Yangjiaopu protective district located in Fengfeng mining site is a large water source district. About 90 000 m3 of karst water from Ordovician is explored in Yangjiaopu every day. According the state’s regulation, this paper simulate and forecast the solute transport of Yangjiaopu karst groundwater system using numerical simulation method with visual modflow software, to divide the extent of the water source protective zones in different grade. The area delimited by the radius of solutes transport for 1 000 days, is consider as the second-grade protection zone. The bare Ordovician Limestone area recharging the karst water subsystem could be divided into prospective protection zone.