1% in the study group and 13.5% in the control group.There was no significant difference between the two groups(χ~2=1.632, P>0.05). Conclusion Efficacy of dexamethasone combined with ofloxacin is superior to triamcinolone acetonide combined with ofloxacin in the treatment of chronic suppurative otitis media. It is beneficial to improve the hearing of patients and shorten the recovery time and has less adverse reactions and high safety, which is worthy of popularization and application.
Objective To explore the efficacy of dexamethasone and triamcinolone acetonide combined with ofloxacin in the treatment of chronic suppurative otitis media. Methods From January 2016 to January 2017, 74 patients with chronic suppurative otitis media were selected. Patients were randomly divided into two groups according to the difference in treatment methods, with 37 cases in each group. The control group was treated with triamcinolone acetonide combined with ofloxacin and the study group was treated with dexamethasone combined with ofloxacin. The clinical efficacy, the improvement of hearing, the improvement time of clinical symptoms and the incidence of adverse reactions were compared between two groups to evaluate the combined effect of ofloxacin and dexamethasone in the treatment of chronic suppurative otitis media. Results The total effective rate of the treatment group was 94.6%,which was significantly higher than that of the control group(67.6%, χ~2=4.472, P<0.05);The improvement rate of hearing in the study group was 97.3%, which was significantly higher than that in the control group(70.3%)(χ~2=4.365, P<0.05);The study group of tympanic membrane perforation healing, congestion disappeared, earache subsided and middle ear empyema disappeared time(6.9 ±4.3) d respectively,(7.9±5.1) d,(5.7±3.7) d,(7.6±4.7) d, significantly for the patients in the control group(10.4±5.2) d,(15.4± 6.5) d,(9.8±4.9) d,(13.8±5.8) d(P<0.05);The incidence of adverse reactions was 8.1% in the study group and 13.5% in the control group.There was no significant difference between the two groups(χ~2=1.632, P>0.05). Conclusion Efficacy of dexamethasone combined with ofloxacin is superior to triamcinolone acetonide combined with ofloxacin in the treatment of chronic suppurative otitis media. It is beneficial to improve the hearing of patients and shorten the recovery time and has less adverse reactions and high safety, which is worthy of popularization and application.
引文
1王江.氧氟沙星滴耳液治疗化脓性中耳炎47例疗效观察[J].重庆医学,2011,40(23):2363-2364.
2樊秀江.联合应用左氧氟沙星注射液和地塞米松治疗化脓性中耳炎的疗效分析[J].当代医药论丛,2015,5(5):268-269.
3沈川,陈玲玲,傅江涛,等.曲安奈德注射液联合左氧氟沙星滴耳液治疗急性化脓性中耳炎的临床研究[J].中国临床药理学杂志,2018,34(7):767-769.
4闫完平.联用左氧氟沙星和地塞米松治疗化脓性中耳炎的效果分析[J].当代医药论丛,2015,5(18):156-157.
5付文义.外耳道负压引流联合左氧氟沙星治疗慢性化脓性中耳炎疗效观察[J].北华大学学报(自然科学版),2016,17(3):387-389.
6李慎玲,张孝田,姜晓丹,等.53例慢性化脓性中耳炎患者分泌物细菌培养及药敏学分析[J].山东大学耳鼻喉眼学报,2015,3:31-34.
7邱剑波,李治美.氧氟沙星滴耳液用于急性化脓性中耳炎治疗的临床效果分析[J].中华医院感染学杂志,2013,23(19):4784-4785.
8牛靖锋.氧氟沙星滴耳液灌注中耳治疗化脓性中耳炎[J].陕西医学杂志,2015,1:123-123.
9蒋学范,浦立,苏立众,等.盐酸左氧氟沙星滴耳液治疗急性化脓性中耳炎的疗效观察[J].中华医院感染学杂志,2015,2:352-354.
10邵丽,ShaoLi.耳内镜下鼓膜置管术在药物治疗无效的儿童分泌性中耳炎治疗中的应用效果[J].中国基层医药,2017,24(3):408-411.
11胡铁阳,李胜,官建军,等.120例慢性化脓性中耳炎患者耳道分泌物病原菌及治疗效果分析[J].中华医院感染学杂志,2017,10:2317-2320.
12刘佳丽,王维,王子萌,等.555例慢性化脓性中耳炎的病原学及药物敏感性分析[J].第三军医大学学报,2016,38(21):2349-2352.
13徐成波.地塞米松联合前列地尔治疗不同类型突发性聋疗效观察[J].中国基层医药,2015,22(9):1417-1419.
14吕宇,陈朝辉,胡章威,等.氧氟沙星联合地塞米松治疗中耳炎临床疗效观察[J].海南医学,2017,28(4):586-588.
15 Guo-Hong WU,Fan QZ,Ent DO.Observation of Curative Effect of Oxidation for the Treatment of Chronic Suppurative Otitis Media[J].Journal of Henan Medical College for Staff&Workers,2014,26(4):393-395.
16刘炜.化脓性中耳炎采用氧氟沙星治疗效果分析[J].吉林医学,2013,34(34):7187-7188.
17胡全福,欧阳绍基,姚榕威,等.曲安奈德联合盐酸氨溴索治疗分泌性中耳炎患者的临床疗效及对机体炎性因子、细胞免疫指标的影响[J].海南医学院学报,2016,22(23):2897-2900.
18江文博,张建耀,胡建道,等.腺样体切除术同时行鼓膜置管或鼓膜切开对分泌性中耳炎的疗效分析[J].中国中西医结合耳鼻咽喉科杂志,2018,26(1):13-15.
2樊秀江.联合应用左氧氟沙星注射液和地塞米松治疗化脓性中耳炎的疗效分析[J].当代医药论丛,2015,5(5):268-269.
3沈川,陈玲玲,傅江涛,等.曲安奈德注射液联合左氧氟沙星滴耳液治疗急性化脓性中耳炎的临床研究[J].中国临床药理学杂志,2018,34(7):767-769.
4闫完平.联用左氧氟沙星和地塞米松治疗化脓性中耳炎的效果分析[J].当代医药论丛,2015,5(18):156-157.
5付文义.外耳道负压引流联合左氧氟沙星治疗慢性化脓性中耳炎疗效观察[J].北华大学学报(自然科学版),2016,17(3):387-389.
6李慎玲,张孝田,姜晓丹,等.53例慢性化脓性中耳炎患者分泌物细菌培养及药敏学分析[J].山东大学耳鼻喉眼学报,2015,3:31-34.
7邱剑波,李治美.氧氟沙星滴耳液用于急性化脓性中耳炎治疗的临床效果分析[J].中华医院感染学杂志,2013,23(19):4784-4785.
8牛靖锋.氧氟沙星滴耳液灌注中耳治疗化脓性中耳炎[J].陕西医学杂志,2015,1:123-123.
9蒋学范,浦立,苏立众,等.盐酸左氧氟沙星滴耳液治疗急性化脓性中耳炎的疗效观察[J].中华医院感染学杂志,2015,2:352-354.
10邵丽,ShaoLi.耳内镜下鼓膜置管术在药物治疗无效的儿童分泌性中耳炎治疗中的应用效果[J].中国基层医药,2017,24(3):408-411.
11胡铁阳,李胜,官建军,等.120例慢性化脓性中耳炎患者耳道分泌物病原菌及治疗效果分析[J].中华医院感染学杂志,2017,10:2317-2320.
12刘佳丽,王维,王子萌,等.555例慢性化脓性中耳炎的病原学及药物敏感性分析[J].第三军医大学学报,2016,38(21):2349-2352.
13徐成波.地塞米松联合前列地尔治疗不同类型突发性聋疗效观察[J].中国基层医药,2015,22(9):1417-1419.
14吕宇,陈朝辉,胡章威,等.氧氟沙星联合地塞米松治疗中耳炎临床疗效观察[J].海南医学,2017,28(4):586-588.
15 Guo-Hong WU,Fan QZ,Ent DO.Observation of Curative Effect of Oxidation for the Treatment of Chronic Suppurative Otitis Media[J].Journal of Henan Medical College for Staff&Workers,2014,26(4):393-395.
16刘炜.化脓性中耳炎采用氧氟沙星治疗效果分析[J].吉林医学,2013,34(34):7187-7188.
17胡全福,欧阳绍基,姚榕威,等.曲安奈德联合盐酸氨溴索治疗分泌性中耳炎患者的临床疗效及对机体炎性因子、细胞免疫指标的影响[J].海南医学院学报,2016,22(23):2897-2900.
18江文博,张建耀,胡建道,等.腺样体切除术同时行鼓膜置管或鼓膜切开对分泌性中耳炎的疗效分析[J].中国中西医结合耳鼻咽喉科杂志,2018,26(1):13-15.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |