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台北地区外感热病证治特点与湿热体质人群调查分析研究
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摘要
研究目的:
     本次研究通过结合流行病学和临床调查研究,总结分析台北地区的外感热病的患者的各种病历资料及调查台北人群中医体质情况,分析与外感热病与临床病种的相关性,以期能大体上对台北地区外感热病的证型规律、发病时间特点、外感热病患者的症状群、中药、方剂使用的相关特点,以及湿热质人群与血脂四项、免疫指标相关性的认识。
     研究方法:
     首先通过调查收集2012年1月至2012年12月台北市五个地区的(松山区、大安区、木栅区、内湖区、北投区)中医诊所的当地的(外地人除外)外感病患者100例外感热病的筛选纳入,对纳入的外感热病患者进行中医辨证和分组分析(对照组:暑温证和风温证,实验组为湿温证),分析各种证型在发病时间、外感热病患者的症状群、用药规律等方面研究;最后通过300例体检者中医体质调查,选取各100例湿热质人群及与非湿热质人群进行抽血检验检查:血脂四项、免疫指标(IgA、IgM、IgG、C3、C4)的对照比较,总结出血脂四项以及免疫指标(IgA、IgM、IgG、C3、C4)与湿热质的相关性和联系性。
     结果:
     (1)纳入研究的外感热病的100例患者根据不同外感病的表现,中医辨证诊断为湿热证共有49例,占49%;诊断为风温证共有22例,占22%;诊断为暑温的共有29例,占29%。
     (2)100例外感热病患者当中,分别对其症状出现到就诊的时间及病程时间的长短进行统计。其中湿热证的患者从起病到就诊的时间平均为14.5-16.9天左右,病程天数平均为35.9-47.8天。风温证的患者从起病到就诊时间平均为8.3-10.1天,病程为21.3-27.1天;暑温证的患者从起病到就诊时间平均为4.1天,病程平均为10.5天。
     (3)纳入的49例外感热病湿热证的患者中,诊断为上呼吸道感染有14例(28.6%);诊断为胃肠型感冒有10例(20.4%);诊断为急性胃肠炎有20例(40.8%);泌尿系感染3例(6.1%);细菌性痢疾2例(4.1%)。22例风温证患者当中,诊断为上呼吸道感染有14例(63.6%),炎有8例(36.4%);诊断为泌尿系感染4例(13.8%);诊断为胃肠型感冒有15例(51.7%);诊断为流行性感冒有10例(34.5%)。
     (4)本研究病例的中药运用统计共出现了147种药物,总频次2039次,涵盖了《中药学》分类中除收涩药、涌吐药、拔毒生肌药、驱虫药之外的17类药物,其中用频率由高到低前10位依次为清热药,化湿药,解表药,化痰止咳,理气药,补气药,利水渗湿药,消食药,补阴药,凉血药。
     (5)纳入本研究100例外感热病患者主要辩证分型为湿热证、风温证、暑温证三种不同证型,使用的中药共147种。其中使用排前15味中药从高到低依次为:黄芩(12.1%),黄连(9.9%),藿香(9.5%),黄柏(7.8%),苍术(7.6%),茯苓(7.1%),桑叶(6.4%),香薷(5.0%),厚朴(4.6%),金银花(4.2%),连翘(3.9%),杏仁(3.6%),玄参(3.4%),鱼腥草(3.3%),薏苡仁(3.2%)。
     (7)100例湿热质患者与100例非湿热质人群进行抽血实验检验对照比较,其中血脂四项(TC、TG、 HDL-C、LDL-C)比较方面,其中HDL-C两组间比较P>0.05,经统计学处理,两组间差距不明显,TC及TG两组间比较P<0.05,经统计学处理,有显著性变化,有明显差距,LDL-C两组间比较P<0.01,经统计学处理,有显著性变化,有极明显差距。
     (8)100例湿热质患者与100例非湿热质人群进行抽血实验检验对照比较,在免疫指标(IgA、IgM、IgG、C3、C4)比较方面,其中C4两组间比较P>0.05,经统计学处理,两组间差距不明显;IgA、IgG及C3两组间比较P<0.05,经统计学处理,有显著性变化,有明显差距,IgM两组间比较P<0.01,经统计学处理,有显著性变化,有极明显差距。
     结论:
     (1)台北地区的特有的地理环境,台北地区居民的生活饮食习惯以及台北地区受到湿热气候的影响,决定了该地区容易滋生湿热外邪,湿热之邪容易缠绵难化。加上该地区居民因脾阳受伤,脾胃失运,易生痰湿,且台湾地区水产丰富,膏粱厚味为脾胃酝酿湿热提供了条件,因此总体来说中医体质分类以湿热证居多。
     (2)台北地区的外感热病患者中属于暑温证得发病最急,症状来势较为凶险,但病程最短,其次是风温,而湿热证患者的发病程度最为缓慢,
     (3)本研究病例的中药运用统计共出现了147种药物,总频次2039次,其中用频率由高到低前10位依次为清热药,化湿药,解表药,化痰止咳,理气药,补气药,利水渗湿药,消食药,补阴药,凉血药。
     (4)在对本研究100例外感热病患者诊治过程中,共使用的中药共147种。其中使用排前15味中药从高到低依次为:黄芩(12.1%),黄连(9.9%),藿香(9.5%),黄柏(7.8%),苍术(7.6%),茯苓(7.1%),桑叶(6.4%),香薷(5.0%),厚朴(4.6%),金银花(4.2%),连翘(3.9%),杏仁(3.6%),玄参(3.4%),鱼腥草(3.3%),薏苡仁(3.2%)。
     (5)本研究100例外感热病主要辨证为湿热证、风温证、暑温证三种不同外感证型,最常使用的方剂前10位前后依次为:龙胆泻肝汤,甘露消毒丹,藿香正气散,葛根芩连汤,新加香薷饮,黄连解毒汤,三黄泻心汤,清暑益气汤,竹叶石膏汤,甘露饮,秦艽鳖甲散。
     (6)台北地区的湿热质人群在免疫指标(IgA、IgM、IgG、C3、C4)方面,其中检测指标C4与非湿热质人群差距不明显;IgA、IgG及C3明显高于非湿热质人群,差距有显著性意义。
     (7)台北地区的湿热质人群在血脂四项(TC、TG、 HDL-C、LDL-C)方面,其中检测指标HDL-C与非湿热质人群差距不明显:在TC、TG及LDL-C明显高于非湿热质人群,差距有显著性意义。
Objective:
     Through combining of epidemiological and analyzing TCM constitution scale survey, the study summarized and analyzed the patients with a variety of medical records, included in the study living in the Taipei area diagnosed exogenous febrile, analyzed the correlation to make a further understanding of the laws of the TCM constitution classification in exogenous disease, the using features of Chinese medicine, as well as the relations between blood lipids, immune parameters and damp-heat constitution.
     Methods:
     In traditional chinese medicine clinics of the five areas in Taipei(Songshan District, Da-an District, Xindian District, Neihu District, Beitou District),firstly100local exogenous patients were collected for questionnaire from January2012to December2012. The survey method was to design of a unified Chinese medicine constitution classification questionnaire, mainly in the form of questions and answers, to understand the usual physical condition of patients, filling in the questionnaire. The study analyzed the distribution of the various syndromes in the Taipei area, and make a research for the symptom clusters of the damp-heat syndrome patients to understand the group characteristics and the herbal prescription rule of the paitents diagnosed damp-heat syndrome of exogenous disease.Finally compared the damp-heat constitution volunteer'blood tests with no-damp-heat constitution volunteers, such as blood lipids, the immune parameters (IgA, IgM, IgG, C3, C4),in order to summarize the relation between blood lipids, immune parameters (IgA, IgM, IgG, C3, C4) and the damp-heat constitution. Results:
     (1) Combining with the Chinese medicine constitution classification of the100patients with exogenous disease, the damp-heat patients accounted for a large proportion of33.3%, followed by17%of the Qi deficiency, other segment accounted approximately for49.7%.
     (2) Based on the performance of different exogenous disease,49of the100patients classified as exogenous disease were diagnosed damp-heat syndrome (summer-heat and damp syndrome, damp-heat syndrome), accounting for49%;22were diagnosed hot blast temperature syndrome, accounting for22%;29were diagnosed summer-heat syndrome, accounting for29%.
     (3) Collected statistics for the length of time from their symptoms appearing to the treatment and duration for the100patients classified as exogenous disease. The average time of damp-heat syndrome patients (summer-heat and damp syndrome, damp-Heat syndrome) for treatment was14.5-16.9days, the average length of duration was35.9-47.8days. The average time of hot blast temperature syndrome for treatment was8.3-10.1days, the average length of duration was21.3-27.1days. The average time of summer-heat syndrome for treatment was4.1days, the average length of duration was10.5days.
     (4) In this study,14of the49damp-heat syndrome patients were diagnosed as upper respiratory tract infection (28.6%).10patients were diagnosed as gastrointestinal flu(20.4%),20patients were diagnosed as acute gastroenteritis(40.8%).3patients were diagnosed as urinary tract infection(6.1%).2patients were diagnosed as bacillary dysentery cases(4.1%).14of the22hot blast temperature syndrome patients were diagnosed as upper respiratory tract infection(63.6%),8patients were diagnosed as pneumonia.4of the29summer-heat syndrome patients were diagnosed as urinary tract infection(13.8%).15patients were diagnosed as urinary tract infection(51.7%).10patients were diagnosed as influenza (34.5%)
     (5) In this study,147kinds of traditional Chinese medicine were used for the patients.The total frequency was2039, covering17classifications from the Chinese medcine, in addition to the astringent medicine, emetic medicine, the Sida and the myogenic medicine, anthelmintic medicine, the ranking in the top10in turn were antipyretic medicine, dampness medicine, medicine for relieving exterior syndrome, expectorant cough medicine, medicine for regulating Qi flow, qi tonifying medicine, eliminating dampness through diuresis medicine, digestion medicine, yin tonic medicine, blood-cooling medicine.
     (6) In this study,100patienets classified as exogenous disease were diagnosed summer-heat and damp syndrome, damp-heat syndrome, summer-heat syndrome,147kinds of traditional Chinese medicine were used for them. The ranking in the top15in turn were skullcap (12.1%), berberine (9.9%), Agastache (9.5%), Cork (7.8%), herb (7.6%), Poria (7.1%), folium mori (6.4%), Elsholtzia (5.0%), Magnolia (4.6%), honeysuckle (4.2%) the forsythia (3.9%), almonds (3.6%), the Scrophulariaceae (3.4%), Nepeta (3.3%), Coix (3.2%).
     (7) Comparing the blood test of the100volunteers classified as hot and humid quality with100no-damp-heat constitution volunteers. The result of the lipids four (TC, TG, HDL-C, LDL-C) showed HDL-C were not statistically different between the two groups (P>0.05), TC and TG between the two groups were statistically different (P<0.05), LDL-C between two groups were also statistically different(P<0.01).
     (8) Comparing the blood test of the100volunteers classified as damp-heat constitution with100no-damp-heat volunteers. The result of immune parameters (IgA, IgM, IgG, C3, C4) showed C4between the two groups were not statistically different (P>0.05), IgA, IgG and C3between the two groups were statistically different (P<0.05), IgM between two groups were also statistically different (P (0.01).
     Conclusion:
     (1) Because of the unique geographical environment, the eating habits of life of the residents and the hot and humid climate in Taipei, it is easy to breed heat evils in this area, and damp heat evil is easy to lingering hard. Coupled with The damaged Spleen Yang of the inhabitants in this area, it led to the loss of transport of spleen and stomachstomach, and metaplasia of phlegm prone phlegm. Taiwan is rich in aquatic products, too much greasy food become the condition for hot and humid, therefore damp-heat syndrome occupies most of the inhabitants in this area.
     (2) In Taipei area, among the the exogenous disease, the one belonging to Damp-heat syndrome was the most acute disease, the symptoms of the disease come with a more terrifying force, but duration was the shortest, followed by the hot blast temperature syndrome, the onset of summer-heat syndrome was the slowest.
     (3) In this study,147kinds of traditional Chinese medicine were used for the patients. The total frequency was2039, the ranking in the top10in turn were antipyretic medicine, dampness medicine, medicine for relieving exterior syndrome, expectorant cough medicine, medicine for regulating QI flow, qi tonifying medicine, eliminating dampness through diuresis medicine, digestion medicine, yin tonic medicine, blood-cooling medicine.
     (4) In this study,100patienets classified as exogenous disease were diagnosed summer-heat and damp syndrome, Damp-Heat syndrome, summer-heat syndrome,147kinds of traditional Chinese medicine were used for them. The ranking in the top15in turn were skullcap (12.1%), berberine (9.9%), Agastache (9.5%), Cork (7.8%), herb (7.6%), Poria (7.1%), folium mori (6.4%), Elsholtzia (5.0%), Magnolia (4.6%), honeysuckle (4.2%) the forsythia (3.9%), almonds (3.6%), the Scrophulariaceae (3.4%), Nepeta (3.3%), Coix (3.2%).
     (5) In this study, different kinds of prescriptions were usd for the patients classified as hot and humid quality when they were diagnosed summer-heat and damp syndrome.The ranking of the most commonly used prescriptions in the top15in turn were as follows:Damp-Heat syndrome, summer-heat syndrome, Longdan Xiegan decoction, ganlu xiaodu micropills, huoxiang zhengqi powder, gegen qinlian decoction, Xin Jia Xiang Ru Yin, huanglian jiedu decoction, Sanhuang Xiexin Decoction, qingshu yiqi decoction, zhuye shigao decoction, Gan Lu Yin, Qin Jiu Bie Jia San.
     (6) The result of the immune parameters (IgA、IgM、IgG、C3、C4) of the volunteers classified as hot and humid quality in Taipei showed that C4was not obviously different comparing with no-damp-heat volunteers, while the level of IgA, IgG and C3were much higher than they were checked in the healthy, and the gap was significant.
     (7) The result of the lipids four (TC、TG、HDL-C、LDL-C) of the volunteers classified as hot and humid quality in Taipei area showed that HDL-C was not obviously different comparing with no-damp-heat constitution volunteers, while the level of TC, TG and LDL-C were much higher than they were checked in the healthy, and the gap was significant.
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