温针结合中药治疗慢性前列腺增生的临床研究
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摘要
前列腺增生症是中老年男性常见疾病。随着人口老龄化进程,其发病率将进一步增加,严重影响老年男性的生活质量,甚至出现各种并发症,威胁病人的生命,成为影响我国老年男性健康的最重要的疾病之一,是二十一世纪面临的严峻课题。
温针疗法是将针刺和艾灸结合的中医特色疗法,在治疗许多疾病中,尤其是对中医辨证虚证的病症发挥其独特疗效。本研究拟采用温针疗法治疗慢性前列腺增生虚证患者,期望借此研究能开拓该病治疗的有效途径,为目前在人群中发病率较高的慢性前列腺增生提供一种新的安全有效的治疗方案。
目的
本课题采用临床流行病学、临床科研方法学及数理统计分析方法,进行临床随机对照研究,观察温针灸结合中药治疗中医辨证属虚症(肾阳不足、肝肾亏虚)的慢性前列腺增生症,以期证实温针灸治疗前列腺增生症虚症的确切疗效。
方法
根据《中药新药临床研究指导原则》关于癃闭的诊断标准,收集2008年2月至2009年2月期间在台湾贺安中医诊所就诊的符合病例筛选标准的50例慢性前列腺增生症患者。采用单盲随机化方法,按1：1对照原则分为试验组、对照组,试验组采用温针灸结合中药治疗,对照组采用单纯中药治疗。一周为一个疗程,连续二个疗程后观察治疗前后前列腺体积、残余尿量及其临床疗效。用EPIDATA3.1软件建立数据库,用SPSS15.0软件进行统计分析。计量资料用均数±标准差(x±S)表示,计数资料用构成比(%)表示。计量资料组间比较采用t检验(方差不齐采用t’检验或秩和检验),自身前后比较用配对t检验或Wilcoxon配对秩和检验。分类资料组间比较采用χ2检验,等级资料组间比较采用Wilcoxon秩和检验。统计图形的制作采用软件Graph Pad Prism 4.03完成。
结果
临床共收集合格病例50例,均为50岁以上的老年人。温针灸结合中药治疗组(简称试验组)25例,年龄最小50岁,最大73岁,平均年龄61.34±5.32岁,病程最短者3年,最长者15年,平均8.34±2.78年；中药治疗组(简称对照组)25例,年龄最小51岁,最大66岁,平均年龄58.92±4.96岁。病程最短者1年,最长者12年,平均6.89±2.63年。
患者基线特征的可比性分析中,试验组与对照组年龄、病程、病情程度、治疗前前列腺体积、残余尿量比较,差异均无统计学意义,两组患者基线特征具有可比性。
主要研究指标疗效,在改善前列腺体积方面,试验组与对照组治疗后差异无统计学意义。各组治疗前与治疗后比较,两组均无统计学意义。提示：提示温针灸结合中药治疗组和单纯中药组对前列腺体积无明显影响。在改善残余尿量方面,治疗后两组差异有统计学意义。各组治疗前与治疗后比较,两组均有统计学意义。提示：两组治疗方法都能改善尿路的梗阻状态,试验组残余尿量改变量较对照组大,提示温针灸结合中药治疗组解除尿路梗阻的疗效优于对照组。在临床疗效方面,试验组25例患者,显效5例,有效17例,总有效率88.0%；单纯中药组25例患者,显效0例,有效16例,总有效率64.0%。两组临床疗效与总有效率的比较,差异均有统计学意义。且试验组的总有效率较对照组高。提示：经温针灸结合中药治疗后,前列腺增生患者的临床症状明显改善,效果显著。
结论
结合临床,温针灸结合中药治疗组能解除尿路梗阻症状,疗效肯定,初步证明了采用温针灸结合中药的方法治疗慢性前列腺增生虚证可有效提高其临床疗效,值得推广。
Hyperplasia of prostate is a common disease in older men. With the population aging process, the incidence rate will further increase, seriously affecting quality of life of older men, or even complications, threatening the patients'life. It has been one of the most important diseases that infects the health of old men and become a very topic in the 21st century.
Warm needling moxibustion is a therapy combined with needling and moxibustion, which has the Chinese characteristics in the treatment of many diseases, especially diseases with deficency syndrome by TCM differentiation of symptoms and signs. This therapy can play an unique effect. In this study, We intend to apply warm needling moxibustion therapy in patients with chronic hyperplasia of prostate of deficency syndrome, and hope that this study will explore an effective way to treat this disease and provid a new safe and effective treatment program for it has a higher disease incidence in present population.
Objective
This study use clinical epidemiology and clinical scientific research, mathematical statistics and analytical method, by randomized controlled study, the objective of this reseach is to observe the clinical effect of warm needling moxibustion conbined with Chinese herbs in treating chronic hyperplasia of prostate of deficency syndrome (deficency of kidney or deficency of liver and kidney) and to confirm the therapy of Warm needling moxibustion has an exact effect n the exact effect in treating this disease.
Methods
According to the diagnostic criteria of retention of urine/uroschesis in guiding principles of new drugs in Chinese medicine clinical research, we collected 50 cases of patients with chronic hyperplasia of prostate who met the criteria from Taiwan Chenzhengang'TCM Clinical during February 2008 and February 2009. Applying randomized single-blind method, we diveded the reseach objects into test group and control group in the ratio of 1:1. The patients in test group were treated with warm needling moxibustion conbined with Chinese herbs, and the other ones treated with pure Chinese herbs. One week for a course of treatment.
After two course, observing the changes on prostate volume, residual urine volume and its clinical effect before and after treatment.
Using EpiData 3.1 software to establish database and statistical software SPSS15.0 to complete statistical analysis.Measurement data with means±tandard deviation (x±S), numeration data with composition ratio (%), measurement data between groups with T-test (heterogeneity of variance with t'test or rank sum test), before and after itself with paired-samples T-test or Wilcoxon paired rank sum test, Categorical data between groups with Chi-Square test, ranked data between groups with Wilcoxon rank sum test. Making use of statistical graphics software Graph Pad Prism 4.03 to complete statistical graph.
Results
5o qualified clinical cases were collected and the patients were all over 50 years old. Warm needling moxibustion conbined with Chinese herbs group(simplely called test group) 25 cases, the youngest 50 years old, the oldest 73 years old, mean age 61.34±5.32, the shortest disease duration 3 years, the longest 15 years, mean disease duration 8.34±2.78 years; Chinese herbs goup(control group) 25 cases, the youngest 51 years old, the oldest 66 years old, mean age 58.92±4.96, the shortest disease duration 1 years, the longest 12 years, mean 6.89±2.63 years.
Comparability of baseline characteristics of patients in the test group and control group in age, duration, severity, prostate volume and residual urine volume before treatment, the difference had no statistical significance,meaning the baseline characteristics of the two groups were comparable.
The effect of main study indicators:the difference was not statistically significant (P> 0.05) in improving prostate volume in the two group. Comparing the difference of each group on this aspect before and after treatment, the results showed no statistically significant difference in both groups, indicating that these two therapies had no impact on Prostate volume. The difference was statistically significant (P<0.05) in improving residual urine volume in the two group. Comparing the difference of each group on this aspect before and after treatment, the results showed statistically significant difference in both groups, indicating that both therapies had effect on improving urinary tract obstruction and the test group was larger in changing the amount of residual urine volume than the control group. It means that the effect of warm needling moxibustion combined with Chinese medicine group was more effective than the control group in relieving urinary tract obstruction.
About clinical efficacy:25 patients in the test group,5 remarkably effective cases,17 effective cases, total effective rate was 88.0%; 25 patients in pure Chinese herbs group,0 remarkably effective cases,16 effective cases, total effective rate was 64.0%. Comparing therapeutic effect and the total effective rate of the two groups,the differences were statistically significant and the total effective rate of the test group was higer than that of control group. After received the treatment of warm moxibustion combined with Chinese medicine, the patients'clinical symptoms were evidently improved, showing that this therapy has an remarkable effect.
Conlcusion
The therapy of warm needling moxibustion conbined with Chinese herbs can relieve the synptoms of urinary tract obstruction and has a remarkable effect. This study has initially proved that this therapy can significantly raise the clinical effet on treating chronic hyperplasia of prostate of deficency syndrome and is worthy of promotion.
温针疗法是将针刺和艾灸结合的中医特色疗法,在治疗许多疾病中,尤其是对中医辨证虚证的病症发挥其独特疗效。本研究拟采用温针疗法治疗慢性前列腺增生虚证患者,期望借此研究能开拓该病治疗的有效途径,为目前在人群中发病率较高的慢性前列腺增生提供一种新的安全有效的治疗方案。
目的
本课题采用临床流行病学、临床科研方法学及数理统计分析方法,进行临床随机对照研究,观察温针灸结合中药治疗中医辨证属虚症(肾阳不足、肝肾亏虚)的慢性前列腺增生症,以期证实温针灸治疗前列腺增生症虚症的确切疗效。
方法
根据《中药新药临床研究指导原则》关于癃闭的诊断标准,收集2008年2月至2009年2月期间在台湾贺安中医诊所就诊的符合病例筛选标准的50例慢性前列腺增生症患者。采用单盲随机化方法,按1：1对照原则分为试验组、对照组,试验组采用温针灸结合中药治疗,对照组采用单纯中药治疗。一周为一个疗程,连续二个疗程后观察治疗前后前列腺体积、残余尿量及其临床疗效。用EPIDATA3.1软件建立数据库,用SPSS15.0软件进行统计分析。计量资料用均数±标准差(x±S)表示,计数资料用构成比(%)表示。计量资料组间比较采用t检验(方差不齐采用t’检验或秩和检验),自身前后比较用配对t检验或Wilcoxon配对秩和检验。分类资料组间比较采用χ2检验,等级资料组间比较采用Wilcoxon秩和检验。统计图形的制作采用软件Graph Pad Prism 4.03完成。
结果
临床共收集合格病例50例,均为50岁以上的老年人。温针灸结合中药治疗组(简称试验组)25例,年龄最小50岁,最大73岁,平均年龄61.34±5.32岁,病程最短者3年,最长者15年,平均8.34±2.78年；中药治疗组(简称对照组)25例,年龄最小51岁,最大66岁,平均年龄58.92±4.96岁。病程最短者1年,最长者12年,平均6.89±2.63年。
患者基线特征的可比性分析中,试验组与对照组年龄、病程、病情程度、治疗前前列腺体积、残余尿量比较,差异均无统计学意义,两组患者基线特征具有可比性。
主要研究指标疗效,在改善前列腺体积方面,试验组与对照组治疗后差异无统计学意义。各组治疗前与治疗后比较,两组均无统计学意义。提示：提示温针灸结合中药治疗组和单纯中药组对前列腺体积无明显影响。在改善残余尿量方面,治疗后两组差异有统计学意义。各组治疗前与治疗后比较,两组均有统计学意义。提示：两组治疗方法都能改善尿路的梗阻状态,试验组残余尿量改变量较对照组大,提示温针灸结合中药治疗组解除尿路梗阻的疗效优于对照组。在临床疗效方面,试验组25例患者,显效5例,有效17例,总有效率88.0%；单纯中药组25例患者,显效0例,有效16例,总有效率64.0%。两组临床疗效与总有效率的比较,差异均有统计学意义。且试验组的总有效率较对照组高。提示：经温针灸结合中药治疗后,前列腺增生患者的临床症状明显改善,效果显著。
结论
结合临床,温针灸结合中药治疗组能解除尿路梗阻症状,疗效肯定,初步证明了采用温针灸结合中药的方法治疗慢性前列腺增生虚证可有效提高其临床疗效,值得推广。
Hyperplasia of prostate is a common disease in older men. With the population aging process, the incidence rate will further increase, seriously affecting quality of life of older men, or even complications, threatening the patients'life. It has been one of the most important diseases that infects the health of old men and become a very topic in the 21st century.
Warm needling moxibustion is a therapy combined with needling and moxibustion, which has the Chinese characteristics in the treatment of many diseases, especially diseases with deficency syndrome by TCM differentiation of symptoms and signs. This therapy can play an unique effect. In this study, We intend to apply warm needling moxibustion therapy in patients with chronic hyperplasia of prostate of deficency syndrome, and hope that this study will explore an effective way to treat this disease and provid a new safe and effective treatment program for it has a higher disease incidence in present population.
Objective
This study use clinical epidemiology and clinical scientific research, mathematical statistics and analytical method, by randomized controlled study, the objective of this reseach is to observe the clinical effect of warm needling moxibustion conbined with Chinese herbs in treating chronic hyperplasia of prostate of deficency syndrome (deficency of kidney or deficency of liver and kidney) and to confirm the therapy of Warm needling moxibustion has an exact effect n the exact effect in treating this disease.
Methods
According to the diagnostic criteria of retention of urine/uroschesis in guiding principles of new drugs in Chinese medicine clinical research, we collected 50 cases of patients with chronic hyperplasia of prostate who met the criteria from Taiwan Chenzhengang'TCM Clinical during February 2008 and February 2009. Applying randomized single-blind method, we diveded the reseach objects into test group and control group in the ratio of 1:1. The patients in test group were treated with warm needling moxibustion conbined with Chinese herbs, and the other ones treated with pure Chinese herbs. One week for a course of treatment.
After two course, observing the changes on prostate volume, residual urine volume and its clinical effect before and after treatment.
Using EpiData 3.1 software to establish database and statistical software SPSS15.0 to complete statistical analysis.Measurement data with means±tandard deviation (x±S), numeration data with composition ratio (%), measurement data between groups with T-test (heterogeneity of variance with t'test or rank sum test), before and after itself with paired-samples T-test or Wilcoxon paired rank sum test, Categorical data between groups with Chi-Square test, ranked data between groups with Wilcoxon rank sum test. Making use of statistical graphics software Graph Pad Prism 4.03 to complete statistical graph.
Results
5o qualified clinical cases were collected and the patients were all over 50 years old. Warm needling moxibustion conbined with Chinese herbs group(simplely called test group) 25 cases, the youngest 50 years old, the oldest 73 years old, mean age 61.34±5.32, the shortest disease duration 3 years, the longest 15 years, mean disease duration 8.34±2.78 years; Chinese herbs goup(control group) 25 cases, the youngest 51 years old, the oldest 66 years old, mean age 58.92±4.96, the shortest disease duration 1 years, the longest 12 years, mean 6.89±2.63 years.
Comparability of baseline characteristics of patients in the test group and control group in age, duration, severity, prostate volume and residual urine volume before treatment, the difference had no statistical significance,meaning the baseline characteristics of the two groups were comparable.
The effect of main study indicators:the difference was not statistically significant (P> 0.05) in improving prostate volume in the two group. Comparing the difference of each group on this aspect before and after treatment, the results showed no statistically significant difference in both groups, indicating that these two therapies had no impact on Prostate volume. The difference was statistically significant (P<0.05) in improving residual urine volume in the two group. Comparing the difference of each group on this aspect before and after treatment, the results showed statistically significant difference in both groups, indicating that both therapies had effect on improving urinary tract obstruction and the test group was larger in changing the amount of residual urine volume than the control group. It means that the effect of warm needling moxibustion combined with Chinese medicine group was more effective than the control group in relieving urinary tract obstruction.
About clinical efficacy:25 patients in the test group,5 remarkably effective cases,17 effective cases, total effective rate was 88.0%; 25 patients in pure Chinese herbs group,0 remarkably effective cases,16 effective cases, total effective rate was 64.0%. Comparing therapeutic effect and the total effective rate of the two groups,the differences were statistically significant and the total effective rate of the test group was higer than that of control group. After received the treatment of warm moxibustion combined with Chinese medicine, the patients'clinical symptoms were evidently improved, showing that this therapy has an remarkable effect.
Conlcusion
The therapy of warm needling moxibustion conbined with Chinese herbs can relieve the synptoms of urinary tract obstruction and has a remarkable effect. This study has initially proved that this therapy can significantly raise the clinical effet on treating chronic hyperplasia of prostate of deficency syndrome and is worthy of promotion.
引文
[1]天津科学技术出版社.实用男性学[M].天津：科学技术出版社,1988：324.
[2]李日庆.前列腺疾病临床荟萃[M].北京：华夏出版社,1996：7-17.
[3]曹开庸.中医男科现代研究[M].成都：四川科学技术出版社,1998：171-172.
[4]戚世伟,熊成熙,郎笑梅.金匮肾气丸防治前列腺增生探析[J].中医药临床杂志,2004,16(5)：499-450.
[5]张氏,郑清国,陈光强.论命门即前列腺[J].福建中医学院学报,2005,15(5)：45-46.
[6]李彪.实用男科临床手册[M].北京：人民军医出版社,1995：158.
[7]李卫真.前列腺病中医诊疗学[M].北京：北京科学技术出版社,1996：122-123.
[8]吴光明,魏秋关.清热利湿化瘀法治疗前列腺肥大33例[J].湖南中医杂志,1993,9(3)：36.
[9]焦安钦.前列腺增生症病机特点与治疗思路[J].贵阳中医学院学报,1996,18(4)：3-5.
[10]周家珩.扶正化痰法治疗前列腺增生症135例[J].江苏中医,1991,12(3)：115.
[11]朱永康.通闭汤治疗前列腺增生症[J].江苏中医,1991,12(11)：32.
[12]周安方,曹继刚.肾虚肝实是前列腺增生的基本病机探析[J].中医药学刊,2004,22(8)：1372-1376.
[13]张亚大,卢子杰.前列腺增生症病机与辨证分型相关性的临床研究[C].中国中西医结合学会泌尿外科专业委员会第三次全国学术会议论文汇编,2001：165-166.
[14]张春和,李海松.李日庆教授治疗前列腺增生症经验[J].中国临床医生,2003,31(10)：56-57.
[15]武传贵,孟繁荣.补肾化瘀通淋法治疗前列腺增生症84例[J].辽宁中医杂志,2004,31(6)：489.
[16]刘清国,王朝阳,李军.针刺治疗良性前列腺增生的临床研究[J].2003,23(4)：200.
[17]Yutaka K, Hiroaki M, Hiroshi T, etal. Transition zone index as a risk factor for acute urinary retention in benign prostatic hyperplasia Urology,1998,51:595-600.
[18]刘跃新,陈山,张光银,等.前列腺体积与移行带体积变化的年龄差异[J].中华泌尿外科杂志,2002,23：478-479.
[19]李晓宝,张进生.良性前列腺增生诊治研究进展[J].中国微创外科杂志,2008,8(2)：186-188.
[20]莫乃新,戎亚雄,吕忠,等.前列腺增生症与饮食的相关性研究[J].江苏医 药,2003,29(12)：921-922.
[21]Sciarra F, Toscano V. Role of estrogens in human benign prostatic hyperplasia. Arch Androl,2000,44(3),213-220.
[22]Carballido, Rodriguez, Rodriguez Vallejo, etal. Benign prostatic hyperplasia and evidence based medicine:its approach in clinical practice. Med Clin(Barc),2000,114 Suppl 2,96-104.
[23]Steers WD.5alpha-reductase activity in the prostate. Urology,2001,58(6 Suppl 1),17-24.
[24]Hammarsten J, Hogstedt B. Hyperinsulinaemia as a risk factor for developing benign prostatic hyperplasia. Eur Urol,2001,39(2),151-158.
[25]Mochtar CA, Rahardj o D, Umbas R. A higher PSA density cut off level in patients with intermediate PSA values for the early detection of prostate cancer. Can To Kagaku Ryoho,2000,27 Suppl 2,514-522.
[26]Hartmann RW, Reichert M. New nonsteroidal steroid 5 alpha-reductase in hibitors. Syntheses and structure-activity studies on carboxamide pheny lalky substituted pyridones and piperidones. Axch-Pharm (Weinheim),2000,333(5),145-153.
[27]Stattin P, Kaaks R, Riboli E, etal. Circulating insulin 7 like growth factor I and benign prostatic hyperplasia-a prospective study. Scand J Urol Nephrol,2001,35(2)122-126.
[28]Luo Jun, Dunn Thomas, Ewing Charles, etal. Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis Prostate,2002,51 (3):189-200.
[29]贺大林.前列腺增生的病因学研究进展[J].临床外临床外科杂志,2005,13(2)：72-74.
[30]Shapira E, Hartanto V, Lepor H. Anti2desminvs anti2actin for quantifying the area density of prostate smooth muscle[J]. Prostate,1992,20:259-262.
[31]Kyprianou N, Litvak JP, Borkowski A, etal. Induction of prostate apoptosis by doxa2zosin in benign prostatic hyperplasia[J]. JUrol,1998,159:1810.
[32]居小兵,吴宏飞,华立新,等,爱普列特治疗良性前列腺增生的疗效观察[J].中华男科学,2002,8(1)：42-44.
[33]李茜,黄冬冬,杜冠华,等.1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙氨基)丙烷盐酸盐对大鼠心脏α1受体的影响[J].中国药理学与毒理学杂志,1990,4(2)：91-94.
[34]郑恒,钱家庆,邵春丽,等.1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙氨基)丙 烷盐酸盐对大鼠膀胱内压及前列腺增生的作用[J].中国药理学与毒理学杂志,2001,15(2)：150-154.
[35]马庆杰,谷欣权,孔祥波,等.90Sr／90Y前列腺增生治疗器(尿道型)的剂量分布及安全性研究[J].中国老年学杂志.2001,21(6)：434-435.张彤,徐祗顺,魏巍等.90Sr／90Y对人良性前列腺增生细胞增殖与凋亡影响的研究[J].中华放射医学与防护杂志,2003,23(2)：98-99.
[36]孔祥波,谷欣权,何小东,等.90Sr／90Y β射线腔内照射治疗前列腺增生症的临床应用研究[J].中国老年学杂志,2002,22(1)：29-30.
[37]王旭昀,赵增彬,商建伟,等.前列腺增生症的中医药治疗[J].杏林中医药,2008,28(9)：631-632.
[38]张国铿.浅谈前列腺肥大症证治体会[J].新中医,1996,28(2)：61.
[39]董襄国,吴明清.良性前列腺增生辨证论治[J].中国医药学报,2004,19(6)：358-359.
[40]叶科贵.辨证论治前列腺增生症67例[J].河南中医,2006,26(7)：43-44.
[41]张亚大,卢子杰,张平,等.益肾逐瘀汤治疗良性前列腺增生症100例疗效观察及对性激素的影响[J].新中医.2003,35(9)：14-15.
[42]李龙骧.黄芪桂枝五物汤临床新用[J].吉林中医药,2007,27(11)：45.
[43]赵建业.戴春福教授以活血法治疗前列腺增生症经验[J].福建中医药,2004,35(2)：21-22.
[44]赵跃红.加味壮元汤治疗前列腺增生症62例[J].湖南中医杂志,2004,20(3)：54.
[45]张振卿.化痰祛瘀软坚化症法治疗前列腺增生症的体会[J].四川中医,2003,21(5)：25-26.
[46]李连贞.痰瘀同治法应用体会[J].吉林中医药,2001,21(2)：4.
[47]杨乾珽.通塞汤治疗良性前列腺增生症36例[J].天津中医药,2007,24(5)：386.
[48]武传贵,孟繁荣.补肾化瘀通淋法治疗前列腺增生症84例[J].辽宁中医杂志,2004,31(6)：489.
[49]黄小波,李宗信,李斌,等.消癃合剂联合消癃散治疗良性前列腺增生症的临床研究[J].中国中西医结合急救杂志,2006,13(2)：73-75.
[50]贾永华,张延杰,周延生,等.通癃胶囊治疗前列腺增生症的临床研究[J].南京中医药大学学报,2006,2(5)：290-293.
[51]刘敬松,宋伟,李烨,等.前列金丹片治疗前列腺增生148例[J].山东中医杂志,2005,24(2)：94.
[52]郭海龙,肖社玲,郭凌云.温阳补肾法治疗前列腺增生[J].中西医结合与祖国医学,2009,8：13-14.
[53]李德干.中医辨证治疗前列腺增生症120例[J].黑龙江中医药,2009,6：27-28.
[54]狄文宗.中医如何分型治疗前列腺增生[J].中医大观,2010,9：49-50.
[55]孔飞,孙聪,陈光亮.中药治疗良性前列腺增生症的研究进展[J].云南中医学院学报,2008,31(4)：67-70.
[56]王宏志.癃闭舒胶囊治疗良性前列腺增生疗效观察[J].中华男科学杂志,2005,11(11)：873.
[57]张亚强.日本应用汉方药治疗前列腺增生的临床研究[J].国外医学中医中药分册,2000,22(3)：145-147.
[58]何本鸿.金匮肾气丸配合穴位针刺治疗良性前列腺增生的疗效观察[J].中华男科学杂志,2007,13(10)：953-954.
[59]陈通文,王文凤,邓春华,等.前列通瘀胶囊治疗湿热瘀阻型前列腺增生症76例临床观察[J].亚太传统医药,2006,7：440-441.
[60]向贵,薛波新,单玉喜,等.中成药前工号方治疗良性前列腺增生90例疗效观察[J].苏州大学学报(医学版),2007,27(5)：822-823.
[61]李祥光,鞠大宏,宋竖旗,等.前列舒通对前列腺增生模型大鼠bcl-2表达的影响[J].中国中西药结合外科杂志,2008,14(2)：141-143.
[62]马卫国,贾金铭,焦拥政,等.癃必消胶囊对体外培养的人前列腺增生间质细胞Fibronectin和Collagen Ⅳ基因表达的影响[J].中国男科学杂志,2008,22(2)：7-10.
[63]贺菊乔,袁轶峰,蔡蔚.前癃通胶囊治疗良性前列腺增生症的临床观察[J].湖南中医药大学学报,2009,29(5)：54-56.
[64]蒋荣伟,岳宗相,王久源,等.桂枝茯苓加味汤治疗良性前列腺增生症[J].现代中西医结合杂志,2008,17(9)：1369.
[65]许国振,崔金涛,严启伟,等.决闭胶囊抗实验性前列腺增生的研究[J].中成药,2001,23(10)：735-737.
[66]叶加,李长龄,吴恩融,等.IPH抗实验性前列腺增生的研究[J].中国药学杂志,2002,37(12)：906-910.
[67]马清钧,李宏杰,孙曙光,等.乾列安胶囊对肾阳亏虚型前列腺增生症影响的研究[J].中医药学刊,2003,21(4)：530-531.
[68]商学军,刘智勇,刘志发,等.福施乐治疗良性前列腺增生的临床研究[J].中华男科学杂志,2008,14(3)：227-230.
[69]张小红.血府逐瘀汤和盐酸特拉唑嗪联合治疗慢性前列腺增生症34例[J].四川中医,2001,19(6)：39.
[70]王元康,余跃平.中药内服加保留灌肠治疗慢性前列腺增生30例[J].中华临床医药杂志,2003,1(59)：9809-9810.
[71]张凯,杨新宇,张军,等.泽桂癃爽胶囊治疗良性前列腺增生疗效和作用机理的初步 研究[J].中华泌尿外科杂志,2003,24(6)：388-390.
[72]曹继刚,周安方.仙甲汤对前列腺增生大鼠前列腺细胞调亡率影响的实验研究[J].中国中医药科技,2005,12(1)：3.
[73]皮后炎.鳖甲煎丸合方治疗前列腺增生症验案举隅[J].中国中医急症,2009,18(11)：1902-1904.
[74]刘金松,冯贵平,潘金霞.软坚消瘀汤治疗前列腺增生症疗效观察[J].河北中医,2009,31(11)：1692.
[75]杨静哲,贾玉森,苏全新.加味阳和汤治疗良性前列腺增生症34例临床分析[J].首都医药,2010,1：52.
[76]赵子山,赵金环,江鹏.癃闭方治疗良性前列腺增生症116例疗效观察[J].实用中西医结合临床,2009,9(6)：45-46.
[77]李松,段登志.自拟清癃汤治疗前列腺增生51例[J].云南中医中药杂志,2009,30(12)：46.
[78]黄少波.自拟方术愈汤对良性前列腺增生行TUBVP术后血尿的影响[J].中国当代医药,2009,16(20)：76-77.
[79]张春和,李焱风,陈天波.前列通窍颗粒联合保列治治疗良性前列腺增生65例疗效观察[J].世界中西医结合杂志,2009,4(11)：797-799.
[80]刘杰田,张翠丽,尹玉花.泽桂癃爽胶囊联合α受体阻滞剂治疗良性前列腺增生症的疗效评价[J].世界中西医结合杂志,2009,5(3)：31.
[81]张正理,王果平,王化明.中药配合葆利安治疗前列腺增生60例[J].陕西中医,2009,30(11)：1489-1490.
[82]Stephan Madersbacher, Anton Ponholzer, Ingrid Berger, etal. Medical Management of BPH:Role of Plant Extracts[J]. European Association of Urology,2007.
[83]解红武.良性前列腺增生的药物治疗[J].天津药学,2002,14(3)：15-17.
[84]Marks LS, Hess DL, Dorey FJ, etal. Tissue effects of sawpalmetto and fi-nasteride. Use of biopsy cores for insitution quantification of prostatic andro-gens. Urology,2001,57:1005.
[85]Berges RR, KassenA, SengeT, Treatment of symptomatic benign prostat-ic hyperplasia with beta-sitosterol:an 18-month follow-up. BJU Int,2000,85:842-846.
[86]Bondarenko B, Walther C, Funk P, etal. Phytomedicine,2003,10(Suppl 4):53-55.
[87]FransD, PeterB, FernandoC, etal. Evaluation of the clinical benefit of Permixon and Tamsulosin in severe BPH patients PERMAL study sub-set analysis. EuropeanUrology,2004,45:773.
[88]赵珍东.穗花牡荆提取物对前列腺上皮细胞增殖的抑制作用和促细胞凋亡作用[J].国外医药,2006,21(6)：263.
[89]Hizli F, Uygur MC.A prospective study of the efficacy of Serenoa repens, tamsulosin, and Serenoa repens plus tamsulosin treatment for patients with benign prostate hyperplasia. Int Urol Nephrol.2007,39(3):879-86.
[90]朱威,胡福良.花粉治疗前列腺增生的研究进展[J].蜜蜂杂志,2005,12：8-10.
[91]刘勇,蔡花芳,赵铮蓉,等.破壁松花粉及软胶囊抗前列腺增生作用[J].中国医疗前沿,2007,2(22)：14-15.
[92]杨兆钢.芒针治疗前列腺炎和前列腺肥大86例临床观察[J].针灸临床杂志,1994,10(1)：23-24.
[93]李惠芳,杨柏如.针灸治疗23例前列腺增生症[J].中国针灸,1994,14(4)：13-15.
[94]付晓红.针刺配合隔姜灸治疗前列腺增生症.针灸临床杂志[J].1998,14(7)：41-42.
[95]胡九凤,王光明.针灸治疗前列腺肥大[J].针灸临床杂志,2000,16(11)：7-8.
[96]饶芳.点刺至阴穴治疗前列腺增生20例[J].中国针灸,2000,20(9)：572.
[97]郭绮云.针灸治疗老年前列腺增生34例疗效观察[J]。中国针灸,2001,21(7)：389-390.
[98]陈蓓琳,黄文燕,张载义.骶部俞穴深刺为主治疗良性前列腺增生的临床观察[J].针灸临床杂志,2005,21(9)：26-27.
[99]杨焱,陈红涛.针刺治疗前列腺增生60例分析[J].实用中医内科杂志,2004,18(3)：269-270.
[100]杨运宽,敖有光,胡幼平.针刺治疗老年前列腺增生症37例[J].上海针灸杂志,2005,24(2)：19-20.
[101]史江峰.针刺足厥阴经穴治疗前列腺增生症临床研究[J].辽宁中医杂志,2005,32(12)：1295-1296.
[102]刘鸿.芒针为主治疗前列腺增生症临床观察[J].针灸临床杂志,2005,21(7)：19
[103]王子臣,王占平,张冰.芒针为主治疗前列腺增生症41例[J].上海针灸杂志,2002,21(3)：13-4.
[104]肖远辉.温针灸为主治疗前列腺增生症疗效观察[J].天津中医学院学报,2002,21(1)：20.
[105]杨春光,廖明霞.针刺加艾灶灸治疗肾阳虚型前列腺增生50例[J].中国针灸,2004,24(11)：752.
[106]张志荣,成润娣.针药治疗前列腺肥大36例[J].陕西中医,1994,15(4)：174.
[107]张希荣,艾淑滨,范求实,等.电针配合竹叶石膏汤加减治疗前列腺肥大症38例临 床报告[J].针灸临床杂志,1997,13(3)：17.
[108]邱林.内服中药合针灸治疗前列腺肥大28例[J].国医论坛,1997,12(3)：40-41.
[109]吴昌宏,石绍伟,张志山.针药结合治疗前列腺肥大30例[J].针灸临床杂志,1998,14(9)：15.
[110]赵跃红.加味壮元汤治疗前列腺增生症62例[J].湖南中医杂志,2004,20(3)：54.
[111]何金柱,李兰英,徐伟.辨证取穴论治前列腺增生症[J].针刺研究,2000,25(4)：300-301.
[112]黄志华,陈凯奋.耳穴电针治疗老年性前列腺增生12例[J].中国针灸,1997,17(6)：34.
[113]路变珍,孙润宝.芒针加耳穴埋针治疗前列腺增生症14例[J].针灸临床杂志,1997,13(12)：27-28.
[114]张耕田.耳针治疗前列腺增生症14例[J].中国针灸,1998,18(5)：316.
[115]汤秀芳.耳针配合超声红外光子治疗前列腺增生临床观察[J].中国针灸,2000,20(9)：531-2.
[116]王祥福,王建德,冯志庆.电磁针治疗前列腺增生症60例[J].陕西中医,1993,14(4)：174-175.
[117]刘艳清,易似红.微波针炙仪治疗前列腺增生症30例观察[J].湖南中医学院学报,1995,15(1)：62-63.
[118]高维滨,白彦龙,曹蠹.电针治疗前列腺增生症41例[J].针灸临床杂志,2005,21(5)：46-7.
[119]朱宇丹.针刺配合药灸贴治疗前列腺增生[J].针灸临床杂志,2004,20(10)：16-7.
[120]刘志顺,刘元石,杨中阳,等.电针治疗症状性良性前列腺增生[J].中国临床医生,2002,30(2)：36-37.
[121]于向华,高维滨,李傲阳.针刺次髎、中髎穴治疗前列腺增生尿潴留的疗效观察[J].针灸临床杂志,2005,21(4)：48-49.
[122]朱秀平,黄少姬.电磁疗合温针灸治疗前列腺增生61例疗效观察[J].上海针灸杂志,2006,25(5)：24-25.
[123]金泽,姜珊珊,包大鹏.电针治疗前列腺增生临床观察[J].上海针灸杂志,2010,29(2)：105-106.
[124]崔丽丽,杨素凤,朱智萍.足三里穴位注射治疗经尿道前列腺电切术后腹胀的观察及护理[J].长春中医药大学学报,2009,25(6)：952.
[125]陈建平.氦氖激光治疗前列腺增生及前列腺炎64例[J].新中医,1993,25(5)：37.
[126]许维新,刘传瑾,伊静秋.电激光针治疗前列腺肥大90例[J].中国针灸,1991,11(6)：3.
[127]马仁海,张丽梅,冀萍,等.激光针灸治疗前列腺增生症132例临床观察[J].中国 中医药科技,1996,3(2)：35.
[128]洪文,莫飞智,李建强.650hm激光穴位照射与针刺治疗良性前列腺增生症的疗效对比观察[J].激光生物学报,2007,16(2)：230-233.
[129]中华人民共和国卫生部.中药新药临床研究指导原则[S].第1辑,13：171-17.
[130]石美鑫.实用外科学[M].北京：人民卫生出版,1995：1729-1731.
[131]郭云绮.针灸治疗老年前列腺增生34例临床观察[J].中国针灸,2001,21(7)：389.
[2]李日庆.前列腺疾病临床荟萃[M].北京：华夏出版社,1996：7-17.
[3]曹开庸.中医男科现代研究[M].成都：四川科学技术出版社,1998：171-172.
[4]戚世伟,熊成熙,郎笑梅.金匮肾气丸防治前列腺增生探析[J].中医药临床杂志,2004,16(5)：499-450.
[5]张氏,郑清国,陈光强.论命门即前列腺[J].福建中医学院学报,2005,15(5)：45-46.
[6]李彪.实用男科临床手册[M].北京：人民军医出版社,1995：158.
[7]李卫真.前列腺病中医诊疗学[M].北京：北京科学技术出版社,1996：122-123.
[8]吴光明,魏秋关.清热利湿化瘀法治疗前列腺肥大33例[J].湖南中医杂志,1993,9(3)：36.
[9]焦安钦.前列腺增生症病机特点与治疗思路[J].贵阳中医学院学报,1996,18(4)：3-5.
[10]周家珩.扶正化痰法治疗前列腺增生症135例[J].江苏中医,1991,12(3)：115.
[11]朱永康.通闭汤治疗前列腺增生症[J].江苏中医,1991,12(11)：32.
[12]周安方,曹继刚.肾虚肝实是前列腺增生的基本病机探析[J].中医药学刊,2004,22(8)：1372-1376.
[13]张亚大,卢子杰.前列腺增生症病机与辨证分型相关性的临床研究[C].中国中西医结合学会泌尿外科专业委员会第三次全国学术会议论文汇编,2001：165-166.
[14]张春和,李海松.李日庆教授治疗前列腺增生症经验[J].中国临床医生,2003,31(10)：56-57.
[15]武传贵,孟繁荣.补肾化瘀通淋法治疗前列腺增生症84例[J].辽宁中医杂志,2004,31(6)：489.
[16]刘清国,王朝阳,李军.针刺治疗良性前列腺增生的临床研究[J].2003,23(4)：200.
[17]Yutaka K, Hiroaki M, Hiroshi T, etal. Transition zone index as a risk factor for acute urinary retention in benign prostatic hyperplasia Urology,1998,51:595-600.
[18]刘跃新,陈山,张光银,等.前列腺体积与移行带体积变化的年龄差异[J].中华泌尿外科杂志,2002,23：478-479.
[19]李晓宝,张进生.良性前列腺增生诊治研究进展[J].中国微创外科杂志,2008,8(2)：186-188.
[20]莫乃新,戎亚雄,吕忠,等.前列腺增生症与饮食的相关性研究[J].江苏医 药,2003,29(12)：921-922.
[21]Sciarra F, Toscano V. Role of estrogens in human benign prostatic hyperplasia. Arch Androl,2000,44(3),213-220.
[22]Carballido, Rodriguez, Rodriguez Vallejo, etal. Benign prostatic hyperplasia and evidence based medicine:its approach in clinical practice. Med Clin(Barc),2000,114 Suppl 2,96-104.
[23]Steers WD.5alpha-reductase activity in the prostate. Urology,2001,58(6 Suppl 1),17-24.
[24]Hammarsten J, Hogstedt B. Hyperinsulinaemia as a risk factor for developing benign prostatic hyperplasia. Eur Urol,2001,39(2),151-158.
[25]Mochtar CA, Rahardj o D, Umbas R. A higher PSA density cut off level in patients with intermediate PSA values for the early detection of prostate cancer. Can To Kagaku Ryoho,2000,27 Suppl 2,514-522.
[26]Hartmann RW, Reichert M. New nonsteroidal steroid 5 alpha-reductase in hibitors. Syntheses and structure-activity studies on carboxamide pheny lalky substituted pyridones and piperidones. Axch-Pharm (Weinheim),2000,333(5),145-153.
[27]Stattin P, Kaaks R, Riboli E, etal. Circulating insulin 7 like growth factor I and benign prostatic hyperplasia-a prospective study. Scand J Urol Nephrol,2001,35(2)122-126.
[28]Luo Jun, Dunn Thomas, Ewing Charles, etal. Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis Prostate,2002,51 (3):189-200.
[29]贺大林.前列腺增生的病因学研究进展[J].临床外临床外科杂志,2005,13(2)：72-74.
[30]Shapira E, Hartanto V, Lepor H. Anti2desminvs anti2actin for quantifying the area density of prostate smooth muscle[J]. Prostate,1992,20:259-262.
[31]Kyprianou N, Litvak JP, Borkowski A, etal. Induction of prostate apoptosis by doxa2zosin in benign prostatic hyperplasia[J]. JUrol,1998,159:1810.
[32]居小兵,吴宏飞,华立新,等,爱普列特治疗良性前列腺增生的疗效观察[J].中华男科学,2002,8(1)：42-44.
[33]李茜,黄冬冬,杜冠华,等.1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙氨基)丙烷盐酸盐对大鼠心脏α1受体的影响[J].中国药理学与毒理学杂志,1990,4(2)：91-94.
[34]郑恒,钱家庆,邵春丽,等.1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙氨基)丙 烷盐酸盐对大鼠膀胱内压及前列腺增生的作用[J].中国药理学与毒理学杂志,2001,15(2)：150-154.
[35]马庆杰,谷欣权,孔祥波,等.90Sr／90Y前列腺增生治疗器(尿道型)的剂量分布及安全性研究[J].中国老年学杂志.2001,21(6)：434-435.张彤,徐祗顺,魏巍等.90Sr／90Y对人良性前列腺增生细胞增殖与凋亡影响的研究[J].中华放射医学与防护杂志,2003,23(2)：98-99.
[36]孔祥波,谷欣权,何小东,等.90Sr／90Y β射线腔内照射治疗前列腺增生症的临床应用研究[J].中国老年学杂志,2002,22(1)：29-30.
[37]王旭昀,赵增彬,商建伟,等.前列腺增生症的中医药治疗[J].杏林中医药,2008,28(9)：631-632.
[38]张国铿.浅谈前列腺肥大症证治体会[J].新中医,1996,28(2)：61.
[39]董襄国,吴明清.良性前列腺增生辨证论治[J].中国医药学报,2004,19(6)：358-359.
[40]叶科贵.辨证论治前列腺增生症67例[J].河南中医,2006,26(7)：43-44.
[41]张亚大,卢子杰,张平,等.益肾逐瘀汤治疗良性前列腺增生症100例疗效观察及对性激素的影响[J].新中医.2003,35(9)：14-15.
[42]李龙骧.黄芪桂枝五物汤临床新用[J].吉林中医药,2007,27(11)：45.
[43]赵建业.戴春福教授以活血法治疗前列腺增生症经验[J].福建中医药,2004,35(2)：21-22.
[44]赵跃红.加味壮元汤治疗前列腺增生症62例[J].湖南中医杂志,2004,20(3)：54.
[45]张振卿.化痰祛瘀软坚化症法治疗前列腺增生症的体会[J].四川中医,2003,21(5)：25-26.
[46]李连贞.痰瘀同治法应用体会[J].吉林中医药,2001,21(2)：4.
[47]杨乾珽.通塞汤治疗良性前列腺增生症36例[J].天津中医药,2007,24(5)：386.
[48]武传贵,孟繁荣.补肾化瘀通淋法治疗前列腺增生症84例[J].辽宁中医杂志,2004,31(6)：489.
[49]黄小波,李宗信,李斌,等.消癃合剂联合消癃散治疗良性前列腺增生症的临床研究[J].中国中西医结合急救杂志,2006,13(2)：73-75.
[50]贾永华,张延杰,周延生,等.通癃胶囊治疗前列腺增生症的临床研究[J].南京中医药大学学报,2006,2(5)：290-293.
[51]刘敬松,宋伟,李烨,等.前列金丹片治疗前列腺增生148例[J].山东中医杂志,2005,24(2)：94.
[52]郭海龙,肖社玲,郭凌云.温阳补肾法治疗前列腺增生[J].中西医结合与祖国医学,2009,8：13-14.
[53]李德干.中医辨证治疗前列腺增生症120例[J].黑龙江中医药,2009,6：27-28.
[54]狄文宗.中医如何分型治疗前列腺增生[J].中医大观,2010,9：49-50.
[55]孔飞,孙聪,陈光亮.中药治疗良性前列腺增生症的研究进展[J].云南中医学院学报,2008,31(4)：67-70.
[56]王宏志.癃闭舒胶囊治疗良性前列腺增生疗效观察[J].中华男科学杂志,2005,11(11)：873.
[57]张亚强.日本应用汉方药治疗前列腺增生的临床研究[J].国外医学中医中药分册,2000,22(3)：145-147.
[58]何本鸿.金匮肾气丸配合穴位针刺治疗良性前列腺增生的疗效观察[J].中华男科学杂志,2007,13(10)：953-954.
[59]陈通文,王文凤,邓春华,等.前列通瘀胶囊治疗湿热瘀阻型前列腺增生症76例临床观察[J].亚太传统医药,2006,7：440-441.
[60]向贵,薛波新,单玉喜,等.中成药前工号方治疗良性前列腺增生90例疗效观察[J].苏州大学学报(医学版),2007,27(5)：822-823.
[61]李祥光,鞠大宏,宋竖旗,等.前列舒通对前列腺增生模型大鼠bcl-2表达的影响[J].中国中西药结合外科杂志,2008,14(2)：141-143.
[62]马卫国,贾金铭,焦拥政,等.癃必消胶囊对体外培养的人前列腺增生间质细胞Fibronectin和Collagen Ⅳ基因表达的影响[J].中国男科学杂志,2008,22(2)：7-10.
[63]贺菊乔,袁轶峰,蔡蔚.前癃通胶囊治疗良性前列腺增生症的临床观察[J].湖南中医药大学学报,2009,29(5)：54-56.
[64]蒋荣伟,岳宗相,王久源,等.桂枝茯苓加味汤治疗良性前列腺增生症[J].现代中西医结合杂志,2008,17(9)：1369.
[65]许国振,崔金涛,严启伟,等.决闭胶囊抗实验性前列腺增生的研究[J].中成药,2001,23(10)：735-737.
[66]叶加,李长龄,吴恩融,等.IPH抗实验性前列腺增生的研究[J].中国药学杂志,2002,37(12)：906-910.
[67]马清钧,李宏杰,孙曙光,等.乾列安胶囊对肾阳亏虚型前列腺增生症影响的研究[J].中医药学刊,2003,21(4)：530-531.
[68]商学军,刘智勇,刘志发,等.福施乐治疗良性前列腺增生的临床研究[J].中华男科学杂志,2008,14(3)：227-230.
[69]张小红.血府逐瘀汤和盐酸特拉唑嗪联合治疗慢性前列腺增生症34例[J].四川中医,2001,19(6)：39.
[70]王元康,余跃平.中药内服加保留灌肠治疗慢性前列腺增生30例[J].中华临床医药杂志,2003,1(59)：9809-9810.
[71]张凯,杨新宇,张军,等.泽桂癃爽胶囊治疗良性前列腺增生疗效和作用机理的初步 研究[J].中华泌尿外科杂志,2003,24(6)：388-390.
[72]曹继刚,周安方.仙甲汤对前列腺增生大鼠前列腺细胞调亡率影响的实验研究[J].中国中医药科技,2005,12(1)：3.
[73]皮后炎.鳖甲煎丸合方治疗前列腺增生症验案举隅[J].中国中医急症,2009,18(11)：1902-1904.
[74]刘金松,冯贵平,潘金霞.软坚消瘀汤治疗前列腺增生症疗效观察[J].河北中医,2009,31(11)：1692.
[75]杨静哲,贾玉森,苏全新.加味阳和汤治疗良性前列腺增生症34例临床分析[J].首都医药,2010,1：52.
[76]赵子山,赵金环,江鹏.癃闭方治疗良性前列腺增生症116例疗效观察[J].实用中西医结合临床,2009,9(6)：45-46.
[77]李松,段登志.自拟清癃汤治疗前列腺增生51例[J].云南中医中药杂志,2009,30(12)：46.
[78]黄少波.自拟方术愈汤对良性前列腺增生行TUBVP术后血尿的影响[J].中国当代医药,2009,16(20)：76-77.
[79]张春和,李焱风,陈天波.前列通窍颗粒联合保列治治疗良性前列腺增生65例疗效观察[J].世界中西医结合杂志,2009,4(11)：797-799.
[80]刘杰田,张翠丽,尹玉花.泽桂癃爽胶囊联合α受体阻滞剂治疗良性前列腺增生症的疗效评价[J].世界中西医结合杂志,2009,5(3)：31.
[81]张正理,王果平,王化明.中药配合葆利安治疗前列腺增生60例[J].陕西中医,2009,30(11)：1489-1490.
[82]Stephan Madersbacher, Anton Ponholzer, Ingrid Berger, etal. Medical Management of BPH:Role of Plant Extracts[J]. European Association of Urology,2007.
[83]解红武.良性前列腺增生的药物治疗[J].天津药学,2002,14(3)：15-17.
[84]Marks LS, Hess DL, Dorey FJ, etal. Tissue effects of sawpalmetto and fi-nasteride. Use of biopsy cores for insitution quantification of prostatic andro-gens. Urology,2001,57:1005.
[85]Berges RR, KassenA, SengeT, Treatment of symptomatic benign prostat-ic hyperplasia with beta-sitosterol:an 18-month follow-up. BJU Int,2000,85:842-846.
[86]Bondarenko B, Walther C, Funk P, etal. Phytomedicine,2003,10(Suppl 4):53-55.
[87]FransD, PeterB, FernandoC, etal. Evaluation of the clinical benefit of Permixon and Tamsulosin in severe BPH patients PERMAL study sub-set analysis. EuropeanUrology,2004,45:773.
[88]赵珍东.穗花牡荆提取物对前列腺上皮细胞增殖的抑制作用和促细胞凋亡作用[J].国外医药,2006,21(6)：263.
[89]Hizli F, Uygur MC.A prospective study of the efficacy of Serenoa repens, tamsulosin, and Serenoa repens plus tamsulosin treatment for patients with benign prostate hyperplasia. Int Urol Nephrol.2007,39(3):879-86.
[90]朱威,胡福良.花粉治疗前列腺增生的研究进展[J].蜜蜂杂志,2005,12：8-10.
[91]刘勇,蔡花芳,赵铮蓉,等.破壁松花粉及软胶囊抗前列腺增生作用[J].中国医疗前沿,2007,2(22)：14-15.
[92]杨兆钢.芒针治疗前列腺炎和前列腺肥大86例临床观察[J].针灸临床杂志,1994,10(1)：23-24.
[93]李惠芳,杨柏如.针灸治疗23例前列腺增生症[J].中国针灸,1994,14(4)：13-15.
[94]付晓红.针刺配合隔姜灸治疗前列腺增生症.针灸临床杂志[J].1998,14(7)：41-42.
[95]胡九凤,王光明.针灸治疗前列腺肥大[J].针灸临床杂志,2000,16(11)：7-8.
[96]饶芳.点刺至阴穴治疗前列腺增生20例[J].中国针灸,2000,20(9)：572.
[97]郭绮云.针灸治疗老年前列腺增生34例疗效观察[J]。中国针灸,2001,21(7)：389-390.
[98]陈蓓琳,黄文燕,张载义.骶部俞穴深刺为主治疗良性前列腺增生的临床观察[J].针灸临床杂志,2005,21(9)：26-27.
[99]杨焱,陈红涛.针刺治疗前列腺增生60例分析[J].实用中医内科杂志,2004,18(3)：269-270.
[100]杨运宽,敖有光,胡幼平.针刺治疗老年前列腺增生症37例[J].上海针灸杂志,2005,24(2)：19-20.
[101]史江峰.针刺足厥阴经穴治疗前列腺增生症临床研究[J].辽宁中医杂志,2005,32(12)：1295-1296.
[102]刘鸿.芒针为主治疗前列腺增生症临床观察[J].针灸临床杂志,2005,21(7)：19
[103]王子臣,王占平,张冰.芒针为主治疗前列腺增生症41例[J].上海针灸杂志,2002,21(3)：13-4.
[104]肖远辉.温针灸为主治疗前列腺增生症疗效观察[J].天津中医学院学报,2002,21(1)：20.
[105]杨春光,廖明霞.针刺加艾灶灸治疗肾阳虚型前列腺增生50例[J].中国针灸,2004,24(11)：752.
[106]张志荣,成润娣.针药治疗前列腺肥大36例[J].陕西中医,1994,15(4)：174.
[107]张希荣,艾淑滨,范求实,等.电针配合竹叶石膏汤加减治疗前列腺肥大症38例临 床报告[J].针灸临床杂志,1997,13(3)：17.
[108]邱林.内服中药合针灸治疗前列腺肥大28例[J].国医论坛,1997,12(3)：40-41.
[109]吴昌宏,石绍伟,张志山.针药结合治疗前列腺肥大30例[J].针灸临床杂志,1998,14(9)：15.
[110]赵跃红.加味壮元汤治疗前列腺增生症62例[J].湖南中医杂志,2004,20(3)：54.
[111]何金柱,李兰英,徐伟.辨证取穴论治前列腺增生症[J].针刺研究,2000,25(4)：300-301.
[112]黄志华,陈凯奋.耳穴电针治疗老年性前列腺增生12例[J].中国针灸,1997,17(6)：34.
[113]路变珍,孙润宝.芒针加耳穴埋针治疗前列腺增生症14例[J].针灸临床杂志,1997,13(12)：27-28.
[114]张耕田.耳针治疗前列腺增生症14例[J].中国针灸,1998,18(5)：316.
[115]汤秀芳.耳针配合超声红外光子治疗前列腺增生临床观察[J].中国针灸,2000,20(9)：531-2.
[116]王祥福,王建德,冯志庆.电磁针治疗前列腺增生症60例[J].陕西中医,1993,14(4)：174-175.
[117]刘艳清,易似红.微波针炙仪治疗前列腺增生症30例观察[J].湖南中医学院学报,1995,15(1)：62-63.
[118]高维滨,白彦龙,曹蠹.电针治疗前列腺增生症41例[J].针灸临床杂志,2005,21(5)：46-7.
[119]朱宇丹.针刺配合药灸贴治疗前列腺增生[J].针灸临床杂志,2004,20(10)：16-7.
[120]刘志顺,刘元石,杨中阳,等.电针治疗症状性良性前列腺增生[J].中国临床医生,2002,30(2)：36-37.
[121]于向华,高维滨,李傲阳.针刺次髎、中髎穴治疗前列腺增生尿潴留的疗效观察[J].针灸临床杂志,2005,21(4)：48-49.
[122]朱秀平,黄少姬.电磁疗合温针灸治疗前列腺增生61例疗效观察[J].上海针灸杂志,2006,25(5)：24-25.
[123]金泽,姜珊珊,包大鹏.电针治疗前列腺增生临床观察[J].上海针灸杂志,2010,29(2)：105-106.
[124]崔丽丽,杨素凤,朱智萍.足三里穴位注射治疗经尿道前列腺电切术后腹胀的观察及护理[J].长春中医药大学学报,2009,25(6)：952.
[125]陈建平.氦氖激光治疗前列腺增生及前列腺炎64例[J].新中医,1993,25(5)：37.
[126]许维新,刘传瑾,伊静秋.电激光针治疗前列腺肥大90例[J].中国针灸,1991,11(6)：3.
[127]马仁海,张丽梅,冀萍,等.激光针灸治疗前列腺增生症132例临床观察[J].中国 中医药科技,1996,3(2)：35.
[128]洪文,莫飞智,李建强.650hm激光穴位照射与针刺治疗良性前列腺增生症的疗效对比观察[J].激光生物学报,2007,16(2)：230-233.
[129]中华人民共和国卫生部.中药新药临床研究指导原则[S].第1辑,13：171-17.
[130]石美鑫.实用外科学[M].北京：人民卫生出版,1995：1729-1731.
[131]郭云绮.针灸治疗老年前列腺增生34例临床观察[J].中国针灸,2001,21(7)：389.