聚乳酸/壳聚糖/Nisin复合纳米纤维膜的同轴静电纺丝制备及其抗菌性能研究

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• 英文论文题名：Preparation of Polylactic acid/Chitosan/Nisin Composite Nanofiber Membranes by Coaxial Electrospinning and their Antibacterial Properties
• 论文作者：李吉年 ; 李想 ; 胡梦欣
• 英文论文作者：LI Jinian ; LI Xiang ; HU Mengxin ; School of Food Science and Biotechnology ; Zhejiang Gongshang University ; Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang Province
• 年：2016
• 作者机构：浙江工商大学食品与生物工程学院;浙江省新型吸附分离材料与应用技术重点实验室;
• 论文关键词：壳聚糖 ; 乳酸链球菌素 ; 同轴静电纺丝 ; 纳米纤维膜 ; 抗菌
• 会议召开时间：2016-11-18
• 会议录名称：中国第四届静电纺丝大会（CICE 2016）摘要集
• 语种：中文
• 分类号：TQ340.64
• 学会代码：ZGNM
• 会议名称：中国第四届静电纺丝大会(CICE 2016)
• 会议地点：中国北京
• 主办单位：中国复合材料学会超细纤维材料分会（筹）
• 学会名称：中关村科创纳米技术创新研究会
• 页数：1
• 文件大小：511k
• 原文格式：D
• 会议级别：全国

摘要

静电纺丝法是有效且简单的制备纳米纤维的方法。静电纺丝制备的纳米纤维膜具有优异的透气性,但又可以阻挡细菌和灰尘,从而减少创伤感染,是一种理想的伤口敷料。壳聚糖和乳酸链球菌素(nisin)是两种广泛被研究的天然抗菌成分,本工作采用同轴静电纺丝技术,制备出具有核-壳结构的聚乳酸(PLA)/壳聚糖(CS)/乳酸链球菌素(nisin)复合纳米纤维膜,制备一种新型的伤口敷料。聚乳酸为核层材料,壳聚糖和nisin为壳层材料。考察电压、流速、接收距离等纺丝参数对纤维尺寸的影响,采用扫描电镜和红外光谱表征纳米纤维膜的形貌和结构,研究聚乳酸/壳聚糖/nisin复合纳米纤维膜的抗菌性能。实验发现,在最佳纺丝条件下,复合纳米纤维膜的纤维尺寸为100~200 nm,与聚乳酸/壳聚糖纳米纤维膜相比,复合nisin的聚乳酸/壳聚糖/nisin纳米纤维膜具有更好的抗菌性能,且抗菌性能随纤维中nisin含量的增加而进一步增强。
Electrospinning is an simple and effective method to prepare nanofibers. Nanofiber membranes possess many advantages, such as high breathability and high resistance for microorganisms and dusts. These properties of nanofiber membranes make them an idea wound dressing. Chitosan and nisin are widely studied natural antibacterial agents. In this work, polylactic acid/chitosan/nisin core-shell nanofiber membranes were prepared via coaxial electrospinning. Polylactic acid was the core material, and chitosan and nisin were the shell materials. This core-shell nanofiber membranes is a new wound dressing. The influence of electrospinning parameters on the nanofiber size was studied. The morphology and structure of the nanofiber membranes were characterized with SEM and ATR/FT-IR. The size of nanofiber was about 100~200 nm with suitable electrospinning parameters. The antibacterial ability of the polylactic acid/chitosan/nisin nanofiber membranes was better than that of the polylactic acid/chitosan nanofiber membranes. And the antibacterial ability increased with the content of nisin in the membranes.

引文

[1]张福婷,周金龙,黄海瑞,等.高等学校化学学报,2016,37(4):781-785.
    [2]Xu J W,Wang Y,Yang Y F,et al.Colloids&Surfaces B Biointerfaces,2015,133:148-155.