基于猪肠道功能靶标的饲料添加剂研究进展
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摘要
肠道健康是制约猪生长潜力发挥的重要因素,在增进肠道健康的诸多方法中,营养调控被认为是最有效且安全的方法。一些营养素被证实可有效维护肠道完整性和改善肠道功能、维护肠道健康。探索基于肠道功能靶标的饲料添加剂对促进养猪业的发展具有重要意义。本文结合我们多年的研究成果,就基于肠道功能靶标的饲料添加剂研究进展作一综述。
引文
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[2]Lambert G P.Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects[J].Journal of Animal Science,2009,87:E101-E108.
[3]Lalles J P,Boudry G,Favier C,et al..Gut function and dysfunction in young pigs:physiology[J].Animal Research,2004,53:301-316.
[4]Boudry G,Peron V,Le Huerou-Luron I,et al..Weaning induces both transient and long-lasting modifications of absorptive,secretory,and barrier properties of piglet intestine[J].Journal of Nutrition,2004,134:2256-2262.
[5]陈雪萍,肖敏,曾跃红,等.危重症患者胃肠道功能障碍评价研究进展[J].湖北医药学院学报,2012,31(6):439-443.
[6]赵敏,周思远,毛廷丽,等.代谢组学技术在功能性胃肠病中的应用[J].2015,30(7):2450-2452.
[7]刘娟,吴巧凤,孙博,等.利用气质联用方法研究功能性消化不良患者血浆代谢谱的变化[J].军事医学,2011,35(6):454-458.
[8]Kajander K,Myllyluoma E,Kyronpalo S,et al..Elevated proinflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome[J].World Journal of Gastroenterology,2009,15(48):6068-6074.
[9]Rodriguez L,Roberts L D,Larosa J,et al..Relationship between postprandial metabolomics and colon motility in children with constipation[J].Neurogastroenterology and Motility,2013,25(5):420-426.
[10]Tana C,Umesaki Y,Imaoka A,et al..Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome[J].Neurogastroenterology and Motility,2010,22(5):512-519.
[11]Ahmed I,Greenwood R,Costello Bde L,et al..An investigation of fecal volatile organic metabolites in irritable bowel syndrome[J].PLoS One,2013,8(3):e58204.
[12]Johnston S D,Smye M,Watson R P.Intestinal permeability tests in coeliac disease[J].Clinical Laboratory,2001,47(3-4):143-150.
[13]Alberda C,Gramlich L,Meddings J,et al..Effects of probiotic therapy in critically ill patients:a randomized,double-blind,placebo-controlled trial[J].American Journal of Clinical Nutrition,2007,85(3):816-823.
[14]何桂珍.肠道屏障功能和检测方法的研究进展[J].现代检验医学杂志,2009(6):136-141.
[15]夏阳,秦环龙.肠道屏障功能临床评估方法[J].中国实用外科杂志2008,28(11):1006-1008.
[16]胡泉舟,侯永清,王猛.血中二胺氧化酶活性与仔猪腹泻程度的相关性分析.猪业科学,2007(12):73-74.
[17]熊德鑫,伍丽萍.注意菌群失调检测的方法[J].中华医学杂志,2005,85(39):2746-2748.
[18]Kim E.Mechanisms of amino acid sensing in mTOR signaling pathway[J].Nutrition Research and Practice.2009,3(1):64-71.
[19]Hay N,Sonenberg N.Upstream and downstream of mTOR[J].Genes&Development,2004,18:1926-1945.
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[21]Hou Y Q,Wang L,Ding B Y,et al..Dietary a-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets[J].Amino Acids,2010,39:555-564.
[22]Hou Y Q,Wang L,Ding B Y,et al..α-Ketoglutarate and intestinal function[J].Frontiers in Bioscience,2011,16:1186-1196.
[23]Yao K,Yin Y L,Li X L,et al..Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells[J].Amino Acids,2012,42:2491-2500.
[24]Normanno N,De Luca A,Bianco C,et al..Epidermal growth factor receptor(EGFR):ignaling in cancer[J].Gene.2006,366(1):2-16.
[25]Ladanyi M,Pao W.Lung adenocarcinoma:guiding EGFR-targeted therapy and beyond[J].Modern Pathology,2008,21:S16-S22.
[26]Hou Y Q,Wang L,Yi D,et al..N-acetylcysteine reduces inflammation in the small intestine by regulating redox,EGF and TLR4 signaling[J].Amino Acids,2013,45:513-522.
[27]Hou Y Q,Wang L,Yi D,et al..N-acetylcysteine and intestinal health:a focus on its mechanism of action[J].Frontiers in Bioscience,Landmark,2015,20:872-891.
[28]Hou Y Q,Yao K,Wang L,et al..Effects of a-ketoglutarate on energy status in the intestinal mucosa of weaned piglets chronically challenged with lipopolysaccharide[J].British Journal of Nutrition,2011,106:357-363.
[29]Wang W W,Qiao S Y,Li D F.Amino acids and gut function[J].Amino Acids,2009,37:105-110.
[30]Rhoads J M,Wu G.Glutamine,arginine,and leucine signaling in the intestine[J].Amino Acids,2009,37:111-122.
[31]伍烽,金先庆.肠营养素对短肠综合征残留肠管代偿性变化的促进作用[J].中华小儿外科杂志,1997,18(4):249—251.
[32]伍烽.肠营养素治疗儿童短肠综合征的实验研究及其分子机理[D].博士学位论文.重庆:重庆医科大学,1997.
[33]Duggan C,Gannon J,Walker W A.Protective nutrients and functional foods for the gastrointestinal tract[J].American Journal of Clinical Nutrition,2002,75:789-808.
[34]Wu G.Functional amino acids in nutrition and health[J].Amino Acids,2013,45:407-411.
[35]Zhu H L,Liu Y L,Xie X L,et al..Effect of L-arginine on intestinal mucosal immune barrier function in weaned pigs after Escherichia coli LPS challenge[J].Innate Immunity,2013,19:242-252.
[36]Takuya S,Shoko Y,Hiroshi H.Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability[J].British Journal of Nutrition,2008,100(2):297-305.
[37]Calder P C.Polyunsaturated fatty acids,inflammatory processes and inflammatory bowel diseases[J].Molecular Nutrition&Food Research,2008,52:885-897.
[38]Liu Y L,Chen F,Li Q,et al..Fish oil alleviates activation of hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaning pigs after an LPS challenge[J].Journal of Nutrition,2013,143:1799-1807.
[39]张明鸣,程惊秋,翟宏军,等.添加特需营养素的营养支持对手术创伤后肠黏膜形态和屏障功能的影响[J].中华胃肠外科杂志,2009(3):306-309.
[40]Kelly G S.Clinical applications of N-acetylcysteine[J].Alternative Medicine Review,1998,3(2):114-127.
[41]张再重,王瑜,王烈,林克荣.N-乙酰半胱氨酸对肠屏障功能障碍防治作用的研究现状[J].福州总医院学报,2010(1):52-55.
[42]Hou Y Q,Wang L,Zhang W,et al..Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide[J].Amino Acids,2012,43:1233-1242.
[43]Roederer M,Ela S W,Staal F J,et al..N-acetylcysteine:a new approach to anti-HIV therapy[J].AIDS Research and Human Retroviruses,1992,8(2):209-217.
[44]MilleaPJ.N-Acetylcysteine:multiple clinical applications[J].American Family Physician,2009,80(3):265-269.
[45]Garigliany M M,Desmecht D J.N-acetylcysteine lacks universal inhibitory activity against influenza A viruses[J].Journal of Negative Results in Biomedicine,2011,10:5.
[46]Chen X,Ren F,Hesketh J,et al..Reactive oxygen species regulate the replication of porcine circovirus type 2 via NF-κB pathway[J].Virology,2012,426(1):66-72.
[47]Geiler J,Michaelis M,Naczk P,et al..N-acetyl-1-cysteine(NAC)inhibits virus replication and expression of proinflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus[J].Biochemical Pharmacology,2010,79(3):413-420.
[48]Patrick L.Nutrients and HIV:part three-N-acetylcysteine,alpha-lipoic acid,L-glutamine,and L-carnitine[J].Alternative Medicine Review,2000,5(4):290-305.
[49]陈星.三丁酸甘油酯对乙酸诱导仔猪结肠炎的影响及其机理[D].硕士学位论文.武汉:武汉轻工大学,2013.
[50]Hou Y Q,Wang L,Y I D,et al..Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid[J].British Journal of Nutrition,2014,111(10):1748-1758.
[51]李娇龙.三丁酸甘油酯对LPS多次刺激肉鸡小肠形态结构和功能的影响[D].硕士学位论文.武汉:武汉轻工大学,2014.
[52]侯永清.三丁酸甘油酯作为饲料添加剂的应用:ZL03128368.3[P],2006.
[53]李抗.短链脂肪酸酯对仔猪肠道功能与脂肪代谢的影响及机理[D].硕士学位论文.武汉:武汉轻工大学,2016.
[54]侯永清,丁斌鹰.三乳酸甘油酯作为饲料酸化剂的应用:ZL201310039966.1[P],2014.
[55]侯永清,丁斌鹰,张开诚.乳酸丁酸甘油酯作为饲料添加剂的应用:ZL201310039695.X[P],2014.
[56]赵钰.凝结芽孢杆菌抑菌物质分离鉴定及其对大黄鱼保鲜效果的研究[D].硕士学位论文.杭州:浙江工商大学,2015.
[57]徐贤.一株益生凝结芽孢杆菌的选育及特性研究[D].硕士学位论文.杭州:浙江工业大学,2014.
[58]高书锋,郭照辉,胡新旭,等.凝结芽孢杆菌制剂对断奶仔猪临床应用效果的研究[J].饲料研究,2015(6):42-47.
[59]Araa K,Meguro S,Hase T,et al..Effect of spore-bearing lactic acid-forming bacteria(Bacillus coagulans SANK70258)administration on the intestinal environment,defecation frequency,fecal characteristics and dermal characteristics in humans and rats[J].Microbial Ecology in Health and Disease,2002,14(1):4-13.
[60]Zhou X,Wang Y,Gu Q,et al..Effect of dietary probiotic,Bacillus coagulans,on growth performance,chemical composition,and meat quality of Guangxi yellow chicken[J].Poultry Science,2010,89(3):588-593.
[61]房一粟.凝结芽孢杆菌培养基的优化及其制备工艺的研究[D].硕士学位论文.武汉:武汉轻工大学,2015.
[62]曾弘华.凝结芽孢杆菌治疗小儿腹泻的疗效[J].实用临床医学,2016(4):51-52.
[63]李宝成.功能性氨基酸复合物对仔猪肠道功能与肌肉生长的影响及机理[D].硕士学位论文.武汉:武汉轻工大学,2016.
[64]孔祥峰,印遇龙,伍国耀.猪功能性氨基酸营养研究进展[J].动物营养学报,2009,21(1):1-7.
[65]侯永清,丁斌鹰,易丹.一种复合型功能性氨基酸饲料添加剂与应用:CN201410690266.3[P],2014.
[2]Lambert G P.Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects[J].Journal of Animal Science,2009,87:E101-E108.
[3]Lalles J P,Boudry G,Favier C,et al..Gut function and dysfunction in young pigs:physiology[J].Animal Research,2004,53:301-316.
[4]Boudry G,Peron V,Le Huerou-Luron I,et al..Weaning induces both transient and long-lasting modifications of absorptive,secretory,and barrier properties of piglet intestine[J].Journal of Nutrition,2004,134:2256-2262.
[5]陈雪萍,肖敏,曾跃红,等.危重症患者胃肠道功能障碍评价研究进展[J].湖北医药学院学报,2012,31(6):439-443.
[6]赵敏,周思远,毛廷丽,等.代谢组学技术在功能性胃肠病中的应用[J].2015,30(7):2450-2452.
[7]刘娟,吴巧凤,孙博,等.利用气质联用方法研究功能性消化不良患者血浆代谢谱的变化[J].军事医学,2011,35(6):454-458.
[8]Kajander K,Myllyluoma E,Kyronpalo S,et al..Elevated proinflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome[J].World Journal of Gastroenterology,2009,15(48):6068-6074.
[9]Rodriguez L,Roberts L D,Larosa J,et al..Relationship between postprandial metabolomics and colon motility in children with constipation[J].Neurogastroenterology and Motility,2013,25(5):420-426.
[10]Tana C,Umesaki Y,Imaoka A,et al..Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome[J].Neurogastroenterology and Motility,2010,22(5):512-519.
[11]Ahmed I,Greenwood R,Costello Bde L,et al..An investigation of fecal volatile organic metabolites in irritable bowel syndrome[J].PLoS One,2013,8(3):e58204.
[12]Johnston S D,Smye M,Watson R P.Intestinal permeability tests in coeliac disease[J].Clinical Laboratory,2001,47(3-4):143-150.
[13]Alberda C,Gramlich L,Meddings J,et al..Effects of probiotic therapy in critically ill patients:a randomized,double-blind,placebo-controlled trial[J].American Journal of Clinical Nutrition,2007,85(3):816-823.
[14]何桂珍.肠道屏障功能和检测方法的研究进展[J].现代检验医学杂志,2009(6):136-141.
[15]夏阳,秦环龙.肠道屏障功能临床评估方法[J].中国实用外科杂志2008,28(11):1006-1008.
[16]胡泉舟,侯永清,王猛.血中二胺氧化酶活性与仔猪腹泻程度的相关性分析.猪业科学,2007(12):73-74.
[17]熊德鑫,伍丽萍.注意菌群失调检测的方法[J].中华医学杂志,2005,85(39):2746-2748.
[18]Kim E.Mechanisms of amino acid sensing in mTOR signaling pathway[J].Nutrition Research and Practice.2009,3(1):64-71.
[19]Hay N,Sonenberg N.Upstream and downstream of mTOR[J].Genes&Development,2004,18:1926-1945.
[20]Sarbassov D D,Ali S M,Sabatini D M.Growing roles for the mTOR pathway[J].Current Opinion in Cell Biology,2005,17(6):596-603.
[21]Hou Y Q,Wang L,Ding B Y,et al..Dietary a-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets[J].Amino Acids,2010,39:555-564.
[22]Hou Y Q,Wang L,Ding B Y,et al..α-Ketoglutarate and intestinal function[J].Frontiers in Bioscience,2011,16:1186-1196.
[23]Yao K,Yin Y L,Li X L,et al..Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells[J].Amino Acids,2012,42:2491-2500.
[24]Normanno N,De Luca A,Bianco C,et al..Epidermal growth factor receptor(EGFR):ignaling in cancer[J].Gene.2006,366(1):2-16.
[25]Ladanyi M,Pao W.Lung adenocarcinoma:guiding EGFR-targeted therapy and beyond[J].Modern Pathology,2008,21:S16-S22.
[26]Hou Y Q,Wang L,Yi D,et al..N-acetylcysteine reduces inflammation in the small intestine by regulating redox,EGF and TLR4 signaling[J].Amino Acids,2013,45:513-522.
[27]Hou Y Q,Wang L,Yi D,et al..N-acetylcysteine and intestinal health:a focus on its mechanism of action[J].Frontiers in Bioscience,Landmark,2015,20:872-891.
[28]Hou Y Q,Yao K,Wang L,et al..Effects of a-ketoglutarate on energy status in the intestinal mucosa of weaned piglets chronically challenged with lipopolysaccharide[J].British Journal of Nutrition,2011,106:357-363.
[29]Wang W W,Qiao S Y,Li D F.Amino acids and gut function[J].Amino Acids,2009,37:105-110.
[30]Rhoads J M,Wu G.Glutamine,arginine,and leucine signaling in the intestine[J].Amino Acids,2009,37:111-122.
[31]伍烽,金先庆.肠营养素对短肠综合征残留肠管代偿性变化的促进作用[J].中华小儿外科杂志,1997,18(4):249—251.
[32]伍烽.肠营养素治疗儿童短肠综合征的实验研究及其分子机理[D].博士学位论文.重庆:重庆医科大学,1997.
[33]Duggan C,Gannon J,Walker W A.Protective nutrients and functional foods for the gastrointestinal tract[J].American Journal of Clinical Nutrition,2002,75:789-808.
[34]Wu G.Functional amino acids in nutrition and health[J].Amino Acids,2013,45:407-411.
[35]Zhu H L,Liu Y L,Xie X L,et al..Effect of L-arginine on intestinal mucosal immune barrier function in weaned pigs after Escherichia coli LPS challenge[J].Innate Immunity,2013,19:242-252.
[36]Takuya S,Shoko Y,Hiroshi H.Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability[J].British Journal of Nutrition,2008,100(2):297-305.
[37]Calder P C.Polyunsaturated fatty acids,inflammatory processes and inflammatory bowel diseases[J].Molecular Nutrition&Food Research,2008,52:885-897.
[38]Liu Y L,Chen F,Li Q,et al..Fish oil alleviates activation of hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaning pigs after an LPS challenge[J].Journal of Nutrition,2013,143:1799-1807.
[39]张明鸣,程惊秋,翟宏军,等.添加特需营养素的营养支持对手术创伤后肠黏膜形态和屏障功能的影响[J].中华胃肠外科杂志,2009(3):306-309.
[40]Kelly G S.Clinical applications of N-acetylcysteine[J].Alternative Medicine Review,1998,3(2):114-127.
[41]张再重,王瑜,王烈,林克荣.N-乙酰半胱氨酸对肠屏障功能障碍防治作用的研究现状[J].福州总医院学报,2010(1):52-55.
[42]Hou Y Q,Wang L,Zhang W,et al..Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide[J].Amino Acids,2012,43:1233-1242.
[43]Roederer M,Ela S W,Staal F J,et al..N-acetylcysteine:a new approach to anti-HIV therapy[J].AIDS Research and Human Retroviruses,1992,8(2):209-217.
[44]MilleaPJ.N-Acetylcysteine:multiple clinical applications[J].American Family Physician,2009,80(3):265-269.
[45]Garigliany M M,Desmecht D J.N-acetylcysteine lacks universal inhibitory activity against influenza A viruses[J].Journal of Negative Results in Biomedicine,2011,10:5.
[46]Chen X,Ren F,Hesketh J,et al..Reactive oxygen species regulate the replication of porcine circovirus type 2 via NF-κB pathway[J].Virology,2012,426(1):66-72.
[47]Geiler J,Michaelis M,Naczk P,et al..N-acetyl-1-cysteine(NAC)inhibits virus replication and expression of proinflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus[J].Biochemical Pharmacology,2010,79(3):413-420.
[48]Patrick L.Nutrients and HIV:part three-N-acetylcysteine,alpha-lipoic acid,L-glutamine,and L-carnitine[J].Alternative Medicine Review,2000,5(4):290-305.
[49]陈星.三丁酸甘油酯对乙酸诱导仔猪结肠炎的影响及其机理[D].硕士学位论文.武汉:武汉轻工大学,2013.
[50]Hou Y Q,Wang L,Y I D,et al..Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid[J].British Journal of Nutrition,2014,111(10):1748-1758.
[51]李娇龙.三丁酸甘油酯对LPS多次刺激肉鸡小肠形态结构和功能的影响[D].硕士学位论文.武汉:武汉轻工大学,2014.
[52]侯永清.三丁酸甘油酯作为饲料添加剂的应用:ZL03128368.3[P],2006.
[53]李抗.短链脂肪酸酯对仔猪肠道功能与脂肪代谢的影响及机理[D].硕士学位论文.武汉:武汉轻工大学,2016.
[54]侯永清,丁斌鹰.三乳酸甘油酯作为饲料酸化剂的应用:ZL201310039966.1[P],2014.
[55]侯永清,丁斌鹰,张开诚.乳酸丁酸甘油酯作为饲料添加剂的应用:ZL201310039695.X[P],2014.
[56]赵钰.凝结芽孢杆菌抑菌物质分离鉴定及其对大黄鱼保鲜效果的研究[D].硕士学位论文.杭州:浙江工商大学,2015.
[57]徐贤.一株益生凝结芽孢杆菌的选育及特性研究[D].硕士学位论文.杭州:浙江工业大学,2014.
[58]高书锋,郭照辉,胡新旭,等.凝结芽孢杆菌制剂对断奶仔猪临床应用效果的研究[J].饲料研究,2015(6):42-47.
[59]Araa K,Meguro S,Hase T,et al..Effect of spore-bearing lactic acid-forming bacteria(Bacillus coagulans SANK70258)administration on the intestinal environment,defecation frequency,fecal characteristics and dermal characteristics in humans and rats[J].Microbial Ecology in Health and Disease,2002,14(1):4-13.
[60]Zhou X,Wang Y,Gu Q,et al..Effect of dietary probiotic,Bacillus coagulans,on growth performance,chemical composition,and meat quality of Guangxi yellow chicken[J].Poultry Science,2010,89(3):588-593.
[61]房一粟.凝结芽孢杆菌培养基的优化及其制备工艺的研究[D].硕士学位论文.武汉:武汉轻工大学,2015.
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[63]李宝成.功能性氨基酸复合物对仔猪肠道功能与肌肉生长的影响及机理[D].硕士学位论文.武汉:武汉轻工大学,2016.
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