猪胰岛素样生长因子IGF-1与生长发育的相关研究进展
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- 英文论文题名：Study Of The Correlation Between Porcine Insulin-like Growth Factor IGF-1 and Growth
- 论文作者：张飞燕 ; 张钧利 ; 李伟 ; 潘康成
- 英文论文作者：Feiyan Zhang ; Junli Zhang ; Wei Li ; Kangcheng Pan ; Animal Microecology Institute ; College of Veterinary Medicine ; Sichuan AgricμLtural University ; Wuxi Arbaor Biology Engineering Co.LTD ; Jiangsu
- 年：2016
- 作者机构：四川农业大学动物医学院动物微生态研究中心;江苏无锡阿尔宝尔生物工程有限公司;
- 论文关键词：猪 ; IGF-1 ; 生长 ; 发育
- 英文论文关键词：pig ; insulin-like growth factor 1 IGF-1 ; growth ; development
- 会议召开时间：2016-11-04
- 会议录名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会论文集
- 语种：中文
- 分类号：S828
- 学会代码：ZGXJ
- 会议名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会
- 会议地点：中国山东青岛
- 主办单位：中国畜牧兽医学会动物微生态学分会
- 学会名称：中国畜牧兽医学会
- 页数：4
- 文件大小：679k
- 原文格式：O
- 会议级别：全国
摘要
胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)是一种与胰岛素原结构高度同源的多肽,调控脊椎动物机体生长的所有发展阶段,属于胰岛素样生长因子家族中的一员,具有非常复杂的生物学功能,在细胞的分化、增殖及个体的生长发育中有重要促进作用,主要介导生长激素(GH)发挥促生长作用,故也称其为生长介素C(SM-C)。本文从IGFBPS、猪IGF-1基因SNP位点、IGF-1受体、IGF-1信号通路和饲料水平方面综述其对IGF-1的影响并进一步影响猪生长发育的关系。
Insulin-like growth factor I(IGF-I) is a polypeptide that belongs to a member of the insulin-like growth factor family with structural homology to proinsulin,which regulates growth during all stages of development in vertebrates.IGF-1 also called somatomedin C(SM-C),which displays a complex interaction scheme,as the hormone has a key function in the regulation of cellular proliferation and differentiation.The paper reviews influences of IGFBPS,SNPs of porcine IGF-I gene,IGF-I receptor,IGF-I signaling pathway and feed level on IGF-I,Morever,The correlation between porcine insulin-like growth factor IGF-I and growth.
Insulin-like growth factor I(IGF-I) is a polypeptide that belongs to a member of the insulin-like growth factor family with structural homology to proinsulin,which regulates growth during all stages of development in vertebrates.IGF-1 also called somatomedin C(SM-C),which displays a complex interaction scheme,as the hormone has a key function in the regulation of cellular proliferation and differentiation.The paper reviews influences of IGFBPS,SNPs of porcine IGF-I gene,IGF-I receptor,IGF-I signaling pathway and feed level on IGF-I,Morever,The correlation between porcine insulin-like growth factor IGF-I and growth.
引文
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[11]Cong Z,Xiao-Lian L,Wei-Min W,et al.Characterization of GHRs,IGFs and MSTNs,and analysis of their expression relationships in blunt snout bream,Megalobrama amblycephala.[J].Gene,2013,535(2):239-249.
[12]Zhang H,Tong F D,Lu Q E.Cloning of Qiantang River Triangular Bream(Megalobrama terminalis)IGF-I Gene and Expression of the Recombinant pre-IGF-I in Escherichia coli[J].Applied Biochemistry&Biotechnology,2008,150(1):15-24.
[13]叶诚沛,刘梦珊,徐单单,等.在哺乳动物细胞中表达hIGF-1[J].生物技术,2013(06):26-30.
[14]李伟,张飞燕,宋婷婷,等.藏猪与雅南猪IGF-I基因的克隆与序列分析[J].浙江农业学报,2015,27(08):1 324-1 330.
[15]Forsberg E A,Botusan I R,Wang J,et al.Carnosine decreases IGFBP1 production in db/db mice through suppression of HIF-1[J].Journal of Endocrinology,2015,225(3):159-167.
[16]Kang Z,Yu Y,Zhu Y J,et al.Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma.[J].Oncogene,2014,33(50):5697-5705.
[17]Lund P K,Hoyt E C,Yanwykj J.The size heterogeneity of rat insulin-like growth factor I mRNAs is due primarily to different、in the length of 3'-untranslated sequence[J].Molecular Endocrinolot,1989,3(12):2054-2061..
[18]Xin C,Zhu S,Duan D,et al.Investigation of the binding network of IGF-I on the cavity surface of IGFBP4[J].Journal of Molecular Modeling,2013,19(12):5257-5266.
[19]Simon C M,Rauskolb S,Gunnersen J M,et al.Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy[J].Acta Neuropathologica,2015,130(3):1-15.
[2]Tang S,Sun D,Ou J,et al.Evaluation of the IGFs(IGF1 and IGF2)genes as candidates for growth,body measurement,carcass,and reproduction traits in Beijing You and Silkie chickens[J].Animal biotechnology,2010,21(2):104-113.
[3]Perri A,Dallard B,Baravalle C,et al.Cellular proliferation rate and insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development.Journal Of Dairy Science.2015,97(8):4985-4996.
[4]Moriyama S,Ayson F G,Kawauchi H.Growth Regulation by Insulin-like Growth Factor-I in Fish[J].Bioscience Biotechnology&Biochemistry,2000,64(8):1553-1562.
[5]Dubey P,Nath A,Chandra V,et al.Expression of mRNA Encoding IGF-I,IGF-II,Type-I,and II IGF-Receptors and IGF-Binding Proteins-1-4 during Ovarian Follicular Development in Buffalo(Bubalus bubalis)[J].Animal Biotechnology,2015,26(2):81-91..
[6]Tian Y,Yue M,Gu Y,Gu W,Wang Y.Single-nucleotide polymorphism analysis of GH,GHR,and IGF-I genes in minipigs.Brazilian Journal Of Medical And Biological Research[J]2014;47(9):753-758.
[7]Roberts C T,Brown A L,Graham D E,et al.Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver[J].Journal of biological chemistry,1986,261(22):10025-10028.
[8]Straus D S,Takemoto C D.Specific decrease in liver insulin-like growth factor-I and brain insulin-like growth factor-II gene expression in energy-restricted rats[J].The Journal of nutrition,1991,121(8):1279-1286.
[9]Dayton,W.R.,Hembree,J R.,Hathaway,M.R.Isolation and culture of fetal porcine myogenic cells and the effectof insulin,IGF-I,and sera on protein turnover in porcine myotube cultures.Journal Of Animal Science,1991;69(8):32-41
[10]奚刚,许梓荣,戚益军.杜大长猪IGF-1基因的克隆及其序列分析[J].中国兽医学报,2000,20(1):74-76.
[11]Cong Z,Xiao-Lian L,Wei-Min W,et al.Characterization of GHRs,IGFs and MSTNs,and analysis of their expression relationships in blunt snout bream,Megalobrama amblycephala.[J].Gene,2013,535(2):239-249.
[12]Zhang H,Tong F D,Lu Q E.Cloning of Qiantang River Triangular Bream(Megalobrama terminalis)IGF-I Gene and Expression of the Recombinant pre-IGF-I in Escherichia coli[J].Applied Biochemistry&Biotechnology,2008,150(1):15-24.
[13]叶诚沛,刘梦珊,徐单单,等.在哺乳动物细胞中表达hIGF-1[J].生物技术,2013(06):26-30.
[14]李伟,张飞燕,宋婷婷,等.藏猪与雅南猪IGF-I基因的克隆与序列分析[J].浙江农业学报,2015,27(08):1 324-1 330.
[15]Forsberg E A,Botusan I R,Wang J,et al.Carnosine decreases IGFBP1 production in db/db mice through suppression of HIF-1[J].Journal of Endocrinology,2015,225(3):159-167.
[16]Kang Z,Yu Y,Zhu Y J,et al.Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma.[J].Oncogene,2014,33(50):5697-5705.
[17]Lund P K,Hoyt E C,Yanwykj J.The size heterogeneity of rat insulin-like growth factor I mRNAs is due primarily to different、in the length of 3'-untranslated sequence[J].Molecular Endocrinolot,1989,3(12):2054-2061..
[18]Xin C,Zhu S,Duan D,et al.Investigation of the binding network of IGF-I on the cavity surface of IGFBP4[J].Journal of Molecular Modeling,2013,19(12):5257-5266.
[19]Simon C M,Rauskolb S,Gunnersen J M,et al.Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy[J].Acta Neuropathologica,2015,130(3):1-15.
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