膝骨关节炎人群中血清锌与血脂紊乱的相关性研究
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摘要
目的:探讨膝骨关节炎(Osteoarthritis,OA)人群中血清锌(Zinc,Zn)水平与血脂紊乱的相关性。方法:采用横断面研究,纳入在中南大学湘雅医院健康管理中心进行健康体检的935例膝OA患者作为研究对象。通过分光光度法检测纳入研究对象的血清Zn水平,并通过贝克曼库尔特AU 5800全自动生化分析仪检测血脂水平。根据血清Zn水平将研究人群进行五分类,采用Logistic回归模型探讨血清Zn水平与血脂紊乱的相关性。结果:Logistic回归模型结果显示,校正年龄和性别后,与第1分类(最低)血清Zn组相比,第2-5分类血清Zn组血脂紊乱患病率比值比和95%可信区间(95%confidence interval, 95%CI)分别为1.66 (95%CI:1.08, 2.56)、1.25 (95%CI:0.81, 1.93)、1.61 (95%CI:1.04, 2.49)和3.04 (95%CI:1.97, 4.68)(趋势检验P<0.001)。多因素校正和性别亚组分析结果无明显变化。结论:膝OA人群血清Zn水平与血脂紊乱患病呈正相关,OA人群高血Zn可能为发生血脂紊乱的危险因素。
Objective: To examine the association between serum zinc(Zn) and dyslipidemia in knee osteoarthritis(OA) patients.Methods: A cross-sectional study was conducted in the Department of Health Examination Center, Xiangya Hospital, Central South University, and 935 knee OA patients were included. Serum Zn was measured by spectrophotometry method and blood lipid assessment was performed on a Beckman Coulter AU 5800 system. The serum Zn concentration was classified into five categories. Results:Compared with the lowest quintile, the age-sex adjusted odds ratios and 95% confidence interval(95% CI) for dyslipidemia were 1.66(95% CI: 1.08, 2.56), 1.25(95% CI: 0.81, 1.93), 1.61(95% CI: 1.04, 2.49), and 3.04(95% CI: 1.97, 4.68) from the second to fifth quintiles of serum Zn, respectively(P value for trend <0.001). The findings were not materially altered by adjustment for more potential confounders, and similar results were observed for men and women separately. Conclusions: The findings of the present study indicated that there was a positive association between the level of serum Zn and dyslipidemia in knee OA patients, and high level of Serum Zn may be a risk factor for developing dyslipidemia.
Objective: To examine the association between serum zinc(Zn) and dyslipidemia in knee osteoarthritis(OA) patients.Methods: A cross-sectional study was conducted in the Department of Health Examination Center, Xiangya Hospital, Central South University, and 935 knee OA patients were included. Serum Zn was measured by spectrophotometry method and blood lipid assessment was performed on a Beckman Coulter AU 5800 system. The serum Zn concentration was classified into five categories. Results:Compared with the lowest quintile, the age-sex adjusted odds ratios and 95% confidence interval(95% CI) for dyslipidemia were 1.66(95% CI: 1.08, 2.56), 1.25(95% CI: 0.81, 1.93), 1.61(95% CI: 1.04, 2.49), and 3.04(95% CI: 1.97, 4.68) from the second to fifth quintiles of serum Zn, respectively(P value for trend <0.001). The findings were not materially altered by adjustment for more potential confounders, and similar results were observed for men and women separately. Conclusions: The findings of the present study indicated that there was a positive association between the level of serum Zn and dyslipidemia in knee OA patients, and high level of Serum Zn may be a risk factor for developing dyslipidemia.
引文
[1]中华医学会骨科学分会关节外科学组.骨关节炎诊治指南(2018年版)[J].中华骨科杂志,2018,38(12):705-715
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[3]Jevotovsky D S,Alfonso A R,Einhorn T A,et al.Osteoarthritis and stem cell therapy in humans:a systematic review[J].Osteoarthritis Cartilage,2018,26(6):711-729
[4]Baudart P,Louati K,Marcelli C,et al.Association between osteoarthritis and dyslipidaemia:a systematic literature review and meta-analysis[J].RMD Open,2017,3(2):e442
[5]Lin W,Li D.Zinc and Zinc Transporters:Novel Regulators of Ventricular Myocardial Development[J].Pediatr Cardiol,2018,39(5):1042-1051
[6]Zeng C,Wei J,Li H,et al.Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis[J].J Rheumatol,2015,42(7):1231-1236
[7]Zeng C,Wei J,Terkeltaub R,et al.Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis[J].Arthritis Res Ther,2017,19(1):236
[8]Xie D X,Wei J,Zeng C,et al.Association between metabolic syndrome and knee osteoarthritis:a cross-sectional study[J].BMCMusculoskelet Disord,2017,18(1):533
[9]中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中华糖尿病杂志,2004,12(3):156-161
[10]Calvet J,Orellana C,Larrosa M,et al.High prevalence of cardiovascular co-morbidities in patients with symptomatic knee or hand osteoarthritis[J].Scand J Rheumatol,2016,45(1):41-44
[11]Hart D J,Doyle D V,Spector T D.Association between metabolic factors and knee osteoarthritis in women:the Chingford Study[J].JRheumatol,1995,22(6):1118-1123
[12]Oliviero F,Sfriso P,Baldo G,et al.Apolipoprotein A-I and cholesterol in synovial fluid of patients with rheumatoid arthritis,psoriatic arthritis and osteoarthritis[J].Clin Exp Rheumatol,2009,27(1):79-83
[13]Fallah A,Mohammad-Hasani A,Colagar A H.Zinc is an Essential Element for Male Fertility:A Review of Zn Roles in Men's Health,Germination,Sperm Quality,and Fertilization[J].J Reprod Infertil,2018,19(2):69-81
[14]Tuerk M J,Fazel N.Zinc deficiency[J].Curr Opin Gastroenterol,2009,25(2):136-143
[15]Sun W,Yang J,Wang W,et al.The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes[J].J Trace Elem Med Biol,2018,46:117-127
[16]Alker W,Haase H.Zinc and Sepsis[J].Nutrients,2018.[Epub ahead of print]
[17]Milton A H,Vashum K P,Mc Evoy M,et al.Prospective Study of Dietary Zinc Intake and Risk of Cardiovascular Disease in Women[J].Nutrients,2018.[Epub ahead of print]
[18]Yary T,Virtanen J K,Ruusunen A,et al.Association between serum zinc and later development of metabolic syndrome in middle aged and older men:The Kuopio Ischaemic Heart Disease Risk Factor Study[J].Nutrition,2017,37:43-47
[19]Chen F,Wang J,Chen J,et al.Serum copper and zinc levels and the risk of oral cancer:A new insight based on large-scale case-control study[J].Oral Dis,2018.[Epub ahead of print]
[20]燕小梅,孟秀香,张莹.老年人血清总胆固醇、甘油三酯、铜、锌的测定与相关性分析[J].中国老年学杂志,2013,33(11):2630-2631
[21]朱惠莲,王身笏,许月初,等.单纯性肥胖症儿童血脂、载脂蛋白A1、B100的研究[J].卫生研究,2000,29(2):104-105
[22]Black M R,Medeiros D M,Brunett E,et al.Zinc supplements and serum lipids in young adult white males[J].Am J Clin Nutr,1988,47(6):970-975
[2]薛庆云,王坤正,裴福兴,等.中国40岁以上人群原发性骨关节炎患病状况调查[J].中华骨科杂志,2015,35(12):1206-1212
[3]Jevotovsky D S,Alfonso A R,Einhorn T A,et al.Osteoarthritis and stem cell therapy in humans:a systematic review[J].Osteoarthritis Cartilage,2018,26(6):711-729
[4]Baudart P,Louati K,Marcelli C,et al.Association between osteoarthritis and dyslipidaemia:a systematic literature review and meta-analysis[J].RMD Open,2017,3(2):e442
[5]Lin W,Li D.Zinc and Zinc Transporters:Novel Regulators of Ventricular Myocardial Development[J].Pediatr Cardiol,2018,39(5):1042-1051
[6]Zeng C,Wei J,Li H,et al.Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis[J].J Rheumatol,2015,42(7):1231-1236
[7]Zeng C,Wei J,Terkeltaub R,et al.Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis[J].Arthritis Res Ther,2017,19(1):236
[8]Xie D X,Wei J,Zeng C,et al.Association between metabolic syndrome and knee osteoarthritis:a cross-sectional study[J].BMCMusculoskelet Disord,2017,18(1):533
[9]中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中华糖尿病杂志,2004,12(3):156-161
[10]Calvet J,Orellana C,Larrosa M,et al.High prevalence of cardiovascular co-morbidities in patients with symptomatic knee or hand osteoarthritis[J].Scand J Rheumatol,2016,45(1):41-44
[11]Hart D J,Doyle D V,Spector T D.Association between metabolic factors and knee osteoarthritis in women:the Chingford Study[J].JRheumatol,1995,22(6):1118-1123
[12]Oliviero F,Sfriso P,Baldo G,et al.Apolipoprotein A-I and cholesterol in synovial fluid of patients with rheumatoid arthritis,psoriatic arthritis and osteoarthritis[J].Clin Exp Rheumatol,2009,27(1):79-83
[13]Fallah A,Mohammad-Hasani A,Colagar A H.Zinc is an Essential Element for Male Fertility:A Review of Zn Roles in Men's Health,Germination,Sperm Quality,and Fertilization[J].J Reprod Infertil,2018,19(2):69-81
[14]Tuerk M J,Fazel N.Zinc deficiency[J].Curr Opin Gastroenterol,2009,25(2):136-143
[15]Sun W,Yang J,Wang W,et al.The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes[J].J Trace Elem Med Biol,2018,46:117-127
[16]Alker W,Haase H.Zinc and Sepsis[J].Nutrients,2018.[Epub ahead of print]
[17]Milton A H,Vashum K P,Mc Evoy M,et al.Prospective Study of Dietary Zinc Intake and Risk of Cardiovascular Disease in Women[J].Nutrients,2018.[Epub ahead of print]
[18]Yary T,Virtanen J K,Ruusunen A,et al.Association between serum zinc and later development of metabolic syndrome in middle aged and older men:The Kuopio Ischaemic Heart Disease Risk Factor Study[J].Nutrition,2017,37:43-47
[19]Chen F,Wang J,Chen J,et al.Serum copper and zinc levels and the risk of oral cancer:A new insight based on large-scale case-control study[J].Oral Dis,2018.[Epub ahead of print]
[20]燕小梅,孟秀香,张莹.老年人血清总胆固醇、甘油三酯、铜、锌的测定与相关性分析[J].中国老年学杂志,2013,33(11):2630-2631
[21]朱惠莲,王身笏,许月初,等.单纯性肥胖症儿童血脂、载脂蛋白A1、B100的研究[J].卫生研究,2000,29(2):104-105
[22]Black M R,Medeiros D M,Brunett E,et al.Zinc supplements and serum lipids in young adult white males[J].Am J Clin Nutr,1988,47(6):970-975
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