骨髓间充质干细胞中与miRNA相关的研究进展
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摘要
骨髓间充质干细胞是一种多功能分化潜能细胞,在损伤组织修复重构中具有显著的"明星"效果,但临床应用仍存在许多限制性因素。伴随微小RNA(miRNA)在国际生物学研究领域中的逐渐升温,大量文献指出,miRNA在BMSCs中重要的调控机制,能够微观促使BMSCs性能发生改变,一定程度上规避单纯骨髓间充质干细胞治疗中的实际限制因素。本文就骨髓间充质干细胞与miRNA间的相互作用机制作以归总。
Bone marrow mesenchymal stem cells(BMSCs) are multifunctional differentiation potential cells, which have significant"star" effect in the repair and reconstruction of injured tissues, but there are still many restrictive factors in clinical application. With the gradual warming of micro-RNA(miRNA) in the field of international biological research, a large number of literatures have pointed out that the important regulatory mechanism of miRNA in BMSCs can microscopically change the performance of BMSCs. To a certain extent, avoid the actual constraints in the treatment of bone marrow mesenchymal stem cells. In this paper, the interaction mechanism between bone marrow mesenchymal stem cells and miRNA was summarized.
Bone marrow mesenchymal stem cells(BMSCs) are multifunctional differentiation potential cells, which have significant"star" effect in the repair and reconstruction of injured tissues, but there are still many restrictive factors in clinical application. With the gradual warming of micro-RNA(miRNA) in the field of international biological research, a large number of literatures have pointed out that the important regulatory mechanism of miRNA in BMSCs can microscopically change the performance of BMSCs. To a certain extent, avoid the actual constraints in the treatment of bone marrow mesenchymal stem cells. In this paper, the interaction mechanism between bone marrow mesenchymal stem cells and miRNA was summarized.
引文
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[2]J Zhang,Z Feng,J Wei,et al.Repair of Critical-Sized Mandible Defects in Aged Rat Using Hypoxia Preconditioned BMSCs with Up-regulation of Hif-1α[J].International Journal of Biological Sciences,2018,14(4):449-460.
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[4]Ma Q,Fang L,Jiang N,et al.Bone mesenchymal stem cell secretion of sRANKL/OPG/M-CSF in response to macrophage-mediated inflammatory response influences osteogenesis on nanostructured Ti surfaces[J].Biomaterials,2018,154:234-247.
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[6]Zeng Y L,Zheng H,Chen Q R,et al.Bone marrow-derived mesenchymal stem cells overexpressing MiR-21 efficiently repair myocardial damage in rats[J].Oncotarget,2017,8(17):29161-29173.
[7]黄伟聪,王钰,杨凯,等.rno-miRNA-133b对大鼠骨髓间充质干细胞增殖的影响[J].温州医学院学报,2012,43(5):445-448,452.
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[10]An X,Ma K,Zhang Z,et al.miR-17,miR-21,and miR-143 Enhance Adipogenic Differentiation from Porcine Bone Marrow-Derived Mesenchymal Stem Cells[J].Dna&Cell Biology,2016,35(8):410.
[11]王光辉,李月白,李明,等.微小RNA-27a靶向调控过氧化物酶体增殖子活化受体-γ和骨形态发生蛋白-2对激素诱导大鼠骨髓间充质干细胞分化的影响[J].中华实验外科杂志,2015,32(12):3110-3112.
[12]Clark E A,Kalomoiris S,Nolta J A,et al.Concise review:microRNA function in multipotent mesenchymal stromal cells[J].Stem Cells,2014,32(5):1074-1082.
[13]Hwang S,Park S K,Lee H Y,et al.MiR-140-5p suppresses BMP2-mediated osteogenesis in undifferentiated human mesenchymal stem cells[J].FEBSLett,2014,588(17):2957-2963.
[14]H Kang,H Chen,P Huang,et al.Glucocorticoids impair bone formation of bone marrow stromal stem cells by reciprocally regulating microRNA-34a-5p[J].Osteoporosis International,2016,27(4):1493-1505.
[15]Chen S,Yang L,Jie Q,et al.MicroRNA 125b suppresses the proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells[J].Molecular Medicine Reports,2014,9(5):1820.
[16]Y Gong,J Lu,X Yu,et al.Expression of Sp7 in Satb2-induced osteogenic differentiation of mouse bone marrow stromal cells is regulated by microRNA-27a[J].Molecular&Cellular Biochemistry,2016,417(1-2):7-16.
[17]王颖,张雷,周咏,等.miR-21诱导犬BMSCs骨向分化的体外实验研究[J].安徽医科大学学报,2017,52(9):1318-1323.
[18]Yan Z,Guo Y,Wang Y,et al.Micro RNA profiles of BMSCs induced into osteoblasts with osteoinductive medium[J].Experimental and therapeutic medicine,2018,15(3):2589.
[19]Tang Z,Wei J,Yu Y,et al.γ-Secretase inhibitor reverts the Notch signaling attenuation of osteogenic differentiation in aged bone marrow mesenchymal stem cells[J].Cell Biol Int,2016,40(4):439-447.
[20]刘建和,赵吉锐,雷娄芳,等.柴胡三参胶囊对p38MAPK通路介导BMSCs向心肌细胞分化的干预研究[J].中国中医急症,2018,27(07):1163-1166,1170.
[21]Dai F,Du P,Chang Y,et al.Downregulation of MiR-199b-5p Inducing Differentiation of Bone-Marrow Mesenchymal Stem Cells(BMSCs)Toward Cardiomyocyte-Like Cells via HSF1/HSP70 Pathway[J].Medical Science Monitor International Medical Journal of Experimental&Clinical Research,2018,24:2700.
[22]Xu Q,Seeger F H,Castillo J,et al.Micro-RNA-34a contributes to the Impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease[J].J Am Cell Cardiol,2012,59(23):2107-2117.
[23]张秀敏,于波,李学渊.过表达miR-378骨髓间充质干细胞移植治疗心肌梗死[J].中国组织工程研究,2017,21(09):1390-1396.
[24]Chen L,Lu F B,Chen D Z,et al.BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis[J].Molecular Immunology,2018,93:38-46.
[25]张赛圣,程丽霞.骨髓间充质干细胞mi R-126高表达在游离皮瓣移植后皮瓣血管新生中的促进作用及机制研究[J].现代医学,2018,46(02):126-130.
[26]Lu M H,Li C Z,Hu C J,et al.MicroRNA-27b suppresses mouse MSCmigration to the liver by targeting SDF-1αin vitro[J].Biochem Biophys Res Commun,2012,421(2):389-395.
[27]李欣然,何援利,王雪峰,等.过表达miR-21的骨髓间充质干细胞在化疗性卵巢早衰大鼠模型中的治疗潜能及机制[J].现代妇产科进展,2018,27(12):924-928.
[28]张文才,宫俊龙,杨帆,等.mi R-148a通过靶定DNMT1调节大鼠间充质干细胞向心肌细胞的分化[J].武汉大学学报(医学版),2019,40(01):11-16.
[2]J Zhang,Z Feng,J Wei,et al.Repair of Critical-Sized Mandible Defects in Aged Rat Using Hypoxia Preconditioned BMSCs with Up-regulation of Hif-1α[J].International Journal of Biological Sciences,2018,14(4):449-460.
[3]Moll G,Ignatowicz L,Catar R,et al.Different Procoagulant activity of therapeutic mesenchymal stromal cells devived from home marrow and placental decidua[J].Stem Cells Dev,2015,24(19):2269-2279.
[4]Ma Q,Fang L,Jiang N,et al.Bone mesenchymal stem cell secretion of sRANKL/OPG/M-CSF in response to macrophage-mediated inflammatory response influences osteogenesis on nanostructured Ti surfaces[J].Biomaterials,2018,154:234-247.
[5]Le Henaff C,Mansouri R,Modrowski D,et al.Increased NF-κB activity and decreased Wnt/β-catenin signaling mediate reduced osteoblast differentiation and function inΔF508 cystic fibrosis transmembrane conductance regulator(CFTR)mice[J].Journal of Biological Chemistry,2015,290(29):18009-18017.
[6]Zeng Y L,Zheng H,Chen Q R,et al.Bone marrow-derived mesenchymal stem cells overexpressing MiR-21 efficiently repair myocardial damage in rats[J].Oncotarget,2017,8(17):29161-29173.
[7]黄伟聪,王钰,杨凯,等.rno-miRNA-133b对大鼠骨髓间充质干细胞增殖的影响[J].温州医学院学报,2012,43(5):445-448,452.
[8]李明哲,龚哲,王静,等.let-7f对骨髓间充质干细胞增殖的影响[J].中国组织工程研究,2015,19(50):8048-8055.
[9]Mudhasani R,Imbalzano AN,Jones SN.An essential role for Dicer in adipocyte differentiation[J].J Cell Biochem,2010,110(4):812-816.
[10]An X,Ma K,Zhang Z,et al.miR-17,miR-21,and miR-143 Enhance Adipogenic Differentiation from Porcine Bone Marrow-Derived Mesenchymal Stem Cells[J].Dna&Cell Biology,2016,35(8):410.
[11]王光辉,李月白,李明,等.微小RNA-27a靶向调控过氧化物酶体增殖子活化受体-γ和骨形态发生蛋白-2对激素诱导大鼠骨髓间充质干细胞分化的影响[J].中华实验外科杂志,2015,32(12):3110-3112.
[12]Clark E A,Kalomoiris S,Nolta J A,et al.Concise review:microRNA function in multipotent mesenchymal stromal cells[J].Stem Cells,2014,32(5):1074-1082.
[13]Hwang S,Park S K,Lee H Y,et al.MiR-140-5p suppresses BMP2-mediated osteogenesis in undifferentiated human mesenchymal stem cells[J].FEBSLett,2014,588(17):2957-2963.
[14]H Kang,H Chen,P Huang,et al.Glucocorticoids impair bone formation of bone marrow stromal stem cells by reciprocally regulating microRNA-34a-5p[J].Osteoporosis International,2016,27(4):1493-1505.
[15]Chen S,Yang L,Jie Q,et al.MicroRNA 125b suppresses the proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells[J].Molecular Medicine Reports,2014,9(5):1820.
[16]Y Gong,J Lu,X Yu,et al.Expression of Sp7 in Satb2-induced osteogenic differentiation of mouse bone marrow stromal cells is regulated by microRNA-27a[J].Molecular&Cellular Biochemistry,2016,417(1-2):7-16.
[17]王颖,张雷,周咏,等.miR-21诱导犬BMSCs骨向分化的体外实验研究[J].安徽医科大学学报,2017,52(9):1318-1323.
[18]Yan Z,Guo Y,Wang Y,et al.Micro RNA profiles of BMSCs induced into osteoblasts with osteoinductive medium[J].Experimental and therapeutic medicine,2018,15(3):2589.
[19]Tang Z,Wei J,Yu Y,et al.γ-Secretase inhibitor reverts the Notch signaling attenuation of osteogenic differentiation in aged bone marrow mesenchymal stem cells[J].Cell Biol Int,2016,40(4):439-447.
[20]刘建和,赵吉锐,雷娄芳,等.柴胡三参胶囊对p38MAPK通路介导BMSCs向心肌细胞分化的干预研究[J].中国中医急症,2018,27(07):1163-1166,1170.
[21]Dai F,Du P,Chang Y,et al.Downregulation of MiR-199b-5p Inducing Differentiation of Bone-Marrow Mesenchymal Stem Cells(BMSCs)Toward Cardiomyocyte-Like Cells via HSF1/HSP70 Pathway[J].Medical Science Monitor International Medical Journal of Experimental&Clinical Research,2018,24:2700.
[22]Xu Q,Seeger F H,Castillo J,et al.Micro-RNA-34a contributes to the Impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease[J].J Am Cell Cardiol,2012,59(23):2107-2117.
[23]张秀敏,于波,李学渊.过表达miR-378骨髓间充质干细胞移植治疗心肌梗死[J].中国组织工程研究,2017,21(09):1390-1396.
[24]Chen L,Lu F B,Chen D Z,et al.BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis[J].Molecular Immunology,2018,93:38-46.
[25]张赛圣,程丽霞.骨髓间充质干细胞mi R-126高表达在游离皮瓣移植后皮瓣血管新生中的促进作用及机制研究[J].现代医学,2018,46(02):126-130.
[26]Lu M H,Li C Z,Hu C J,et al.MicroRNA-27b suppresses mouse MSCmigration to the liver by targeting SDF-1αin vitro[J].Biochem Biophys Res Commun,2012,421(2):389-395.
[27]李欣然,何援利,王雪峰,等.过表达miR-21的骨髓间充质干细胞在化疗性卵巢早衰大鼠模型中的治疗潜能及机制[J].现代妇产科进展,2018,27(12):924-928.
[28]张文才,宫俊龙,杨帆,等.mi R-148a通过靶定DNMT1调节大鼠间充质干细胞向心肌细胞的分化[J].武汉大学学报(医学版),2019,40(01):11-16.
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