高通量透析和常规低通量血液透析对尿毒症血液透析患者CRP和BNP的影响对比

详细信息    查看全文 | 推荐本文 |

英文篇名：Comparison of the effects of high-flux hemodialysis and conventional low-flux hemodialysis on CRP and BNP in hemodialysis patients with uremia 作者：谢树锋 ; 凌志雄 ; 赖志君 ; 冯明涛 英文作者：XIE Shufeng;LING Zhixiong;LAI Zhijun;FENG Mingtao;Department of Intensive Care Unit,the Eighth People's Hospital of Dongguan;Blood Purification Center,the Eighth People's Hospital of Dongguan;Department of Pediatric Intensive Care Unit,the Eighth People's Hospital of Dongguan;Department of Clinical Laboratory,the Eighth People's Hospital of Dongguan; 关键词：尿毒症患者 ; 持续血液透析 ; 高通量血液透析 ; CRP ; BNP 英文关键词：Patients with uremia;;Maintenance hemodialysis;;High-flux hemodialysis;;CRP;;BNP 中文刊名：GYKX 英文刊名：China Medicine and Pharmacy 机构：广东省东莞市第八人民医院ICU;广东省东莞市第八人民医院血液净化中心;广东省东莞市第八人民医院PICU;广东省东莞市第八人民医院检验科; 出版日期：2019-05-15 出版单位：中国医药科学 年：2019 期：v.9;No.201 基金：广东省东莞市社会科技发展一般项目(201750715028121) 语种：中文; 页：GYKX201909062 页数：3 CN：09 ISSN：11-6006/R 分类号：210-212

摘要

目的观察高通量透析(HFHD)和常规低通量透析(HD)对尿毒症血液透析患者C-反应蛋白(CRP和脑钠肽(BNP)的影响。方法选取2015年1月～2017年2月于我院诊治需行维持性血液透析(MHD)的尿毒症患者40例,随机分成观察组(20例)和对照组(20例),观察组患者给予高通量血液透析,对照组患者给予低通量血液透析,比较两组患者首次血液透析前和治疗6月后的炎症因子C反应蛋白(CRP)及脑钠肽(BNP)的变化。结果治疗前两组患者血清炎症因子CRP水平及血清BNP水平比较差异无统计学意义(P> 0.05);首次治疗后两组患者的CRP和BNP水平比较差异无统计学意义(P> 0.05),治疗6月后观察组患者的CRP和BNP水平显著低于对照组(P <0.05)。结论高通量血液透析能够更有效降低尿毒症患者血清CRP水平及血清BNP水平,有助于改善患者的长期预后。
        Objective To observe the effects of high-flux hemodialysis(HFHD)and conventional low flux hemodialysis(HD) on C-reactive protein(CRP)and brain natriuretic peptide(BNP)in hemodialysis patients with uremia. Methods Forty patients with uremia who were required to undergo maintenance hemodialysis(MHD)in our hospital from January 2015 to February 2017 were selected.They were randomly divided into the observation group(20 cases)and the control group(20 cases).Patients in the observation group were given high-flux hemodialysis while patients in the control group were given conventional low-flux hemodialysis.The changes of inflammatory cytokine C-reactive protein(CRP)and brain natriuretic peptide(BNP)before the first hemodialysis and 6 months after treatment were compared between the two groups. Results There was no significant difference in serum inflammatory cytokine CRP level and serum BNP level between the two groups before treatment(P > 0.05).There was no significant difference in CRP and BNP levels between the two groups after the first treatment(P > 0.05).After 6 months of treatment,CRP and BNP levels in the observation group were significantly lower than those in the control group(P < 0.05). Conclusion High-flux hemodialysis can effectively reduce the levels of serum CRP and serum BNP in patients with uremia,which helps to improve long-term prognosis of patients.

引文

[1]Xu J,Mao ZG,Kong M,et al.Scientific publications in nephrology and urology journals from Chinese authors in East Asia:a 10-year survey of the literature[J].PLoS One,2011,6(4):e14781.
    [2]李朝园,赵令君,刘潇,等.两种透析模式对尿毒症性脑病患者生化指标及生命体征的影响[J].中国实验诊断学,2017,21(1):101-102.
    [3]郭皓,杨向东,鲜万华.不同血液净化方式对维持性血液透析患者微炎症指标及Fetuin-A的相关性研究[J].医学与哲学,2014,35(20):29-31,34.
    [4]张少鑫.血液透析联合血液灌流治疗对尿毒症患者β2-微球蛋白的清除效果研究[J].中国临床医生杂志,2017,45(10):30-33.
    [5]郝艳华,姜亚芳.维持性血液透析患者症状经历的调查研究[J].中华护理杂志,2016,51(3):299-303.
    [6]郭学娜,任建伟,康志敏.血清N端脑钠肽与维持性血液透析患者心血管功能的关系[J].中国血液净化,2015,14(10):600-603.
    [7]何援军,金劼,潘晓红.尿毒症患者持续血液透析医院感染血清炎症指标的变化研究[J].中华医院感染学杂志,2015,25(12):2652-2654.
    [8]董海霞,吕玉凤.高通量透析对尿毒症患者血液透析炎症因子和脑钠肽的影响[J].中国医师杂志,2016,18(4):532-535.
    [9]王心亮,王德光,郝丽,等.初次血液透析患者血管通路选择及影响因素分析[J].中国临床保健杂志,2015,18(6):597-600.
    [10]刘娜,周露,丁鲲,等.高通量血液透析对尿毒症患者微炎症及营养状态的影响[J].临床肾脏病杂志,2017,17(11):667-670.
    [11]李杰,张启蒙.N端脑钠肽前体评价透析患者容量负荷影响因素的研究进展[J].北京医学,2015,37(2):151-153.
    [12]梅艳,李雄,袁飞远.尿毒症患者首次血液透析的血管通路临床研究[J].中国医刊,2016,51(7):75-77.
    [13]龚德华,季大玺,谢红浪.高通量透析器复用的研究[J].医学研究生学报,2000,13(5):307-310.
    [14]王俊霞,张鹏,肖雄木,等.高通量透析对维持性血液透析患者血脂和微炎症状态的影响[J].中国血液净化,2013,12(10):566-569.
    [15]贺云岚,邬碧波,张黎明,等.血液透析患者脑钠肽水平与左心功能不全及血容量负荷的关系[J].中国血液净化,2010,9(10):546-549.