For the Ms7.1 earthquake in Yushu on April 14, 2010, we used InSAR data to give the spatial distribution of the seismogenic fault which is determined by the displacement in co-seismic line of sight, and used the co-seismic dislocation as constraints in the inversion to determine the co-seismic slip distribution of main shock and the largest aftershock. The results showed that, the co-seismic slip of main shock occurred in East Yushu fault, and the co seismic slip of the largest aftershock occurred at the eastern end of the West Yushu fault. Based on this slip distribution, we calculated the co-seismic Coulomb stress changes, and discussed its relationship with the seismicity in the western aftershocks concentration area. The result indicates that the most active aftershock activity after Yushu main shock was probably controlled by the secondary fault in near EW direction (strike about 85~), instead of Yushu main fault. The Yushu fault overall presents the left-lateral strike-slip movement, however, the specific movement form of fault shows different deformation characteristics, typical strike-slip movement on major fault, extensional and thrust secondary movement between strike-slip faults, and the more complex multi-directional secondary fault activity under the interaction of the secondary faults and the major fault. The co-seismic slip of main shock and spatial distribution of aftershocks both has a close relationship with these different fault deformations.