摘要
示波测定就是利用示波图上切口深度或峰高进行微量乃至于痕量物质直接或间接测定的方法。该法具有简单、方便、快速、经济、不需要通氮除氧和适于例行分析和过程分析等优点,在环境、医药和冶金等领域有广阔的应用前景。本论文主要开展药物的直接和间接示波测定方法的应用研究。全文共分四章,作者的主要贡献有以下三点:
1、分别根据酚磺乙胺和盐酸普罗帕酮在示波图阴极支上的切口深度随加入量的增加而变深的示波特性建立了这两种药物示波直接测定法。
2、根据β-环糊精(β-CD)与头孢哌酮钠、盐酸金刚烷胺及烟酰胺与Cd~(2+)、烟酸与Cr~(3+)形成配合物的性质,建立了测定头孢哌酮钠、盐酸金刚烷胺、烟酰胺和烟酸的示波测定新方法,并测定了β-CD-盐酸金刚烷胺包结物的包结比和包结常数。
3、KIO_3在示波图上能产生一灵敏切口或峰,还原性物质Vc能使KIO_3的切口变浅或峰高降低。根据KIO_3的示波特性建立了直接测定KIO_3和间接测定Vc的示波方法。
在上述研究中,配位体系和氧化还原体系中的示波测定方法研究是提高示波分析灵敏度、扩大示波分析应用范围的一条重要途径。
Oscillographic chronopotentiometric determination is a kind of direct or indirect determination method for microanalysis or trace analysis based on the incision depth or peak height on oscillogram. The method has the advantages of simplicity, convenience, economy and no need of O2-eliminated. In addition, the method can be applied to routine analysis and process analysis. Hence the method has extensive application foreground in environment, medicament, metallurgy and other fields. In this thesis, application of direct and indirect oscillographic determination methods in pharmaceutical analysis was investigated. This thesis consists of four chapters, author's main contribution is as follows:
1. The incision depth of etamsylate and propafenone hydrochloride on the cathodic branch of oscillogram get deep when these two medicaments are added to the solution of NaOH, respectively. Based on this, the direct determination method of these medicaments was established.
2. Oscillographic determination methods of cefoperazone sodium, amantadine hydrochloride, nicotinamide and nicotinic acid were proposed based on the characteristics of complex formed between B-CD and cefoperazone sodium or amantadine hydrochloride, nicotinamide and Cd2+, nicotinic acid and Cr3+. At the same time, inclusion rate and inclusion constant on inclusion complex of |3-CD-amantadine hydrochloride were determined.
3. KIO3 can cause a sensitive incision or a peak on oscillogram, and the incision depth would get shallow when Vc was added into the solution. Upon that, a direct determination method of KIO3 and indirect determination method of Vc were established.
Thus, the investigation of oscillographic determination in complex system and redox system is an important approach of improving the sensitivity of oscillographic determination and enlarging the application range of oscillographic analysis.
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