环境内分泌干扰物与多囊卵巢综合征关系的研究进展
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摘要
环境内分泌干扰物(EED)广泛存在于日常生活中,是一类可以干扰激素行为的外源性化学物。EED可以结合人体内不同的受体,通过多种机制增强或抑制体内正常的内分泌功能,从而引发多种疾病。多囊卵巢综合征(PCOS)病因复杂,已有研究结果表明PCOS的发生与环境因素有关。相关流行病学和基础实验研究表明,EED参与PCOS的发生、发展,但具体作用机制仍需进一步研究。现就EED与PCOS的关系及可能的相关作用机制进行阐述,总结EED与PCOS的关系,为干预PCOS患者的生活方式并阻断疾病发生提供新的线索。
Environmental endocrine disruptors(EED) widely exist in daily life, as a kind of exogenous chemicals that can interfere with hormonal behavior. EEDs can bind to different receptors in the human body, to enhance or inhibit the normal endocrine function through a variety of mechanisms, resulting in a variety of diseases. The etiology of polycystic ovary syndrome(PCOS) is complex. Previous studies have shown that the pathogenesis of PCOS is related to environmental factors. The epidemiological and basic experiments showed that EEDs were involved in the pathogenesis of PCOS. However, it is necessary to study furtherly the potential mechanism. In this paper, the relationship between EEDs and PCOS, as well as possible mechanism, was expounded. It provides a new clue for those people to block the development of PCOS by improving their lifestyle.
Environmental endocrine disruptors(EED) widely exist in daily life, as a kind of exogenous chemicals that can interfere with hormonal behavior. EEDs can bind to different receptors in the human body, to enhance or inhibit the normal endocrine function through a variety of mechanisms, resulting in a variety of diseases. The etiology of polycystic ovary syndrome(PCOS) is complex. Previous studies have shown that the pathogenesis of PCOS is related to environmental factors. The epidemiological and basic experiments showed that EEDs were involved in the pathogenesis of PCOS. However, it is necessary to study furtherly the potential mechanism. In this paper, the relationship between EEDs and PCOS, as well as possible mechanism, was expounded. It provides a new clue for those people to block the development of PCOS by improving their lifestyle.
引文
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[15]Fernández M,Bourguignon N,Lux-Lantos V,et al.Neonatal exposure to bisphenol a and reproductive and endocrine alterations resembling the polycystic ovarian syndrome in adult rats[J].Environ Health Perspect,2010,11(9):1217-1222.
[16]Morgan M,Deoraj A,Felty Q,et al.Environmental estrogen-like endocrine disrupting chemicals and breast cancer[J].Mol Cell Endocrinol,2017,457:89-102.
[17]Matsushima A,Teramoto T,Okada H,et al.ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner[J].Biochem Biophys Res Commun,2008,373(3):408-413.
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[22]Geng S,Wang S,Zhu W,et al.Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38pathways[J].Toxicol Lett,2017,272:75-83.
[23]Déchaud H,Ravard C,Claustrat F,et al.Xenoestrogen interaction with human sex hormone-binding globulin(hSHBG)[J].Steroids,1999,64(5):328-334.
[24]潘洁雪.内分泌干扰物双酚A及DNA甲基化致多囊卵巢综合征高雄发生的机制研究[D].杭州:浙江大学,2015.
[25]Kim SH,Turnbull J,Guimond S.Extracellular matrix and cell signalling:the dynamic cooperation of integrin,proteoglycan and growth factor receptor[J].J Endocrinol,2011,209(2):139-151.
[26]Alonso-Magdalena P,Quesada I,Nadal魣.Prenatal Exposure to BPA and Offspring Outcomes:The Diabesogenic Behavior of BPA[J].Dose Response,2015,13(2):1559325815590395.
[27]Lind L,Zethelius B,Salihovic S,et al.Circulating levels of perfluoroalkyl substances and prevalent diabetes in the elderly[J].Diabetologia,2014,57(3):473-479.
[28]Lee DH,Steffes MW,Sj觟din A,et al.Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity,dyslipidemia,and insulin resistance among people free of diabetes[J].PLoS One,2011,6(1):e15977.
[29]Carnevali O,Tosti L,Speciale C,et al.DEHP impairs zebrafish reproduction by affecting critical factors in oogenesis[J].PLoS One,2010,5(4):e10201.
[30]Sekiguchi S,Ito S,Honma T.Experimental model to study reproductive toxicity of chemicals using induced ovulation in immature F344 rats[J].Ind Health,2003,41(3):287-290.
[31]Skledar DG,Schmidt J,Fic A,et al.Influence of metabolism on endocrine activities of bisphenol S[J].Chemosphere,2016,157:152-159.
[32]Dreier DA,Connors KA,Brooks BW3.Comparative endpoint sensitivity of in vitro estrogen agonist assays[J].Regul Toxicol Pharmacol,2015,72(2):185-193.
[33]Rochester JR,Bolden AL.Bisphenol S and F:A Systematic Review and Comparison of the Hormonal Activity of Bisphenol ASubstitutes[J].Environ Health Perspect,2015,123(7):643-650.
[2]Zoeller RT,Brown TR,Doan LL,et al.Endocrine-disrupting chemicals and public health protection:a statement of principles from The Endocrine Society[J].Endocrinology,2012,153(9):4097-4110.
[3]Kabir ER,Rahman MS,Rahman I.A review on endocrine disruptors and their possible impacts on human health[J].Environ Toxicol Pharmacol,2015,40(1):241-258.
[4]Jeng HA.Exposure to endocrine disrupting chemicals and male reproductive health[J].Front Public Health,2014,2:55.
[5]Ponzo OJ,Silvia C.Evidence of reproductive disruption associated with neuroendocrine changes induced by UV-B filters,phthalates and nonylphenol during sexual maturation in rats of both gender[J].Toxicology,2013,311(1/2):41-51.
[6]Hong H,Branham WS,Ng HW,et al.Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor,estrogen receptor,andα-fetoprotein[J].Toxicol Sci,2015,143(2):333-348.
[7]Kavlock RJ,Daston GP,De Rosa C,et al.Research needs for the risk assessment of health and environmental effects of endocrine disruptors:a report of the U.S.EPA-sponsored workshop[J].Environ Health Perspect,1996,104(Suppl 4):715-740.
[8]Livadas S,Pappas C,Karachalios A,et al.Prevalence and impact of hyperandrogenemia in 1,218 women with polycystic ovary syndrome[J].Endocrine,2014,47(2):631-638.
[9]Ak覦n L,Kendirci M,Narin F,et al.The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls[J].Acta Paediatr,2015,104(4):e171-e177.
[10]Yang Q,Zhao Y,Qiu X,et al.Association of serum levels of typical organic pollutants with polycystic ovary syndrome(PCOS):a casecontrol study[J].Hum Reprod,2015,30(8):1964-1973.
[11]Palioura E,Diamanti-Kandarakis E.Polycystic ovary syndrome(PCOS)and endocrine disrupting chemicals(EDCs)[J].Rev Endocr Metab Disord,2015,16(4):365-371.
[12]Manikkam M,Haque MM,Guerrero-Bosagna C,et al.Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult-onset disease through the female germline[J].PLoS One,2014,9(7):e102091.
[13]Dumesic DA,Goodarzi MO,Chazenbalk GD,et al.Intrauterine environment and polycystic ovary syndrome[J].Semin Reprod Med,2014,32(3):159-165.
[14]Hewlett M,Chow E,Aschengrau A,et al.Prenatal Exposure to Endocrine Disruptors:A Developmental Etiology for Polycystic Ovary Syndrome[J].Reprod Sci,2017,24(1):19-27.
[15]Fernández M,Bourguignon N,Lux-Lantos V,et al.Neonatal exposure to bisphenol a and reproductive and endocrine alterations resembling the polycystic ovarian syndrome in adult rats[J].Environ Health Perspect,2010,11(9):1217-1222.
[16]Morgan M,Deoraj A,Felty Q,et al.Environmental estrogen-like endocrine disrupting chemicals and breast cancer[J].Mol Cell Endocrinol,2017,457:89-102.
[17]Matsushima A,Teramoto T,Okada H,et al.ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner[J].Biochem Biophys Res Commun,2008,373(3):408-413.
[18]Takeuchi T,Tsutsumi O,Ikezuki Y,et al.Elevated serum bisphenol A levels under hyperandrogenic conditions may be caused by decreased UDP-glucuronosyltransferase activity[J].Endocr J,2006,53(4):485-491.
[19]Zhou W,Liu J,Liao L,et al.Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells[J].Mol Cell Endocrinol,2008,283(1/2):12-18.
[20]Thompson PA,Khatami M,Baglole CJ,et al.Environmental immune disruptors,inflammation and cancer risk[J].Carcinogenesis,2015,36(Suppl 1):S232-S253.
[21]Tarantino G,Valentino R,Di Somma C,et al.Bisphenol A in polycystic ovary syndrome and its association with liver-spleen axis[J].Clin Endocrinol(Oxf),2013,78(3):447-453.
[22]Geng S,Wang S,Zhu W,et al.Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38pathways[J].Toxicol Lett,2017,272:75-83.
[23]Déchaud H,Ravard C,Claustrat F,et al.Xenoestrogen interaction with human sex hormone-binding globulin(hSHBG)[J].Steroids,1999,64(5):328-334.
[24]潘洁雪.内分泌干扰物双酚A及DNA甲基化致多囊卵巢综合征高雄发生的机制研究[D].杭州:浙江大学,2015.
[25]Kim SH,Turnbull J,Guimond S.Extracellular matrix and cell signalling:the dynamic cooperation of integrin,proteoglycan and growth factor receptor[J].J Endocrinol,2011,209(2):139-151.
[26]Alonso-Magdalena P,Quesada I,Nadal魣.Prenatal Exposure to BPA and Offspring Outcomes:The Diabesogenic Behavior of BPA[J].Dose Response,2015,13(2):1559325815590395.
[27]Lind L,Zethelius B,Salihovic S,et al.Circulating levels of perfluoroalkyl substances and prevalent diabetes in the elderly[J].Diabetologia,2014,57(3):473-479.
[28]Lee DH,Steffes MW,Sj觟din A,et al.Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity,dyslipidemia,and insulin resistance among people free of diabetes[J].PLoS One,2011,6(1):e15977.
[29]Carnevali O,Tosti L,Speciale C,et al.DEHP impairs zebrafish reproduction by affecting critical factors in oogenesis[J].PLoS One,2010,5(4):e10201.
[30]Sekiguchi S,Ito S,Honma T.Experimental model to study reproductive toxicity of chemicals using induced ovulation in immature F344 rats[J].Ind Health,2003,41(3):287-290.
[31]Skledar DG,Schmidt J,Fic A,et al.Influence of metabolism on endocrine activities of bisphenol S[J].Chemosphere,2016,157:152-159.
[32]Dreier DA,Connors KA,Brooks BW3.Comparative endpoint sensitivity of in vitro estrogen agonist assays[J].Regul Toxicol Pharmacol,2015,72(2):185-193.
[33]Rochester JR,Bolden AL.Bisphenol S and F:A Systematic Review and Comparison of the Hormonal Activity of Bisphenol ASubstitutes[J].Environ Health Perspect,2015,123(7):643-650.
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