右美托咪定和咪达唑仑对重型颅脑外伤患者血流动力学的影响及镇静效果比较

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• 英文论文题名：The comparison of hemodynamics and sedative effect between dexmedetomidine and midazolam in patients with severe traumatic brain injury
• 论文作者：孙宝迪 ; 杨志洲 ; 孙兆瑞 ; 张炜 ; 任艺 ; 邵旦兵 ; 刘红梅 ; 聂时南
• 英文论文作者：SUN Bao-Di ; YANG Zhi-Zhou ; SUN Zhao-Rui ; ZHANG Wei ; REN Yi ; SHAO Dan-Bing ; LIU Hong-mei ; NIE Shi-Nan ; Department of Emergency Medicine ; General Hospital of Nanjing Military Region
• 年：2016
• 作者机构：南京军区南京总医院急救医学科;
• 论文关键词：右美托咪定 ; 咪达唑仑 ; 颅脑外伤
• 英文论文关键词：dexmedetomidine ; midazolam ; traumatic brain injury
• 会议召开时间：2016-06-17
• 会议录名称：2016中国中毒救治首都论坛——暨第八届全国中毒及危重症救治学术会议论文集
• 语种：中文
• 分类号：R651.15
• 学会代码：ZGDV
• 会议名称：2016中国中毒救治首都论坛——暨第八届全国中毒及危重症救治学术会议
• 会议地点：中国北京
• 主办单位：中国毒理学会中毒与救治专业委员会
• 学会名称：中国毒理学会
• 页数：3
• 文件大小：270k
• 原文格式：O
• 会议级别：全国

摘要

目的:明确右美托咪定及咪达唑仑对重型颅脑外伤患者血流动力学的影响及镇静效果。方法:选取EICU收治的重型颅脑外伤患者98例,随机分为两组,右美托咪定组(D组)49例及咪达唑仑组(M组)49例。D组患者采用静脉泵入右美托咪定镇静治疗,M组患者采用静脉泵入咪达唑仑镇静,记录两组患者用药前及用药后5、30、60、120 min的心率、血压、血氧饱和度,并评估不同时间点的Ramsay镇静评分。结果:D组患者在镇静前后各个时间点的心率、舒张压、脉氧维持稳定(P>0.05),M组患者的血流动力学参数则波动明显(P<0.05),且D组患者镇静后30、60 min的Ramsay镇静评分均大于M组(P<0.05)。结论:右美托咪定对重型颅脑外伤患者血流动力学的影响较小,镇静效果优于咪达唑仑。
Objective:In order to clarify the hemodynamic effect and sedation effect between dexmedetomidine and midazolam in patients with severe traumatic brain injury.Methods:98 patients of severe traumatic brain injury were randomly divided into two groups,49 cases of dexmedetomidine group(D group) and 49 cases of midazolam group(group M).Heart rate,blood pressure,blood oxygen saturation in two groups were recorded at the time points of before sedation,and 5min,30 min,60min,120 min after sedation.Ramsay sedation score were evaluated at different time points.Results:Heart rate,diastolic blood pressure,blood oxygen saturation in group D were maintain stability at every time points after sedation(P>0.05),The hemodynamic parameters in patients of group M were obvious fluctuation(P<0.05).Ramsay sedation score after 5min,30 min,60min of sedation in patients of group D were higher than group M(P<0.05).Conclusion:Dexmedetomidine has smaller effects on hemodynamics in patients with severe traumatic brain injury during sedation.And the sedation effect is better than midazolam.

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