胃复春片联合兰索拉唑治疗慢性萎缩性胃炎的临床疗效及对血清相关指标的影响
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摘要
目的探讨胃复春片联合兰索拉唑治疗慢性萎缩性胃炎的临床疗效及对血清IL-1β、sIL-2R和MTL水平的影响。方法选取2016年9月～2018年2月到我院消化内科接受治疗的慢性萎缩性胃炎患者180例作为研究对象,患者按照入院前后治疗顺序分为对照组与观察组,各组90例。对照组给予口服兰索拉唑片治疗,观察组给予口服胃复春片联合兰索拉唑片治疗,比较两组临床疗效、临床症状评分、不同症状情况、血清学指标、病理分级及胃底黏膜幽门腺黏膜萎缩及肠上皮化生的变化。结果观察组总有效率优于对照组(P<0.05);治疗后,观察组胃脘疼痛、胃中嘈杂、嗳气泛酸与口苦口干评分明显下降,且低于对照组(P<0.05);观察组治疗后不同病症发生率小于对照组,且观察组不同病症改善水平高于对照组(P<0.05);治疗后,两组血清IL-1β、SIL-2R、GAS、MTL水平显著下降,G-17水平升高;观察组血清学指标改善程度优于对照组(P<0.05);观察组治疗后内镜分级优于对照组(P<0.05);治疗后观察组腺体萎缩评分与肠上皮化生评分低于对照组(P<0.05),治疗后观察组腺体萎缩减少低于对照组(P<0.05),两组肠上皮化生变化比较差异无统计学意义(P>0.05)。结论胃复春片联合兰索拉唑治疗慢性萎缩性胃炎临床疗效显著,可优化临床症状,明显改善血清IL-1β、SIL-2R、GAS、MTL水平与G-17水平,胃黏膜萎缩与肠上皮化生明显转归,具有临床价值,可在临床推广应用。
Objective To investigate the clinical efficacy of Weifuchun tablet combined with lansoprazole on serum IL-1β, sIL-2 R and MTL levels in the treatment of chronic atrophic gastritis. Methods 180 patients with chronic atrophic gastritis treated in the Gastroenterology Department of our hospital from September 2016 to February 2018 were selected and divided into two groups according to the admission order, each with 90 cases. The control group received lansoprazole. Based on this, the observation group received the Weifuchun tablet. The clinical efficacy, clinical symptom scores, pathological grades, different pathological conditions, serological indicators, gastric atrophy and intestinal metaplasia were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group(97.78% vs 88.88%, P<0.05). A significant decrease showed in the scores of epigastric pain, noisiness in the stomach, beryllium pantothenic acid and oral dry mouth in both groups(P<0.05). The incidence rate of different complications in the observation group was lower than that in the control group, and the amelioration of various symptoms was more significant in the observation group than in the control group(P<0.05). The endoscopic grading of the observation group was significantly better than that of the control group(P<0.05). The levels of serum IL-1β, SIL-2 R, GAS, and MTL were significantly decreased in both groups, moreover, the G-17 levels were significantly increased, and both changes were more obvious in the observation group than in the control group(P<0.05). The scores of gastric atrophy and intestinal metaplasia in the observation group were lower than those of the control group after treatment(P<0.05). The gland atrophy of the observation group was lower than that of the control group(P<0.05), while no difference was found in the intestinal metaplasia(P>0.05).Conclusion Weifuchun tablet combined with lansoprazole can effectively ameliorate the clinical symptoms, serum IL-1β, sIL-2 R, GAS, MTL and G-17 levels, along with the gastric atrophy and intestinal metaplasia, regulate gastrointestinal hormone levels for patients with chronic atrophic gastritis, which is worth promoting.
Objective To investigate the clinical efficacy of Weifuchun tablet combined with lansoprazole on serum IL-1β, sIL-2 R and MTL levels in the treatment of chronic atrophic gastritis. Methods 180 patients with chronic atrophic gastritis treated in the Gastroenterology Department of our hospital from September 2016 to February 2018 were selected and divided into two groups according to the admission order, each with 90 cases. The control group received lansoprazole. Based on this, the observation group received the Weifuchun tablet. The clinical efficacy, clinical symptom scores, pathological grades, different pathological conditions, serological indicators, gastric atrophy and intestinal metaplasia were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group(97.78% vs 88.88%, P<0.05). A significant decrease showed in the scores of epigastric pain, noisiness in the stomach, beryllium pantothenic acid and oral dry mouth in both groups(P<0.05). The incidence rate of different complications in the observation group was lower than that in the control group, and the amelioration of various symptoms was more significant in the observation group than in the control group(P<0.05). The endoscopic grading of the observation group was significantly better than that of the control group(P<0.05). The levels of serum IL-1β, SIL-2 R, GAS, and MTL were significantly decreased in both groups, moreover, the G-17 levels were significantly increased, and both changes were more obvious in the observation group than in the control group(P<0.05). The scores of gastric atrophy and intestinal metaplasia in the observation group were lower than those of the control group after treatment(P<0.05). The gland atrophy of the observation group was lower than that of the control group(P<0.05), while no difference was found in the intestinal metaplasia(P>0.05).Conclusion Weifuchun tablet combined with lansoprazole can effectively ameliorate the clinical symptoms, serum IL-1β, sIL-2 R, GAS, MTL and G-17 levels, along with the gastric atrophy and intestinal metaplasia, regulate gastrointestinal hormone levels for patients with chronic atrophic gastritis, which is worth promoting.
引文
[1] 邵蓉,高泽立.胃复春片联合莫沙必利治疗慢性萎缩性胃炎的临床研究[J].现代药物与临床,2017,32(11):2157-2160.
[2] Chen YC,Ho CC,Yi CH,et al.Exendin-4,a glucagon-like peptide-1 analogue accelerates healing of chronic gastric ulcer in diabetic rats[J].Plos One,2017,12(11):e0187434.
[3] 朱玲丽,张绚辉,沈怿.慢性胃溃疡患者人格及心理因素对其自护能力的影响[J].职业与健康,2018,34(7):913-916,920.
[4] 刘小玉,冯义朝.幽门螺杆菌感染及核转录因子-κBp65表达与胃癌的关系[J].西部医学,2012,24(2):236-238.
[5] Bian S.Effects of Omeprazole and Aluminum Magnesium Carbonate Tablets in Treatment of Chronic Peptic Ulcer[J].China Health Standard Management,2017.
[6] LI JQ,Lin D,Center JH,et al.Investigation and Analysis of Depression and Anxiety in Patients With Chronic Peptic Ulcer in Jinjiang Health Center of Chengmai County From 2012 to 2016[J].Journal of Preventive Medicine Information,2018.
[7] 中华医学会消化内镜学分会.慢性胃炎的内镜分型分级标准及治疗的试行意见[J].中华消化内镜杂志,2004,21(2):77-78.
[8] 房静远,萧树东.解读和评述《中国慢性胃炎共识意见》[C]// 中华医学会第七次全国消化病学术会议论文汇编(上册).2007:513-515.
[9] Rao GZ.Influence by comprehensive nursing intervention on quality of life in patients with chronic gastritis and peptic ulcer[J].Chinese Journal of Modern Drug Application,2017.
[10] 杨华.猴头菌颗粒治疗慢性萎缩性胃炎作用机制研究[J].西部医学,2009,21(10):72-75.
[11] Peng H,Gastroenterology DO.Effect evaluation of targeted nursing in improving the clinical efficacy and quality of life of patients with chronic gastric ulcer[J].China Practical Medicine,2017.
[12] 牟汝伟.克拉霉素、阿莫西林、兰索拉唑三联疗法联合瑞巴派特治疗老年消化性胃溃疡效果及对胃黏膜形态学的影响[J].医药,2017,5 (21):200.
[13] 段华容,付强强,翟玉荣.酪酸梭菌对慢性胃炎及消化道溃疡伴幽门螺杆菌感染治疗效果的Meta分析[J].公共卫生与预防医学,2017,28(5):82-86.
[14] Matsueda K,Toyokawa T,Sakata M,et al.Hemorrhagic Stress-induced Gastric Ulcer in a Healthy Toddler[J].Internal Medicine,2018,57(19):2833-2836.
[15] 刘晓会.慢性胃溃疡患者的针对性护理分析[J].现代医学与健康研究电子杂志,2017,1(5):5-7.
[16] 卜维静,王威,许晓蓓,等.逆灸对应激性损伤胃黏膜组织形态和血流量的影响[J].时珍国医国药,2017,28(11):2813-2816.
[17] 廖桂香,刘丽,胡田兰.慢性胃溃疡患者护理中针对性护理的应用效果探析[J].当代医学,2017,23(8):167-169.
[18] 通拉嘎,梅红,其木格,等.大鼠乙酸型胃溃疡模型的建立与评价[J].中国民族民间医药杂志,2017,(11):49-51,55.
[19] 王鹤.针对性护理在慢性胃溃疡患者临床护理中的效果[J].医药卫生:全文版,2017,(1):84.
[20] 容海燕.探讨慢性胃溃疡患者的针对性护理效果[J].世界最新医学信息文摘,2017,17(36):231-232.
[2] Chen YC,Ho CC,Yi CH,et al.Exendin-4,a glucagon-like peptide-1 analogue accelerates healing of chronic gastric ulcer in diabetic rats[J].Plos One,2017,12(11):e0187434.
[3] 朱玲丽,张绚辉,沈怿.慢性胃溃疡患者人格及心理因素对其自护能力的影响[J].职业与健康,2018,34(7):913-916,920.
[4] 刘小玉,冯义朝.幽门螺杆菌感染及核转录因子-κBp65表达与胃癌的关系[J].西部医学,2012,24(2):236-238.
[5] Bian S.Effects of Omeprazole and Aluminum Magnesium Carbonate Tablets in Treatment of Chronic Peptic Ulcer[J].China Health Standard Management,2017.
[6] LI JQ,Lin D,Center JH,et al.Investigation and Analysis of Depression and Anxiety in Patients With Chronic Peptic Ulcer in Jinjiang Health Center of Chengmai County From 2012 to 2016[J].Journal of Preventive Medicine Information,2018.
[7] 中华医学会消化内镜学分会.慢性胃炎的内镜分型分级标准及治疗的试行意见[J].中华消化内镜杂志,2004,21(2):77-78.
[8] 房静远,萧树东.解读和评述《中国慢性胃炎共识意见》[C]// 中华医学会第七次全国消化病学术会议论文汇编(上册).2007:513-515.
[9] Rao GZ.Influence by comprehensive nursing intervention on quality of life in patients with chronic gastritis and peptic ulcer[J].Chinese Journal of Modern Drug Application,2017.
[10] 杨华.猴头菌颗粒治疗慢性萎缩性胃炎作用机制研究[J].西部医学,2009,21(10):72-75.
[11] Peng H,Gastroenterology DO.Effect evaluation of targeted nursing in improving the clinical efficacy and quality of life of patients with chronic gastric ulcer[J].China Practical Medicine,2017.
[12] 牟汝伟.克拉霉素、阿莫西林、兰索拉唑三联疗法联合瑞巴派特治疗老年消化性胃溃疡效果及对胃黏膜形态学的影响[J].医药,2017,5 (21):200.
[13] 段华容,付强强,翟玉荣.酪酸梭菌对慢性胃炎及消化道溃疡伴幽门螺杆菌感染治疗效果的Meta分析[J].公共卫生与预防医学,2017,28(5):82-86.
[14] Matsueda K,Toyokawa T,Sakata M,et al.Hemorrhagic Stress-induced Gastric Ulcer in a Healthy Toddler[J].Internal Medicine,2018,57(19):2833-2836.
[15] 刘晓会.慢性胃溃疡患者的针对性护理分析[J].现代医学与健康研究电子杂志,2017,1(5):5-7.
[16] 卜维静,王威,许晓蓓,等.逆灸对应激性损伤胃黏膜组织形态和血流量的影响[J].时珍国医国药,2017,28(11):2813-2816.
[17] 廖桂香,刘丽,胡田兰.慢性胃溃疡患者护理中针对性护理的应用效果探析[J].当代医学,2017,23(8):167-169.
[18] 通拉嘎,梅红,其木格,等.大鼠乙酸型胃溃疡模型的建立与评价[J].中国民族民间医药杂志,2017,(11):49-51,55.
[19] 王鹤.针对性护理在慢性胃溃疡患者临床护理中的效果[J].医药卫生:全文版,2017,(1):84.
[20] 容海燕.探讨慢性胃溃疡患者的针对性护理效果[J].世界最新医学信息文摘,2017,17(36):231-232.
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