养阴活血方对胃癌前病变肠道菌群变化及转归的影响

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英文篇名：Yangyin Huoxue Prescription Has Effect on Intestinal Flora Changes and Prognosis of Gastric Precancerous Lesions 作者：贾圣喜 ; 夏秋敏 ; 魏国兰 ; 李保玺 ; 李春 英文作者：JIA Shengxi;XIA Qiumin;WEI Guolan;LI Baoxi;LI Chun; 关键词：胃癌前病变 ; 养阴活血方 ; 肠道菌群 ; 乳酸杆菌 ; 双歧杆菌 英文关键词：Gastric precancerous lesions;;Yangyin Huoxue prescription;;Intestinal flora;;Lactobacillus;;Bifidobacterium 中文刊名：REND 英文刊名：Journal of New Chinese Medicine 机构：安吉县中医医院; 出版日期：2019-05-05 出版单位：新中医 年：2019 期：v.51;No.540 基金：浙江省中医药科技计划项目(2016ZB122) 语种：中文; 页：REND201905049 页数：3 CN：05 ISSN：44-1231/R 分类号：164-166

摘要

目的:观察养阴活血方对胃癌前病变肠道菌群变化及转归的影响。方法:将66例胃癌前病变患者分为2组各33例。对照组为口服四联给药方案,治疗组在对照组基础上加用养阴活血方,通过比较临床疗效,胃黏膜组织病理检测及肠道菌群(乳酸杆菌、大肠杆菌、双歧杆菌)数量进行疗效评定。结果:治疗组总有效率为87.88%,优于对照组总有效率66.67%,经秩和检验,差异有统计学意义(P <0.05)。经治疗,治疗组提高患者肠道菌群中乳酸杆菌、双歧杆菌,降低大肠杆菌,与治疗前比较,差异有统计学意义(P <0.05)。治疗组治疗后乳酸杆菌、大肠杆菌、双歧杆菌与对照组比较,差异有统计学意义(P <0.05)。治疗后,治疗组胃镜下黏膜病变积分大体分级、部分分级均较治疗前改善(P <0.05),且治疗组治疗后2个分级积分与对照组比较,差异均有统计学意义(P <0.05)。结论:养阴活血方能调控胃癌前病变患者肠道菌群平衡,改善胃黏膜病理变化,有益于胃癌前病变的转归。
        Objective: To observe the effect of Yangyin Huoxue prescription on intestinal flora changes and prognosis of gastric precancerous lesions. Methods:Divided 66 cases of patients with precancerous lesions into two groups,33 cases in each group. The control group was treated with the oral application of four combined drug administration, while the treatment group was additionally given with Yangyin Huoxue prescription. Evaluated the curative effect by comparing the clinical effect, pathological examination of gastric mucosa and the number of intestinal flora(lactobacillus,escherichia coli,bifidobacterium). Results:The total effective rate was87.88% in the treatment group, being higher than that of 66.67% in the control group, difference being significant(P < 0.05). After treatment, lactobacillus and bifidobacteria of the intestinal flora in the treatment group were increased and escherichia coli was decreased, compared with those before treatment, difference being significant(P < 0.05). After treatment, there was significant difference being found in the comparison between the lactobacillus,escherichia coli and bifidobacterium in the treatment group and that in the control group,difference being significant(P < 0.05). After treatment,the general classification and partial classification of the gastroscopic mucosal lesion scores in the treatment group were improved when compared with those before treatment(P < 0.05);there was significant difference being found in the comparison between the score of these two classifications in the treatment group and that in the control group,difference being significant(P < 0.05). Conclusion:The application of Yangyin Huoxue prescription can regulate the balance of intestinal flora in patients with precancerous lesions and improve the pathological changes of gastric mucosa, which is beneficial to the prognosis of precancerous lesions.

引文

[1]白宇宁,张平,李理,等.健脾通络解毒方对胃癌前病变患者胃黏膜COX-2,NF-κB p65B及Bcl-2表达的影响[J].中国中西医结合杂志,2015,35(2):167-173.
    [2]赵琳丽,彭铁立,梁大立,等.MG7联合CEA检测在胃癌及胃癌早期病变中的诊断价值[J].中国现代医学杂志,2013,23(10):98-100.
    [3]高冉,李亮,高海燕.胃癌患者肠道细菌的探讨[J].济宁医学院学报,2011,34(3):178-179.
    [4] ORLANDO A,REFOLO M G,MESSA C,et al.Antiproliferative and proapoptotic effects of viable or heat-killed Lactobacillus paracasei IMPC2.1 and Lactobacillus rhamnosus GG in HGC-27 gastric and DLD-1 colon cell lines[J].Nutr Cancer,2012,64(7):1103-1111.
    [5]中华医学会消化病学分会.中国慢性胃炎共识意见(2012年,上海)[J].中华消化杂志,2013,33(1):674-684.
    [6]中国中西医结合学会消化系统疾病专业委员会.慢性胃炎中西医结合诊疗共识意见(2011年,天津)[J].中国中西医结合杂志,2012,32(6):738-743.
    [7]姜宁,黄宣,范一宏,等.中西医结合治疗胃癌前病变疗效的系统评价[J].中华中医药学刊,2015,33(1):149-154.
    [8]刘龙,苏文.胃肠道微生态与肿瘤关系的研究进展[J].中国微生态学杂志,2016,28(11):1349-1352.
    [9]朱燕燕,温建勋,任晓萌,等.胃癌患者肠道菌群的分布特点分析[J].中国微生态学杂志,2017,29(6):655-657.
    [10]黄亚,吴红艳.肠道菌群与抗肿瘤治疗[J].中国微生态学杂志,2016,28(12):1859-1861.
    [11]牟海军,陈小燕,化伟利,等.胃癌患者幽门螺杆菌的感染与预后的关系[J].中华医院感染学杂志,2016,26(16):3643-3644,3647.