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在“Elsevier”中，命中：28条，耗时：0.0129821 秒

1.A尾42 production in brain capillary endothelial cells after oxygen and glucose deprivation

作者：Alessandra Bulbarelli^a ; ^{alessandra.bulbarelli@unimib.it} ; Elena Lonati^a ; ^{elena.lonati1@unimib.it} ; Anna Brambilla^a ; ^{a.brambilla18@campus.unimib.it} ; Antonina Orlando^a ; ^{a.orlando7@campus.unimib.it} ; Emanuela Cazzaniga^a ; ^{emanuela.cazzaniga@unimib.it} ; Fabrizio Piazza^b ; ^{fabrizio.piazza@unimib.it} ; Carlo Ferrarese^b ; ^c ; ^{carlo.ferrarese@unimib.it} ; Massimo Masserini^a ; ^{massimo.masserini@unimib.it} ; Giulio Sancini^a ; ^{giulio.sancini@unimib.it}

关键词：AD ; Alzheimer's disease ; A 尾 42 ; amyloid-尾 (1-42) ; BBB ; Blood Brain Barrier ; A尾PP ; amyloid-尾 protein precursor ; OGD ; Oxygen Glucose Deprivation ; HIF-1伪 ; Hypoxia Inducible Factor-1alpha ; RBE4 ; rat brain capillary endothelial cells ; BACE1 ; 尾-secretase

刊名：Molecular and Cellular Neuroscience

出版年：2012

2.Lead optimization of 4,4-biaryl piperidine amides as 纬-secretase inhibitors

作者：Joshua Close^a ; ^{joshua_close@merck.com} ; Richard Heidebrecht Jr.^a ; John Hendrix^a ; Chaomin Li^a ; Ben Munoz^a ; Laura Surdi^a ; Solomon Kattar^a ; Paul Tempest^a ; Paul Moses^a ; Xiaoliu Geng^a ; Bethany Hughes^a ; Nadya Smotrov^a ; Chris Moxham^a ; Jennifer Chapnick^a ; Ilona Kariv^a ; George Nikov^a ; Julie Elizabeth Burke^a ; Sujal Deshmukh^a ; Valentina Jeliazkova-Mecheva^a ; John Kevin Leach^a ; Damaris Diaz^a ; Lin Xu^a ; Ziping Yang^a ; Gloria Kwei^a ; Lily Moy^a ; Sanjiv Shah^a ; Flobert Tanga^a ; Candia Kenefic^a ; Dan Savage^a ; Mark Shearman^a ; Richard G. Ball^b ; Michael J. McNevin^b ; Amanda Markarewicz^b ; Thomas Miller^a

关键词：Alzheimer&rsquo ; s disease ; 纬-Secretase ; A尾42 ; APP-YAC ; In vivo clearance

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

3.Structure guided P1鈥?modifications of HEA derived 尾-secretase inhibitors for the treatment of Alzheimer鈥檚 disease

作者：Holger Monenschein^c ; ^&dagger ; ; Daniel B. Horne^a ; ^{dhorne@amgen.com} ; Michael D. Bartberger^b ; Stephen A. Hitchcock^c ; ^&dagger ; ; Thomas T. Nguyen^a ; Vinod F. Patel^d ; ^&dagger ; ; Lewis D. Pennington^a ; Wenge Zhong^a

关键词：A尾 amyloid ; Alzheimer&rsquo ; s disease ; Aspartyl protease ; 尾-secretase ; BACE inhibitors ; Hydroxyethylene derivatives ; Protease inhibitors

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

4.Multicenter, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Study of the Oral 纬-Secretase Inhibitor BMS-708163 (Avagacestat): Tolerability Profile, Pharmacokinetic Parameters, and Pharmacodynamic Markers

作者：Gary Tong ; MD ; PhD¹ ; ^{Gary.Tong@bms.com} ; Jun-Sheng Wang ; PhD¹ ; Oleksandr Sverdlov ; PhD² ; Shu-Pang Huang ; PhD² ; Randy Slemmon ; PhD¹ ; Robert Croop ; MD² ; Lorna Castaneda ; MS¹ ; Huidong Gu ; MS² ; Oi Wong ; BS² ; Hewei Li ; MD ; PhD² ; Robert M. Berman ; MD³ ; Christina Smith ; DPhil² ; Charles F. Albright ; PhD³ ; Randy C. Dockens ; PhD¹

关键词：avagacestat ; Alzheimer's disease ; A尾1&ndash ; 40 ; gamma-secretase inhibitor ; pharmacodynamic ; pharmacokinetic ; tolerability

刊名：Clinical Therapeutics

出版年：2012

5.MicroRNA networks surrounding APP and amyloid-尾 metabolism 鈥?Implications for Alzheimer's disease

作者：Nicole Schonrock^a ; ^{n.schonrock@victorchang.edu.au} ; Miriam Matamales^b ; Lars M. Ittner^c ; Jü ; rgen Gö ; tz^b ; ^{juergen.goetz@sydney.edu.au}

关键词：Alzheimer ; A尾 (amyloid-尾) ; APP (amyloid precursor protein) ; Animal model ; BACE1 ; 尾-secretase ; MicroRNA ; Neurodegeneration ; Splicing ; Tau

刊名：Experimental Neurology

出版年：2012

6.Pro-oxidant diet enhances 尾/纬 secretase-mediated APP processing in APP/PS1 transgenic mice

作者：Fahd Choudhry^a ; David R. Howlett^b ; ¹ ; Jill C. Richardson^b ; Paul T. Francis^a ; ² ; Robert J. Williams^a ; ^c ; ² ; ^{r.j.williams@bath.ac.uk}

关键词：Oxidative stress ; APP ; Alzheimer's disease ; TASTPM mice ; BACE ; presenilin

刊名：Neurobiology of Aging

出版年：2012

7.In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3尾 and secretases

作者：Juan Ignacio Diaz-Hernandez^a ; ^b ; ^f ; Rosa Gomez-Villafuertes^a ; ^b ; ^f ; Miriam Leó ; n-Otegui^a ; ^b ; Lourdes Hontecillas-Prieto^c ; Ana del Puerto^c ; ^d ; Jose Luis Trejo^c ; Jose Javier Lucas^d ; ^e ; Juan Jose Garrido^c ; ^d ; Javier Gualix^a ; ^b ; ^f ; Maria Teresa Miras-Portugal^a ; ^b ; ^f ; Miguel Diaz-Hernandez^a ; ^b ; ^f ; ^{migueldiaz@vet.ucm.es}

关键词：P2X7 ; Familiar Alzheimer's disease ; APP transgenic mice ; GSK-3 ; 伪-secretase ; APP ; Amyloid plaques

刊名：Neurobiology of Aging

出版年：2012

8.Protective effects of astragalosides on dexamethasone and A尾_25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats

作者：Wei-Zu Li^a ; ^b ; ¹ ; Wang-Yang Wu^a ; ^b ; ¹ ; Da-Ke Huang^c ; Yan-Yan Yin^a ; ^b ; Hong-Wei Kan^d ; Xin Wang^e ; Yu-You Yao^a ; ^b ; Wei-Ping Li^a ; ^b ; ^{lwp19@126.com}

关键词：Dexamethasone ; A尾25&ndash ; 35 ; Memory and learning impairment ; APP ; Astragalosides

刊名：Food and Chemical Toxicology

出版年：2012

9.Notch signaling mediates TGF-尾1-induced epithelial-mesenchymal transition through the induction of Snai1

作者：Yosuke Matsuno^a ; ^{yosukem@umich.edu} ; Ana Lucia Coelho^a ; Gabor Jarai^b ; John Westwick^b ; Cory M. Hogaboam^a

关键词：EMT ; epithelial&ndash ; mesenchymal transition ; TGF ; tumor growth factor ; NICD ; notch intracellular domain ; GSI ; 纬-secretase inhibitor

刊名：The International Journal of Biochemistry and Cell Biology

出版年：2012

10.Triazoloamides as potent 纬-secretase modulators with reduced hERG liability

作者：Christian Fischer ; ^{christian_fischer@merck.com} ; Susan L. Zultanski ; Hua Zhou ; Joey L. Methot ; Sanjiv Shah ; Hugh Nuthall ; Bethany L. Hughes ; Nadja Smotrov ; Armetta Hill ; Alexander A. Szewczak ; Christopher M. Moxham ; Nathan Bays ; Richard E. Middleton ; Benito Munoz ; Mark S. Shearman

关键词：Gamma secretase modulator ; Alzheimer&rsquos ; Amyloid beta

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

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