新型光微流体光器件的设计、制备及其应用研究
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摘要
微流控光学是光学和微流控技术的结合。相对于传统的固体器件，微流控光学器件在尺寸上微型化、可调谐手段上更多样化、可集成于芯片实验室中用于化学生物分析检测。本论文研究了基于PDMS芯片的微流控光学器件及拓展了其应用，对微流控光学器件的光学特性进行表征及探讨。
磁流体在磁场作用下显示出比较显著的磁光效应。我们首次制备了磁流体液芯光纤，液芯为磁性颗粒半径为10nm的石蜡基Fe3O4磁流体。在不同磁场下对光纤出射光强进行调谐及理论计算了光纤中光波模式。实验结果与理论计算相吻合，并给出了磁流体液芯光纤的传输损耗。
集成型光源对于微全分析系统中生物化学分析检测有着深远的意义。在上述背景下，我们展开了微型染料激光器的研究。采用传统的光刻及PDMS快速原型复制制备了微环形谐振腔结构。因其损耗较大，泵浦阈值较高，通过结构设计上的改进，大大降低了激光泵浦阈值。
我们运用两种相溶液体的层流机制进行了微型干涉仪的研究。结果表明，改变两相液体注入的流速比时，干涉曲线发生变化，干涉峰个数逐渐增加。为了更清晰表征微通道中的液体的扩散情况，在理论上进行了折射率分布的模拟。同时，我们也记录了在不同流速比情况下，两相液体交界面位置的变化。基于干涉现象的折射率计在传感器中应用比较广泛。
随着近期微流控液滴的应用方面的广泛研究，我们利用产生微液滴的机制制备了微型信号发生器，并拓展了其应用。实验结果表明，产生的信号频率及波形通过改变液体的流速比来控制，给出了信号频率与流速比不变情况下的关系曲线。在信号发生器的基础上，设计双T结构实现信号编码器。微流控光学器件的研究促使了集成光学的发展，也对芯片实验室提供更多更便携化的功能。
Optofluidics, where optics and microfluidics are working together, is defined as a newfield and technology. Compared with traditional rigid optical devices, optofluidic elementsshow features due to the miniaturization in the size, various tunable mechanisms andintegration for analysis and detection of biochemistry. This dissertation is mainly concernedwith the optofluidic devices and its applications based on PDMS. Moreover, the opticalproperties of optofluidic devices are characterized and discussed.
We firstly report the fabrication of magnetic fluid core optical fiber. Paraffin-basedFe3O4magnetic fluid is selected as the liquid and filled in a hollow core fiber. The magneticparticle size is10nm. Transmitted intensity of magnetic fluid core optical fiber dependent onmagnetic field is studied. The theoretical about mode calculation is in accordance with theexperimental results and the optical loss is also given.
The integration of dye lasers with microfluidics facilitates the implementation of“lab-on-a-chip” for analysis of biochemistry. We studied microring dye laser in the abovecontext. The PDMS chip is fabricated through conventional lithography and the rapidprototyping. The threshold is relatively high resulting from cavity loss. A reduced threshold isrealized by the unique design of the bus waveguide across the center of the microringstructure.
We experimentally demonstrated a tunable interferometer controlled by diffusion throughthe laminar flow of two miscible liquids. The results show that the peak numbers of theinterference curves are increasing with the flow rate ratio. A program is written in COMOSL to calculate the refractive index gradient at different flow rates. Micrographs of the differentlocation of the interface under the different flow rate ratio are given. Such an interferometerpaves the way for biochemical tests in sensing system.
Droplet microfluidics has drawn much attention due to its intensive applications. A signalgenerator is realized by droplet grating which is generated through a typical microfluidicT-junction. Experimental results show that the frequency and waveforms of signals can bemodulated by flow rate ratio. The coding device serves as an example for applications byintegrating the signal generator with another T-junction. The investigation of optofluidicdevices facilitate the development of integrated optics and also offer more functionalities to“Lab-on-a chip”.
磁流体在磁场作用下显示出比较显著的磁光效应。我们首次制备了磁流体液芯光纤，液芯为磁性颗粒半径为10nm的石蜡基Fe3O4磁流体。在不同磁场下对光纤出射光强进行调谐及理论计算了光纤中光波模式。实验结果与理论计算相吻合，并给出了磁流体液芯光纤的传输损耗。
集成型光源对于微全分析系统中生物化学分析检测有着深远的意义。在上述背景下，我们展开了微型染料激光器的研究。采用传统的光刻及PDMS快速原型复制制备了微环形谐振腔结构。因其损耗较大，泵浦阈值较高，通过结构设计上的改进，大大降低了激光泵浦阈值。
我们运用两种相溶液体的层流机制进行了微型干涉仪的研究。结果表明，改变两相液体注入的流速比时，干涉曲线发生变化，干涉峰个数逐渐增加。为了更清晰表征微通道中的液体的扩散情况，在理论上进行了折射率分布的模拟。同时，我们也记录了在不同流速比情况下，两相液体交界面位置的变化。基于干涉现象的折射率计在传感器中应用比较广泛。
随着近期微流控液滴的应用方面的广泛研究，我们利用产生微液滴的机制制备了微型信号发生器，并拓展了其应用。实验结果表明，产生的信号频率及波形通过改变液体的流速比来控制，给出了信号频率与流速比不变情况下的关系曲线。在信号发生器的基础上，设计双T结构实现信号编码器。微流控光学器件的研究促使了集成光学的发展，也对芯片实验室提供更多更便携化的功能。
Optofluidics, where optics and microfluidics are working together, is defined as a newfield and technology. Compared with traditional rigid optical devices, optofluidic elementsshow features due to the miniaturization in the size, various tunable mechanisms andintegration for analysis and detection of biochemistry. This dissertation is mainly concernedwith the optofluidic devices and its applications based on PDMS. Moreover, the opticalproperties of optofluidic devices are characterized and discussed.
We firstly report the fabrication of magnetic fluid core optical fiber. Paraffin-basedFe3O4magnetic fluid is selected as the liquid and filled in a hollow core fiber. The magneticparticle size is10nm. Transmitted intensity of magnetic fluid core optical fiber dependent onmagnetic field is studied. The theoretical about mode calculation is in accordance with theexperimental results and the optical loss is also given.
The integration of dye lasers with microfluidics facilitates the implementation of“lab-on-a-chip” for analysis of biochemistry. We studied microring dye laser in the abovecontext. The PDMS chip is fabricated through conventional lithography and the rapidprototyping. The threshold is relatively high resulting from cavity loss. A reduced threshold isrealized by the unique design of the bus waveguide across the center of the microringstructure.
We experimentally demonstrated a tunable interferometer controlled by diffusion throughthe laminar flow of two miscible liquids. The results show that the peak numbers of theinterference curves are increasing with the flow rate ratio. A program is written in COMOSL to calculate the refractive index gradient at different flow rates. Micrographs of the differentlocation of the interface under the different flow rate ratio are given. Such an interferometerpaves the way for biochemical tests in sensing system.
Droplet microfluidics has drawn much attention due to its intensive applications. A signalgenerator is realized by droplet grating which is generated through a typical microfluidicT-junction. Experimental results show that the frequency and waveforms of signals can bemodulated by flow rate ratio. The coding device serves as an example for applications byintegrating the signal generator with another T-junction. The investigation of optofluidicdevices facilitate the development of integrated optics and also offer more functionalities to“Lab-on-a chip”.
引文
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