靳瑞学术思想和临证经验传承暨颤三针治疗帕金森病的研究
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摘要
研究目的:
整理、总结和提炼靳瑞教授的针灸学学术思想和临证经验体系,研究靳三针新组方一颤三针,探讨其治疗帕金森病的临床疗效和脑功能作用机制。
研究方法与内容:
本文属于国家十五科技攻关课题重要的继承性研究项目,回顾性系统整理并提炼靳瑞教授的学术思想和临证经验,开展靳三针新组方前瞻性研究。
1、回顾性研究部分:
以文献研究、采访、跟诊和病例病案整理等主要方法,整理、总结和提炼靳瑞教授的针灸学学术思想和临证经验。调查统计靳三针疗法学术体系发表的有关文章,查询靳瑞及其学生、弟子等71人,自建国以来所发表学术论文,范围包括:靳瑞有关学术思想、临证经验、靳三针临床和实验研究的论文219篇,所有论文均为在公开期刊上发表。靳老主编著作18本,参编和其它8本。临床研究文献166篇,占76%,其中临床疗效研究127篇研究占58%,临床实验研究39篇占18%;动物实验研究29篇占13%;理论研究20篇占9%;其它报道类4篇占2%。靳三针疗法体系是一个以临床研究为主体,动物实验和理论研究相结合,宣传辅助的综合型学术体系,特色鲜明,综合性和开放性好。主要围绕针灸治疗脑病核心展开各项工作。
通过文献整理,总结了靳三针学术体系的发展历程,60年代、70年代萌芽,80年代的积累,90年代发展,21世纪初迅速发展。由整理靳老的人生成长之路,总结出靳三针学术体系的发展分期:雏形期、形成期、发展期和壮大期。总结了靳老的成功人格培养。三心:开心、爱心和宽心。靳瑞学术思想和临证经验总结,重点发掘了靳老针灸学术的家传和师承渊源,尤其主宗《内经》的针灸学派值得发扬,具有重要的历史价值,并对对目前针灸学科的发展提出建设性意见:读书心要总结靳老经典学习心得;初步整理传统岭南针灸学派源流脉络;
重点提炼靳瑞针灸治神要诀,针刺临证过程的前、中、后三阶段,皆贯穿治神之道,总结出针刺治神九字诀:定、察、安、聚、入、合、和、实、养,综合概括提炼“生”一字总诀。只有充分理解和运用针刺过程中的精神心理因素,才能取得完整、
Research goal:The reorganization, the summary and the refinement Jin-rui professor's acupuncture and moxibustion study academic thought and clinical experience system, studies the Jin-three needles new groups side - to Tremble three needles, discusses clinical curative effect and brain function mechanism which its treatment parkinson disease.Research method and content:This article belongs to the national 15 ten-five tackle key problems in science and technology, which it is the inheritance topics important inheritance research project, the review system reorganization and the refinement Jin-rui professor's academic thought and clinical experience, develops the Jin-three needles new groups side foresightedness research.1st, review research part: By the literature research, the interview, with examines with case of illness medical record reorganization and so on the main method, reorganizes, the summary and the refinement Jin-rui professor's acupuncture and moxibustion study academic thought and clinical experience. The investigation statistics Jin-three needles therapies academic system publication relevant paper, inquires Jin-rui and its the student, the disciple and so on 71 people, has published the dissertation since the founding of the nation, the scope includes: Jin-rui related academic thought, clinical experience, Jin-three needles clinical and experimental study paper 219, all papers for publish in the public periodical. Jin-rui senior chief editor work 18, the senate arranges with other 8. Clinical research literature 166, account for 76%, clinical curative effect studies 127 research to account for 58%, clinical experimental study 39 account for 18%;The animal experimentation studies 29 to account for 13%;Fundamental research 20 account for 9%;Other report class 4 account for 2%. The Jin- three needles therapies system is take the clinical research as the main body, the animal experimentation and the fundamental research unifies, propagandizes the auxiliary synthesis academic system, the characteristic bright, the comprehensive nature and openness are good. Mainly revolves the acupuncture
and moxibustion to treat brain illness core to launch each work.Reorganized through the literature, summarized Jin- three needles academic systems development course, 60's, 70's seeds, 80's accumulations, 90's development, at the beginning of 21st century rapid development. By reorganizes road of the Jin-rui life growth, summarizes Jin-three needles academic systems development by stages: The embryonic form time, the formative year, the period of expansion and expand the time. Summarized Jin-rui successful personality raise. Three hearts: Happy, the compassion and feels relieved. The Jin-rui academic thought and summarizes Clinical experience, has excavated the Jin-rui acupuncture and moxibustion with emphasis academic handed down in the family and transits the discipling from the origin, advocates the ancestor especially "Nei Jing" the acupuncture and moxibustion school of thought is worth developing, has the important historical value, and to gives the constructive comment to the present acupuncture and moxibustion discipline development;Reads the printed part of a page to have to summarize the Jin-rui classics what one has learned from study;Edit tradition Lingnan acupuncture and moxibustion school of thought source and course vein;Key refines Jin-rui needle moxibustion treatment god secret, The acupuncture clinical process front, center, the latter three stages, all passes through governs road of the god, summarizes the acupuncture to govern the god nine characters knacks: calm, observes, peaceful, gathers, enters, gathers, harmony, enrich, raises, the synthesis summary refinement "living" a character total knack. Only then fully understood and in the utilization acupuncture process mental and psychological factor, can completely obtain, the good acupuncture effect.The ancient and modern reinforcing and reducing senate, summarizes the Jin-rui acupuncture reinforcing and reducing main point mutually, the academic origin in "Neijing", "Nanjing", emphasized the traditional technique, take the channels and collaterals theory as a foundation, take the internal organs channels and collaterals actual situation as the object, the deficiency syndrome uses the tonic method, the real diagnosis with to flow swiftly the law, after the reinforcing and reducing technique response standard is the good reinforcing and reducing sufficient is abundant because of the vitality but has under the needle the hot response, after the line flows swiftly the law, because of perverse trend decrease, but has under the needle the cold response;With the modern acupuncture technique emphasized the nerve felt and the function differs from. The Jin-rui always thought that, The ancient and modern technique understanding angle is different, but may coexist, may the senate, be
possible to unify the application mutually.In the time medicine aspect, to the traditional acupuncture and moxibustion in "the nine palace eight holes", "the spirit turtle eight law", "the midnight and noon flows into" and so on to open the hole law to have the thorough research on time, has applied the day moxibustion time therapy with emphasis.Enumerates passes through the long-term clinical practice to summarize, outstandingly has the curative effect decorative leather harness three needles groups side 39, discusses it to match the hole characteristic and the operation main point.This part final has discussed the Jin-three needles to treat brain illness potency. Brain illness for Jin-three needles therapies main attack direction, Jin-three needles therapies clinical research literature adult brain illness class 51, accounts for 31%, child brain illness 63, accounts for total quantity 38%, two equals 69%, Jin-three needles treats brain illness the experience to be specially rich, in the head-needle combination, stimulates the quantity arrangement, dialectical with the hole and aspect and so on synthesis therapy utilization has the originality.2nd, foresightedness research part:The subject summarizes which based on the review research "governs the brain to have to govern the god" and the clue "the acupuncture - brain function" but carries out foresightedness research. Parkinson disease, is middle and old age common nervous system denatured disease, can the neuron denatured flaw and the Louis small build becomes the characteristic by the opsoninum multi- Pakistan amine. Along with the social population elder development, the disease incidence rate which this gets sick has the gradual rise the tendency. The parkinson disease the method which up to now still did not have permanently cures, the PD western medicine treatment only can control the symptom, always treated the principle was: Takes medicine for a long time, the control symptom, just right for the illness medication , the dialectical addition and subtraction;The smallest dosage, the desired effect, nowadays treat the essential target is: The greatest degree reduces the patient clinical symptom, the improvement and the enhancement survival quality. Therefore, the acupuncture and moxibustion treatment parkinson disease in recent years the research more and more received the attention, the acupuncture and moxibustion therapy in the improvement parkinson movement and the non- movement function symptom, reduces poisonously synergizes and so on the aspect has the certain superiority, the experimental^
study gradually is also thorough.The parkinson disease in recent years after the summary the acupuncture and moxibustion treatment clinical and the experimental study proposed that, the PD non-kinematic scheme function barrier symptom also was affects the PD patient to survive the quality and the curative effect important attribute, since long ago, the acupuncture and moxibustion treated PD the research to concentrate completely the attention the movement barrier symptom which caused in disease (trembles, strong straight and movement slow and so on), has neglected its oneself to the PD non- movement barrier symptom improvement function, like lost sleep, the constipation, the energetic symptom, the spoken language is disadvantageous and so on, the direction needs to adjust, should fully display the traditional Chinese medicine and the acupuncture and moxibustion therapy in the adjustment to the body and mind condition superiority, strengthened this aspect the research, Manifests the acupuncture and moxibustion to treat PD the characteristic to be at.Tremble three needles is aims at specially trembles the Jin-three needles groups side which gets sick for the main symptom parkinson, by four gods needles, four passes, the feng-chi is composed, is effective proven prescription which reorganizes in the massive clinical potency foundation. Trembles the clinical stochastic control experiment and the animal experimentation which three needles treatments parkinson disease study, the curative effect research is the development take the stress disorder factor as the main body, coordinates in the decorative leather harness three needles academic thought "to govern the god" and "treats brain illness" the subject, the development trembles the research which three needles treatments parkinson gets sick, take parkinson unification meter and Chinese quality of life meter as main observation target;The mechanism research then by "governs the god - brain function" primarily the clue, carries out the brain function order of complexity research clinical and the animal experimentation.The research observe 72 cases of PD altogerter, the findings discovered acupuncture group in the conventional treatment foundation which three needles treats, the tendency which the kinematic scheme function restores is higher than the pure western medicine convention treatment control group, but obviously is higher than control group in the non-kinematic scheme function and the survival quality improvement aspect. (Stationary character trembles, posture gait exceptionally, myo- to the PD movement function barrier four big hosts sickness strong straight, movement slow) the adjustment, the acupuncture can urge the patient varying degree to restore the movement function, by trembles the
improvement quite to be obvious. But compares with medicine control group, the improvement extremely is by no means ideal, two differences are not big. Continues (to lose sleep, despondent, spoken language swallows swallows, constipation) the adjustment to the non- kinematic scheme function barrier four first mates sickness, may observe after the treatment despondent, loses sleep, the spoken language swallows swallows and so on the symptom change obviously, is especially most prominent by the sleep improvement, next is the despondent condition and the spoken language swallows swallows the improvement, obviously is higher than control group. These projects have nothing to do with with the movement function, but regarding enhances the patient to survive the quality, is the important foundation actually.After the treatment discovered control group the survival quality total score enhances, has remarkable difference P<0 05. The acupuncture group's survival quality total score enhances, has extremely remarkable difference P<0 01. The detail analysis discovery, the control group mainly is in the spiritual, the thought aspect sub- project enhancement is remarkable, other aspects: Aspect and so on color, diet, energy has not changed, the sleep index also slightly reduces, the diet, the climate, the look, the language expression, seven sentiments have slightly elevate, but has not had statistics significance. The acupuncture group in the color, the sleep, the energy, the spirit, the thought, happy, the anger, sad sorrow, is panic-stricken and so on to have the distinct improvement, statistics has the obvious difference. The Chinese quality of life can respond the Chinese medicine acupuncture and moxibustion treatment the curative effect characteristic.The brain electricity physiology target indicated that, The parkinson electroencephalogram changes mainly reduces speed for alpha the rhythm or vanishes, or the adjustment amplitude modulation unsatisfactory, mainly slows down for the background rhythm, moreover increases, course of an illness longer, movement function harm heavier. EEG along with the patient age to be exceptionally also more. Is accompanied by despondent PD patient abnormality rate to be higher. The acupuncture group treatment result surpasses control group, can obviously improve the brain function, enhances the key brain area the brain wave energy, the parkinson partner despress patient's improvement is more obvious..In the improvement brain function aspect, after two groups treat various brains area order of complexity to have the improvement, explained the patient brain function/ strengthens from the organization characteristic, but the acupuncture group improves
obviously, and has the certain specificity. Brain area order of complexity and so on FPl, F7, P3, CZ, T4 remarkably is higher than the normal group, this is possible because the acupuncture is special, the selective enhancement weak trend brain area adjusts the function from the organization. In PD the most sensitive parietal lobe P3 area reflection outstandingly, prompts possibly has pointed.The animal experimentation brain function findings similarly also support this result, after the acupuncture treatment the left front - right cerebellum axis of symmetry and the right front - left cerebellum axis of symmetry function restore the basic balanced condition, is higher than the normal state, obviously is higher than the function low condition, the improvement effect is obvious.Conclusion:The research reorganization has refined Jin-rui professor's some important academic thought and clinical experience. Summarized the Jin-three needles therapies system law of development, for further will develop from now on lays the important foundation.Tremble three needles to make the new group side which develops for the Jin-three needles, in the parkinson treatment domain, with the conventional foundation treatment union, can improve the patient kinematic scheme function well, comprehensively, prominently improves the non- kinematic scheme function barrier, improves the quality of life, advantageously is restored to health. The Chinese quality of life meter suits the Chinese medicine curative effect characteristic to appraise extremely that, is worth continuing to study further consummates. The acupuncture treatment parkinson can in the brain electricity physiology, to the brain function order of complexity discovery improvement, prompt the acupuncture to be able especially to enhance the human body function from the organization ability, this new research area also needs further thoroughly to explore.
整理、总结和提炼靳瑞教授的针灸学学术思想和临证经验体系,研究靳三针新组方一颤三针,探讨其治疗帕金森病的临床疗效和脑功能作用机制。
研究方法与内容:
本文属于国家十五科技攻关课题重要的继承性研究项目,回顾性系统整理并提炼靳瑞教授的学术思想和临证经验,开展靳三针新组方前瞻性研究。
1、回顾性研究部分:
以文献研究、采访、跟诊和病例病案整理等主要方法,整理、总结和提炼靳瑞教授的针灸学学术思想和临证经验。调查统计靳三针疗法学术体系发表的有关文章,查询靳瑞及其学生、弟子等71人,自建国以来所发表学术论文,范围包括:靳瑞有关学术思想、临证经验、靳三针临床和实验研究的论文219篇,所有论文均为在公开期刊上发表。靳老主编著作18本,参编和其它8本。临床研究文献166篇,占76%,其中临床疗效研究127篇研究占58%,临床实验研究39篇占18%;动物实验研究29篇占13%;理论研究20篇占9%;其它报道类4篇占2%。靳三针疗法体系是一个以临床研究为主体,动物实验和理论研究相结合,宣传辅助的综合型学术体系,特色鲜明,综合性和开放性好。主要围绕针灸治疗脑病核心展开各项工作。
通过文献整理,总结了靳三针学术体系的发展历程,60年代、70年代萌芽,80年代的积累,90年代发展,21世纪初迅速发展。由整理靳老的人生成长之路,总结出靳三针学术体系的发展分期:雏形期、形成期、发展期和壮大期。总结了靳老的成功人格培养。三心:开心、爱心和宽心。靳瑞学术思想和临证经验总结,重点发掘了靳老针灸学术的家传和师承渊源,尤其主宗《内经》的针灸学派值得发扬,具有重要的历史价值,并对对目前针灸学科的发展提出建设性意见:读书心要总结靳老经典学习心得;初步整理传统岭南针灸学派源流脉络;
重点提炼靳瑞针灸治神要诀,针刺临证过程的前、中、后三阶段,皆贯穿治神之道,总结出针刺治神九字诀:定、察、安、聚、入、合、和、实、养,综合概括提炼“生”一字总诀。只有充分理解和运用针刺过程中的精神心理因素,才能取得完整、
Research goal:The reorganization, the summary and the refinement Jin-rui professor's acupuncture and moxibustion study academic thought and clinical experience system, studies the Jin-three needles new groups side - to Tremble three needles, discusses clinical curative effect and brain function mechanism which its treatment parkinson disease.Research method and content:This article belongs to the national 15 ten-five tackle key problems in science and technology, which it is the inheritance topics important inheritance research project, the review system reorganization and the refinement Jin-rui professor's academic thought and clinical experience, develops the Jin-three needles new groups side foresightedness research.1st, review research part: By the literature research, the interview, with examines with case of illness medical record reorganization and so on the main method, reorganizes, the summary and the refinement Jin-rui professor's acupuncture and moxibustion study academic thought and clinical experience. The investigation statistics Jin-three needles therapies academic system publication relevant paper, inquires Jin-rui and its the student, the disciple and so on 71 people, has published the dissertation since the founding of the nation, the scope includes: Jin-rui related academic thought, clinical experience, Jin-three needles clinical and experimental study paper 219, all papers for publish in the public periodical. Jin-rui senior chief editor work 18, the senate arranges with other 8. Clinical research literature 166, account for 76%, clinical curative effect studies 127 research to account for 58%, clinical experimental study 39 account for 18%;The animal experimentation studies 29 to account for 13%;Fundamental research 20 account for 9%;Other report class 4 account for 2%. The Jin- three needles therapies system is take the clinical research as the main body, the animal experimentation and the fundamental research unifies, propagandizes the auxiliary synthesis academic system, the characteristic bright, the comprehensive nature and openness are good. Mainly revolves the acupuncture
and moxibustion to treat brain illness core to launch each work.Reorganized through the literature, summarized Jin- three needles academic systems development course, 60's, 70's seeds, 80's accumulations, 90's development, at the beginning of 21st century rapid development. By reorganizes road of the Jin-rui life growth, summarizes Jin-three needles academic systems development by stages: The embryonic form time, the formative year, the period of expansion and expand the time. Summarized Jin-rui successful personality raise. Three hearts: Happy, the compassion and feels relieved. The Jin-rui academic thought and summarizes Clinical experience, has excavated the Jin-rui acupuncture and moxibustion with emphasis academic handed down in the family and transits the discipling from the origin, advocates the ancestor especially "Nei Jing" the acupuncture and moxibustion school of thought is worth developing, has the important historical value, and to gives the constructive comment to the present acupuncture and moxibustion discipline development;Reads the printed part of a page to have to summarize the Jin-rui classics what one has learned from study;Edit tradition Lingnan acupuncture and moxibustion school of thought source and course vein;Key refines Jin-rui needle moxibustion treatment god secret, The acupuncture clinical process front, center, the latter three stages, all passes through governs road of the god, summarizes the acupuncture to govern the god nine characters knacks: calm, observes, peaceful, gathers, enters, gathers, harmony, enrich, raises, the synthesis summary refinement "living" a character total knack. Only then fully understood and in the utilization acupuncture process mental and psychological factor, can completely obtain, the good acupuncture effect.The ancient and modern reinforcing and reducing senate, summarizes the Jin-rui acupuncture reinforcing and reducing main point mutually, the academic origin in "Neijing", "Nanjing", emphasized the traditional technique, take the channels and collaterals theory as a foundation, take the internal organs channels and collaterals actual situation as the object, the deficiency syndrome uses the tonic method, the real diagnosis with to flow swiftly the law, after the reinforcing and reducing technique response standard is the good reinforcing and reducing sufficient is abundant because of the vitality but has under the needle the hot response, after the line flows swiftly the law, because of perverse trend decrease, but has under the needle the cold response;With the modern acupuncture technique emphasized the nerve felt and the function differs from. The Jin-rui always thought that, The ancient and modern technique understanding angle is different, but may coexist, may the senate, be
possible to unify the application mutually.In the time medicine aspect, to the traditional acupuncture and moxibustion in "the nine palace eight holes", "the spirit turtle eight law", "the midnight and noon flows into" and so on to open the hole law to have the thorough research on time, has applied the day moxibustion time therapy with emphasis.Enumerates passes through the long-term clinical practice to summarize, outstandingly has the curative effect decorative leather harness three needles groups side 39, discusses it to match the hole characteristic and the operation main point.This part final has discussed the Jin-three needles to treat brain illness potency. Brain illness for Jin-three needles therapies main attack direction, Jin-three needles therapies clinical research literature adult brain illness class 51, accounts for 31%, child brain illness 63, accounts for total quantity 38%, two equals 69%, Jin-three needles treats brain illness the experience to be specially rich, in the head-needle combination, stimulates the quantity arrangement, dialectical with the hole and aspect and so on synthesis therapy utilization has the originality.2nd, foresightedness research part:The subject summarizes which based on the review research "governs the brain to have to govern the god" and the clue "the acupuncture - brain function" but carries out foresightedness research. Parkinson disease, is middle and old age common nervous system denatured disease, can the neuron denatured flaw and the Louis small build becomes the characteristic by the opsoninum multi- Pakistan amine. Along with the social population elder development, the disease incidence rate which this gets sick has the gradual rise the tendency. The parkinson disease the method which up to now still did not have permanently cures, the PD western medicine treatment only can control the symptom, always treated the principle was: Takes medicine for a long time, the control symptom, just right for the illness medication , the dialectical addition and subtraction;The smallest dosage, the desired effect, nowadays treat the essential target is: The greatest degree reduces the patient clinical symptom, the improvement and the enhancement survival quality. Therefore, the acupuncture and moxibustion treatment parkinson disease in recent years the research more and more received the attention, the acupuncture and moxibustion therapy in the improvement parkinson movement and the non- movement function symptom, reduces poisonously synergizes and so on the aspect has the certain superiority, the experimental^
study gradually is also thorough.The parkinson disease in recent years after the summary the acupuncture and moxibustion treatment clinical and the experimental study proposed that, the PD non-kinematic scheme function barrier symptom also was affects the PD patient to survive the quality and the curative effect important attribute, since long ago, the acupuncture and moxibustion treated PD the research to concentrate completely the attention the movement barrier symptom which caused in disease (trembles, strong straight and movement slow and so on), has neglected its oneself to the PD non- movement barrier symptom improvement function, like lost sleep, the constipation, the energetic symptom, the spoken language is disadvantageous and so on, the direction needs to adjust, should fully display the traditional Chinese medicine and the acupuncture and moxibustion therapy in the adjustment to the body and mind condition superiority, strengthened this aspect the research, Manifests the acupuncture and moxibustion to treat PD the characteristic to be at.Tremble three needles is aims at specially trembles the Jin-three needles groups side which gets sick for the main symptom parkinson, by four gods needles, four passes, the feng-chi is composed, is effective proven prescription which reorganizes in the massive clinical potency foundation. Trembles the clinical stochastic control experiment and the animal experimentation which three needles treatments parkinson disease study, the curative effect research is the development take the stress disorder factor as the main body, coordinates in the decorative leather harness three needles academic thought "to govern the god" and "treats brain illness" the subject, the development trembles the research which three needles treatments parkinson gets sick, take parkinson unification meter and Chinese quality of life meter as main observation target;The mechanism research then by "governs the god - brain function" primarily the clue, carries out the brain function order of complexity research clinical and the animal experimentation.The research observe 72 cases of PD altogerter, the findings discovered acupuncture group in the conventional treatment foundation which three needles treats, the tendency which the kinematic scheme function restores is higher than the pure western medicine convention treatment control group, but obviously is higher than control group in the non-kinematic scheme function and the survival quality improvement aspect. (Stationary character trembles, posture gait exceptionally, myo- to the PD movement function barrier four big hosts sickness strong straight, movement slow) the adjustment, the acupuncture can urge the patient varying degree to restore the movement function, by trembles the
improvement quite to be obvious. But compares with medicine control group, the improvement extremely is by no means ideal, two differences are not big. Continues (to lose sleep, despondent, spoken language swallows swallows, constipation) the adjustment to the non- kinematic scheme function barrier four first mates sickness, may observe after the treatment despondent, loses sleep, the spoken language swallows swallows and so on the symptom change obviously, is especially most prominent by the sleep improvement, next is the despondent condition and the spoken language swallows swallows the improvement, obviously is higher than control group. These projects have nothing to do with with the movement function, but regarding enhances the patient to survive the quality, is the important foundation actually.After the treatment discovered control group the survival quality total score enhances, has remarkable difference P<0 05. The acupuncture group's survival quality total score enhances, has extremely remarkable difference P<0 01. The detail analysis discovery, the control group mainly is in the spiritual, the thought aspect sub- project enhancement is remarkable, other aspects: Aspect and so on color, diet, energy has not changed, the sleep index also slightly reduces, the diet, the climate, the look, the language expression, seven sentiments have slightly elevate, but has not had statistics significance. The acupuncture group in the color, the sleep, the energy, the spirit, the thought, happy, the anger, sad sorrow, is panic-stricken and so on to have the distinct improvement, statistics has the obvious difference. The Chinese quality of life can respond the Chinese medicine acupuncture and moxibustion treatment the curative effect characteristic.The brain electricity physiology target indicated that, The parkinson electroencephalogram changes mainly reduces speed for alpha the rhythm or vanishes, or the adjustment amplitude modulation unsatisfactory, mainly slows down for the background rhythm, moreover increases, course of an illness longer, movement function harm heavier. EEG along with the patient age to be exceptionally also more. Is accompanied by despondent PD patient abnormality rate to be higher. The acupuncture group treatment result surpasses control group, can obviously improve the brain function, enhances the key brain area the brain wave energy, the parkinson partner despress patient's improvement is more obvious..In the improvement brain function aspect, after two groups treat various brains area order of complexity to have the improvement, explained the patient brain function/ strengthens from the organization characteristic, but the acupuncture group improves
obviously, and has the certain specificity. Brain area order of complexity and so on FPl, F7, P3, CZ, T4 remarkably is higher than the normal group, this is possible because the acupuncture is special, the selective enhancement weak trend brain area adjusts the function from the organization. In PD the most sensitive parietal lobe P3 area reflection outstandingly, prompts possibly has pointed.The animal experimentation brain function findings similarly also support this result, after the acupuncture treatment the left front - right cerebellum axis of symmetry and the right front - left cerebellum axis of symmetry function restore the basic balanced condition, is higher than the normal state, obviously is higher than the function low condition, the improvement effect is obvious.Conclusion:The research reorganization has refined Jin-rui professor's some important academic thought and clinical experience. Summarized the Jin-three needles therapies system law of development, for further will develop from now on lays the important foundation.Tremble three needles to make the new group side which develops for the Jin-three needles, in the parkinson treatment domain, with the conventional foundation treatment union, can improve the patient kinematic scheme function well, comprehensively, prominently improves the non- kinematic scheme function barrier, improves the quality of life, advantageously is restored to health. The Chinese quality of life meter suits the Chinese medicine curative effect characteristic to appraise extremely that, is worth continuing to study further consummates. The acupuncture treatment parkinson can in the brain electricity physiology, to the brain function order of complexity discovery improvement, prompt the acupuncture to be able especially to enhance the human body function from the organization ability, this new research area also needs further thoroughly to explore.
引文
1、俞竹青.头皮针合四关穴为主治帕金森氏症[J] 浙江中医学院学报 1994.18(6):45
2、郑翎,金宇.针刺治疗震颤麻痹52例临床观察[J] 针灸临床杂志 1997.17(3):13
3、冉茂东,郭蕴屏.头针配合体针治疗帕金森病36例[J] 中国针灸 2000.20(9):544
4、奚桂芳,蔡德亨.头部穴位电刺激结合中药治疗帕金森病的临床研究[J] 针刺研究,1997,(10):1-2
5、张海波,张召平.电针治疗帕金森病50例临床观察[J] 中国中酉医结合杂志,1995,15(4):246-247
6、唐大全.头针配梅花针治疗震颤麻痹12例[J] 黑龙江中医药,1994,(3):49.
7、王玲玲 针灸治疗帕金森氏症的临证体会[A] 世界针灸学会联合会成立十周年学术大会论文摘要汇编
8、周华青 针灸治疗帕金森病疗效观察[J] 安徽中医临床杂志.[J] 2001.13(5):370
9、梁凤英,刘式祺 针刺配合药物治疗中老年帕金森55例[J] 广西中医药,1997,20(5):34～35
10、朱政 针灸结合中药对帕金森病康复治疗的疗郊观察[J] 现代康复,2001,11(5):125
11、徐道祥,赵学英,罗和春 经络氧疗法治疗震颤麻痹35例临床观察[J]中国针灸2000,10(6):337
12、李圣平 帕金森综合征的针灸康复疗法[J] 四川中医1993,11(8):51
13、吴奇 难治性老年病与中医天人太极合一共振[J] 天津中医,2002,19(5):63-66.
14、徐斌,马聘,王玲玲,等 穴位注射治疗实验性震颤麻痹的研究[J] 针刺研究,1998,(1):49-51.
15、张京峰 孙国胜 赵国华 隔药灸神阙穴治疗帕金森病54例疗效观察 中国针灸 2005,25(9):610—612
16、李小军 督脉穴为主治疗帕金森病临床分析[J] 中国针灸2003,23(8)
17、符冰,伦新,荣莉,等 电针头穴及督脉穴治疗帕金森病:随机对照观察[J] 中国临床康复,2004,8(24):4524—5
18、李种泰 杨文波 综合疗法为主治疗帕金森病30例疗效观察 新中医 2005,37(10):52—53
19、Shulmnn LM, Wen X, Weiner WJ, et al. Acupuncture therapy for the symptoms of parkinson's diease. Mov disord 2002;17(4): 799
20、奚桂芳,蔡德亨,陈国美等 头部穴位电刺激对帕金森病震颤肌电位的影响[J] 上海针灸杂志,1996,(3):5.
21、朱莉莉 针刺对帕金森病脑干诱发电位影响的分析[J] 江苏中医 2000,21(5):42～43
22、董晓彤,王双昆,任小群,等 针刺治疗震颤麻痹对患者血中LPO和SOD含量的影响[J] 针刺研究 2001,26(1):28
23、徐斌,马聘,陈国志 针刺调节原发性帕金森病脑脊液中单胺类递质临床观察[J] 中国针灸,2002,22(3):183
24、徐斌,马聘,陈国志 穴位注射对帕金森病中枢单胺类递质的影响[J] 上海针灸杂志2002,21(2):1
25、睢久红,奚桂芳,余爱珍.针刺结合复方中药治疗对帕金森病患者血浆中DA含量的影响[J] 针刺研究1997,22(2)106
26、王玲玲,何崇,赵玫,等.针灸对帕金森病脑部血流状态的影响[J].中国针灸,1999,19(2):115.
27、何崇,王玲玲,董洪涛,等针灸对帕金森病大鼠模型脑内单胺类递质含量的影响[J].针刺研究,1998,23(1):44.
28、梁希彬,刘贤宇,李丰桥 电针治疗部分损伤帕金森病大鼠的实验研究[J] 针刺研究,2001,26(3):209
29、唐勇 余曙光 陈瑾 电针促进帕金森小鼠黑质致密突触形态可塑性的研究[J] 成都中医药大学学报2005,28(1):30—32
30、刘晓棠,卞金玲 针灸治疗帕金森病的临床研究进展[J] 中医药信息2005,22(4):45—47
31 梅磊,刘月红,陈小星等 帕金森氏症的大脑涨落图分析[J].中华医学杂志 1990,70(2)
32、NurmiE, Ruottinen H, Kaasinen V, et al. Progressive Parkinson's disease: a positron emission tomography study with a dopamine transport ligand18F-CFT[J]. Ann Neurol, 2000, 47:804～808
33、Ribeiro MJ, Vidaihet M, Loc'h C, et al. Dopaminergic function and dopamine transporter binding assessed with poritron emission tomography in Parkinson's disease[J].Arch Neurol, 2002, 59:580～586
34 Rinne JO, Ruottinen H, Bergman J, et al. Usefulness of dopamine transporter PET ligandl8F-beta-CFT in a sessing disability in Parkinson's disease [J]. J Neuro Neur-surg Psychiatry, 1999, 67:737～741
35、孙伯民 李殿友 左传涛 等 中晚期帕金森病患者的脑功能影像研究 中华神经科杂志 2005,38(3):175～178
36、高波 刘树伟 帕金森病的功能影像学研究进展 中华老年医学杂志 2005,24(5):389～392
37、李可,单保慈,刘华等 针刺合谷穴脑功能磁共振成像研究 中国医学影像技术2005,21(9):329～1331
38、王葳 李坤成 单保慈等 针刺太冲穴的脑功能研究 中华放射学杂志2006,40(1):32～35
39、倪皖东 罗述谦 脑功能成像技术与针灸研究疗效机制[J].中国临床康复 2004,8(4):718～719
40、卓鹰,黄泳,姜雪梅等 头针对帕金森病患者脑葡萄糖代谢的影响 中国中医基础医学杂志2006,12(1)
41、姜雪梅,黄泳,王升旭 针刺治疗帕金森病的疗效评价及思考[J].中医药学刊2005,(23)7:1240～1242
42、方积乾,主编.生存质量测定方法及应用[M].第1版.北京:北京医科大学出版社,2000.49-53
43、中华医学会神经病学分会 原发性帕金森病治疗的建议(1998年)[J] 中华神经科杂志,1999,32(4):237—238
44、郑国庆 蔡业峰、雒晓东,等,帕金森病的综合性治疗 中国临床康复 2002,6(15):2234～2235
45、陈圣鑫,陈生弟 帕金森病患者的健康相关生活质量及其影响因素[J] 中国临床康复 2003.7(1):48～49
46. Schrag A, Selai C, Jahanahahi M, et al The EQ-5D-a generic quality of life measure- in a useful instrument to measure quality of life in patients with Parkinson's disease. [J] J Neurol Neurosurg Psychiatry 2000: 69(1): 67～73
47、Schrag A, Jahanahahi M, Quiun N. What contributes to quality of life in patients with Parkinson's disease? [J] J Neurol Neurosurg Psychiatry 2000;69(3): 308～12
48、Karleon KH, Tandberg E, Alsland D, et al. Health related quality of life in Parkinson' disease: a prospective longitudinal study. [J] J Neurol Neurosurg Psy-chiatry 2000, 69(5): 584～9
49、陈圣鑫 翁中芳 陈生弟 影响帕金森病患者健康相关生活质量因素的研究[J] 现代神经疾病杂志2002,2(5):274～277
50、宋建良,诸国嘉,孙新芳,等 老年帕金森病患者智能和生活质量状况的对照观察[J] 中华全科医师杂志 2003,2(3):147—149
51、尹伟华,刘春风,罗蔚峰,等 影响帕金森病患者生活质量因素的研究[J] 临床神经病学杂2004,17(6):446～448
52、吴逸雯,张景,千静,翁中芳,刘振国,陈生弟 影响帕金森病患者生活质量的主要因素[J] 临床神经病学杂志 2005,18(1):16～18
53、苏玉兰 老年帕金森病的康复护理效果观察[J] 中国临床康复2002年,6(5):750
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67.李飞 谷德祥 李燕君等 帕金森病患者抑郁与脑功能相关研究 神经疾病与精神卫生2002,2(5):280～281
68.包新民,舒斯云.大鼠脑立体定向图谱[M].北京:人民卫生出版社,1991:49—58.
2、郑翎,金宇.针刺治疗震颤麻痹52例临床观察[J] 针灸临床杂志 1997.17(3):13
3、冉茂东,郭蕴屏.头针配合体针治疗帕金森病36例[J] 中国针灸 2000.20(9):544
4、奚桂芳,蔡德亨.头部穴位电刺激结合中药治疗帕金森病的临床研究[J] 针刺研究,1997,(10):1-2
5、张海波,张召平.电针治疗帕金森病50例临床观察[J] 中国中酉医结合杂志,1995,15(4):246-247
6、唐大全.头针配梅花针治疗震颤麻痹12例[J] 黑龙江中医药,1994,(3):49.
7、王玲玲 针灸治疗帕金森氏症的临证体会[A] 世界针灸学会联合会成立十周年学术大会论文摘要汇编
8、周华青 针灸治疗帕金森病疗效观察[J] 安徽中医临床杂志.[J] 2001.13(5):370
9、梁凤英,刘式祺 针刺配合药物治疗中老年帕金森55例[J] 广西中医药,1997,20(5):34～35
10、朱政 针灸结合中药对帕金森病康复治疗的疗郊观察[J] 现代康复,2001,11(5):125
11、徐道祥,赵学英,罗和春 经络氧疗法治疗震颤麻痹35例临床观察[J]中国针灸2000,10(6):337
12、李圣平 帕金森综合征的针灸康复疗法[J] 四川中医1993,11(8):51
13、吴奇 难治性老年病与中医天人太极合一共振[J] 天津中医,2002,19(5):63-66.
14、徐斌,马聘,王玲玲,等 穴位注射治疗实验性震颤麻痹的研究[J] 针刺研究,1998,(1):49-51.
15、张京峰 孙国胜 赵国华 隔药灸神阙穴治疗帕金森病54例疗效观察 中国针灸 2005,25(9):610—612
16、李小军 督脉穴为主治疗帕金森病临床分析[J] 中国针灸2003,23(8)
17、符冰,伦新,荣莉,等 电针头穴及督脉穴治疗帕金森病:随机对照观察[J] 中国临床康复,2004,8(24):4524—5
18、李种泰 杨文波 综合疗法为主治疗帕金森病30例疗效观察 新中医 2005,37(10):52—53
19、Shulmnn LM, Wen X, Weiner WJ, et al. Acupuncture therapy for the symptoms of parkinson's diease. Mov disord 2002;17(4): 799
20、奚桂芳,蔡德亨,陈国美等 头部穴位电刺激对帕金森病震颤肌电位的影响[J] 上海针灸杂志,1996,(3):5.
21、朱莉莉 针刺对帕金森病脑干诱发电位影响的分析[J] 江苏中医 2000,21(5):42～43
22、董晓彤,王双昆,任小群,等 针刺治疗震颤麻痹对患者血中LPO和SOD含量的影响[J] 针刺研究 2001,26(1):28
23、徐斌,马聘,陈国志 针刺调节原发性帕金森病脑脊液中单胺类递质临床观察[J] 中国针灸,2002,22(3):183
24、徐斌,马聘,陈国志 穴位注射对帕金森病中枢单胺类递质的影响[J] 上海针灸杂志2002,21(2):1
25、睢久红,奚桂芳,余爱珍.针刺结合复方中药治疗对帕金森病患者血浆中DA含量的影响[J] 针刺研究1997,22(2)106
26、王玲玲,何崇,赵玫,等.针灸对帕金森病脑部血流状态的影响[J].中国针灸,1999,19(2):115.
27、何崇,王玲玲,董洪涛,等针灸对帕金森病大鼠模型脑内单胺类递质含量的影响[J].针刺研究,1998,23(1):44.
28、梁希彬,刘贤宇,李丰桥 电针治疗部分损伤帕金森病大鼠的实验研究[J] 针刺研究,2001,26(3):209
29、唐勇 余曙光 陈瑾 电针促进帕金森小鼠黑质致密突触形态可塑性的研究[J] 成都中医药大学学报2005,28(1):30—32
30、刘晓棠,卞金玲 针灸治疗帕金森病的临床研究进展[J] 中医药信息2005,22(4):45—47
31 梅磊,刘月红,陈小星等 帕金森氏症的大脑涨落图分析[J].中华医学杂志 1990,70(2)
32、NurmiE, Ruottinen H, Kaasinen V, et al. Progressive Parkinson's disease: a positron emission tomography study with a dopamine transport ligand18F-CFT[J]. Ann Neurol, 2000, 47:804～808
33、Ribeiro MJ, Vidaihet M, Loc'h C, et al. Dopaminergic function and dopamine transporter binding assessed with poritron emission tomography in Parkinson's disease[J].Arch Neurol, 2002, 59:580～586
34 Rinne JO, Ruottinen H, Bergman J, et al. Usefulness of dopamine transporter PET ligandl8F-beta-CFT in a sessing disability in Parkinson's disease [J]. J Neuro Neur-surg Psychiatry, 1999, 67:737～741
35、孙伯民 李殿友 左传涛 等 中晚期帕金森病患者的脑功能影像研究 中华神经科杂志 2005,38(3):175～178
36、高波 刘树伟 帕金森病的功能影像学研究进展 中华老年医学杂志 2005,24(5):389～392
37、李可,单保慈,刘华等 针刺合谷穴脑功能磁共振成像研究 中国医学影像技术2005,21(9):329～1331
38、王葳 李坤成 单保慈等 针刺太冲穴的脑功能研究 中华放射学杂志2006,40(1):32～35
39、倪皖东 罗述谦 脑功能成像技术与针灸研究疗效机制[J].中国临床康复 2004,8(4):718～719
40、卓鹰,黄泳,姜雪梅等 头针对帕金森病患者脑葡萄糖代谢的影响 中国中医基础医学杂志2006,12(1)
41、姜雪梅,黄泳,王升旭 针刺治疗帕金森病的疗效评价及思考[J].中医药学刊2005,(23)7:1240～1242
42、方积乾,主编.生存质量测定方法及应用[M].第1版.北京:北京医科大学出版社,2000.49-53
43、中华医学会神经病学分会 原发性帕金森病治疗的建议(1998年)[J] 中华神经科杂志,1999,32(4):237—238
44、郑国庆 蔡业峰、雒晓东,等,帕金森病的综合性治疗 中国临床康复 2002,6(15):2234～2235
45、陈圣鑫,陈生弟 帕金森病患者的健康相关生活质量及其影响因素[J] 中国临床康复 2003.7(1):48～49
46. Schrag A, Selai C, Jahanahahi M, et al The EQ-5D-a generic quality of life measure- in a useful instrument to measure quality of life in patients with Parkinson's disease. [J] J Neurol Neurosurg Psychiatry 2000: 69(1): 67～73
47、Schrag A, Jahanahahi M, Quiun N. What contributes to quality of life in patients with Parkinson's disease? [J] J Neurol Neurosurg Psychiatry 2000;69(3): 308～12
48、Karleon KH, Tandberg E, Alsland D, et al. Health related quality of life in Parkinson' disease: a prospective longitudinal study. [J] J Neurol Neurosurg Psy-chiatry 2000, 69(5): 584～9
49、陈圣鑫 翁中芳 陈生弟 影响帕金森病患者健康相关生活质量因素的研究[J] 现代神经疾病杂志2002,2(5):274～277
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