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在“Elsevier”中，命中：705条，耗时：0.0919522 秒

1.Prodrug approaches to reduce hyperexcitation in the CNS

作者：Devaiah Vytla^a ; ^b ; Rosamund E. Combs-Bachmann^b ; Amanda M. Hussey^a ; ¹ ; Stephen T. McCarron^a ; ¹ ; Devon S. McCarthy^a ; James J. Chambers^a ; ^b ; ^{chambers@chem.umass.edu}

关键词：CNS prodrug ; Hyperexcitation prodrug ; Receptors ; Targeting ; Stroke ; Alzheimer's disease

刊名：Advanced Drug Delivery Reviews

出版年：2012

2.Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs

作者：Rahul S. Nandurdikar^a ; ^{nandurdikarr@mail.nih.gov} ; Anna E. Maciag^b ; Ryan J. Holland^a ; Zhao Cao^b ; Paul J. Shami^c ; Lucy M. Anderson^a ; Larry K. Keefer^a ; Joseph E. Saavedra^b ; ^{saavedjo@mail.nih.gov}

关键词：Nitric oxide ; Diazeniumdiolate prodrugs ; JS-K ; Glutathione ; Anti-cancer agents

刊名：Bioorganic and Medicinal Chemistry

出版年：2012

3.Therapeutic efficacy of a lipid-based prodrug of mitomycin C in pegylated liposomes: Studies with human gastro-entero-pancreatic ectopic tumor models

作者：Alberto Gabizon^a ; ^b ; ^{albertog@ekmd.huji.ac.il} ; Yasmine Amitay^c ; Dina Tzemach^a ; Jenny Gorin^a ; Hilary Shmeeda^a ; Samuel Zalipsky^d

关键词：Liposome ; Mitomycin C ; Cancer ; Chemotherapy ; Prodrug

刊名：Journal of Controlled Release

出版年：2012

4.Assessment of enzymatic prodrug stability in human, dog and simulated intestinal fluids

作者：A.S. Borde^a ; E.M. Karlsson^a ; K. Andersson^a ; K. Bjö ; rhall^a ; H. Lennernä ; s^b ; B. Abrahamsson^a ; ^{bertil.abrahamsson@astrazeneca.com}

关键词：Enzymatic stability ; Prodrug ; Human intestinal fluid ; Pancreatin ; FaSSIF ; SDS&ndash ; PAGE gel

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2012

5.An unusually cold active nitroreductase for prodrug activations

作者：Ayhan Ç ; elik ; ^{ayhancelik@gyte.edu.tr} ; Gü ; lden Yeti艧

关键词：Nitroreductase ; Cold active enzyme ; Prodrug activation ; CB1954 ; Staphylococcus saprophyticus ; Nitrofurazone

刊名：Bioorganic and Medicinal Chemistry

出版年：2012

6.PEG prodrug of gambogic acid: Amino acid and dipeptide spacer effects

作者：Ya Ding^a ; ^b ; Peng Zhang^b ; Xiao-Yan Tang^b ; Can Zhang^a ; ^b ; ^{zhangcan@cpu.edu.cn} ; Song Ding^b ; Hai Ye^b ; Qi-Long Ding^b ; Wen-Bin Shen^c ; Qi-Neng Ping^b

关键词：Polymeric prodrug ; Gambogic acid ; Poly(ethylene glycol)

刊名：Polymer

出版年：2012

7.Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin 鈥?are they prodrugs?

作者：Cica Vissiennon^a ; ^b ; Karen Nieber^b ; Olaf Kelber^c ; Veronika Butterweck^a ; ^{butterwk@cop.ufl.edu}

关键词：Flavonoids ; Prodrugs ; Intestinal microflora ; Gut sterilization ; p-Hydroxyphenylacetic acid ; DOPAC

刊名：Journal of Nutritional Biochemistry

出版年：2012

8.Discovery of 4鈥?azido-2鈥?deoxy-2鈥?C-methyl cytidine and prodrugs thereof: A potent inhibitor of Hepatitis C virus replication

作者：Magnus Nilsson^a ; ^{magnus.k.nilsson@telia.com} ; Genadiy Kalayanov^a ; Anna Winqvist^a ; Pedro Pinho^a ; Christian Sund^a ; Xiao-Xiong Zhou^a ; Horst Wä ; hling^a ; Anna-Karin Belfrage^a ; Michael Pelcman^a ; Tatiana Agback^a ; Kurt Benckestock^a ; Kristina Wikströ ; m^a ; Mirva Boothee^a ; Anneli Lindqvist^a ; Christina Rydegå ; rd^a ; Tim H.M. Jonckers^b ; Koen Vandyck^b ; Pierre Raboisson^b ; Tse-I Lin^b ; Sophie Lachau-Durand^b ; Herman de Kock^b ; David B. Smith^c ; Joseph A. Martin^c ; Klaus Klumpp^c ; Kenneth Simmen^b ; Lotta Vrang^a ; Ylva Terelius^a ; Bertil Samuelsson^a ; Å ; sa Rosenquist^a ; Nils Gunnar Johansson^a

关键词：Hepatitis C virus ; NS5B polymerase ; Antivirals ; Nucleoside ; Prodrug ; Phosphoramidate

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

9.Design and synthesis of prodrugs of the rat selective toxicant norbormide

作者：David Rennison^a ; ^{d.rennison@auckland.ac.nz} ; Olivia Laita^a ; Sergio Bova^b ; Maurizio Cavalli^b ; Brian Hopkins^c ; Darwin S. Linthicum^c ; Margaret A. Brimble^a ; ^{d.rennison@auckland.ac.nz}

关键词：Norbormide ; Prodrug ; Rodenticide ; Rat toxicant

刊名：Bioorganic and Medicinal Chemistry

出版年：2012

10.A histone deacetylase inhibitory prodrug - Butyroyloxymethyl diethyl phosphate - Protects the heart and cardiomyocytes against ischemia injury

作者：G. Kessler-Icekson^a ; ^b ; ^{icekson@post.tau.ac.il} ; E. Hochhauser^a ; ^c ; T. Sinai^a ; ^b ; A. Kremer^a ; ^b ; J. Dick^a ; ^b ; N. Tarasenko^a ; V. Nudelman^a ; ^b ; H. Schlesinger^a ; S. Abraham^a ; A. Nudelman^d ; A. Rephaeli^a

关键词：Histone deacetylase inhibitor ; Butyric acid ; Prodrug ; Ischemia/reperfusion ; Cardioprotection ; Heme oxygenase-1

刊名：European Journal of Pharmaceutical Sciences

出版年：2012

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