促甲状腺激素与视网膜新生血管形成
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摘要
视网膜新生血管形成主要见于糖尿病视网膜病变(DR)、早产儿视网膜病(ROP)及视网膜中央静脉阻塞(CRVO),是视网膜病变的主要致盲原因。有研究表明高水平促甲状腺激素(TSH)可能促进了视网膜新生血管形成,其作用机制可能与TSH与其受体结合后激活了血管内皮生长因子(VEGF)和环磷酸腺苷-雷帕霉素靶蛋白(cAMP-mTOR)信号通路而使血管生成增加有关。
As the primary cause of blindness in retinopathy, retinal neovascularization can be found in diabetic retinopathy(DR), retinopathy of prematurity(ROP) and central retinal vein occlusion(CRVO). Recent studies have shown that the retinal neovascularization could be promoted by the high level of thyroid stimulating hormone(TSH). The mechanism may be that the vascular endothelial growth factor(VEGF) and cyclic adenosine monophosphate-mammalian target of rapamycin(cAMP-mTOR) signaling pathway is activated by the combination of TSH and its receptor.
As the primary cause of blindness in retinopathy, retinal neovascularization can be found in diabetic retinopathy(DR), retinopathy of prematurity(ROP) and central retinal vein occlusion(CRVO). Recent studies have shown that the retinal neovascularization could be promoted by the high level of thyroid stimulating hormone(TSH). The mechanism may be that the vascular endothelial growth factor(VEGF) and cyclic adenosine monophosphate-mammalian target of rapamycin(cAMP-mTOR) signaling pathway is activated by the combination of TSH and its receptor.
引文
1 田利民,高聆,赵家军.促甲状腺激素的甲状腺外作用[J].国际内分泌代谢杂志,2010,30(3):148-150.
2 Davies T,Marians R,Latif R.The TSH receptor reveals itself[J].Journal of Clinical Investigation,2002,110(2):161-164.
3 杨光燃,杨芳远,曹曦,等.促甲状腺激素受体可在微血管内皮细胞表达[J].微循环学杂志,2015,25(3):9-12.
4 Lawrence PF,Oderich GS.Ophthalmologic findings as predictors of carotid artery disease[J].Vascular Endovascular Surgery,2002,36(6):415-424.
5 冯宇梁,李杰,刘巾男,等.视网膜脉络膜新生血管性疾病机制及治疗研究进展[J].西部医学,2016,28(9):1 328-1 332.
6 Wu J,Yue S,Geng J,et al.Relationship between diabetic retinopathy and subclinical hypothyroidism:A meta analysis[J].Scientific Reports,2015,5:12 212.
7 Mutapcic L,Wren SM,Leske DA,et al.The effect of L-thyroxine supplementation on retinal vascular development in neonatal rats[J].Current Eye Research,2009,30(12):1 035-1 040.
8 Pearce SH,Brabant G,Duntas LH,et al.2013 ETA guideline:Management of subclinical hypothyroidism[J].European thyroid journal,2013,2(4):215-228.
9 Distler JH,Hirth A,Kurowska-Stolarska M,et al.Angiogenic and angiostatic factors in the molecular control of angiogenesis[J].The Quarterly Journal of Nuclear Medicine and Molecular Imaging,2003,47(3):149.
10 Raval AD,Sambamoorthi U.Incremental healthcare expenditures associated with thyroid disorders among individuals with diabetes[J].Journal of Thyroid Research,2012,2012(7):1-10.
11 Jali MV,Kambar S,Jali SM,et al.Prevalence of thyroid dysfunction among type 2 diabetes mellitus patients[J].Diabetes Metabolic Syndrome,2017,11 (Suppl):S105-108.
12 Barmpari ME,Kokkorou M,Micheli A,et al.Thyroid dysfunction among Greek patients with type 1 and type 2 diabetes mellitus as a disregarded comorbidity[J].Journal of Diabetes Research,2017,2017(8):6 505 814.
13 高谷,夏斯桂,郁新迪,等.2型糖尿病合并甲状腺功能异常的临床分析[J].中国糖尿病杂志,2014,22(6):507-510.
14 Chen HS,Wu TE,Jap TS,et al.Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in type 2 diabetic patients[J].Diabetic Medicine,2010,24(12):1 336-1 344.
15 Yang GR,Yang JK,Zhang L,et al.Association between subclinical hypothyroidism and proliferative diabetic retinopathy in type 2 diabetic patients:A case-control study[J].Tohoku Journal of Experimental Medicine,2010,222(4):303-310.
16 Yang JK,Liu W,Shi J,et al.An association between subclinical hypothyroidism and sight-threatening diabetic retinopathy in type 2 diabetic patients[J].Diabetes Care,2010,33(5):1 018-1 020.
17 Zhang L,Yang G,Su Z,et al.Correlation between subclinical hypothyroidism and renal function in patients with diabetes mellitus[J].Nephrology,2016,22(10):790-795.
18 Leske MC,Wu SY,Nemesure B,et al.Causes of visual loss and their risk factors:An incidence summary from the Barbados eye studies[J].Revista Panamericana De Salud Publica,2010,27(4):259-267.
19 郭丹.亚临床甲状腺功能减退症与2型糖尿病患者微血管病变的相关性分析[D].沈阳:中国医科大学,2012:1-27.
20 Kim BY,Kim CH,Jung CH,et al.Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes[J].Endocrine Journal,2011,58(12):1 065-1 070.
21 袁娟,张松.2型糖尿病患者血清TSH水平与糖尿病视网膜病变的相关性研究[J].陕西医学杂志,2017,46(12):1 678-1 679.
22 陈吉海,卞茸文,欧阳晓俊,等.亚临床甲减对老年2型糖尿病患者视网膜病变的影响[J].实用老年医学,2012,26(6):497-500.
23 Korkmaz L,Battue O,Daar G,et al.The effects of thyroid function on retinopathy of prematurity[J].Journal of Neonatal Perinatal Medicine,2016,9(4):349-356.
24 谷万章,王玉国,周丽霞.浅谈视网膜新生血管[J].航空航天医学杂志,2004,15(2):124-125.
25 Mookadam M,Leske DA,Fautsch MP,et al.The anti-thyroid drug methimazole induces neovascularization in the neonatal rat analogous to ROP[J].Investigative Ophthalmology Visual Science,2004,45(11):4 145-4 150.
26 Pierce EA ,Foley ED ,Smith LE.Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity[J].Arch Ophthalmol,1996,114(10):1 219-1 228.
27 司冰心,张卯年.视网膜中央静脉阻塞的治疗现状[J].中国康复理论与实践,2006,12(4):314-316.
28 Zimmermann M,Seifert V.Endothelin and subarachnoid hemorrhage:An overview[J].Neurosurgery,1998,43(4):863-875.
29 Hoffmann S,Hofbauer LC,Scharrenbach V,et al.Thyrotropin (TSH)-induced production of vascular endothelial growth factor in thyroid cancer cells in vitro:Evaluation of TSH signal transduction and of angiogenesis-stimulating growth factors[J].Journal of Clinical Endocrinology Metabolism,2004,89(12):6 139-6 145.
30 Balzan S,Del CR,Nicolini G,et al.Proangiogenic effect of TSH in human microvascular endothelial cells through its membrane receptor[J].Journal of Clinical Endocrinology Metabolism,2012,97(5):1 763-1 770.
2 Davies T,Marians R,Latif R.The TSH receptor reveals itself[J].Journal of Clinical Investigation,2002,110(2):161-164.
3 杨光燃,杨芳远,曹曦,等.促甲状腺激素受体可在微血管内皮细胞表达[J].微循环学杂志,2015,25(3):9-12.
4 Lawrence PF,Oderich GS.Ophthalmologic findings as predictors of carotid artery disease[J].Vascular Endovascular Surgery,2002,36(6):415-424.
5 冯宇梁,李杰,刘巾男,等.视网膜脉络膜新生血管性疾病机制及治疗研究进展[J].西部医学,2016,28(9):1 328-1 332.
6 Wu J,Yue S,Geng J,et al.Relationship between diabetic retinopathy and subclinical hypothyroidism:A meta analysis[J].Scientific Reports,2015,5:12 212.
7 Mutapcic L,Wren SM,Leske DA,et al.The effect of L-thyroxine supplementation on retinal vascular development in neonatal rats[J].Current Eye Research,2009,30(12):1 035-1 040.
8 Pearce SH,Brabant G,Duntas LH,et al.2013 ETA guideline:Management of subclinical hypothyroidism[J].European thyroid journal,2013,2(4):215-228.
9 Distler JH,Hirth A,Kurowska-Stolarska M,et al.Angiogenic and angiostatic factors in the molecular control of angiogenesis[J].The Quarterly Journal of Nuclear Medicine and Molecular Imaging,2003,47(3):149.
10 Raval AD,Sambamoorthi U.Incremental healthcare expenditures associated with thyroid disorders among individuals with diabetes[J].Journal of Thyroid Research,2012,2012(7):1-10.
11 Jali MV,Kambar S,Jali SM,et al.Prevalence of thyroid dysfunction among type 2 diabetes mellitus patients[J].Diabetes Metabolic Syndrome,2017,11 (Suppl):S105-108.
12 Barmpari ME,Kokkorou M,Micheli A,et al.Thyroid dysfunction among Greek patients with type 1 and type 2 diabetes mellitus as a disregarded comorbidity[J].Journal of Diabetes Research,2017,2017(8):6 505 814.
13 高谷,夏斯桂,郁新迪,等.2型糖尿病合并甲状腺功能异常的临床分析[J].中国糖尿病杂志,2014,22(6):507-510.
14 Chen HS,Wu TE,Jap TS,et al.Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in type 2 diabetic patients[J].Diabetic Medicine,2010,24(12):1 336-1 344.
15 Yang GR,Yang JK,Zhang L,et al.Association between subclinical hypothyroidism and proliferative diabetic retinopathy in type 2 diabetic patients:A case-control study[J].Tohoku Journal of Experimental Medicine,2010,222(4):303-310.
16 Yang JK,Liu W,Shi J,et al.An association between subclinical hypothyroidism and sight-threatening diabetic retinopathy in type 2 diabetic patients[J].Diabetes Care,2010,33(5):1 018-1 020.
17 Zhang L,Yang G,Su Z,et al.Correlation between subclinical hypothyroidism and renal function in patients with diabetes mellitus[J].Nephrology,2016,22(10):790-795.
18 Leske MC,Wu SY,Nemesure B,et al.Causes of visual loss and their risk factors:An incidence summary from the Barbados eye studies[J].Revista Panamericana De Salud Publica,2010,27(4):259-267.
19 郭丹.亚临床甲状腺功能减退症与2型糖尿病患者微血管病变的相关性分析[D].沈阳:中国医科大学,2012:1-27.
20 Kim BY,Kim CH,Jung CH,et al.Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes[J].Endocrine Journal,2011,58(12):1 065-1 070.
21 袁娟,张松.2型糖尿病患者血清TSH水平与糖尿病视网膜病变的相关性研究[J].陕西医学杂志,2017,46(12):1 678-1 679.
22 陈吉海,卞茸文,欧阳晓俊,等.亚临床甲减对老年2型糖尿病患者视网膜病变的影响[J].实用老年医学,2012,26(6):497-500.
23 Korkmaz L,Battue O,Daar G,et al.The effects of thyroid function on retinopathy of prematurity[J].Journal of Neonatal Perinatal Medicine,2016,9(4):349-356.
24 谷万章,王玉国,周丽霞.浅谈视网膜新生血管[J].航空航天医学杂志,2004,15(2):124-125.
25 Mookadam M,Leske DA,Fautsch MP,et al.The anti-thyroid drug methimazole induces neovascularization in the neonatal rat analogous to ROP[J].Investigative Ophthalmology Visual Science,2004,45(11):4 145-4 150.
26 Pierce EA ,Foley ED ,Smith LE.Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity[J].Arch Ophthalmol,1996,114(10):1 219-1 228.
27 司冰心,张卯年.视网膜中央静脉阻塞的治疗现状[J].中国康复理论与实践,2006,12(4):314-316.
28 Zimmermann M,Seifert V.Endothelin and subarachnoid hemorrhage:An overview[J].Neurosurgery,1998,43(4):863-875.
29 Hoffmann S,Hofbauer LC,Scharrenbach V,et al.Thyrotropin (TSH)-induced production of vascular endothelial growth factor in thyroid cancer cells in vitro:Evaluation of TSH signal transduction and of angiogenesis-stimulating growth factors[J].Journal of Clinical Endocrinology Metabolism,2004,89(12):6 139-6 145.
30 Balzan S,Del CR,Nicolini G,et al.Proangiogenic effect of TSH in human microvascular endothelial cells through its membrane receptor[J].Journal of Clinical Endocrinology Metabolism,2012,97(5):1 763-1 770.
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