环境介质中喹诺酮类抗生素的前处理与检测方法研究进展
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摘要
由于在人类医疗保健与集约化禽畜和水产养殖中的大量使用,痕量水平的喹诺酮类抗生素在水体、土壤及沉积物中广泛出现.因此,使用灵敏度高、选择性强的分析方法来检测环境中的痕量喹诺酮类抗生素,对了解其潜在的环境风险极为重要.本文综述了水体、土壤及沉积物样品中喹诺酮类抗生素萃取、富集与检测方法的最新进展.固相萃取(solid phase extraction,SPE)和超声/微波辅助萃取联合SPE分别是萃取和富集液相和固相(土壤和沉积物)样品中喹诺酮类抗生素最成熟可靠的方法.液相色谱-荧光检测联用和液相色谱-串联质谱联用技术是使用最为广泛的常规分析方法.此外,近年发展的免疫测定、生物传感器与电化学方法有望在筛检方面替代昂贵的仪器分析,尤其在现场实时监测领域具有较好的应用前景.
Due to their heavy use in human health care and industrial food animal production,quinolones occur widely in surface water,soils,and sediments. Development of highly sensitive and selective analytical techniques for the detection of quinolones,often at trace levels,in environmental matrices is necessary to understand their risk to the environment. This review summarizes the recent development in sample pretreatment and determination of quinolone residues in aqueous samples,soils and sediments. Despite the recent development of novel extraction and pre-concentration methods,solid phase extraction( SPE), ultrasound-assisted extraction or microwave-assisted extraction followed by SPE are the most developede and reliable methods for the extraction and enrichment of quinolones in aqueous and solid samples, respectively. Liquid chromatographyfluorescence and liquid chromatography-triple quadrupole tandem mass spectrometry are widely used for the routine analyses of quinolones,while novel immunoassays,biosensors and electrochemical methods show promises as alternatives to the expensive instrumental analyses in screening,particularly for on-site real-time monitoring of these pollutants.
Due to their heavy use in human health care and industrial food animal production,quinolones occur widely in surface water,soils,and sediments. Development of highly sensitive and selective analytical techniques for the detection of quinolones,often at trace levels,in environmental matrices is necessary to understand their risk to the environment. This review summarizes the recent development in sample pretreatment and determination of quinolone residues in aqueous samples,soils and sediments. Despite the recent development of novel extraction and pre-concentration methods,solid phase extraction( SPE), ultrasound-assisted extraction or microwave-assisted extraction followed by SPE are the most developede and reliable methods for the extraction and enrichment of quinolones in aqueous and solid samples, respectively. Liquid chromatographyfluorescence and liquid chromatography-triple quadrupole tandem mass spectrometry are widely used for the routine analyses of quinolones,while novel immunoassays,biosensors and electrochemical methods show promises as alternatives to the expensive instrumental analyses in screening,particularly for on-site real-time monitoring of these pollutants.
引文
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[2] BOXALL A B A. The environmental side effects of medication:How are human and veterinary medicines in soils and water bodies affecting human and environmental health[J]. EMBO Reports,2004,5(2):1110-1116.
[3] BRUHN S T. Pharmaceutical antibiotic compounds in soils-A review[J]. Journal of Plant Nutrition and Soil Science,2003,166(2):145-167.
[4] MIGLIORE L,COZZOLINO S,FIORI M. Phytotoxicity to and uptake of enrofloxacin in crop plants[J]. Chemosphere,2003,52(7):1233-1244.
[5] HU X G,ZHOU Q X,LUO Y I. Occurrence and source analysis of typical veterinary antibiotics in manure,soil,vegetables and groundwater from organic vegetable bases,northern China[J]. Environmental Pollution,2010,158(9):2992-2998.
[6] WATKINSON A J,MURBY E J,KOLPIN D W,et al. The occurrence of antibiotics in an urban watershed:From wastewater to drinking water[J]. Science of the Total Environment,2009,407(8):2711-2723.
[7] HU Y A,CHENG H F. Use of veterinary antimicrobials in China and efforts to improve their rational use[J]. Journal of Global Antimicrobial Resistance,2015,3(2):144-146.
[8] HU Y A,CHENG H F. Research opportunities for antimicrobial resistance control in China's factory farming[J]. Environmental Science&Technology,2014,48(10):5364-5365.
[9] ANDREU V,BLASCO C,PICO Y. Analytical strategies to determine quinolone residues in food and the environment[J]. Tr AC Trends in Analytical Chemistry,2007,26(6):534-556.
[10] BELAL F,EL-ENANY N,WAHBA M E K. Analytical methods for the determination of some selected 4-quinolone antibacterials[J].Reviews in Analytical Chemistry,2017,doi:10.1515/revac-2015-0020.
[11] SPELTINI A,STURINI M,MARASCHI F,et al. Fluoroquinolone antibiotics in environmental waters:Sample preparation and determination[J]. Journal of Separation Science,2010,33(8):1115-1131.
[12] SPELTINI A,STURINI M,MARASCHI F,et al. Analytical methods for the determination of fluoroquinolones in solid environmental matrices[J]. Tr AC Trends in Analytical Chemistry,2011,30(8):1337-1350.
[13] ZHANG Z C,CHENG H F. Recent development in sample preparation and analytical techniques for determination of quinolone residues in food products[J]. Critical Reviews in Analytical Chemistry,2017,47:223-250.
[14] LOMBARDO-AGUIM,CRUCES-BLANCO C,GARCIA-CAMPANA M A,et al. Multiresidue analysis of quinolones in water by ultra-high perfomance liquid chromatography with tandem mass spectrometry using a simple and effective sample treatment[J]. Journal of Separation Science,2014,37(16):2145-2152.
[15] LOMBARDO-AGUIM,CRUCES-BLANCO C,GARCIA-CAMPANA M A,et al. Sensitive determination of fluoroquinolone residues in waters by capillary electrophoresis with laser-induced fluorescence detection[J]. Analytical and Bioanalytical Chemistry,2010,396(4):1551-1557.
[16] GROS M,RODRIGUEZ-MOZAZ,BARCELO D. Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in surface and treated waters by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry[J]. Journal of Chromatography A,2012,1248:104-121.
[17] CHRISTIAN T,SCHNEIDER R J,FARBER H A. et al. Determination of antibiotic residues in manure,soil,and surface waters[J]. Acta Hydrochimica et Hydrobiologica,2003,31(1):36-44.
[18] GBYLIK-SIKORSKA M,POSYNIAK A,SNIEGOCKI T,et al. Liquid chromatography-tandem mass spectrometry multiclass method for the determination of antibiotics residues in water samples from water supply systems in food-producing animal farms[J]. Chemosphere,2015,119:8-15.
[19] ZHOU J L,MASKAOUI K,LUFADEJU A. Optimization of antibiotic analysis in water by solid-phase extraction and high performance liquid chromatography-mass spectrometry/mass spectrometry[J]. Analytica Chimica Acta,2012,731:32-39.
[20] DORIVAL-GARC N,ZAFRA-GOMEZ A,CANTARERO S. et al. Simultaneous determination of 13 quinolone antibiotic derivatives in wastewater samples using solid-phase extraction and ultra performance liquid chromatography-tandem mass spectrometry[J]. Microchemical Journal,2013,106:323-333.
[21] ZHOU J,LIANG K,YUE H. Matrix effect in high-performance liquid chromatography-tandem mass spectrometry analysis of antibiotics in environmental water samples[J]. Journal of Separation Science,2013,36(3):564-571.
[22] TAMTAM F,MERCIER F,EURIN J,et al. Ultra performance liquid chromatography tandem mass spectrometry performance evaluation for analysis of antibiotics in natural waters[J]. Analytical and Bioanalytical Chemistry,2009,393(6-7):1709-1718.
[23] GARCIA-CAMPANA A M,GMIZ-GRACIA L,LARA F J,et al. Applications of capillary electrophoresis to the determination of antibiotics in food and environmental samples[J]. Analytical and Bioanalytical Chemistry,2009,395(4):967-986.
[24] CHEN B,WANG W D,H Y M. Cigarette filters as adsorbents of solid-phase extraction for determination of fluoroquinolone antibiotics in environmental water samples coupled with high-performance liquid chromatography[J]. Talanta,2012,88:237-243.
[25] GARCIA M D G,GALLEGOS A B,VALVERDE R S,et al. Determination of(fluoro)quinolones in environmental water using online preconcentration with column switching linked to large sample volumes and fluorescence detection[J]. Journal of Separation Science,2012,35(7):823-831.
[26] LOPEZ-SERNA R,PEREZ S,GINEBREDA A,et al. Fully automated determination of 74 pharmaceuticals in environmental and waste waters by online solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry[J]. Talanta,2010,83(2):410-424.
[27] CHEN L G,ZHANG X P,XU Y,et al. Determination of fluoroquinolone antibiotics in environmental water samples based on magnetic molecularly imprinted polymer extraction followed by liquid chromatography-tandem mass spectrometry[J]. Analytica Chimica Acta,2010,662(1):31-38.
[28] ESPONDA S M,PADRON M E T,FERRERA Z S,et al. Solid-phase microextraction with micellar desorption and HPLC-fluorescence detection for the analysis of fluoroquinolones residues in water samples[J]. Analytical and Bioanalytical Chemistry,2009,394(4):927-935.
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