枳壳化学成分及药理作用研究进展
|
摘要
枳壳为芸香科植物酸橙(Citrus aurantium)及其栽培变种黄皮酸橙(C. aurantium ‘huangpi’)、代代花(C.aurantium ‘daidai’)、朱栾(C. aurantium ‘zhuluan’)、塘橙(C. aurantium ‘tangcheng’)的干燥未成熟果实。总结枳壳黄酮类、挥发油类、生物碱类和苯丙素类等主要化学成分,并对中药材枳壳的药理作用的研究进展进行详细的综述,旨在为枳壳的相关研究提供参考。
Fructus Aurantii was the dried immature fruits of Rutaceae plants as the Citrus aurantium L.and its cultivars,C.aurantium 'huangpi',C.aurantium 'daidai',C.aurantium 'zhuluan',and C.aurantium 'tangcheng'.In this paper,the main chemical constituents of Fructus Aurantii were summarized,such as flavonoids,volatile oils,alkaloids and phenylpropanoids,and the research progress of the pharmacological effects of Fructus Aurantii was reviewed in detail,in order to provide references for the related research of Fructus Aurantii.
Fructus Aurantii was the dried immature fruits of Rutaceae plants as the Citrus aurantium L.and its cultivars,C.aurantium 'huangpi',C.aurantium 'daidai',C.aurantium 'zhuluan',and C.aurantium 'tangcheng'.In this paper,the main chemical constituents of Fructus Aurantii were summarized,such as flavonoids,volatile oils,alkaloids and phenylpropanoids,and the research progress of the pharmacological effects of Fructus Aurantii was reviewed in detail,in order to provide references for the related research of Fructus Aurantii.
引文
[1]国家药典委员会.中华人民共和国药典(一部)[M].北京:中国医药科技出版社,2015:246.
[2]蒋以号,王晶,曹旻旻,等.中药枳壳的研究概况[J].中国医药导刊,2008,10(8):1238-1240.
[3]李敏.枳壳化学成分的研究[D].吉林:吉林大学,2014.
[4]肖培根.新编中药志(第二卷)[M].北京:化学工业出版社,2002:4431.
[5]陈振鹤,吴国泰,任远.枳壳的化学成·理作用及临床应用[J].安徽农业科学,2016,44(26):95-97.
[6]毕春慧.蜜桔幼果化学成分的提取、分离及生物活性研究[D].杭州:浙江工商大学,2011.
[7]丁邑强,熊英,周斌,等.枳壳中黄酮类成分的分离与鉴定[J].中国中药杂志,2015,40(12):2352-2356.
[8]Zhou D Y,Chen D L,XU Q,et al.Characterization of polymethoxylated flavones in Fructus aurantii by liquid chormatography with atmosphericpressure chemical ionzation combined with tandem mass spectorometry[J].Journal of Pharmaceutical and Biomedical Analysis,2007,43:1692-1699.
[9]杨武亮,陈海芳,余宝金,等.枳壳活性化学成分研究[J].中药材,2008,31(12):1187-1815.
[10]Chen H F,Zhang W G,Yuan J B,et al.Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS[J].Journal of Pharmaceutical and Biomedical Analysis,2012,59:90-95.
[11]徐欢,陈海芳,介磊,等.枳实、枳壳的化学成分及胃肠动力学研究[J].江西中医学院学报,2009,21(1):42-43.
[12]Lin Z T,Wang H,Xu Y,et al.Idetification of antioxidants in Fruchtus aurantii and its quality evaluation using a new online combination of analytical techniques[J].Food Chemistry,2012,134:1181-1191.
[13]Nakabayashi T.Studies on the Citrus Flavonoids.Part VI:Chemical Structure of the Disaccharide of Neohesperidin,Naringin and Poncirin[J].Journal of the Agricultural Chemical Society of Japan,1961,35(1):45-48.
[14]付小梅,吴志瑰,褚小兰,等.枳壳中黄酮类成分的研究[J].中药材,2006,29(11):1187-1188.
[15]徐英,董静,王弘,等.使用ESI-IT-TOF高分辨率质谱及在线柱后衍生技术枳壳药材指纹图谱中二氢黄酮类成分的鉴定[C]//第九届全国中药和天然药物学术研讨会大会报告及论文集,2007:394-403.
[16]周大勇,徐青,薛兴亚,等.高效液相色谱-电喷雾质谱法测定枳壳中黄酮苷类化合物[J].分析化学研究报告,2006,34(S1):31-35.
[17]张庆华,龚千锋,蒋以号,等.枳壳樟帮炮制品黄酮类化学成分研究[J].时珍国医国药,2010,21(10):2536-2537.
[18]马超一,高文远,高颖,等.枳壳化学成分和代谢成分的UPLC-PAD-Q-TOF/MS分析[J].药物评价研究,2010,33(2):110-115.
[19]施学骄,张杰红,樊丹青,等.枳实、枳壳挥发油化学成分及抑菌活性的比较研究[J].中药与临床,2012,3(2):25-27,32.
[20]张宏武.枳壳的质量标准和药代动力学研究[D].北京:北京协和医学院,2008.
[21]郑莹,王帅,孟宪生,等.中药枳壳挥发油成分气相色谱-质谱联用分析和促进胃肠动力药效研究[J].时珍国医国药,2015,26(3):516-518.
[22]于欢,宁希鲜,陈泣,等.江枳壳炮制品挥发油的GC-MS分析[J].中成药,2015,37(3):592-598.
[23]张金莲,刘明贵,钟凌云,等.枳壳挥发油提取工艺优选及其化学成分GC-MS分析[J].中国实验方剂学杂志,2016,22(19):27-31.
[24]陈希华,张建康,黄检平,等.枳壳研究进展[J].今日药学,2015,25(3):229-231.
[25]Karsten P,Catherine A R,Katherine E S,et al.Determination of Bitter Orange alkaloids in dietary supplements standard reference materials by liquid chromatography with ultraviolet absorbance and fluorescence detection[J].Journal of Chromatography A,2007,1156:304-311.
[26]Karsten P,Catherine A R,Katherine E S,et al.Determination of bitter orange alkaloids in dietary supplement Standard Reference Materials by liquid chromatography with atmosphericpressure ionization mass spectrometry[J].Analytical and Bioanalytical Chemistry,2007,389:197-205.
[27]邓可众,丁邑强,周斌,等.枳壳化学成分的分离与鉴定[J].中国实验方剂学杂志,2015,21(14):36-38.
[28]彭文文,闫合,谭宁华.中药枳壳中一个新的色原烷苷衍生物[J].中国中药杂志,2013,38(1):60-63.
[29]任树林,常虎,马悦,等.ICP-AES法测定枳壳中的8种金属素[J].延安大学学报,2011,33(1):51-52.
[30]徐耀庭,李劲松,顾炜,等.D-柠檬烯诱导人膀胱癌细胞周期阻滞及凋亡的研究[J].中国医学工程,2010,18(3):6-9.
[31]罗刚,曾云,朱玲,等.川陈皮素对肺癌的增殖抑制作用及其机制[J].四川大学学报(医学版),2009,40(3):449-452.
[32]赵妍妍,马秀英,周黎明.川陈皮素对肝癌细胞的抑制作用[J].华西药学杂志,2007,22(2):149-151.
[33]刘义,吴科锋,李延平.川陈皮素体外对微管蛋白聚合的影响[J].中国中药杂志,2008,33(18):2113-2115.
[34]冯颖倩,左学兰,李瑞芳,等.柚皮素对阿霉素损伤的正常血细胞的保护作用[J].中国实验血液学杂志,2008,16(4):790-793.
[35]李桃园,王昕,赵旋,等.柚皮素对四氯化碳致小鼠化学性肝损伤中氧化应激介质生成影响的实验研究[J].中国临床药理学杂志,2010,26(6):420-423.
[36]张晓南,黄世敬.枳实、枳壳的抗抑郁作用[J].环球中医药,2014,7(1):77-80.
[37]Yi L T,Li C F,Zhan X,et al.Involvement of monoaminergic system in the antidepressant-like effect of the flavonoid naringenin in mice[J].Progress in Neuro Psychopharmacology&Biological Psychiatry,2010,34:1223-1228.
[38]徐颖,冯劼,郭建友.枳壳提取物抗抑郁作用及其机制探讨[J].中国临床药理学与治疗学,2013,18(10):1086-1092.
[39]谢仁峰,文双娥,李洋,等.柚皮苷抗炎镇痛作用的实验研究[J].湖南师范大学学报,2011,8(4):5-9.
[40]熊立,李俊,王雯,等.橙皮苷对大鼠胶原性关节炎的治疗作用及部分机制[J].安徽医科大学学报,2011,46(10):1013-1017.
[41]田远耀,李俊,黄成,等.橙皮素衍生物Y12抗炎活性评价[J].安徽医科大学学报,2016,51(4):526-530.
[42]彭磊,张茜,李荣,等.橙皮苷衍生物抗炎活性的筛选研究[J].安徽医科大学学报,2011,46(1):36-39.
[43]Chen K H,Weng M S,Lin J K.Tangeretin suppresses JNK,IL-1β-induced cyclooxygenase(COX)-2 expression through inhibition of p38 MAPK and AKT activation in human lung carcinoma cells[J].Biochemical Pharmacology,2007,73:215-227.
[44]Lina N,Satoa T,Takayamaa Y,et al.Novel anti-inflammatory actions of nobiletin,a citrus polymethoxy flavonoid,on human synovial fibroblasts and mouse macrophages[J].Biochemical Pharmacology,2003,65(12):2065-2071.
[45]李顺文,吴琦,赵诗云,等.枳壳总黄酮降血脂作用的实验研究[J].实用中西医结合临床,2013,13(3):91,94.
[46]周燕文,时雪峰.柚皮苷对实验性2型糖尿病大鼠的作用研究[J].中国药师,2012,15(4):471-474.
[47]毛炜,江巍,郑广娟.小陷胸汤加味对ApoE基因敲除小鼠动脉粥样硬化斑块的影响[J].时珍国医国药,2012,23(4):1030-1031.
[48]吴铿,游琼,黄瑞娜,等.柚皮苷对实验性2型糖尿病心肌病大鼠模型糖脂代谢的影响[J].广东医学,2012,33(13):1863-1866.
[49]吴铿,黄瑞娜,游琼,等.柚皮苷对糖尿病心肌病大鼠心肌的保护作用[J].国际心血管病杂志,2012,39(5):302-305.
[50]吴铿,游琼,黄瑞娜,等.柚皮苷调控心肌PPARγ表达对实验性2型糖尿病心肌病大鼠模型心肌损伤的防治作用[J].中国药理学通报,2012,28(4):526-530.
[51]Pari L,Amudha K.Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats[J].European Journal of Pharmacology,2011,650(1):364-370.
[52]蔡莉,李荣,胡成穆.橙皮苷治疗大鼠非酒精性脂肪肝的研究[J].中药药理与临床,2009,25(3):18-20.
[53]王焱,李俊,王保伟.橙皮苷对非酒精性脂肪肝大鼠的保护作用及其机制的初探[J].安徽医科大学学报,2010,45(5):646-650.
[54]王雯,李俊,李荣,等.橙皮苷对非酒精性脂肪肝大鼠COX-2表达及活性的影响[J].中国医药通讯,2011,28(2):72.
[55]邢娜,舒尊鹏,徐炳清,等.枳壳多糖CALB-1的提取、分离纯化及免疫调节活性研究[J].中草药,2015,46(5):639-644.
[56]李荣,李俊,胡成穆,等.橙皮苷对免疫功能低下小鼠免疫调节作用的实验研究[J].中国药理学通报,2007,23(2):169-172.
[57]李荣,李俊,胡成穆,等.橙皮苷对大鼠佐剂性关节炎的治疗作用及机制[J].中国药理学通报,2008,24(4):494-498.
[58]崔亚玲.气滞胃痛颗粒中枳壳有效组分表征及药代动力学研究[D].沈阳:辽宁中医药大学,2013.
[59]柏晓武,蒋以号,林森.枳壳胃肠动力学研究概况[J].江西化工,2013(2):65.
[60]王刚,张静泽,陈虹,等.中药枳壳提取物对大鼠不同肠段平滑肌运动功能的影响[J].武警后勤学院学报(医学版),2013,22(8):679-682.
[61]易徐航,夏放高,陈海芳,等.枳壳中黄酮苷类成分对正常小鼠小肠推进的影响[J].时珍国医国药,2015,26(2):278-280.
[62]庄须国,潘振伟,刘晓丹,等.枳壳醇提物对大鼠体外胸主动脉环的收缩作用与机制[J].中国药理学通报,2008,24(6):810-813.
[63]苏明媛,牛江龙,李林,等.川陈皮素的体外抑癌活性及其机制研究[J].中成药,2011,33(9):1479-1483.
[64]黄彬,陈黄琴.橙皮苷对人舌癌Tca8113细胞体外增殖的影响[J].现代中西医结合杂志,2011,20(27):3399-3400.
[65]廖霞,刘文,丁航.柚皮素对凝血酶诱导的兔血小板聚集的影响[J].时珍国医国药,2010,21(11):2909-2910.
[66]Rajadurai M,Prince P S M.Preventive effect of naringin on lipids,lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in wistar rats[J].Journal of biochemical and molecular toxicology,2006,20(4):191-197.
[67]李雪飞,江洪,胡笑容,等.橙皮苷减轻大鼠心肌缺血/再灌注损伤所致的炎症反应[J].武汉大学学报(医学版),2016,37(3):390-394.
[2]蒋以号,王晶,曹旻旻,等.中药枳壳的研究概况[J].中国医药导刊,2008,10(8):1238-1240.
[3]李敏.枳壳化学成分的研究[D].吉林:吉林大学,2014.
[4]肖培根.新编中药志(第二卷)[M].北京:化学工业出版社,2002:4431.
[5]陈振鹤,吴国泰,任远.枳壳的化学成·理作用及临床应用[J].安徽农业科学,2016,44(26):95-97.
[6]毕春慧.蜜桔幼果化学成分的提取、分离及生物活性研究[D].杭州:浙江工商大学,2011.
[7]丁邑强,熊英,周斌,等.枳壳中黄酮类成分的分离与鉴定[J].中国中药杂志,2015,40(12):2352-2356.
[8]Zhou D Y,Chen D L,XU Q,et al.Characterization of polymethoxylated flavones in Fructus aurantii by liquid chormatography with atmosphericpressure chemical ionzation combined with tandem mass spectorometry[J].Journal of Pharmaceutical and Biomedical Analysis,2007,43:1692-1699.
[9]杨武亮,陈海芳,余宝金,等.枳壳活性化学成分研究[J].中药材,2008,31(12):1187-1815.
[10]Chen H F,Zhang W G,Yuan J B,et al.Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS[J].Journal of Pharmaceutical and Biomedical Analysis,2012,59:90-95.
[11]徐欢,陈海芳,介磊,等.枳实、枳壳的化学成分及胃肠动力学研究[J].江西中医学院学报,2009,21(1):42-43.
[12]Lin Z T,Wang H,Xu Y,et al.Idetification of antioxidants in Fruchtus aurantii and its quality evaluation using a new online combination of analytical techniques[J].Food Chemistry,2012,134:1181-1191.
[13]Nakabayashi T.Studies on the Citrus Flavonoids.Part VI:Chemical Structure of the Disaccharide of Neohesperidin,Naringin and Poncirin[J].Journal of the Agricultural Chemical Society of Japan,1961,35(1):45-48.
[14]付小梅,吴志瑰,褚小兰,等.枳壳中黄酮类成分的研究[J].中药材,2006,29(11):1187-1188.
[15]徐英,董静,王弘,等.使用ESI-IT-TOF高分辨率质谱及在线柱后衍生技术枳壳药材指纹图谱中二氢黄酮类成分的鉴定[C]//第九届全国中药和天然药物学术研讨会大会报告及论文集,2007:394-403.
[16]周大勇,徐青,薛兴亚,等.高效液相色谱-电喷雾质谱法测定枳壳中黄酮苷类化合物[J].分析化学研究报告,2006,34(S1):31-35.
[17]张庆华,龚千锋,蒋以号,等.枳壳樟帮炮制品黄酮类化学成分研究[J].时珍国医国药,2010,21(10):2536-2537.
[18]马超一,高文远,高颖,等.枳壳化学成分和代谢成分的UPLC-PAD-Q-TOF/MS分析[J].药物评价研究,2010,33(2):110-115.
[19]施学骄,张杰红,樊丹青,等.枳实、枳壳挥发油化学成分及抑菌活性的比较研究[J].中药与临床,2012,3(2):25-27,32.
[20]张宏武.枳壳的质量标准和药代动力学研究[D].北京:北京协和医学院,2008.
[21]郑莹,王帅,孟宪生,等.中药枳壳挥发油成分气相色谱-质谱联用分析和促进胃肠动力药效研究[J].时珍国医国药,2015,26(3):516-518.
[22]于欢,宁希鲜,陈泣,等.江枳壳炮制品挥发油的GC-MS分析[J].中成药,2015,37(3):592-598.
[23]张金莲,刘明贵,钟凌云,等.枳壳挥发油提取工艺优选及其化学成分GC-MS分析[J].中国实验方剂学杂志,2016,22(19):27-31.
[24]陈希华,张建康,黄检平,等.枳壳研究进展[J].今日药学,2015,25(3):229-231.
[25]Karsten P,Catherine A R,Katherine E S,et al.Determination of Bitter Orange alkaloids in dietary supplements standard reference materials by liquid chromatography with ultraviolet absorbance and fluorescence detection[J].Journal of Chromatography A,2007,1156:304-311.
[26]Karsten P,Catherine A R,Katherine E S,et al.Determination of bitter orange alkaloids in dietary supplement Standard Reference Materials by liquid chromatography with atmosphericpressure ionization mass spectrometry[J].Analytical and Bioanalytical Chemistry,2007,389:197-205.
[27]邓可众,丁邑强,周斌,等.枳壳化学成分的分离与鉴定[J].中国实验方剂学杂志,2015,21(14):36-38.
[28]彭文文,闫合,谭宁华.中药枳壳中一个新的色原烷苷衍生物[J].中国中药杂志,2013,38(1):60-63.
[29]任树林,常虎,马悦,等.ICP-AES法测定枳壳中的8种金属素[J].延安大学学报,2011,33(1):51-52.
[30]徐耀庭,李劲松,顾炜,等.D-柠檬烯诱导人膀胱癌细胞周期阻滞及凋亡的研究[J].中国医学工程,2010,18(3):6-9.
[31]罗刚,曾云,朱玲,等.川陈皮素对肺癌的增殖抑制作用及其机制[J].四川大学学报(医学版),2009,40(3):449-452.
[32]赵妍妍,马秀英,周黎明.川陈皮素对肝癌细胞的抑制作用[J].华西药学杂志,2007,22(2):149-151.
[33]刘义,吴科锋,李延平.川陈皮素体外对微管蛋白聚合的影响[J].中国中药杂志,2008,33(18):2113-2115.
[34]冯颖倩,左学兰,李瑞芳,等.柚皮素对阿霉素损伤的正常血细胞的保护作用[J].中国实验血液学杂志,2008,16(4):790-793.
[35]李桃园,王昕,赵旋,等.柚皮素对四氯化碳致小鼠化学性肝损伤中氧化应激介质生成影响的实验研究[J].中国临床药理学杂志,2010,26(6):420-423.
[36]张晓南,黄世敬.枳实、枳壳的抗抑郁作用[J].环球中医药,2014,7(1):77-80.
[37]Yi L T,Li C F,Zhan X,et al.Involvement of monoaminergic system in the antidepressant-like effect of the flavonoid naringenin in mice[J].Progress in Neuro Psychopharmacology&Biological Psychiatry,2010,34:1223-1228.
[38]徐颖,冯劼,郭建友.枳壳提取物抗抑郁作用及其机制探讨[J].中国临床药理学与治疗学,2013,18(10):1086-1092.
[39]谢仁峰,文双娥,李洋,等.柚皮苷抗炎镇痛作用的实验研究[J].湖南师范大学学报,2011,8(4):5-9.
[40]熊立,李俊,王雯,等.橙皮苷对大鼠胶原性关节炎的治疗作用及部分机制[J].安徽医科大学学报,2011,46(10):1013-1017.
[41]田远耀,李俊,黄成,等.橙皮素衍生物Y12抗炎活性评价[J].安徽医科大学学报,2016,51(4):526-530.
[42]彭磊,张茜,李荣,等.橙皮苷衍生物抗炎活性的筛选研究[J].安徽医科大学学报,2011,46(1):36-39.
[43]Chen K H,Weng M S,Lin J K.Tangeretin suppresses JNK,IL-1β-induced cyclooxygenase(COX)-2 expression through inhibition of p38 MAPK and AKT activation in human lung carcinoma cells[J].Biochemical Pharmacology,2007,73:215-227.
[44]Lina N,Satoa T,Takayamaa Y,et al.Novel anti-inflammatory actions of nobiletin,a citrus polymethoxy flavonoid,on human synovial fibroblasts and mouse macrophages[J].Biochemical Pharmacology,2003,65(12):2065-2071.
[45]李顺文,吴琦,赵诗云,等.枳壳总黄酮降血脂作用的实验研究[J].实用中西医结合临床,2013,13(3):91,94.
[46]周燕文,时雪峰.柚皮苷对实验性2型糖尿病大鼠的作用研究[J].中国药师,2012,15(4):471-474.
[47]毛炜,江巍,郑广娟.小陷胸汤加味对ApoE基因敲除小鼠动脉粥样硬化斑块的影响[J].时珍国医国药,2012,23(4):1030-1031.
[48]吴铿,游琼,黄瑞娜,等.柚皮苷对实验性2型糖尿病心肌病大鼠模型糖脂代谢的影响[J].广东医学,2012,33(13):1863-1866.
[49]吴铿,黄瑞娜,游琼,等.柚皮苷对糖尿病心肌病大鼠心肌的保护作用[J].国际心血管病杂志,2012,39(5):302-305.
[50]吴铿,游琼,黄瑞娜,等.柚皮苷调控心肌PPARγ表达对实验性2型糖尿病心肌病大鼠模型心肌损伤的防治作用[J].中国药理学通报,2012,28(4):526-530.
[51]Pari L,Amudha K.Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats[J].European Journal of Pharmacology,2011,650(1):364-370.
[52]蔡莉,李荣,胡成穆.橙皮苷治疗大鼠非酒精性脂肪肝的研究[J].中药药理与临床,2009,25(3):18-20.
[53]王焱,李俊,王保伟.橙皮苷对非酒精性脂肪肝大鼠的保护作用及其机制的初探[J].安徽医科大学学报,2010,45(5):646-650.
[54]王雯,李俊,李荣,等.橙皮苷对非酒精性脂肪肝大鼠COX-2表达及活性的影响[J].中国医药通讯,2011,28(2):72.
[55]邢娜,舒尊鹏,徐炳清,等.枳壳多糖CALB-1的提取、分离纯化及免疫调节活性研究[J].中草药,2015,46(5):639-644.
[56]李荣,李俊,胡成穆,等.橙皮苷对免疫功能低下小鼠免疫调节作用的实验研究[J].中国药理学通报,2007,23(2):169-172.
[57]李荣,李俊,胡成穆,等.橙皮苷对大鼠佐剂性关节炎的治疗作用及机制[J].中国药理学通报,2008,24(4):494-498.
[58]崔亚玲.气滞胃痛颗粒中枳壳有效组分表征及药代动力学研究[D].沈阳:辽宁中医药大学,2013.
[59]柏晓武,蒋以号,林森.枳壳胃肠动力学研究概况[J].江西化工,2013(2):65.
[60]王刚,张静泽,陈虹,等.中药枳壳提取物对大鼠不同肠段平滑肌运动功能的影响[J].武警后勤学院学报(医学版),2013,22(8):679-682.
[61]易徐航,夏放高,陈海芳,等.枳壳中黄酮苷类成分对正常小鼠小肠推进的影响[J].时珍国医国药,2015,26(2):278-280.
[62]庄须国,潘振伟,刘晓丹,等.枳壳醇提物对大鼠体外胸主动脉环的收缩作用与机制[J].中国药理学通报,2008,24(6):810-813.
[63]苏明媛,牛江龙,李林,等.川陈皮素的体外抑癌活性及其机制研究[J].中成药,2011,33(9):1479-1483.
[64]黄彬,陈黄琴.橙皮苷对人舌癌Tca8113细胞体外增殖的影响[J].现代中西医结合杂志,2011,20(27):3399-3400.
[65]廖霞,刘文,丁航.柚皮素对凝血酶诱导的兔血小板聚集的影响[J].时珍国医国药,2010,21(11):2909-2910.
[66]Rajadurai M,Prince P S M.Preventive effect of naringin on lipids,lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in wistar rats[J].Journal of biochemical and molecular toxicology,2006,20(4):191-197.
[67]李雪飞,江洪,胡笑容,等.橙皮苷减轻大鼠心肌缺血/再灌注损伤所致的炎症反应[J].武汉大学学报(医学版),2016,37(3):390-394.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |