血塞通协同氯吡格雷抗血小板聚集
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- 英文论文题名：Synergistic antiplatelet aggregation of Xue saitong and Clopidogrel Bisulfate
- 论文作者：马世堂 ; 毕肖林 ; 龚美蓉
- 英文论文作者：MA shi-tang ; BI Xiao-lin ; GONG Mei-rong ; Anhui Science and Technology University ; Nanjing University of Chinese Medicine
- 年：2016
- 作者机构：安徽科技学院;南京中医药大学;
- 论文关键词：血细胞 ; 血液流变学 ; 血凝参数 ; 氯吡格雷 ; 血塞通 ; 协同效应
- 英文论文关键词：hemorheology ; haemostatic parameters ; blood corpuscle parameters ; Xue saitong ; synergistic action
- 会议召开时间：2016-09-27
- 会议录名称：中国药学会第十三届青年药学科研成果交流会论文集
- 语种：中文
- 分类号：R285.5
- 学会代码：YYWS
- 会议名称：中国药学会第十三届青年药学科研成果交流会
- 会议地点：中国江西南昌
- 主办单位：中国药学会
- 学会名称：中国药学会
- 页数：7
- 文件大小：1174k
- 原文格式：O
- 会议级别：全国
摘要
目的:选择血液流变学(7个)、血凝参数(3个)、血细胞参数(22个)三种共计32个指标,观察血塞通与氯吡格雷协同效应。方法:SD大鼠60只,随机分为4组,即空白对照组(口服灌胃等体积生理盐水)、氯吡格雷单独给药组(口服灌胃30mg·kg~(-1))、血塞通单独组(口服灌胃50mg·kg~(-1))和合并给药组(灌胃氯吡格雷30mg·kg~(-1)和血塞通50mg·kg~(-1)),每组15只,连续给药100d,分别在第3、14、28、42、56、70、84天时检测白细胞、红细胞、血小板三类计22个血细胞指标动态变化趋势,第6、20、34、48、62、76、90天时分别采血检测血凝参数动态变化特征,第100天时检测体外血栓长度、血栓湿重、干重测定全血和血浆粘度测定,观察各组间血凝参数、血细胞参数动态趋势及血液流变学指标间差异,多角度考察两种药物协同增效。结果:除正常对照组外,其余各组均可在一定程度上降低白细胞、红细胞、血小板指标,延长血凝参数TT、APTT、PT,降低血液粘度,合用组较各单独给药组相比较,上述作用增强,与血塞通组相比较有统计学差异(p<0.05),与氯吡格雷单独组相比较,无统计学差异,但可改善氯吡格雷的药效抵抗效应。结论:在血液流变学、血凝参数、血细胞参数三种32个指标层面,两种药物联合应用时具有协同效应,可能具有改善氯吡格雷长期服药时药效低抵抗现象。
Objective To investigate the synergistic effection of Xue saitong and Clopidogrel Bisulfate(CPG) counteracting hemorheology,haemostatic and blood corpuscle index.Methods totally 60 SD rats were randomized into 4 groups included:normal control group(equal volume of saline),CPG alone group(30 mg·kg~(-1)),Xue saitong alone group(50 mg·kg~(-1)),co-administration group(CPG30 mg·kg~(-1) and Xue saitong 50 mg·kg~(-1) respectively).The rats received gastric infusion of corresponding drugs for 100 continuous days.Blood sample of SD rats were then collected by puncture of the orbital vein for the investigation of red blood cells,blood cells,platelet parameters' dynamic trend at the 3、 14、 28、 42、 56、 70、 84~(th) day respectively,and for the haemostatic parameters' dynamic tendency at the 6、20、34、48、 62、76、 90~(th) day respectively.Finally,the length,wet weight dry weight of in vitro thrombus,and the whole blood and plasma viscosity were determined by puncture of the abdominal artery at the 100~(th) day.Results The leukocyte,red blood cells,platelet parameters of blood cell index and blood viscosity was reduced,and the bleeding time of haemostatic parameters(TT、 APTT、 PT) was prolonged in the medication group.The above effect was much better in the combination groups.There were statistical differences between the combination and Xue saitong alone group(p<0.05),and no statistical differences between the combination and CPG alone group.Conclusion there were synergistic effect of Xue saitong and CPG combination by modulating hemorheology、 haemostatic and blood corpuscle parameters
Objective To investigate the synergistic effection of Xue saitong and Clopidogrel Bisulfate(CPG) counteracting hemorheology,haemostatic and blood corpuscle index.Methods totally 60 SD rats were randomized into 4 groups included:normal control group(equal volume of saline),CPG alone group(30 mg·kg~(-1)),Xue saitong alone group(50 mg·kg~(-1)),co-administration group(CPG30 mg·kg~(-1) and Xue saitong 50 mg·kg~(-1) respectively).The rats received gastric infusion of corresponding drugs for 100 continuous days.Blood sample of SD rats were then collected by puncture of the orbital vein for the investigation of red blood cells,blood cells,platelet parameters' dynamic trend at the 3、 14、 28、 42、 56、 70、 84~(th) day respectively,and for the haemostatic parameters' dynamic tendency at the 6、20、34、48、 62、76、 90~(th) day respectively.Finally,the length,wet weight dry weight of in vitro thrombus,and the whole blood and plasma viscosity were determined by puncture of the abdominal artery at the 100~(th) day.Results The leukocyte,red blood cells,platelet parameters of blood cell index and blood viscosity was reduced,and the bleeding time of haemostatic parameters(TT、 APTT、 PT) was prolonged in the medication group.The above effect was much better in the combination groups.There were statistical differences between the combination and Xue saitong alone group(p<0.05),and no statistical differences between the combination and CPG alone group.Conclusion there were synergistic effect of Xue saitong and CPG combination by modulating hemorheology、 haemostatic and blood corpuscle parameters
引文
[1]马世堂,戴国梁,赵文珠,等.基于液相色谱质谱联用氯吡格雷-人参皂苷血浆蛋白结合率协同效应[J].南方医科大学学报,2015,01:109-112.
[2]区腾飞,李艳秋,王鹏,等.氟桂利嗪联合血塞通治疗偏头痛的临床疗效研究[J].中国医学工程,2015,01:111+114.
[3]刘强,邓华聪,何辉,等.银丹心脑通软胶囊对2型糖尿病患者血小板活化因子、血液流变学和血管内皮细胞功能的影响[J].中国现代应用药学,2015,01:86-89.
[4]鲍凤香,张书嘉,张燕平,等.突发性聋患者血凝常规及血常规参数临床分析[J].临床耳鼻咽喉头颈外科杂志,2015,01:52-56.
[5]吕辉,郝世勇.乙型肝炎肝硬化患者血细胞参数的变化及意义[J].临床血液学杂志(输血与检验),2015,01:115-117.
[6]张文清,唐萍.迈瑞BC-5500血液细胞分析仪在异型淋巴细胞检测中的临床应用[J].兵团医学,2013,02:27-28.
[7]赵晓秋,高荣升,张雁来,等.复方丹参注射液联合复方甘草酸苷注射液对银屑病血凝状态影响随机平行对照研究[J].实用中医内科杂志,2014,05:87-90
[8]白云城,赵学凌,周如丹,等.动物模型血栓长度及重量比较探索深静脉血栓形成病变分期[J].中国修复重建外科杂志.2014,04:507-510-2.
[9]张丽,李良.银杏达莫联合洛伐他汀对急性脑梗塞患者全血、血浆粘度,TC、TG、HDL-C及LDL-C水平变化的影响[J].中外医疗,2014,12:130-131.
[10]赵小梅,彭成,熊亮,等.益母草注射液有效部位提取及其对凝血系统的影响研究[J].中国中医基础医学杂志,2014,03:390-392.
[11]郭云飞,吴永健,肖文琦,等.氯毗格雷抵抗患者应用替格瑞洛临床疗效[J].临床荟萃,2015,01:1-5.
[2]区腾飞,李艳秋,王鹏,等.氟桂利嗪联合血塞通治疗偏头痛的临床疗效研究[J].中国医学工程,2015,01:111+114.
[3]刘强,邓华聪,何辉,等.银丹心脑通软胶囊对2型糖尿病患者血小板活化因子、血液流变学和血管内皮细胞功能的影响[J].中国现代应用药学,2015,01:86-89.
[4]鲍凤香,张书嘉,张燕平,等.突发性聋患者血凝常规及血常规参数临床分析[J].临床耳鼻咽喉头颈外科杂志,2015,01:52-56.
[5]吕辉,郝世勇.乙型肝炎肝硬化患者血细胞参数的变化及意义[J].临床血液学杂志(输血与检验),2015,01:115-117.
[6]张文清,唐萍.迈瑞BC-5500血液细胞分析仪在异型淋巴细胞检测中的临床应用[J].兵团医学,2013,02:27-28.
[7]赵晓秋,高荣升,张雁来,等.复方丹参注射液联合复方甘草酸苷注射液对银屑病血凝状态影响随机平行对照研究[J].实用中医内科杂志,2014,05:87-90
[8]白云城,赵学凌,周如丹,等.动物模型血栓长度及重量比较探索深静脉血栓形成病变分期[J].中国修复重建外科杂志.2014,04:507-510-2.
[9]张丽,李良.银杏达莫联合洛伐他汀对急性脑梗塞患者全血、血浆粘度,TC、TG、HDL-C及LDL-C水平变化的影响[J].中外医疗,2014,12:130-131.
[10]赵小梅,彭成,熊亮,等.益母草注射液有效部位提取及其对凝血系统的影响研究[J].中国中医基础医学杂志,2014,03:390-392.
[11]郭云飞,吴永健,肖文琦,等.氯毗格雷抵抗患者应用替格瑞洛临床疗效[J].临床荟萃,2015,01:1-5.
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