搜索页_Toxicology+and+Applied+Pharmacology

网站地图 | English | 公务邮箱

读者指南

学术客户端

NSTL服务站

科技查新

在“Elsevier”中，命中：885条，耗时：0.0699992 秒

1.Characterization and validation of an in silico toxicology model to predict the mutagenic potential of drug impurities*

作者：Luis G. Valerio ; Jr.^a ; ^{luis.valerio@fda.hhs.gov} ; Kevin P. Cross^b

关键词：Safety ; Mutagenicity ; QSAR ; Modeling

刊名：Toxicology and Applied Pharmacology

出版年：2012

2.HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity

作者：Joseph G. Reynolds^a ; ¹ ; Elena Geretti^a ; ¹ ; Bart S. Hendriks^a ; ¹ ; Helen Lee^a ; Shannon C. Leonard^a ; Stephan G. Klinz^a ; Charles O. Noble^a ; Petra B. Lü ; cker^b ; Peter W. Zandstra^b ; Daryl C. Drummond^a ; Kenneth J. Olivier Jr.^a ; Ulrik B. Nielsen^a ; Clet Niyikiza^a ; Samuel V. Agresta^a ; Thomas J. Wickham^a ; ^{twickham@merrimackpharma.com}

关键词：Stem cell-derived cardiomyocytes ; Doxorubicin ; Preclinical safety ; HER2-targeted liposomal doxorubicin ; Cardiotoxicity ; Safety sciences

刊名：Toxicology and Applied Pharmacology

出版年：2012

3.Application of computational toxicological approaches in human health risk assessment. I. A tiered surrogate approach

作者：Nina Ching Yi Wang^a ; ^{wang.nina@epa.gov} ; Q. Jay Zhao^a ; Scott C. Wesselkamper^a ; Jason C. Lambert^a ; Dan Petersen^a ; Janet K. Hess-Wilson^b

关键词：Structure&ndash ; activity relationships ; Human health risk assessment ; Surrogate ; n-Butylbenzene ; Computational toxicology and predictive toxicology

刊名：Regulatory Toxicology and Pharmacology

出版年：2012

4.VirtualToxLab 鈥?A platform for estimating the toxic potential of drugs, chemicals and natural products

作者：Angelo Vedani^a ; ^b ; ^{angelo.vedani@unibas.ch} ; ; Max Dobler^a ; Martin Smie&scaron ; ko^b

关键词：VirtualToxLab ; In silico toxicology ; Toxicity alerts ; Automated ; flexible docking ; Multi-dimensional QSAR ; Open-access platform

刊名：Toxicology and Applied Pharmacology

出版年：2012

5.Guidelines and pharmacopoeial standards for pharmaceutical impurities: Overview and critical assessment

作者：David J. Snodin^a ; ^{snodind@xiphora.com} ; Sean D. McCrossen^b

关键词：Impurities ; Toxicology ; Genotoxic ; TTC ; Drug safety ; Risk assessment ; Analysis ; Pharmacopoeia ; ICH ; Guideline ; Qualification

刊名：Regulatory Toxicology and Pharmacology

出版年：2012

6.Validation of an in vitro contractility assay using canine ventricular myocytes

作者：A.R. Harmer ; ^{alex.harmer@astrazeneca.com} ; N. Abi-Gerges ; M.J. Morton ; G.F. Pullen ; J.P. Valentin ; C.E. Pollard

关键词：Safety assessment ; Cardiac contractility ; Inotropy ; Cardiotoxicity ; Cardiomyocyte ; Left ventricular function

刊名：Toxicology and Applied Pharmacology

出版年：2012

7.Comparative toxicokinetics of low-viscosity mineral oil in Fischer 344 rats, Sprague-Dawley rats, and humans - Implications for an Acceptable Daily Intake (ADI)

作者：Peter J. Boogaard^a ; ^{peter.boogaard@shell.com} ; Katy O. Goyak^b ; Robert W. Biles^b ; Leo L.P. van Stee^c ; Matthew S. Miller^d ; Mary Jo Miller^d

关键词：Highly refined base oil ; Low-viscosity white oil ; White oil ; Mineral oil ; Toxicokinetics ; ADI ; Rat ; Human ; Strain differences ; Internal dose metric ; Steady-state concentration ; Target dose

刊名：Regulatory Toxicology and Pharmacology

出版年：2012

8.In vivo genotoxicity of furan in F344 rats at cancer bioassay doses

作者：Wei Ding^a ; ^{Wei.Ding@fda.hhs.gov} ; Dayton M. Petibone^a ; John R. Latendresse^b ; Mason G. Pearce^a ; Levan Muskhelishvili^b ; Gene A. White^b ; Ching-Wei Chang^c ; Roberta A. Mittelstaedt^a ; Joseph G. Shaddock^a ; Lea P. McDaniel^a ; Daniel R. Doerge^d ; Suzanne M. Morris^a ; Michelle E. Bishop^a ; Mugimane G. Manjanatha^a ; Anane Aidoo^a ; Robert H. Heflich^a

关键词：Fpg ; formamidopyrimidine DNA glycosylase ; EndoIII ; endonuclease-III ; BDA ; cis-2-butene-1 ; 4-dial ; ROS ; reactive oxygen species ; GSH ; glutathione ; BER ; base excision repair ; NER ; nucleotide excision repair ; DSBR ; DNA double-strand break repair ; MMR ; DNA mis

刊名：Toxicology and Applied Pharmacology

出版年：2012

9.The use of ex vivo human skin tissue for genotoxicity testing

作者：Astrid A. Reus^a ; Mustafa Usta^a ; Cyrille A.M. Krul^b ; ^{cyrille.krul@tno.nl}

关键词：Genotoxicity testing ; Ex vivo human skin ; Comet assay

刊名：Toxicology and Applied Pharmacology

出版年：2012

10.Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells

作者：Yi Luo ; ^{yi.luo@pfizer.com} ; Payal Rana ; Yvonne Will

关键词：CsA ; cyclosporine A ; ROS ; reactive oxygen species ; LDH ; Lactate Dehydrogenase ; OCR ; Oxygen Consumption Rate ; GSH ; Reduced glutathione ; GSSG ; oxidized glutathione ; JNK ; c-Jun N-terminal kinase ; FFA ; free fatty acids

刊名：Toxicology and Applied Pharmacology

出版年：2012

1

2

3

4

5

6

7

8

9

按检索点细分(885)

刊名(846)

文摘(2)

按出版年细分(885)

2000年及以前(46)

2002年(5)

2003年(9)

2004年(32)

2005年(410)

2006年(191)

2007年(86)

2008年(1)

2009年(5)

2012年(100)

常见问题　|　交通位置　|　联系我们　|　OA远程办公

© 2004-2018 中国地质图书馆版权所有京ICP备05064691号京公网安备11010802017129号

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700