非小细胞肺癌化疗患者应对方式与生活质量的相关性研究
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摘要
目的:调查非小细胞肺癌(NSCLC)化疗患者应对方式与生活质量的相关性。方法:选择2016年5月-2018年5月在我院接受化疗的NSCLC患者共110例,分别采用肺癌生命质量量表(EORTC-QLQ.C30)、肺癌患者生活质量调查问卷(EORTC-QLQ.LC13)和医学应对方式问卷(MCMQ)对患者生活质量与应对方式进行调查,分析其相关性,并采用多元逐步回归分析整体生活质量的影响因素。结果:不同化疗阶段,患者功能维度得分和整体生活质量得分显著下降,差异有统计学意义(P<0.05),症状维度得分和化疗相关副反应得分显著升高,差异有统计学意义(P<0.05)。肺癌表现得分的差异和三种应对方式得分的差异均无统计学意义(P>0.05)。患者采取面对方式和回避方式的得分均高于屈服方式(P<0.05)。面对方式与患者整体生活质量呈正相关,回避方式、屈服方式与患者整体生活质量呈负相关。多元逐步回归分析显示:年龄、疾病转移及面对方式是NSCLC化疗患者整体生活质量的影响因素(P<0.05)。结论:NSCLC化疗患者应对方式与生活质量存在一定的相关性,应有效的发挥积极应对方式对生活质量的促进作用,提高患者生活质量。
Objective: To explore the correlation between coping style and quality of life in chemotherapy patients with non-small cell lung cancer(NSCLC). Methods: A total of 110 patients with NSCLC, who were treated in No.302 Hospital of China Guizhou Aviation Group from May 2016 to May 2018, were selected. The lung cancer life quality scale(EORTC-QLQ.C30), lung cancer patients' quality of life questionnaire(EORTC-QLQ.LC13) and Medical Coping Style Questionnaire(MCMQ)were used to investigate the quality of life and coping style of the patients, the correlation was analyzed, and the influencing factors of overall quality of life were analyzed by multiple stepwise regression. Results: Functional dimension scores and whole quality of life scores of the patients decreased significantly during different chemotherapy phases, the differences were statistically significant(P<0.05). The scores of symptom dimension and side effects associated with chemotherapy increased significantly, the differences were statistically significant(P<0.05). The differences of lung cancer performance scores and three kinds of coping scores were not statistically significant(P>0.05). The scores of patients taking the facing style and the evasion style were higher than those of the yield style(P<0.05). The facing style and quality of life showed a positive correlation. The evasion style and the yield style showed a negative correlation with quality of life.Multiple stepwise regression analysis showed that age, disease metastasis and the way to face were the influencing factors of the overall quality of life chemotherapy patients with NSCLC. Conclusion: There is a certain correlation between the coping style and the quality of life in chemotherapy patients with NSCLC. The positive coping style of patients should be advocated to improve their quality of life.
Objective: To explore the correlation between coping style and quality of life in chemotherapy patients with non-small cell lung cancer(NSCLC). Methods: A total of 110 patients with NSCLC, who were treated in No.302 Hospital of China Guizhou Aviation Group from May 2016 to May 2018, were selected. The lung cancer life quality scale(EORTC-QLQ.C30), lung cancer patients' quality of life questionnaire(EORTC-QLQ.LC13) and Medical Coping Style Questionnaire(MCMQ)were used to investigate the quality of life and coping style of the patients, the correlation was analyzed, and the influencing factors of overall quality of life were analyzed by multiple stepwise regression. Results: Functional dimension scores and whole quality of life scores of the patients decreased significantly during different chemotherapy phases, the differences were statistically significant(P<0.05). The scores of symptom dimension and side effects associated with chemotherapy increased significantly, the differences were statistically significant(P<0.05). The differences of lung cancer performance scores and three kinds of coping scores were not statistically significant(P>0.05). The scores of patients taking the facing style and the evasion style were higher than those of the yield style(P<0.05). The facing style and quality of life showed a positive correlation. The evasion style and the yield style showed a negative correlation with quality of life.Multiple stepwise regression analysis showed that age, disease metastasis and the way to face were the influencing factors of the overall quality of life chemotherapy patients with NSCLC. Conclusion: There is a certain correlation between the coping style and the quality of life in chemotherapy patients with NSCLC. The positive coping style of patients should be advocated to improve their quality of life.
引文
[1]邱干,葛明建.胸腔镜肺段切除术治疗早期非小细胞肺癌的研究进展[J].实用心脑肺血管病杂志, 2017, 25(11):12-15
[2] Hata A, Harada D, Okuda C, et al. Docetaxel plus ramucirumab with primary prophylactic pegylated-granulocyte-colony stimulating factor for pretreated non-small cell lung cancer[J]. Oncotarget, 2018, 9(45):27789-27796
[3] Guo W, Hui X, Alfaifi S, et al. Preoperative contralateral lung radiation dose is associated with postoperative pulmonary toxicity in patients with locally advanced non-small cell lung cancer treated with trimodality therapy[J]. Pract Radiat Oncol, 2018, 8(4):e239-e248
[4] Liao YC, Shun SC, Liao WY, et al. Quality of life and related factors in patients with newly diagnosed advanced lung cancer:a longitudinal study[J]. Oncol Nurs Forum, 2014, 41(2):E44-55
[5] Liu J, Lu Z, Wang W, et al. Programmed death-ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer[J]. Oncol Lett, 2018, 16(2):2373-2381
[6] Rossi S, Castello A, Toschi L, et al. Immunotherapy in non-small-cell lung cancer:potential predictors of response and new strategies to assess activity[J]. Immunotherapy, 2018, 10(9):797-805
[7] Fan S, Zou Y, Wang Y, et al. An observational study of apatinib mesylate in treating advanced non-small cell lung cancer with unknown driving gene(s)[J]. J BUON, 2018, 23(3):654-658
[8]盛宏旭,王世敏,王吉平,等.非小细胞肺癌的免疫治疗进展[J].现代生物医学进展, 2017, 17(10):1968-1970, 1985
[9]陆舜,纪文翔,虞永峰,等.2014版《NCCN非小细胞肺癌临床实践指南》更新解读[J].中国医师进修杂志, 2015, 38(5):318-320
[10]陈淑琴,马丽敏,朱晔涵,等.肺癌高龄患者术后4个月内症状和生活质量的变化及其影响因素[J].安徽医药, 2016, 20(6):1108-1111
[11] Koller M, Hjermstad MJ, Tomaszewski KA, et al. An international study to revise the EORTC questionnaire for assessing quality of life in lung cancer patients[J]. Ann Oncol, 2017, 28(11):2874-2881
[12]邵淑红,周彤彤,陈旭芳,等.老年肺癌住院患者应对方式与健康相关生活质量[J].中国老年学杂志, 2016, 36(23):5966-5968
[13] Rossi S, Castello A, Toschi L, et al. Immunotherapy in non-small-cell lung cancer:potential predictors of response and new strategies to assess activity[J]. Immunotherapy, 2018, 10(9):797-805
[14] Kepka L, Socha J, Rucinska M, et al. Sequencing postoperative radiotherapy and adjuvant chemotherapy in non-small cell lung cancer:unanswered questions on the not evidence-based approach[J]. J Thorac Dis, 2016, 8(7):1381-1385
[15] Guo W, Hui X, Alfaifi S, et al. Preoperative contralateral lung radiation dose is associated with postoperative pulmonary toxicity in patients with locally advanced non-small cell lung cancer treated with trimodality therapy[J]. Pract Radiat Oncol, 2018, 8(4):e239-e248
[16] Pierzynski JA, Ye Y, Lippman SM, et al. Socio-demographic,Clinical, and Genetic Determinants of Quality of Life in Lung Cancer Patients[J]. Sci Rep, 2018, 8(1):10640
[17] Gu F, Li XF, Xu JF, et al. Effect of nicotine dependence on quality of life and sleep quality in patients with lung cancer who continue to smoke after diagnosis[J]. J Thorac Dis, 2018, 10(5):2583-2589
[18] Lv Y, Zhang J, Liu Z, et al. Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer[J]. Mol Clin Oncol, 2018,9(1):70-74
[19]李耀丽,马龙,赵久达,等.心理干预与健康教育支持对老年肺癌患者癌痛及生活质量的影响[J].中国健康教育, 2016, 32(8):743-745
[20] Shastri VV, Hankey A, Sharma B, et al. Investigation of Yoga Pranayama and Vedic Mathematics on Mindfulness, Aggression and Emotion Regulation[J]. Int J Yoga, 2017, 10(3):138-144
[21] Wang P, Xiong Z, Yang H. Relationship of Mental Health, Social Support, and Coping Styles among Graduate Students:Evidence from Chinese Universities[J]. Iran J Public Health, 2018, 47(5):689-697
[22] Zhuang H, Ma Y, Wang L, et al. Effect of early palliative care on quality of life in patients with non-small-cell lung cancer[J]. Curr Oncol, 2018, 25(1):e54-e58
[23] Gow CH, Liu YN, Li HY, et al. Oncogenic Function of a KIF5B-MET Fusion Variant in Non-Small Cell Lung Cancer[J]. Neoplasia, 2018, 20(8):838-847
[24] Luo J, Li Q, Pan J, et al. Expression level of long noncoding RNA H19 in plasma of patients with nonsmall cell lung cancerand its clinical significance[J]. J Cancer Res Ther, 2018, 14(4):860-863
[25] Lin X, Liu X, Gong C, et al. Expression of engrailed homeobox 2regulates the proliferation, migration and invasion of non-small cell lung cancer cells[J]. Oncol Lett, 2018, 16(1):536-542
[26]张春燕,黄晓利,杨文.非小细胞肺癌患者化疗后贫血状况分析及其对生活质量的影响[J].海军医学杂志, 2017, 38(3):256-260
[27] Brahmer JR, Govindan R, Anders RA, et al. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer(NSCLC)[J]. J Immunother Cancer, 2018, 6(1):75
[28] Liu HN, Qie P, Yang G, et al. miR-181b inhibits chemoresistance in cisplatin-resistant H446 small cell lung cancer cells by targeting Bcl-2[J]. Arch Med Sci, 2018, 14(4):745-751
[29] Mender I, La Ranger R, Luitel K, et al. Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapyand Chemotherapy Resistance[J]. Neoplasia, 2018, 20(8):826-837
[30] Odegaard K, White D, Petereit DG. Progressive Multifocal Leukoencephalopathy versus Brain Metastasis in a Patient with Locally-Advanced Non-Small Cell Lung Cancer[J]. S D Med, 2018, 71(3):102-106
[2] Hata A, Harada D, Okuda C, et al. Docetaxel plus ramucirumab with primary prophylactic pegylated-granulocyte-colony stimulating factor for pretreated non-small cell lung cancer[J]. Oncotarget, 2018, 9(45):27789-27796
[3] Guo W, Hui X, Alfaifi S, et al. Preoperative contralateral lung radiation dose is associated with postoperative pulmonary toxicity in patients with locally advanced non-small cell lung cancer treated with trimodality therapy[J]. Pract Radiat Oncol, 2018, 8(4):e239-e248
[4] Liao YC, Shun SC, Liao WY, et al. Quality of life and related factors in patients with newly diagnosed advanced lung cancer:a longitudinal study[J]. Oncol Nurs Forum, 2014, 41(2):E44-55
[5] Liu J, Lu Z, Wang W, et al. Programmed death-ligand 1 positivity can predict improved survival and a lower risk of brain metastasis in patients with resectable small cell lung cancer[J]. Oncol Lett, 2018, 16(2):2373-2381
[6] Rossi S, Castello A, Toschi L, et al. Immunotherapy in non-small-cell lung cancer:potential predictors of response and new strategies to assess activity[J]. Immunotherapy, 2018, 10(9):797-805
[7] Fan S, Zou Y, Wang Y, et al. An observational study of apatinib mesylate in treating advanced non-small cell lung cancer with unknown driving gene(s)[J]. J BUON, 2018, 23(3):654-658
[8]盛宏旭,王世敏,王吉平,等.非小细胞肺癌的免疫治疗进展[J].现代生物医学进展, 2017, 17(10):1968-1970, 1985
[9]陆舜,纪文翔,虞永峰,等.2014版《NCCN非小细胞肺癌临床实践指南》更新解读[J].中国医师进修杂志, 2015, 38(5):318-320
[10]陈淑琴,马丽敏,朱晔涵,等.肺癌高龄患者术后4个月内症状和生活质量的变化及其影响因素[J].安徽医药, 2016, 20(6):1108-1111
[11] Koller M, Hjermstad MJ, Tomaszewski KA, et al. An international study to revise the EORTC questionnaire for assessing quality of life in lung cancer patients[J]. Ann Oncol, 2017, 28(11):2874-2881
[12]邵淑红,周彤彤,陈旭芳,等.老年肺癌住院患者应对方式与健康相关生活质量[J].中国老年学杂志, 2016, 36(23):5966-5968
[13] Rossi S, Castello A, Toschi L, et al. Immunotherapy in non-small-cell lung cancer:potential predictors of response and new strategies to assess activity[J]. Immunotherapy, 2018, 10(9):797-805
[14] Kepka L, Socha J, Rucinska M, et al. Sequencing postoperative radiotherapy and adjuvant chemotherapy in non-small cell lung cancer:unanswered questions on the not evidence-based approach[J]. J Thorac Dis, 2016, 8(7):1381-1385
[15] Guo W, Hui X, Alfaifi S, et al. Preoperative contralateral lung radiation dose is associated with postoperative pulmonary toxicity in patients with locally advanced non-small cell lung cancer treated with trimodality therapy[J]. Pract Radiat Oncol, 2018, 8(4):e239-e248
[16] Pierzynski JA, Ye Y, Lippman SM, et al. Socio-demographic,Clinical, and Genetic Determinants of Quality of Life in Lung Cancer Patients[J]. Sci Rep, 2018, 8(1):10640
[17] Gu F, Li XF, Xu JF, et al. Effect of nicotine dependence on quality of life and sleep quality in patients with lung cancer who continue to smoke after diagnosis[J]. J Thorac Dis, 2018, 10(5):2583-2589
[18] Lv Y, Zhang J, Liu Z, et al. Quality of life and efficacy of temozolomide combined with whole-brain radiotherapy in patients with brain metastases from non-small-cell lung cancer[J]. Mol Clin Oncol, 2018,9(1):70-74
[19]李耀丽,马龙,赵久达,等.心理干预与健康教育支持对老年肺癌患者癌痛及生活质量的影响[J].中国健康教育, 2016, 32(8):743-745
[20] Shastri VV, Hankey A, Sharma B, et al. Investigation of Yoga Pranayama and Vedic Mathematics on Mindfulness, Aggression and Emotion Regulation[J]. Int J Yoga, 2017, 10(3):138-144
[21] Wang P, Xiong Z, Yang H. Relationship of Mental Health, Social Support, and Coping Styles among Graduate Students:Evidence from Chinese Universities[J]. Iran J Public Health, 2018, 47(5):689-697
[22] Zhuang H, Ma Y, Wang L, et al. Effect of early palliative care on quality of life in patients with non-small-cell lung cancer[J]. Curr Oncol, 2018, 25(1):e54-e58
[23] Gow CH, Liu YN, Li HY, et al. Oncogenic Function of a KIF5B-MET Fusion Variant in Non-Small Cell Lung Cancer[J]. Neoplasia, 2018, 20(8):838-847
[24] Luo J, Li Q, Pan J, et al. Expression level of long noncoding RNA H19 in plasma of patients with nonsmall cell lung cancerand its clinical significance[J]. J Cancer Res Ther, 2018, 14(4):860-863
[25] Lin X, Liu X, Gong C, et al. Expression of engrailed homeobox 2regulates the proliferation, migration and invasion of non-small cell lung cancer cells[J]. Oncol Lett, 2018, 16(1):536-542
[26]张春燕,黄晓利,杨文.非小细胞肺癌患者化疗后贫血状况分析及其对生活质量的影响[J].海军医学杂志, 2017, 38(3):256-260
[27] Brahmer JR, Govindan R, Anders RA, et al. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer(NSCLC)[J]. J Immunother Cancer, 2018, 6(1):75
[28] Liu HN, Qie P, Yang G, et al. miR-181b inhibits chemoresistance in cisplatin-resistant H446 small cell lung cancer cells by targeting Bcl-2[J]. Arch Med Sci, 2018, 14(4):745-751
[29] Mender I, La Ranger R, Luitel K, et al. Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapyand Chemotherapy Resistance[J]. Neoplasia, 2018, 20(8):826-837
[30] Odegaard K, White D, Petereit DG. Progressive Multifocal Leukoencephalopathy versus Brain Metastasis in a Patient with Locally-Advanced Non-Small Cell Lung Cancer[J]. S D Med, 2018, 71(3):102-106
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