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在“Elsevier”中，命中：1,336条，耗时：小于0.01 秒

1.Clinical and biological significance of Cdk10 in hepatocellular carcinoma

作者：Xiang-yu Zhong^a ; ¹ ; Xiao-xue Xu^b ; ¹ ; Jian-hua Yu^a ; Gui-xing Jiang^a ; Yang Yu^c ; Sheng Tai^a ; Zhi-dong Wang^a ; Yun-fu Cui^a ; ^{yfcui777@yahoo.cn}

关键词：HCC ; Hepatocellular carcinoma ; HBV ; hepatitis B virus ; HCV ; hepatitis C virus ; AFP ; alpha fetoprotein ; Cdk ; Cyclin-dependent kinase ; LOH ; loss of heterozygosity ; pCMV6-CDK10 ; Cdk10-expressing plasmid ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazol

刊名：Gene

出版年：2012

2.Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx

作者：Chi Zhang^a ; ^{Chi5.Zhang@utsouthwestern.edu} ; Hui Dai^b ; Benoit de Crombrugghe^b

关键词：Osx ; osterix ; Dkk1 ; Dickkopf 1 ; OC ; osteocalcin ; E15.5 ; embryonic day 15.5 ; E18.5 ; embryonic day 18.5 ; ChIP ; chromatin immunoprecipitation ; Dox ; Doxycycline ; LRP ; low-density lipoprotein receptor-related protein

刊名：Biochemical and Biophysical Research Communications

出版年：2012

3.2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1

作者：Sté ; phanie Blanchard ; ^{stephanie_blanchard@sbio.com} ; Chang Kai Soh ; Chai Ping Lee ; Anders Poulsen ; Zahid Bonday ; Kay Lin Goh ; Kee Chuan Goh ; Miah Kiat Goh ; Mohammed Khalid Pasha ; Haishan Wang ; Meredith Williams ; Jeanette M. Wood ; Kantharaj Ethirajulu ; Brian W. Dymock

关键词：3-Phosphoinositide-dependent kinase 1 (PDK1) ; PI3K ; Akt ; CDK2 ; 4-Aryl-purine

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

4.Crosstalk between cdk5 and MEK-ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain

作者：A. Ramos-Miguel^&dagger ; ; J.A. Garcí ; a-Sevilla ; ^{jesus.garcia-sevilla@uib.es}

关键词：BCA ; bicinchoninic acid ; cAMP ; cyclic AMP ; cdk5 ; cyclin-dependent kinase 5 ; ctx ; cerebral cortex ; DARPP-32 ; dopamine- and cAMP-regulated phosphoprotein of 32 ; kDa ; DMSO ; dimethyl sulphoxide ; ECL ; enhanced chemiluminescence ; ERK ; extracellular signal-r

刊名：Neuroscience

出版年：2012

5.Role of Mos/MEK/ERK cascade and Cdk1 in Ca²⁺ oscillations in fertilized ascidian eggs

作者：Noburu Sensui^a ; Manabu Yoshida^b ; ^c ; ^{yoshida@mmbs.s.u-tokyo.ac.jp} ; Kazunori Tachibana^d

关键词：[Ca2+]i oscillations ; ERK ; Cdk1 ; Ascidian egg ; Fertilization ; Phallusia nigra

刊名：Developmental Biology

出版年：2012

6.A girl with early-onset epileptic encephalopathy associated with microdeletion involving CDKL5

作者：Hirotomo Saitsu^a ; ^{hsaitsu@yokohama-cu.ac.jp} ; Hitoshi Osaka^b ; Kiyomi Nishiyama^a ; Yoshinori Tsurusaki^a ; Hiroshi Doi^a ; Noriko Miyake^a ; Naomichi Matsumoto^a

关键词：CDKL5 ; Microdeletion ; Early-onset epileptic encephalopathy ; Rett syndrome-like features

刊名：Brain and Development

出版年：2012

7.Pharmacophore identification, docking and 鈥渋n silico鈥?screening for novel CDK1 inhibitors

作者：Xiaowu Dong ; Jingying Yan ; Lilin Du ; Peng Wu ; Shufang Huang ; Tao Liu ; ^{lt601@zju.edu.cn} ; Yongzhou Hu ; ^{huyz@zju.edu.cn}

关键词：CDK1 inhibitors ; Pharmacophore ; HypoGen ; Homology modeling ; LigandFit

刊名：Journal of Molecular Graphics and Modelling

出版年：2012

8.Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation

作者：Mi-Gyeong Kim ; Jae-Su Moon ; Eun-Jung Kim ; Seung-Hoon Lee ; Jong-Won Oh ; ^{jwoh@yonsei.ac.kr}

关键词：Hsp90 ; heat shock protein 90 ; HCV ; hepatitis C virus ; RdRp ; RNA-dependent RNA polymerase ; 17-DMAG ; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin ; PDK1 ; phosphoinositide-dependent kinase-1 ; PRK2 ; protein kinase C-related kinase 2

刊名：Biochemical and Biophysical Research Communications

出版年：2012

9.Role of tau kinases (CDK5R1 and GSK3B) in Parkinson's disease: A study from India

作者：Gautami Das^a ; Amar K. Misra^b ; Shyamal K. Das^b ; Kunal Ray^c ; Jharna Ray^a ; ^{jharnaray@gmail.com} ; ^{thisisjr@rediffmail.com}

关键词：CDK5R1 ; GSK3B ; Gene-gene interaction ; MAPT ; Parkinson's disease (PD) ; SNP

刊名：Neurobiology of Aging

出版年：2012

10.Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening

作者：Angeline C.-H. Lee^&dagger ; ; Pondy Murugappan Ramanujulu^&dagger ; ; Anders Poulsen ; Meredith Williams ; Sté ; phanie Blanchard ; Diana M. Ma ; Zahid Bonday ; Kay Lin Goh ; Kee Chuan Goh ; Miah Kiat Goh ; Jeanette Wood ; Brian W. Dymock ; ^{phadbw@nus.edu.sg}

关键词：3-Phosphoinositide dependent protein kinase-1 (PDK1) ; Fragment screening ; Kinase inhibitor design ; Ligand efficiency

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

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