Records of unconformities and lithologic facies and analysis of paleo-structure show that at least eleven tectonic boundaries exist in the Meso-Cenozoic continental strata in the western Sichuan Depression. Affected by the Longmenshan thrust belt on the west side, Micangshan structural belt on the north side and Chuandian structural belt on the southwest side, NE-trending, sub-EW-trending and sub-NS-trending structures were developed correspondingly in the Western Sichuan Depression. Accurate reconstruction of the Indosinian-Yanshanian paleo-structures and fracture behaviors during the multi-stage and multi-direction structural superimposition are two important aspects that need to be paid more attention to.