鹿复合麻醉剂对鹿无创血压、血浆ANP、CGRP及RAAS的影响
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- 英文论文题名：Effect the Compound Anesthetic for Deer on Blood Pressure,ANP,CGRP and RAAS in Deer
- 论文作者：尹柏双 ; 李雨航 ; 付莹 ; 王楠 ; 王雪莹 ; 沙万里 ; 付连军
- 英文论文作者：Yin Baishuang ; Li Yuhang ; Fu Ying ; Wang Nan ; Wang Xueying ; Sha Wanli ; Fu Lianjun ; Department of Animal Medicine ; JiLin Agricultural Science and technology ; School of Animal Science and Technology ; Jilin Agricultural University
- 年：2016
- 作者机构：吉林农业科技学院动物科技学院;吉林农业大学动物科技学院;
- 论文关键词：鹿复合麻醉剂 ; 肾素 ; 血管紧张素Ⅱ ; 血压
- 英文论文关键词：the compound anesthetic for deer ; renin ; angiotensin Ⅱ ; blood pressure
- 会议召开时间：2016-06-01
- 会议录名称：“十二五” 鹿科学研究进展
- 语种：中文
- 分类号：S859.791
- 学会代码：ZXMY
- 学会名称：中国畜牧业协会
- 页数：10
- 文件大小：1045k
- 原文格式：O
摘要
为明确鹿复合麻醉剂作用下鹿血压变化与血浆肾素-血管紧张素-醛固酮系统、心钠素、降钙素基因相关肽相关性。试验选取6只健康成年梅花鹿,肌注鹿复合麻醉剂0.04mL·kg~(-1),注药前及注药后15、30、45、60、75、90及120min进行血压监测,并同步采集颈静脉血样测定肾素(PRA)、血管紧张素(AⅡ)、醛固酮(ALD)、心钠素(ANP)和降钙素基因相关肽(CGRP)含量。结果表明,梅花鹿麻醉期血浆中ANP、PRA、AⅡ和ALD含量下降,与对照组比较降低显著(P<0.01或P<0.05);CGRP含量升高,与对照组比较升高显著(P<0.01);SBP、DBP和MAP显著将低于对照组(P<0.01)。结果显示,鹿复合麻醉剂作用下引起肾素-血管紧张素-醛固酮系统、心钠素、降钙素基因相关肽变化参与鹿血压变化的调节。
In order to investigate the Compound anesthetic for deer(CAD) on the relationship ANP,CGRP,RAAS in plasma and the changing of blood pressure in deer.6 healthy grown deer were injected drug(0.04mL·kg~(-1)),Jugular vein blood was collected at 0,15,30,45,60,75,90 and 120 min before and after administration,and Systolic blood pressure was monitored at the same time.The atrial natriuretic peptide,calcitonin gene related peptide,rennin,Renin(RPA),angiotensin(A 11) and aldosterone(ALD) in plasma were determined by Elisa.Results showed that the contents of ANP,PRA,A 11 and ALD in plasma were significantly lower than the control group(P < 0.01 or P < 0.05).CGRP was significantly higher than the control group(P < 0.01).The blood pressure was also significantly lower than the control group(P < 0.01).It was concluded that ANP,CGRP,PRA,A Ⅱ and ALD participated in changing of hemodynamics caused by the CAD.
In order to investigate the Compound anesthetic for deer(CAD) on the relationship ANP,CGRP,RAAS in plasma and the changing of blood pressure in deer.6 healthy grown deer were injected drug(0.04mL·kg~(-1)),Jugular vein blood was collected at 0,15,30,45,60,75,90 and 120 min before and after administration,and Systolic blood pressure was monitored at the same time.The atrial natriuretic peptide,calcitonin gene related peptide,rennin,Renin(RPA),angiotensin(A 11) and aldosterone(ALD) in plasma were determined by Elisa.Results showed that the contents of ANP,PRA,A 11 and ALD in plasma were significantly lower than the control group(P < 0.01 or P < 0.05).CGRP was significantly higher than the control group(P < 0.01).The blood pressure was also significantly lower than the control group(P < 0.01).It was concluded that ANP,CGRP,PRA,A Ⅱ and ALD participated in changing of hemodynamics caused by the CAD.
引文
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[19]GaoL,Zhang Z G,Zhang J F,et al.Effects of xylazine on thyroid hormones,insulin,and glucagons in dogs[J].Bull Vet Inst Pulawy,2010,54,401-403.
[20]Yin B S,Wang H B,Gong D Q,et al.Effects of Xylazine on Glutamate and GAB A contents in the hippocampus and thalamencephal in the rat[J].Bull Vet Inst Pulawy,2011,55:537-539.
[21]Ndeerch D R,Mbithi P M,Kihurani D O.The reversal of Rompum hydrochloride by yohimbine and 4-aminopyridine in goats[J].J S Afr Vet Assoc,2001,72,64-70.
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[23]范宏刚,刘焕奇,高利,等.强痛宁在犬血浆中的药代动力学研究[J].中国兽医学报,2009,29(3):327-330.
[24]刘海涛,彭旭,吴曙粤.血浆内皮素及降钙素基因相关肽的研究进展[J].内科,2006,1(2):173-174.
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[27]卢健芳,郭曲练,王锷,等.连续腰麻与硬膜外麻醉下老年手术病产血浆内皮素、心钠素的变化[J].中华麻醉学杂志,2005,25(9):693-694.
[28]Verdonk K,Danser A H,van Esch J H.Angiotensin II type 2 receptor agonists;where should they be applied?[J].Expert Opin Investig Drugs,2012,21;501-513.
[29]Franklin S S,Pio J R,Wong N D,et al.Predictors of new-onset diastolic and systolic hypertension.The Framingham Heart Study[J].Circulation,2005,111:1 121-1 127.
[30]刘焕奇.噻拉唑及其复方制剂-QFM合剂全麻分子机理的实验研究[D].哈尔滨:东北农业大学,2004,86-87.
[31]张昊,胡魁,杨同涛,等.乳化异氟烷复合麻醉对巴马猪无创血压与血浆中肾素-血管紧张素-醛固酮系统的影响[J].畜牧与兽医,2013,45(5):75-77.
[2]陈祖荣,林秋泉,冯华.降钙素基因相关肽与脑血管疾病的关系研究进展[J].中国实用医药,2009,4(6):233-235.
[3]刘再英,金昌道,苏艾中,等.吸入麻醉预处理诱导降钙素基因相关肽对脑胶质细胞胶质纤维酸性蛋白表达的影响[J].临床麻醉学杂志,2006,22(7):534-537.
[4]付华王颖杨胜男,等.降钙素基因相关肽参与外侧缰核对痛觉的调节作用[J].中国免疫学杂志,2014,30(4):449-454.
[5]Dobolyi A,Irwin S,Makara G,et al.Calcitonin gene-related peptide-containing pathways in the rat forebrain[J].J Comp Neurol,2005,489(1):92-199.
[6]Gupta S,Amrutkar D V,Mataji A,et al.Evidence for CGRP re-uptake in rat dura mater encephali[J].Br J Pharmacol,2010,161(8):1885-1898.
[7]卢镜宇,严莉君,马梅芳,等.降钙素基因相关肽(CGRP)对鸡摄食调控的影响[J].畜牧与兽医,2014,46(5):67-71.
[8]肖梅芳.肾素-血管紧张素系统在心血管疾病进展中的作用[J].心血管病学进展,2005,26(2):137-140.
[9]金天明.动物生理学[M].北京:清华大学出版社,2012,387.
[10]刘本君,戴波涛,王洪伟,等.隆朋麻醉及其手术下对犬内皮素和降钙素基因相关肽的影响[J].中国兽医杂志,2010,46(10):15-17.
[11]付强,冯灿,杨军,等.七氟烷对脑动脉瘤手术患者血浆内皮素和降钙素基因相关肽的影响分析[J].中国医药导报,2013,10(4):93-95.
[12]刘刚,孙艳林,申岱.异丙酚麻醉中血浆降钙素基因相关肽及神经降压素改变的观察[J].临床麻醉学杂志,2000,16(2):57-58.
[13]蓝胜文,高晓枫,易仁合,等.异丙酚全麻对患者血浆内皮素、降钙素基因相关肽含量的影响[J].山西医科大学学报,2004,35(1):48-49.
[14]宋旭东,姜胜,侯金龙,等.小型猪特异性麻醉颉颃剂对小型猪血浆RAAS的影响[J].中国兽医杂志,2014,50(3):24-27.
[15]范宏刚,冯国峰,郭蔚,等.外源性H_2S对氯胺酮全麻大鼠麻醉时间、麻醉效果的影响[J].东北农业大学学报,2013,44(12):78-83.
[16]Picker O,Schwarte L A,Rot H J,et al.Comparison of the role of endothelin,vasopressin and angiotensin in arterial pressure regulation during sevoflurane anesthesia in dogs[J].Br J Anaesth,2004,92(1):102-108.
[17]胡魁,侯金龙,宋旭东,等.小型猪乳化异氟醚全身麻醉效果监测[J].东北农业大学学报,2013,44(6):23-27.
[18]Saifzadeh S,Pourjafar M,Naghadeh B D,et al.Caudal extradural analgesia with lidocaine,xylazine,and a combination of lidocaine and xylazine in the Iranian river buffalo[J].Bull Vet Inst Pulawy 2007,51,285-288.
[19]GaoL,Zhang Z G,Zhang J F,et al.Effects of xylazine on thyroid hormones,insulin,and glucagons in dogs[J].Bull Vet Inst Pulawy,2010,54,401-403.
[20]Yin B S,Wang H B,Gong D Q,et al.Effects of Xylazine on Glutamate and GAB A contents in the hippocampus and thalamencephal in the rat[J].Bull Vet Inst Pulawy,2011,55:537-539.
[21]Ndeerch D R,Mbithi P M,Kihurani D O.The reversal of Rompum hydrochloride by yohimbine and 4-aminopyridine in goats[J].J S Afr Vet Assoc,2001,72,64-70.
[22]Massolo A,Sforzi A,Lovari S.Chemical immobilization of crested porcupines with tiletamine Hcl and zolazepam Hcl(Zoletil)under field conditions[J].J Wild life Dis,2003,39(3):727-731.
[23]范宏刚,刘焕奇,高利,等.强痛宁在犬血浆中的药代动力学研究[J].中国兽医学报,2009,29(3):327-330.
[24]刘海涛,彭旭,吴曙粤.血浆内皮素及降钙素基因相关肽的研究进展[J].内科,2006,1(2):173-174.
[25]Brain S D,Grant A D.Vascular Actions of Calcitonin Gene-related peptide and Adrenomedullin[J].Physiol Rev,2004,84(3):903-934.
[26]卢德章,范宏刚,胡魁,等.小型猪复合麻醉剂对小型猪部分心肺指标及血浆内皮素和降钙素基因相关肽含量的影响[J].中国农业科学,2010,43(10):2162-2167.
[27]卢健芳,郭曲练,王锷,等.连续腰麻与硬膜外麻醉下老年手术病产血浆内皮素、心钠素的变化[J].中华麻醉学杂志,2005,25(9):693-694.
[28]Verdonk K,Danser A H,van Esch J H.Angiotensin II type 2 receptor agonists;where should they be applied?[J].Expert Opin Investig Drugs,2012,21;501-513.
[29]Franklin S S,Pio J R,Wong N D,et al.Predictors of new-onset diastolic and systolic hypertension.The Framingham Heart Study[J].Circulation,2005,111:1 121-1 127.
[30]刘焕奇.噻拉唑及其复方制剂-QFM合剂全麻分子机理的实验研究[D].哈尔滨:东北农业大学,2004,86-87.
[31]张昊,胡魁,杨同涛,等.乳化异氟烷复合麻醉对巴马猪无创血压与血浆中肾素-血管紧张素-醛固酮系统的影响[J].畜牧与兽医,2013,45(5):75-77.
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