The Chaoshan Depression, where the Mesozoic strata well developed, is an important mothball area for gas and oil exploration in the South China Sea. This paper analyzes the types and properties of the multiples, trying to suppress multiples using combination method with predictive deconvolution in τ-p domain, Surface Related Multiples Elimination (SRME) and Hyperbolic Radon transform. SRME method is used for suppressing surface-related multiples well, especially in the near-offset range; and hyperbolic radon transform is a good choice to attenuate long-period and surface-related multiples that are not sufficiently suppressed.