凉血解毒汤联合窄谱中波紫外线治疗寻常性银屑病血热证的临床观察

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英文篇名：Clinical observation of Liangxue Jiedu decoction combined with narrow-band UVB in the treatment of blood heat syndrome of psoriasis vulgaris 作者：毛常亮 ; 苏孟 ; 周双琳 ; 杨蓉娅 英文作者：MAO Chang-liang;SU Meng;ZHOU Shuang-lin;Insitute of Skin Damage and Repair, the Seventh Medical Center of PLA General Hospital; 关键词：银屑病 ; 寻常性 ; 凉血解毒汤 ; 窄谱中波紫外线 ; 血热证 英文关键词：Psoriasis,vulgaris;;Liangxue Jiedu decoction;;Narrow-band UVB;;Blood heat syndrome 中文刊名：SYPF 英文刊名：Journal of Practical Dermatology 机构：解放军总医院第七医学中心全军皮肤损伤修复研究所; 出版日期：2019-04-10 出版单位：实用皮肤病学杂志 年：2019 期：v.12 语种：中文; 页：SYPF201902014 页数：3 CN：02 ISSN：11-5654/R 分类号：48-50

摘要

目的观察中药汤剂凉血解毒汤联合窄谱中波紫外线(NB-UVB)治疗寻常性银屑病血热证的临床疗效。方法将96例寻常性银屑病血热证患者随机分为试验组和对照组,每组48例,试验组给予凉血解毒汤联合NB-UVB照射治疗,对照组只给予NB-UVB照射治疗,两组均同时外用白凡士林治疗,4周后采用银屑病皮损面积及严重度指数(PASI)评分评价疗效。结果试验组治愈15例(31.3%)、显效20例(41.7%)、好转11例(22.9%)、无效2例(4.2%),总有效率95.8%;对照组治愈10例(20.8%)、显效13例(27.1%)、好转18例(37.5%)、无效7例(14.6%),总有效率85.4%;两组比较差异有统计学意义(P<0.05)。两组治疗前后PASI评分比较,试验组和对照组治疗前后PASI评分比较,差异均有统计学意义(P均<0.05);两组间治疗前PASI评分比较,差异无统计学意义(P> 0.05),两组治疗后PASI评分差异有统计学意义(P <0.05)。结论两组治疗均有效且试验组疗效优于对照组,中药凉血解毒汤联合NB-UVB治疗寻常性银屑病血热证临床疗效确切,安全性高。
        Objective To observe the clinical efficacy of traditional Chinese medicine Liangxue Jiedu decoction combined with narrowband UVB(NB-UVB) in the treatment of blood heat syndrome of psoriasis vulgaris. Methods A total of 96 patients with psoriasis vulgar blood heat syndrome were randomly divided into treatment group and control group, with 48 cases in each group. The treatment group was treated with Liangxue Jiedu decoction combined with NB-UVB irradiation, while the control group was only treated with NB-UVB irradiation, both the two groups were treated with white petrolatum topically at the same time, and the efficacy was evaluated by PASI score after 4 weeks of the treatment. Results In the experimental group, cured 15 cases(31.3%), markedly effective 20 cases(41.7%), improved 11 cases(22.9%), ineffective 2 cases(4.2%), the total effective rate was 95.8%; in the control group, cured 10 cases(20.8%), markedly effective 13 cases(27.1%), improved 18 cases(37.5%), ineffective 7 cases(14.6%), the total effective rate was 85.4%; the difference between the two groups had statistically significant(P<0.05). There was significant difference in PASI scores before and after treatment in both the two groups(P<0.05); there was no significant difference in the pre-treatment PASI score between the two groups(P>0.05); and there was a statistically significant difference in the PASI score between the two groups after treatment(P<0.05). Conclusion Both the two treatment schemes adopted in this study were effective, and the efficacy of the experimental group was better than that of the control group. The traditional Chinese medicine Liangxue Jiedu decoction combined with NB-UVB is effective in the treatment of psoriasis vulgaris blood heat syndrome, as well as with high safety..

引文

[1]赵炳南,张志礼.简明中医皮肤病学[M].北京:中国展望出版社,1983:200-203.
    [2]Zhang GZ,Wang JS,Wang P,et al.Distribution and development of the TCM syndromes in psoriasis vulgaris[J].J Tradit Chin Med,2009,29(3):195-200.
    [3]赵辨.中国临床皮肤病学[M].南京:江苏科学技术出版社,2010:1008.
    [4]全军中医药学会皮肤病专业委员会.寻常性银屑病中西医结合诊疗共识(2009年讨论稿)[J].中国中西医结合皮肤性病学杂志,2009,8(5):328.
    [5]陈维文,周冬梅,王莒生,等.“辨血为主,从学论治”规范化方药辨证治疗寻常性银屑病研究[J].中华中医药杂志,2015,30(10):3614-3618.